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Protein Overview: CSN12

General Information:
Name(s) found: CSN12 / YJR084W [SGD]
Description(s) found:
Found 27 descriptions.
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  • Subunit of the Cop9 signalosome, which is required for deneddylation, or removal of the ubiquitin-like protein Rub1p from Cdc53p (cullin); involved in mRNA splicing and adaptation to pheromone signaling [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 423 amino acids

    Gene Ontology:
    Cellular Component: signalosome [IDALink to PubMed article]
    Biological Process: adaptation of signaling pathway by response to pheromone involved in conjugation with cellular fusion [IMPLink to PubMed article]
    Molecular Function: molecular_function [ND]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MDVDIGCYFE EKRYDDKLLD FIRYDVKTPK KTKYILQRPT ATDEESVRLQ RFYQLGVDLK  60
   61 LKYSKRRSLK KQGRIKNATE ELLRLANEQL KLFNRIVERE TNWIIYPLWV MAKQLIRLAN 120
  121 ESSELNKDSI EECGRTIHRS FTICLNDRNP RLNENKKIGC YMFANLEFSI YHRLSNKDMI 180
  181 KNLVKVLESR VNARDIPPLN KSLAMEHKSQ VVLYNYYLGQ YYGCLENDHE RGFFHLNEAL 240
  241 LQCPMLYVES TGKFVLQGQM EKIMILLVPL ALLTKRLYPH WDHPVIAGVI TRSKRLSQVY 300
  301 PTLVRSVISG NLSLYEATAA SHERFFLSQG LHVVITLLRE VVFTRLVQRC WQWGNDRKSI 360
  361 MPLKILLATK QHDSSANEDE EEQLDALECR LASAIASGLL RAYLSHSNRC IVFSKKEPFP 420
  421 HSK

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Riffle et al. (2010) (Unpublished Data) CSN12 CUS1 DIB1 HSH155 LEA1 LUC7 MSL1 PRP31 PRP4 PRP40 PRP46 PRP6 PRP9 RSE1 SMB1 SNU114 SNU71 SPP382 STO1
    View Details (MIPS) Mewes HW, et al. (2004) CSN12 CSN9
    View Details Krogan NJ, et al. (2006) ALG5 BRE5 CSN12 CUP2 DBP7 LUG1 MET10 MSC7 MSE1 NOP53 NPY1 PBP4 RPF2 RRS1 SAS5 UME6 YGR126W YHR127W YPR045C YRA1
    View Details Gavin AC, et al. (2002) AAR2 BRR1 BUD31 CBC2 CDC33 CEF1 CLF1 CSN12 CUS1 CWC2 CWC22 CWC23 DHH1 DIB1 ECM2 GCN2 HRT1 HSH155 HSH49 HTA1 IMG1 LEA1 LIN1 LSM1 LSM2 LSM4 LSM5 LSM6 LSM7 LUC7 MRP7 MRPL28 MRPL3 MRPL35 MRPL38 MRPL4 MRPL8 MRPS5 MSL1 MUD1 NAM8 NPL3 PAT1 PRP11 PRP18 PRP19 PRP21 PRP24 PRP28 PRP3 PRP31 PRP38 PRP39 PRP4 PRP40 PRP42 PRP43 PRP46 PRP6 PRP8 PRP9 RSE1 RVB2 SLU7 SMB1 SMD1 SMD2 SMD3 SME1 SMX2 SMX3 SNP1 SNT309 SNU114 SNU23 SNU56 SNU66 SNU71 SPP381 SPP382 SRB2 STO1 SYF1 TIF4631 TIF4632 TOS4 UTP21 YEF3 YML6
    View Details Qiu et al. (2008) CSI1 CSN12 CSN9 RRI1 RRI2

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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      PROTEIN(S) PUBLICATION
    View Data CSN12 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..103] deduced N/A No confident structure predictions are available.
    2 View Details [104..423] MSA 7.028958 View MSA. No confident structure predictions are available.
    3 View Details [356..423] FFAS03 1.96 Solution structure of the PCI domain

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2 No functions predicted.
    3
    Term Confidence Notes
  • transcription regulator activity
    		•  4.13436454849845 bayes_pls_golite062009
  • DNA binding
    		•  3.77959139017704 bayes_pls_golite062009
  • nucleic acid binding
    		•  3.61852605343839 bayes_pls_golite062009
  • binding
    		•  3.37660003833383 bayes_pls_golite062009
  • transcription factor activity
    		•  3.18366984273735 bayes_pls_golite062009
  • transcription repressor activity
    		•  2.13838000453063 bayes_pls_golite062009
  • sequence-specific DNA binding
    		•  1.67826024217505 bayes_pls_golite062009
  • transcription activator activity
    		•  1.36268391567196 bayes_pls_golite062009
  • RNA polymerase II transcription factor activity
    		•  1.01831614309793 bayes_pls_golite062009
  • protein binding
    		•  0.726445167461826 bayes_pls_golite062009
  • RNA binding
    		•  0.309381817803407 bayes_pls_golite062009
  • transcription factor binding
    		•  0.0307736199991748 bayes_pls_golite062009


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.96

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle