Protein Overview: PRP38

General Information:
Name(s) found:	PRP38 / YGR075C [SGD]
Description(s) found: Found 36 descriptions. SHOW ALL	Unique component of the U4/U6.U5 tri-snRNP particle, required for conformational changes which result in the catalytic activation of the spliceosome; dispensible for spliceosome assembly [SGD]
Organism:	Saccharomyces cerevisiae
Length:	242 amino acids
Gene Ontology:
Cellular Component:	U4/U6 x U5 tri-snRNP complex [IDA][IMP][IPI]
Biological Process:	nuclear mRNA splicing, via spliceosome [IPI]
Molecular Function:	molecular_function [ND]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MAVNEFQVES NISPKQLNNQ SVSLVIPRLT RDKIHNSMYY KVNLSNESLR GNTMVELLKV  60
   61 MIGAFGTIKG QNGHLHMMVL GGIEFKCILM KLIEIRPNFQ QLNFLLNVKN ENGFDSKYII 120
  121 ALLLVYARLQ YYYLNGNNKN DDDENDLIKL FKVQLYKYSQ HYFKLKSFPL QVDCFAHSYN 180
  181 EELCIIHIDE LVDWLATQDH IWGIPLGKCQ WNKIYNSDEE SSSSESESNG DSEDDNDTSS 240
  241 ES

Protein Complex Data

	PUBLICATION	TOPOLOGY	COCOMPLEXED PROTEINS
View Details	Riffle et al. (2010) (Unpublished Data)		BRR2 PRP3 PRP31 PRP38 PRP4 PRP6 PRP8 SMB1 SNU114 SNU23 SNU66 SPP381
View Details	(MIPS) Mewes HW, et al. (2004)		AAR2 BRR1 BRR2 CBC2 CDC40 CWC15 CWC2 CWC22 CWC23 DHR2 LSM4 MAK5 MUD2 PRP16 PRP18 PRP2 PRP22 PRP24 PRP28 PRP31 PRP38 PRP39 PRP4 PRP40 PRP43 PRP5 PRP6 PRP8 SLU7 SMD1 SMD3 SME1 SNP1 SPP2 SPP381 STO1 YHC1
View Details	Krogan NJ, et al. (2006)		PRP38 SNU23 SPP381
View Details	Gavin AC, et al. (2002)		AAR2 ASC1 BRR1 BUD31 CDC33 CEF1 CLF1 CSN12 CUS1 CWC2 CWC22 CWC23 DCP2 DHH1 DIB1 ECM2 ERB1 GCN2 HSH155 HTA1 IMG1 KRS1 LEA1 LIN1 LSM1 LSM2 LSM3 LSM4 LSM5 LSM6 LSM7 LUC7 MRP7 MRPL28 MRPL3 MRPL35 MRPL38 MRPL4 MRPL8 MRPS5 MSL1 MUD1 NAM7 NOG2 NOP1 NUG1 PAT1 PRP11 PRP18 PRP19 PRP21 PRP24 PRP28 PRP3 PRP31 PRP38 PRP39 PRP4 PRP40 PRP42 PRP43 PRP46 PRP6 PRP8 PRP9 RSE1 RVB2 SLU7 SMB1 SMD1 SMD2 SMD3 SME1 SMX2 SMX3 SNP1 SNT309 SNU114 SNU23 SNU56 SNU66 SNU71 SPP381 SPP382 SQS1 SRB2 SRO9 STO1 SYF1 TOS4 UTP21 YML6
View Details	Qiu et al. (2008)		AAR2 BRR1 BRR2 BUD31 CBC2 CDC40 CEF1 CLF1 CUS1 CWC15 CWC2 CWC21 CWC22 CWC23 DHR2 DIB1 ECM2 HSH155 ISY1 LEA1 LSM2 LSM3 LSM4 LSM5 LSM6 LSM7 LSM8 LUC7 MAK5 MSL1 MUD1 MUD2 NAM8 NTC20 PRP11 PRP16 PRP18 PRP19 PRP2 PRP21 PRP22 PRP24 PRP28 PRP3 PRP31 PRP38 PRP39 PRP4 PRP40 PRP42 PRP43 PRP45 PRP46 PRP5 PRP6 PRP8 PRP9 RSE1 SLU7 SMB1 SMD1 SMD2 SMD3 SME1 SMX2 SMX3 SNP1 SNT309 SNU114 SNU23 SNU56 SNU66 SNU71 SPP381 SPP382 STO1 SYF1 SYF2 YHC1

Mass Spectrometry Data

No mass spectrometry results found for this protein.

Yeast Two-Hybrid Data

The following interactions contain this protein:

SHOWING SINGLE HITS. [ Hide Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

	BAIT	PREY	HITS	PUBLICATION
View Screen	FRQ1	PRP38	1	Unpublished Fields Lab Data

Microscopy / Localization Data

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	PROTEIN(S)	PUBLICATION
View Data	PRP38	Huh WK, et al. (2003)

Protein Structure Data

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[View Top Sequence Alignments] [Show Ginzu Version Information]

Domains predicted:

#		Region(s)	Method	Confidence	Match Description
1	View Details	[1..242]	Pfam	131.958607	PRP38 family No confident structure predictions are available.

Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

Philius Transmembrane Prediction:

Protein predicted to be:	GLOBULAR (No transmembrane regions or signal peptide)
Confidence of classification:	0.95

Source: Reynolds et al. (2008)

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2