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Protein Overview: RRI1

General Information:
Name(s) found: RRI1 / YDL216C [SGD]
Description(s) found:
Found 18 descriptions.
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  • Catalytic subunit of the COP9 signalosome (CSN) complex that acts as an isopeptidase in cleaving the ubiquitin-like protein Nedd8 from SCF ubiquitin ligases; metalloendopeptidase involved in the adaptation to pheromone signaling [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 455 amino acids

    Gene Ontology:
    Cellular Component: signalosome [IDALink to PubMed article][TASLink to PubMed article]
    Biological Process: protein deneddylation [IMPLink to PubMed articleLink to PubMed article]
    adaptation of signaling pathway by response to pheromone involved in conjugation with cellular fusion [IMPLink to PubMed article]
    Molecular Function: metalloendopeptidase activity [IMPLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MNNNDRKSIK TAGGSMSLSN KTVKELRQLL KERYTVEDEL TESIALSSMR FKPSQEPEFH  60
   61 ALSQSSLLKT KLKQQSSTDI PSYTHVLISK LSCEKITHYA VRGGNIEIMG ILMGFTLKDN 120
  121 IVVMDCFNLP VVGTETRVNA QLESYEYMVQ YIDEMYNHND GGDGRDYKGA KLNVVGWFHS 180
  181 HPGYDCWLSN IDIQTQDLNQ RFQDPYVAIV VDPLKSLEDK ILRMGAFRTI ESKSDDNSAT 240
  241 SYYELETIIF DSELNRALFE TKLNLHCVIE DDESEQISLN RLIDSMKQYS YLMDSKNVRT 300
  301 RIKLATTSER VSNENKKNID YQNRSTRSQF CLNTQRGDST ETSSFGSMFS GDNTSDVDME 360
  361 DRNLTEFDST DTSLCINGEP SIHVNRVERS SRSTDNFHNS KKRMNSNQER CHDEGNDMLQ 420
  421 RNVLETDYAR AKNRILASKI KQYERLRFYK DTFTL

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Qiu et al. (2008) CSI1 CSN12 PCI8 RRI1 RRI2

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run None Entered #17 Mitotic Prep3-TiO2 Phosphopeptide enrichment Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


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    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..54] deduced N/A No confident structure predictions are available.
    2 View Details [55..216] Pfam 44.79588 Mov34/MPN/PAD-1 family No confident structure predictions are available.
    3 View Details [217..368] MSA 3.08299 View MSA. No confident structure predictions are available.
    4 View Details [369..455] deduced N/A No confident structure predictions are available.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle