Protein Overview: MRPL4

General Information:
Name(s) found:	MRPL4 / YLR439W [SGD]
Description(s) found: SHOW ONLY BEST	gi\|665968\|gb\|AAB67513.1\| Mrpl4p: Mitochondrial 60S ribosomal protein L4 [Saccharomyces cerevisiae] [NCBI NR] gi\|6323472\|ref\|NP_013544.1\| Mitochondrial ribosomal protein of the large subunit; Mrpl4p [Saccharomyces cerevisiae] [NCBI NR] pir\|\|S59407 ribosomal protein YmL4 precursor, mitochondrial - yeast (Saccharomyces cerevisiae) [NCBI NR] gi\|1350790\|sp\|P36517.2\|RM04_YEAST RecName: Full=54S ribosomal protein L4, mitochondrial; AltName: Full=YmL4; Flags: Precursor [NCBI NR] 54S ribosomal protein L4, mitochondrial OS=Saccharomyces cerevisiae GN=MRPL4 PE=1 SV=2 [Swiss-Prot] MRPL4 Mitochondrial ribosomal protein, large subunit [mips] Mitochondrial ribosomal protein of the large subunit [SGD] MRPL4, Chr XII from 1014486-1015445 [yeast_orfs2] Chr XII from 1014486-1015445 [yeastorf3.fasta] (P36517) 60S ribosomal protein L4, mitochondrial precursor (YmL4) [4932.FASTACCERV.txt] MRPL4 SGDID:S0004431, Chr XII from 1014487-1015446, Verified ORF [yeastflysequest.fasta] Mitochondrial ribosomal protein of the large subunit [Saccharomyces cerevisiae]gi\|1350790\|sp\|P36517\|RM04_YEAST 60S ribosomal protein L4, mitochondrial precursor (YmL4) (MRP-L4)gi\|1363859\|pir\|\|S59407 ribosomal protein YmL4 precursor, mitochondrial - yeas [nrdb_11152004_Chlamydomonas] (P36517) 60S ribosomal protein L4, mitochondrial precursor (YmL4) (MRP-L4) [cerv4932.FASTAC] MRPL4 SGDID:S000004431, Chr XII from 1014487-1015446, Verified ORF, "Mitochondrial ribosomal protein of the large subunit" [SGD_S-cerevisiae_na_12-16-2005_con_reversed.fasta] MRPL4 SGDID:S000004431, Chr XII from 1014488-1015447, Verified ORF, "Mitochondrial ribosomal protein of the large subunit" [yeast-contam.fasta] Mrpl4p: Mitochondrial 60S ribosomal protein L4 [Saccharomyces cerevisiae] [nr-271106-contam.fasta] Mitochondrial ribosomal protein of the large subunit; Mrpl4p [Saccharomyces cerevisiae] [nr-271106-contam.fasta] 60S ribosomal protein L4, mitochondrial precursor (YmL4) (MRP-L4) [nr-271106-contam.fasta] [chemostatdb.fasta] 54S ribosomal protein L4, mitochondrial OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=MRPL4 PE=1 SV=2 [UniProt_S_cerevisiae_20120516_05-16-2012_reversed.fasta] MRPL4 SGDID:S000004431, Chr XII from 1014491-1015450, Genome Release 64-1-1, Verified ORF, "Mitochondrial ribosomal protein of the large subunit, homolog of prokaryotic L29 ribosomal protein; located at the ribosomal tunnel exit" [yeast-030211-contam.fasta] MRPL4 SGDID:S000004431, Chr XII from 1014491-1015450, Genome Release 64-2-1, Verified ORF, "Mitochondrial ribosomal protein of the large subunit; homolog of prokaryotic L29 ribosomal protein; located at the ribosomal tunnel exit" [20141208_orf_trans.fasta] YLR439W SGDID:S000004431, Chr XII from 1014491-1015450, Genome Release 64-1-1, Verified ORF, "Mitochondrial ribosomal protein of the large subunit, homolog of prokaryotic L29 ribosomal protein; located at the ribosomal tunnel exit" [2016-01-SGD_Yeast_Contam_Riffle_20140507-Ska-Hec-110-tubulin.fasta]
Organism:	Saccharomyces cerevisiae
Length:	319 amino acids
Gene Ontology:
Cellular Component:	mitochondrion [IDA] mitochondrial large ribosomal subunit [TAS]
Biological Process:	translation [TAS]
Molecular Function:	structural constituent of ribosome [TAS]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MWKRSFHSQG GPLRARTKFT KPKPKQPVLP KDKIRPPTQL THHSNNLRIT EPIPPTTSNL  60
   61 RCPDDHPLWQ FFSNKKFIRS ADDLPPSSHI RPWSIPELRH KSFNDLHSLW YNCLREQNVL 120
  121 ARENHLLKNI VGSTHDEFSE LSNSIRTTMW QIRHVLNERE LAYSASREFL QDESERKKFL 180
  181 DTLANDYFLN KDIPDDEVAS MLTRFQLAIF GISETIQDNT VDINFIDGIK FLANLKLQRF 240
  241 KDSNDLISEI SQEPITDVGE SFILFTSDFE PHAVQEACVA IKDLRKSPDN KVPKLDELPT 300
  301 VRKYLKQLIH ASSVEQATA

