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Protein Overview: YOR1

General Information:
Name(s) found: YOR1 / YGR281W [SGD]
Description(s) found:
Found 28 descriptions.
SHOW ALL
  • Plasma membrane ATP-binding cassette (ABC) transporter, multidrug transporter mediates export of many different organic anions including oligomycin; similar to human cystic fibrosis transmembrane receptor (CFTR) [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 1477 amino acids

    Gene Ontology:
    Cellular Component: plasma membrane [IDALink to PubMed article]
    Biological Process: response to drug [TASLink to PubMed article]
    telomere maintenance [IMPLink to PubMed article]
    transport [TASLink to PubMed article]
    Molecular Function: xenobiotic-transporting ATPase activity [TASLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MTITVGDAVS ETELENKSQN VVLSPKASAS SDISTDVDKD TSSSWDDKSL LPTGEYIVDR  60
   61 NKPQTYLNSD DIEKVTESDI FPQKRLFSFL HSKKIPEVPQ TDDERKIYPL FHTNIISNMF 120
  121 FWWVLPILRV GYKRTIQPND LFKMDPRMSI ETLYDDFEKN MIYYFEKTRK KYRKRHPEAT 180
  181 EEEVMENAKL PKHTVLRALL FTFKKQYFMS IVFAILANCT SGFNPMITKR LIEFVEEKAI 240
  241 FHSMHVNKGI GYAIGACLMM FVNGLTFNHF FHTSQLTGVQ AKSILTKAAM KKMFNASNYA 300
  301 RHCFPNGKVT SFVTTDLARI EFALSFQPFL AGFPAILAIC IVLLIVNLGP IALVGIGIFF 360
  361 GGFFISLFAF KLILGFRIAA NIFTDARVTM MREVLNNIKM IKYYTWEDAY EKNIQDIRTK 420
  421 EISKVRKMQL SRNFLIAMAM SLPSIASLVT FLAMYKVNKG GRQPGNIFAS LSLFQVLSLQ 480
  481 MFFLPIAIGT GIDMIIGLGR LQSLLEAPED DPNQMIEMKP SPGFDPKLAL KMTHCSFEWE 540
  541 DYELNDAIEE AKGEAKDEGK KNKKKRKDTW GKPSASTNKA KRLDNMLKDR DGPEDLEKTS 600
  601 FRGFKDLNFD IKKGEFIMIT GPIGTGKSSL LNAMAGSMRK TDGKVEVNGD LLMCGYPWIQ 660
  661 NASVRDNIIF GSPFNKEKYD EVVRVCSLKA DLDILPAGDM TEIGERGITL SGGQKARINL 720
  721 ARSVYKKKDI YLFDDVLSAV DSRVGKHIMD ECLTGMLANK TRILATHQLS LIERASRVIV 780
  781 LGTDGQVDIG TVDELKARNQ TLINLLQFSS QNSEKEDEEQ EAVVAGELGQ LKYESEVKEL 840
  841 TELKKKATEM SQTANSGKIV ADGHTSSKEE RAVNSISLKI YREYIKAAVG KWGFIALPLY 900
  901 AILVVGTTFC SLFSSVWLSY WTENKFKNRP PSFYMGLYSF FVFAAFIFMN GQFTILCAMG 960
  961 IMASKWLNLR AVKRILHTPM SYIDTTPLGR ILNRFTKDTD SLDNELTESL RLMTSQFANI1020
 1021 VGVCVMCIVY LPWFAIAIPF LLVIFVLIAD HYQSSGREIK RLEAVQRSFV YNNLNEVLGG1080
 1081 MDTIKAYRSQ ERFLAKSDFL INKMNEAGYL VVVLQRWVGI FLDMVAIAFA LIITLLCVTR1140
