Protein Overview: AAC1

General Information:
Name(s) found:	AAC1 / YMR056C [SGD]
Description(s) found: SHOW ONLY BEST	pir\|\|A24849 ADP,ATP carrier protein AAC1 - yeast (Saccharomyces cerevisiae) [NCBI NR] gi\|817889\|emb\|CAA89766.1\| Aac1p [Saccharomyces cerevisiae] [NCBI NR] gi\|6323701\|ref\|NP_013772.1\| Mitochondrial inner membrane ADP/ATP translocator, exchanges cytosolic ADP for mitochondrially synthesized ATP; phosphorylated; Aac1p is a minor isoform while Pet9p is the major ADP/ATP translocator; Aac1p [Saccharomyces cerevi [NCBI NR] gi\|172134\|gb\|AAA97486.1\| ADP/ATP translocator [NCBI NR] gi\|113458\|sp\|P04710.1\|ADT1_YEAST RecName: Full=ADP,ATP carrier protein 1; AltName: Full=ADP/ATP translocase 1; AltName: Full=Adenine nucleotide translocator 1; Short=ANT 1 [NCBI NR] ADP,ATP carrier protein 1 OS=Saccharomyces cerevisiae GN=AAC1 PE=1 SV=1 [Swiss-Prot] AAC1 Mitochondrial ADP/ATP carrier - member of the mitochondrial carrier (MCF) family [mips] Mitochondrial inner membrane ADP/ATP translocator, exchanges cytosolic ADP for mitochondrially synthesized ATP; phosphorylated; Aac1p is a minor isoform while Pet9p is the major ADP/ATP translocator [SGD] AAC1, Chr XIII from 387314-388243, reverse complement [yeast_orfs2] Chr XIII from 387314-388243, reverse complement [yeastorf3.fasta] Chr XIII from 388243-387314, reverse complement [yeastorf5.fasta] (P04710) ADP,ATP carrier protein 1 (ADP/ATP translocase 1) (Adenine nucleotide translocator 1) (ANT 1) [4932.FASTACCERV.txt] AAC1 SGDID:S0004660, Chr XIII from 388243-387314, reverse complement, Verified ORF [yeastflysequest.fasta] Aac1p [Saccharomyces cerevisiae]gi\|817889\|emb\|CAA89766.1\| Aac1p [Saccharomyces cerevisiae]gi\|113458\|sp\|P04710\|ADT1_YEAST ADP,ATP carrier protein 1 (ADP/ATP translocase 1) (Adenine nucleotide translocator 1) (ANT 1)gi\|82891\|pir\|\|A24849 ADP,ATP carrier p [nrdb_11152004_Chlamydomonas] AAC1 SGDID:S000004660, Chr XIII from 388243-387314, reverse complement, Verified ORF, "Mitochondrial inner membrane ADP/ATP translocator, exchanges cytosolic ADP for mitochondrially synthesized ATP; Aac1p is a minor isoform while Pet9p is the major ADP/AT [SGD_S-cerevisiae_na_12-16-2005_con_reversed.fasta] AAC1 SGDID:S000004660, Chr XIII from 388243-387314, reverse complement, Verified ORF, "Mitochondrial inner membrane ADP/ATP translocator, exchanges cytosolic ADP for mitochondrially synthesized ATP; phosphorylated; Aac1p is a minor isoform while Pet9p is [SGD_S-cerevisiae_na_08-19-2008_con_reversed.fasta] Aac1p [Saccharomyces cerevisiae] [nr-271106-contam.fasta] ADP/ATP translocator [nr-271106-contam.fasta] ADP,ATP carrier protein 1 (ADP/ATP translocase 1) (Adenine nucleotide translocator 1) (ANT 1) [nr-271106-contam.fasta] Mitochondrial inner membrane ADP/ATP translocator, exchanges cytosolic ADP for mitochondrially synthesized ATP; Aac1p is a minor isoform while Pet9p is the major ADP/ATP translocator; Aac1p [Saccharomyces cerevisiae] [nr-271106-contam.fasta] AAC1 SGDID:S000004660, Chr XIII from 388243-387314, reverse complement, Verified ORF, "Mitochondrial inner membrane ADP/ATP translocator, exchanges cytosolic ADP for mitochondrially synthesized ATP; phosphorylated; Aac1p is a minor isoform while Pet9p is the major ADP/ATP translocator" [yeast-bovrabprots.fasta] AAC1 SGDID:S000004660, Chr XIII from 388243-387314, reverse complement, Verified ORF, "Mitochondrial inner membrane ADP/ATP translocator, exchanges cytosolic ADP for mitochondrially synthesized ATP; Aac1p is a minor isoform while Pet9p is the major ADP/ATP translocator" [yeast-contam_custom.fasta] [chemostatdb.fasta] ADP,ATP carrier protein 1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=AAC1 PE=1 SV=1 [UniProt_S_cerevisiae_20120516_05-16-2012_reversed.fasta] AAC1 SGDID:S000004660, Chr XIII from 388244-387315, Genome Release 64-1-1, reverse complement, Verified ORF, "Mitochondrial inner membrane ADP/ATP translocator, exchanges cytosolic ADP for mitochondrially synthesized ATP; phosphorylated; Aac1p is a minor isoform while Pet9p is the major ADP/ATP translocator" [yeast-030211-contam.fasta] AAC1 SGDID:S000004660, Chr XIII from 388244-387315, Genome Release 64-2-1, reverse complement, Verified ORF, "Mitochondrial inner membrane ADP/ATP translocator; exchanges cytosolic ADP for mitochondrially synthesized ATP; phosphorylated; Aac1p is a minor isoform while Pet9p is the major ADP/ATP translocator; relocalizes from mitochondrion to cytoplasm upon DNA replication stress" [20141208_orf_trans.fasta] YMR056C SGDID:S000004660, Chr XIII from 388244-387315, Genome Release 64-1-1, reverse complement, Verified ORF, "Mitochondrial inner membrane ADP/ATP translocator, exchanges cytosolic ADP for mitochondrially synthesized ATP; phosphorylated; Aac1p is a minor isoform while Pet9p is the major ADP/ATP translocator" [2016-01-SGD_Yeast_Contam_Riffle_20140507-Ska-Hec-110-tubulin.fasta]
Organism:	Saccharomyces cerevisiae
Length:	309 amino acids
Gene Ontology:
Cellular Component:	mitochondrion [IDA] mitochondrial inner membrane [TAS]
Biological Process:	mitochondrial transport [IGI] aerobic respiration [IGI]
Molecular Function:	ATP:ADP antiporter activity [IDA]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSHTETQTQQ SHFGVDFLMG GVSAAIAKTG AAPIERVKLL MQNQEEMLKQ GSLDTRYKGI  60
   61 LDCFKRTATH EGIVSFWRGN TANVLRYFPT QALNFAFKDK IKSLLSYDRE RDGYAKWFAG 120
  121 NLFSGGAAGG LSLLFVYSLD YARTRLAADA RGSKSTSQRQ FNGLLDVYKK TLKTDGLLGL 180
  181 YRGFVPSVLG IIVYRGLYFG LYDSFKPVLL TGALEGSFVA SFLLGWVITM GASTASYPLD 240
  241 TVRRRMMMTS GQTIKYDGAL DCLRKIVQKE GAYSLFKGCG ANIFRGVAAA GVISLYDQLQ 300
  301 LIMFGKKFK

Protein Complex Data

	PUBLICATION	TOPOLOGY	COCOMPLEXED PROTEINS
View Details	Ho Y, et al. (2002)		AAC1 AAC3 ADE5,7 AHA1 ARC1 ARO1 ARP2 ATG11 ATG12 ATG17 ATP3 CAR2 CPA2 CPR6 FET4 GCD11 GFA1 GUS1 IDH2 IPP1 KIN28 MDH1 MET18 PPX1 PRB1 PTC7 RAD3 REP1 REX2 RPN10 RPN11 RPN3 RPN5 RPN6 RPN7 RPN8 RPT1 RPT3 SEC18 TCB1 TFB3 TFP1 TIF1, TIF2 TYR1 YBR184W YHR020W YHR033W YNL208W
View Details	Qiu et al. (2008)		AAC1 AAC3 COB COX1 COX2 COX3 COX4 ODC1 PET9 QCR7 QCR8 QCR9 RIP1

Mass Spectrometry Data

The following runs contain data for this protein:

	BAIT	COMMENTS	PUBLICATION
View Run	ZDS1	Sample 2- cpn2 from june 2005	McCusker D, et al (2007)
View Run	MLP2	#32 Asynchronous Prep-No Phosphopeptide enrichment	Keck JM, et al. (2011)
View Run	MLP2	#03 Alpha Factor Prep1-TiO2 Flowthrough	Keck JM, et al. (2011)

Yeast Two-Hybrid Data

The following interactions contain this protein:

SHOWING SINGLE HITS. [ Hide Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

	BAIT	PREY	HITS	PUBLICATION
View Screen	PHO85	AAC1	1	Unpublished Fields Lab Data

Microscopy / Localization Data

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	PROTEIN(S)	PUBLICATION
View Data	AAC1	Huh WK, et al. (2003)

Protein Structure Data

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Domains predicted:

#		Region(s)	Method	Confidence	Match Description
1	View Details	[1..309]	ORFEUS	7.3	Peroxisomal acyl-CoA oxidase-II, domains 3 and 4; Peroxisomal acyl-CoA oxidase-II, domains 1 and 2

Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

Philius Transmembrane Prediction:

[View Details]

Source: Reynolds et al. 2008. Manuscript submitted

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2