Protein Complex Data

	PUBLICATION	TOPOLOGY	COCOMPLEXED PROTEINS
View Details	Riffle et al. (2010) (Unpublished Data)		IMG1 IMG2 MHR1 MRP20 MRP49 MRP7 MRPL1 MRPL10 MRPL13 MRPL16 MRPL17 MRPL20 MRPL23 MRPL24 MRPL25 MRPL27 MRPL28 MRPL3 MRPL35 MRPL36 MRPL39 MRPL4 MRPL44 MRPL51 MRPL6 MRPL7 MRPL8 RTC6 UTP20 YML6
View Details	(MIPS) Mewes HW, et al. (2004)		IMG1 IMG2 MNP1 MRP20 MRP49 MRP7 MRPL1 MRPL10 MRPL11 MRPL13 MRPL15 MRPL16 MRPL17 MRPL19 MRPL20 MRPL22 MRPL23 MRPL24 MRPL25 MRPL27 MRPL28 MRPL3 MRPL31 MRPL32 MRPL33 MRPL35 MRPL36 MRPL37 MRPL38 MRPL39 MRPL4 MRPL40 MRPL44 MRPL49 MRPL50 MRPL51 MRPL6 MRPL7 MRPL8 MRPL9 RML2 RTC6 YDR115W YML6
View Details	Krogan NJ, et al. (2006)		IMG2 MRP20 MRPL1 MRPL10 MRPL15 MRPL25 MRPL3 MRPL4 MRPL40 MRPL9
View Details	Gavin AC, et al. (2006)		ATG26 BUD3 MRPL10 MRPL16 MRPL23 MRPL4 MRPL51
View Details	Gavin AC, et al. (2002)		AAR2 ATG26 BEM2 BRR1 BUD3 BUD31 CDC33 CEF1 CLF1 COP1 CSN12 CUS1 CWC2 CWC22 CWC23 CYR1 DHH1 DIB1 ECM2 GCN2 HRR25 HSH155 HTA1 IMG1 IMG2 IML1 LEA1 LIN1 LSM1 LSM2 LSM4 LSM5 LSM6 LSM7 LUC7 MHR1 MRH4 MRM1 MRP20 MRP49 MRP7 MRPL1 MRPL10 MRPL13 MRPL16 MRPL17 MRPL19 MRPL20 MRPL23 MRPL24 MRPL25 MRPL27 MRPL28 MRPL3 MRPL35 MRPL36 MRPL38 MRPL39 MRPL4 MRPL44 MRPL51 MRPL6 MRPL7 MRPL8 MRPS5 MSL1 MUD1 NUG1 PAT1 PRP11 PRP18 PRP19 PRP21 PRP24 PRP28 PRP3 PRP31 PRP38 PRP39 PRP4 PRP40 PRP42 PRP43 PRP46 PRP6 PRP8 PRP9 RET2 ROM2 RSE1 RTC6 RVB2 SEC1 SEC26 SEC27 SIN4 SLU7 SMB1 SMD1 SMD2 SMD3 SME1 SMX2 SMX3 SNF2 SNP1 SNT309 SNU114 SNU23 SNU56 SNU66 SNU71 SPP381 SPP382 SRB2 STO1 SWI3 SYF1 SYP1 TAF5 TOS4 UTP20 UTP21 YDR115W YML6
View Details	Qiu et al. (2008)		IMG1 IMG2 MHR1 MNP1 MRP1 MRP10 MRP17 MRP20 MRP21 MRP4 MRP49 MRP7 MRPL1 MRPL10 MRPL11 MRPL13 MRPL15 MRPL16 MRPL17 MRPL19 MRPL20 MRPL22 MRPL23 MRPL24 MRPL25 MRPL27 MRPL28 MRPL3 MRPL31 MRPL32 MRPL33 MRPL35 MRPL36 MRPL37 MRPL38 MRPL39 MRPL4 MRPL40 MRPL44 MRPL49 MRPL50 MRPL51 MRPL6 MRPL7 MRPL8 MRPL9 MRPS12 MRPS16 MRPS17 MRPS18 PET123 RML2 RSM10 RSM22 RSM24 RSM25 RSM26 RSM27 RSM7 RTC6 YDR115W YML6

Mass Spectrometry Data

No mass spectrometry results found for this protein.

Yeast Two-Hybrid Data

The following interactions contain this protein:

NOT SHOWING SINGLE HITS. [ Show Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

	BAIT	PREY	HITS	PUBLICATION
View Screen	APC9	MRPL4	2	Unpublished Fields Lab Data

Microscopy / Localization Data

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	PROTEIN(S)	PUBLICATION
View Data	MRPL4	Huh WK, et al. (2003)

Protein Structure Data

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[View Top Sequence Alignments] [Show Ginzu Version Information]

Domains predicted:

#		Region(s)	Method	Confidence	Match Description
1	View Details	[1..85]	deduced	N/A	No confident structure predictions are available.
2	View Details	[86..191]	ab initio	7.09	No description for 1ffkS was found.
3	View Details	[192..319]	deduced	N/A	No confident structure predictions are available.

Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

Philius Transmembrane Prediction:

Protein predicted to be:	GLOBULAR (No transmembrane regions or signal peptide)
Confidence of classification:	0.99

Source: Reynolds et al. (2008)

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2