 1141 AFPISAASVG VLLTYVLQLP GLLNTILRAM TQTENDMNSA ERLVTYATEL PLEASYRKPE1200
 1201 MTPPESWPSM GEIIFENVDF AYRPGLPIVL KNLNLNIKSG EKIGICGRTG AGKSTIMSAL1260
 1261 YRLNELTAGK ILIDNVDISQ LGLFDLRRKL AIIPQDPVLF RGTIRKNLDP FNERTDDELW1320
 1321 DALVRGGAIA KDDLPEVKLQ KPDENGTHGK MHKFHLDQAV EEEGSNFSLG ERQLLALTRA1380
 1381 LVRQSKILIL DEATSSVDYE TDGKIQTRIV EEFGDCTILC IAHRLKTIVN YDRILVLEKG1440
 1441 EVAEFDTPWT LFSQEDSIFR SMCSRSGIVE NDFENRS

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Krogan NJ, et al. (2006) ARG3 ATP3 BUD30 CIK1 GAL80 PMI40 SGN1 YGR250C YML002W YOR1
    View Details Gavin AC, et al. (2006) RPL26B RPL30 RPL33B RPS16B, RPS16A RSA3 YOR1
    View Details Gavin AC, et al. (2002) BLM10 CDC55 CIN1 ERG13 GUS1 HHF1, HHF2 HOS2 HOS4 IML1 KAP95 KEL1 LTE1 MYO5 PFK1 PPH21 PPH22 PRE1 PRE10 PRE2 PRE4 PRE5 PRE6 PRE7 PRE8 PRE9 PUP1 PUP2 PUP3 RRD2 RTS1 RTS3 SCL1 SET3 SIF2 SNT1 SRP1 TDH2 TDH3 TEF4 TPD3 YBL104C YOR1 YRA1 ZDS1 ZDS2
    View Details Qiu et al. (2008) SNQ2 YOR1

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run RPA135 No Comments Schneider, DA, et al. (2006)
    View Run MLP2 #24 Asynchronous Prep3-TiO2 Phosphopeptide enrichment Keck JM, et al. (2011)
    View Run MLP2 #29 Asynchronous Prep5-TiO2 Flowthrough Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

      BAIT PREY HITS PUBLICATION
    View Screen PLM2 YOR1 1 Unpublished Fields Lab Data
    View Screen PRP16 YOR1 1 Unpublished Fields Lab Data
    View Screen RAD1 YOR1 1 Unpublished Fields Lab Data

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data YOR1 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..99] ORFEUS 7.74 Peptide transporter Tap1, C-terminal ABC domain
    2 View Details [100..189] deduced N/A No confident structure predictions are available.
    3 View Details [190..301] ORFEUS 8.75 Heavy meromyosin subfragment
    4 View Details [302..544] ORFEUS 8.75 Heavy meromyosin subfragment
    5 View Details [545..811] PSI-BLAST 431.232149 No description for 1nbd__ was found.
    6 View Details [812..863] deduced N/A No confident structure predictions are available.
    7 View Details [864..974]
    [993..1191]    		 PSI-BLAST 522.228787 MsbA
    8 View Details [975..992]
    [1192..1477]    		 PSI-BLAST 522.228787 MsbA

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2
    Term Confidence Notes
  • lipid transporter activity
    		•  6.95325922226092 bayes_pls_golite062009
  • ATPase activity, coupled to transmembrane movement of substances
    		•  5.4467861893359 bayes_pls_golite062009
  • hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances
    		•  5.44654566127945 bayes_pls_golite062009
  • ATPase activity, coupled to movement of substances
    		•  5.44654566127945 bayes_pls_golite062009
  • P-P-bond-hydrolysis-driven transmembrane transporter activity
    		•  5.43909190876515 bayes_pls_golite062009
  • primary active transmembrane transporter activity
    		•  5.4304944906989 bayes_pls_golite062009
  • lipopolysaccharide transmembrane transporter activity
    		•  5.38499199434139 bayes_pls_golite062009
  • lipopolysaccharide-transporting ATPase activity
    		•  5.38499199434139 bayes_pls_golite062009
  • active transmembrane transporter activity
    		•  5.38112407181712 bayes_pls_golite062009
  • ATPase activity, coupled
    		•  4.87869064889244 bayes_pls_golite062009
  • polysaccharide transmembrane transporter activity
    		•  4.78108145471169 bayes_pls_golite062009
  • ATPase activity
    		•  4.60773943958528 bayes_pls_golite062009
  • nucleoside-triphosphatase activity
    		•  4.38591214726007 bayes_pls_golite062009
  • pyrophosphatase activity
    		•  4.32673473878039 bayes_pls_golite062009
  • hydrolase activity, acting on acid anhydrides
    		•  4.31087891816858 bayes_pls_golite062009
  • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
    		•  4.31037981322306 bayes_pls_golite062009
  • hydrolase activity
    		•  4.09315408758191 bayes_pls_golite062009
  • transporter activity
    		•  3.47953169973151 bayes_pls_golite062009
  • substrate-specific transmembrane transporter activity
    		•  2.96171085039592 bayes_pls_golite062009
  • transmembrane transporter activity
    		•  2.94175800357966 bayes_pls_golite062009
  • substrate-specific transporter activity
    		•  2.90743799425416 bayes_pls_golite062009
  • ATP binding
    		•  2.83986218503994 bayes_pls_golite062009
  • adenyl ribonucleotide binding
    		•  2.79195527951815 bayes_pls_golite062009
  • adenyl nucleotide binding
    		•  2.74359323245512 bayes_pls_golite062009
  • purine ribonucleotide binding
    		•  2.55506944753783 bayes_pls_golite062009
  • ribonucleotide binding
    		•  2.55426312645972 bayes_pls_golite062009
  • purine nucleotide binding
    		•  2.51344800975739 bayes_pls_golite062009
  • nucleotide binding
    		•  2.48057252852174 bayes_pls_golite062009
  • binding
    		•  1.81483350844459 bayes_pls_golite062009
  • catalytic activity
    		•  0.372934161904337 bayes_pls_golite062009
    3 No functions predicted.
    4
    Term Confidence Notes
  • lipid transporter activity
    		•  7.47642599298853 bayes_pls_golite062009
  • metal ion transmembrane transporter activity
    		•  6.80339337010085 bayes_pls_golite062009
  • lipopolysaccharide transmembrane transporter activity
    		•  5.90177503313326 bayes_pls_golite062009
  • lipopolysaccharide-transporting ATPase activity
    		•  5.90177503313326 bayes_pls_golite062009
  • ATPase activity, coupled to transmembrane movement of substances
    		•  5.57844095962502 bayes_pls_golite062009
  • hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances
    		•  5.57813579764186 bayes_pls_golite062009
  • ATPase activity, coupled to movement of substances
    		•  5.57813579764186 bayes_pls_golite062009
  • P-P-bond-hydrolysis-driven transmembrane transporter activity
    		•  5.5689620139321 bayes_pls_golite062009
  • primary active transmembrane transporter activity
    		•  5.55992639965745 bayes_pls_golite062009
  • active transmembrane transporter activity
    		•  5.50005167063544 bayes_pls_golite062009
  • cation channel activity
    		•  5.46287131955314 bayes_pls_golite062009
  • voltage-gated cation channel activity
    		•  5.29074477899638 bayes_pls_golite062009
  • polysaccharide transmembrane transporter activity
    		•  5.26442752745523 bayes_pls_golite062009
  • voltage-gated ion channel activity
    		•  5.1184221202951 bayes_pls_golite062009
  • potassium channel activity
    		•  5.11125652739479 bayes_pls_golite062009
  • voltage-gated channel activity
    		•  5.10064970232011 bayes_pls_golite062009
  • ATPase activity, coupled
    		•  4.98276715440477 bayes_pls_golite062009
  • ion channel activity
    		•  4.87468443062464 bayes_pls_golite062009
  • heme transporter activity
    		•  4.82479229680991 bayes_pls_golite062009
  • channel activity
    		•  4.74517495695421 bayes_pls_golite062009
  • passive transmembrane transporter activity
    		•  4.74517495695421 bayes_pls_golite062009
  • peptide transporter activity
    		•  4.7442815698413 bayes_pls_golite062009
  • anion transmembrane-transporting ATPase activity
    		•  4.71935767060308 bayes_pls_golite062009
  • substrate-specific channel activity
    		•  4.71152823189573 bayes_pls_golite062009
  • ATPase activity
    		•  4.69795387297193 bayes_pls_golite062009
  • peptide-transporting ATPase activity
    		•  4.63590351019108 bayes_pls_golite062009
  • cadmium ion transmembrane transporter activity
    		•  4.62439240790153 bayes_pls_golite062009
  • gated channel activity
    		•  4.61941650351493 bayes_pls_golite062009
  • nucleoside-triphosphatase activity
    		•  4.45923622153365 bayes_pls_golite062009
  • pyrophosphatase activity
    		•  4.39781350157199 bayes_pls_golite062009
  • hydrolase activity, acting on acid anhydrides
    		•  4.38133275795019 bayes_pls_golite062009
  • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
    		•  4.38085303582726 bayes_pls_golite062009
  • cofactor transporter activity
    		•  4.34709589308604 bayes_pls_golite062009
  • sulfonylurea receptor activity
    		•  4.29224907929661 bayes_pls_golite062009
  • bilirubin transmembrane transporter activity
    		•  4.16465937144981 bayes_pls_golite062009
  • hydrolase activity
    		•  4.12107348093071 bayes_pls_golite062009
  • oligopeptide-transporting ATPase activity
    		•  4.09365342567844 bayes_pls_golite062009
  • transporter activity
    		•  3.71239480053329 bayes_pls_golite062009
  • hydrogen ion transporting ATP synthase activity, rotational mechanism
    		•  3.57926427233638 bayes_pls_golite062009
  • ion transmembrane transporter activity
    		•  3.35436118751376 bayes_pls_golite062009
  • phosphate transmembrane-transporting ATPase activity
    		•  3.20894563245332 bayes_pls_golite062009
  • inorganic anion transmembrane transporter activity
    		•  3.16975154423199 bayes_pls_golite062009
  • transmembrane transporter activity
    		•  3.13960906549884 bayes_pls_golite062009
  • anion transmembrane transporter activity
    		•  3.13913638619234 bayes_pls_golite062009
  • substrate-specific transporter activity
    		•  3.1318898376276 bayes_pls_golite062009
  • cation transmembrane transporter activity
    		•  3.08390071341252 bayes_pls_golite062009
  • iron ion transmembrane transporter activity
    		•  3.05511942104215 bayes_pls_golite062009
  • ATP binding
    		•  3.01346604299372 bayes_pls_golite062009
  • substrate-specific transmembrane transporter activity
    		•  3.00745742755195 bayes_pls_golite062009
  • drug transmembrane transporter activity
    		•  2.97119034312001 bayes_pls_golite062009
  • adenyl ribonucleotide binding
    		•  2.96271391116269 bayes_pls_golite062009
  • monovalent inorganic cation transmembrane transporter activity
    		•  2.9271291809464 bayes_pls_golite062009
  • adenyl nucleotide binding
    		•  2.91131545957759 bayes_pls_golite062009
  • ligand-gated ion channel activity
    		•  2.77610331510393 bayes_pls_golite062009
  • ligand-gated channel activity
    		•  2.77610331510393 bayes_pls_golite062009
  • purine ribonucleotide binding
    		•  2.70262534541085 bayes_pls_golite062009
  • ribonucleotide binding
    		•  2.70178191749524 bayes_pls_golite062009
  • amine-transporting ATPase activity
    		•  2.69529191205818 bayes_pls_golite062009
  • organic acid transmembrane transporter activity
    		•  2.67957846350199 bayes_pls_golite062009
  • carboxylic acid transmembrane transporter activity
    		•  2.67815672695824 bayes_pls_golite062009
  • purine nucleotide binding
    		•  2.6583477492092 bayes_pls_golite062009
  • hydrogen ion transmembrane transporter activity
    		•  2.63419811368692 bayes_pls_golite062009
  • nucleotide binding
    		•  2.62374702628143 bayes_pls_golite062009
  • sterol transporter activity
    		•  2.48473697371886 bayes_pls_golite062009
  • inorganic cation transmembrane transporter activity
    		•  2.40292717311506 bayes_pls_golite062009
  • canalicular bile acid transmembrane transporter activity
    		•  2.33958437214304 bayes_pls_golite062009
  • amine transmembrane transporter activity
    		•  2.29486577878686 bayes_pls_golite062009
  • structural constituent of muscle
    		•  2.27871582090443 bayes_pls_golite062009
    		• 2.20174656498665 bayes_pls_golite062009
  • vitamin transporter activity
    		•  2.1653565229854 bayes_pls_golite062009
  • phosphate transmembrane transporter activity
    		•  2.15147988861177 bayes_pls_golite062009
  • oligopeptide transporter activity
    		•  2.05580564974083 bayes_pls_golite062009
  • voltage-gated calcium channel activity
    		•  1.96314034513078 bayes_pls_golite062009
  • binding
    		•  1.84115074893083 bayes_pls_golite062009
  • transition metal ion transmembrane transporter activity
    		•  1.82177108193332 bayes_pls_golite062009
  • organic anion transmembrane transporter activity
    		•  1.76999970080179 bayes_pls_golite062009
  • motor activity
    		•  1.64238426331767 bayes_pls_golite062009
  • amino acid transmembrane transporter activity
    		•  1.59627719545436 bayes_pls_golite062009
  • phosphonate transmembrane transporter activity
    		•  1.40269234722336 bayes_pls_golite062009
  • protein transporter activity
    		•  1.39215697820305 bayes_pls_golite062009
  • monocarboxylic acid transmembrane transporter activity
    		•  1.37836402136387 bayes_pls_golite062009
  • glutathione transmembrane transporter activity
    		•  1.35514937365621 bayes_pls_golite062009
  • sphingolipid transporter activity
    		•  1.35514937365621 bayes_pls_golite062009
  • molybdate ion transmembrane transporter activity
    		•  1.28313088935613 bayes_pls_golite062009
  • molybdate transmembrane-transporting ATPase activity
    		•  1.28313088935613 bayes_pls_golite062009
  • ATPase activity, coupled to transmembrane movement of ions
    		•  1.23799860254751 bayes_pls_golite062009
  • protein binding
    		•  1.22129154759482 bayes_pls_golite062009
  • peptidase activity
    		•  1.12876670227791 bayes_pls_golite062009
  • sulfate transmembrane-transporting ATPase activity
    		•  1.1220946941463 bayes_pls_golite062009
  • dipeptide transporter activity
    		•  1.01130176523309 bayes_pls_golite062009
  • sulfur amino acid transmembrane transporter activity
    		•  0.993585129677597 bayes_pls_golite062009
  • cytoskeletal protein binding
    		•  0.933937517908868 bayes_pls_golite062009
  • thiamin transmembrane transporter activity
    		•  0.933872128802939 bayes_pls_golite062009
    		• 0.869999622006359 bayes_pls_golite062009
  • GTPase activity
    		•  0.83849854735032 bayes_pls_golite062009
  • copper ion transmembrane transporter activity
    		•  0.798934081014025 bayes_pls_golite062009
  • di-, tri-valent inorganic cation transmembrane transporter activity
    		•  0.767424210804186 bayes_pls_golite062009
  • peptidase activity, acting on L-amino acid peptides
    		•  0.765442336337003 bayes_pls_golite062009
  • phospholipid transporter activity
    		•  0.755445322666929 bayes_pls_golite062009
  • microfilament motor activity
    		•  0.723407201613229 bayes_pls_golite062009
  • glutathione S-conjugate-exporting ATPase activity
    		•  0.719430645205088 bayes_pls_golite062009
  • bile acid transmembrane transporter activity
    		•  0.687612064139871 bayes_pls_golite062009
  • high voltage-gated calcium channel activity
    		•  0.64930610472341 bayes_pls_golite062009
  • cholesterol transporter activity
    		•  0.644421039250979 bayes_pls_golite062009
  • actin binding
    		•  0.563996324417607 bayes_pls_golite062009
  • long-chain fatty acid transporter activity
    		•  0.445784480190949 bayes_pls_golite062009
  • branched-chain aliphatic amino acid transmembrane transporter activity
    		•  0.442220326523999 bayes_pls_golite062009
  • DNA-dependent ATPase activity
    		•  0.43042801294444 bayes_pls_golite062009
  • guanyl nucleotide binding
    		•  0.399434758448606 bayes_pls_golite062009
  • GTP binding
    		•  0.398333597279278 bayes_pls_golite062009
  • guanyl ribonucleotide binding
    		•  0.39332178627529 bayes_pls_golite062009
  • catalytic activity
    		•  0.368034275052766 bayes_pls_golite062009
  • nucleic acid binding
    		•  0.318452816722389 bayes_pls_golite062009
  • signal transducer activity
    		•  0.286367085584159 bayes_pls_golite062009
  • molecular transducer activity
    		•  0.286367085584159 bayes_pls_golite062009
  • fatty acid transporter activity
    		•  0.251070374183928 bayes_pls_golite062009
  • neutral amino acid transmembrane transporter activity
    		•  0.227570438294493 bayes_pls_golite062009
  • proton-transporting ATPase activity, rotational mechanism
    		•  0.219473333671469 bayes_pls_golite062009
  • apolipoprotein receptor activity
    		•  0.201503131198139 bayes_pls_golite062009
  • syntaxin-13 binding
    		•  0.201503131198139 bayes_pls_golite062009
  • apolipoprotein A-I binding
    		•  0.201503131198139 bayes_pls_golite062009
  • apolipoprotein A-I receptor activity
    		•  0.201503131198139 bayes_pls_golite062009
  • protein transmembrane transporter activity
    		•  0.16843768852312 bayes_pls_golite062009
  • amino acid-transporting ATPase activity
    		•  0.147644650870465 bayes_pls_golite062009
  • sulfate transmembrane transporter activity
    		•  0.104477131120205 bayes_pls_golite062009
  • cation-transporting ATPase activity
    		•  0.0536898657672154 bayes_pls_golite062009
    5 No functions predicted.
    6 No functions predicted.
    7 No functions predicted.
    8 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle