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Protein Overview: PRP2

General Information:
Name(s) found: PRP2 / YNR011C [SGD]
Description(s) found:
Found 30 descriptions.
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  • RNA-dependent ATPase in the DEAH-box family, required for activation of the spliceosome before the first transesterification step in RNA splicing [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 876 amino acids

    Gene Ontology:
    Cellular Component: nucleus [TASLink to PubMed article]
    spliceosomal complex [TASLink to PubMed article]
    Biological Process: RNA splicing [IEA]
    generation of catalytic spliceosome for first transesterification step [IDA]
    mRNA processing [IEA]
    Molecular Function: ATP-dependent RNA helicase activity [TASLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSSITSETGK RRVKRTYEVT RQNDNAVRIE PSSLGEEEDK EAKDKNSALQ LKRSRYDPNK  60
   61 VFSNTNQGPE KNNLKGEQLG SQKKSSKYDE KITSNNELTT KKGLLGDSEN ETKYASSNSK 120
  121 FNVEVTHKIK NAKEIDKINR QRMWEEQQLR NAMAGQSDHP DDITLEGSDK YDYVFDTDAM 180
  181 IDYTNEEDDL LPEEKLQYEA RLAQALETEE KRILTIQEAR KLLPVHQYKD ELLQEIKKNQ 240
  241 VLIIMGETGS GKTTQLPQYL VEDGFTDQGK LQIAITQPRR VAATSVAARV ADEMNVVLGK 300
  301 EVGYQIRFED KTTPNKTVLK YMTDGMLLRE FLTDSKLSKY SCIMIDEAHE RTLATDILIG 360
  361 LLKDILPQRP TLKLLISSAT MNAKKFSEFF DNCPIFNVPG RRYPVDIHYT LQPEANYIHA 420
  421 AITTIFQIHT TQSLPGDILV FLTGQEEIER TKTKLEEIMS KLGSRTKQMI ITPIYANLPQ 480
  481 EQQLKIFQPT PENCRKVVLA TNIAETSLTI DGIRYVIDPG FVKENSYVPS TGMTQLLTVP 540
  541 CSRASVDQRA GRAGRVGPGK CFRIFTKWSY LHELELMPKP EITRTNLSNT VLLLLSLGVT 600
  601 DLIKFPLMDK PSIPTLRKSL ENLYILGALN SKGTITRLGK MMCEFPCEPE FAKVLYTAAT 660
  661 HEQCQGVLEE CLTIVSMLHE TPSLFIGQKR DAAASVLSEV ESDHILYLEI FNQWRNSKFS 720
  721 RSWCQDHKIQ FKTMLRVRNI RNQLFRCSEK VGLVEKNDQA RMKIGNIAGY INARITRCFI 780
  781 SGFPMNIVQL GPTGYQTMGR SSGGLNVSVH PTSILFVNHK EKAQRPSKYV LYQQLMLTSK 840
  841 EFIRDCLVIP KEEWLIDMVP QIFKDLIDDK TNRGRR

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Riffle et al. (2010) (Unpublished Data) PRP2 PRP45
    View Details (MIPS) Mewes HW, et al. (2004) AAR2 BRR1 BRR2 CBC2 CDC40 CWC15 CWC2 CWC22 CWC23 DHR2 LSM4 MAK5 MUD2 PRP16 PRP18 PRP2 PRP22 PRP24 PRP28 PRP31 PRP38 PRP39 PRP4 PRP40 PRP43 PRP5 PRP6 PRP8 SLU7 SMD1 SMD3 SME1 SNP1 SPP2 SPP381 STO1 YHC1
    View Details Krogan NJ, et al. (2006) AAR2 BRR1 BRR2 CSE1 LUC7 MUD1 NAM8 PRP2 PRP3 PRP31 PRP39 PRP40 PRP42 PRP6 PRP8 RRG7 SMB1 SMD1 SMD2 SMD3 SME1 SMX2 SMX3 SNP1 SNU114 SNU56 SNU66 SNU71 TAD2 YDL085C-A YHC1 YJU2 YNL092W
    View Details Gavin AC, et al. (2002) BUD31 CDC40 CEF1 CLF1 CWC2 CWC22 CWC23 ECM2 HSH155 ISY1 LEA1 PRP19 PRP2 PRP21 PRP22 PRP43 PRP45 PRP46 RSE1 SMD2 SNT309 SNU114 SPP382 STO1 SYF1
    View Details Qiu et al. (2008) AAR2 BRR1 BRR2 BUD31 CBC2 CDC40 CEF1 CLF1 CUS1 CUS2 CWC15 CWC2 CWC21 CWC22 CWC23 CWC25 DHR2 DIB1 ECM2 GTS1 HSH155 IST3 ISY1 LEA1 LSM2 LSM3 LSM4 LSM5 LSM6 LSM7 LSM8 LUC7 MAK5 MSL1 MUD1 MUD2 NAM8 NTC20 PAB1 PRP11 PRP16 PRP18 PRP19 PRP2 PRP21 PRP22 PRP24 PRP28 PRP3 PRP31 PRP38 PRP39 PRP4 PRP40 PRP42 PRP43 PRP45 PRP46 PRP5 PRP6 PRP8 PRP9 RSE1 SLU7 SMB1 SMD1 SMD2 SMD3 SME1 SMX2 SMX3 SNP1 SNT309 SNU114 SNU23 SNU56 SNU66 SNU71 SPP2 SPP381 SPP382 STO1 SUB2 SYF1 SYF2 YHC1 YJU2

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run MLP2 #25 Asynchronous Prep3-TiO2 Flowthrough Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data PRP2 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..165] MSA 2.520994 View MSA. No confident structure predictions are available.
    2 View Details [166..600] PSI-BLAST 68.09691 Initiation factor 4a
    3 View Details [601..697] MSA 1.52099 View MSA. Confident ab initio structure predictions are available.
    4 View Details [698..876] MSA 3.169976 View MSA. No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2
    Term Confidence Notes
    		• 4.704140727858 bayes_pls_golite062009
  • binding
    		•  2.44689197844883 bayes_pls_golite062009
  • RNA binding
    		•  2.29590582680214 bayes_pls_golite062009
  • structural constituent of ribosome
    		•  1.57653963868443 bayes_pls_golite062009
  • RNA helicase activity
    		•  1.42791449104435 bayes_pls_golite062009
  • nucleic acid binding
    		•  1.41477043612798 bayes_pls_golite062009
  • RNA-dependent ATPase activity
    		•  1.39335733374328 bayes_pls_golite062009
  • ATP-dependent RNA helicase activity
    		•  1.36724390116598 bayes_pls_golite062009
  • DNA binding
    		•  1.11699929651302 bayes_pls_golite062009
  • catalytic activity
    		•  1.00104173493322 bayes_pls_golite062009
  • transcription regulator activity
    		•  0.989226939888218 bayes_pls_golite062009
  • mRNA binding
    		•  0.76699944561918 bayes_pls_golite062009
  • general RNA polymerase II transcription factor activity
    		•  0.652333406433794 bayes_pls_golite062009
  • helicase activity
    		•  0.6191010101321 bayes_pls_golite062009
  • motor activity
    		•  0.61636596887462 bayes_pls_golite062009
  • structural molecule activity
    		•  0.596382945962261 bayes_pls_golite062009
  • hydrolase activity, acting on acid anhydrides
    		•  0.461763181659193 bayes_pls_golite062009
  • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
    		•  0.458831409927227 bayes_pls_golite062009
  • pyrophosphatase activity
    		•  0.455976987338331 bayes_pls_golite062009
  • nucleoside-triphosphatase activity
    		•  0.422944846459286 bayes_pls_golite062009
  • snRNA binding
    		•  0.418985924846052 bayes_pls_golite062009
  • purine NTP-dependent helicase activity
    		•  0.29664013896754 bayes_pls_golite062009
  • ATP-dependent helicase activity
    		•  0.29664013896754 bayes_pls_golite062009
  • translation release factor activity
    		•  0.178286731022211 bayes_pls_golite062009
  • translation termination factor activity
    		•  0.151456842619444 bayes_pls_golite062009
  • nucleotide binding
    		•  0.114848452385726 bayes_pls_golite062009
  • purine nucleotide binding
    		•  0.10713474095071 bayes_pls_golite062009
  • purine ribonucleotide binding
    		•  0.0916519414118148 bayes_pls_golite062009
  • ribonucleotide binding
    		•  0.0915913646217636 bayes_pls_golite062009
  • protein binding
    		•  0.071010918255742 bayes_pls_golite062009
  • transcription factor activity
    		•  0.0434163635422169 bayes_pls_golite062009
  • cytoskeletal protein binding
    		•  0.0272673919333979 bayes_pls_golite062009
    3 No functions predicted.
    4 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.98

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle