Protein Overview: FRQ1

General Information:
Name(s) found:	FRQ1 / YDR373W [SGD]
Description(s) found: Found 35 descriptions. SHOW ALL	N-myristoylated calcium-binding protein that may have a role in intracellular signaling through its regulation of the phosphatidylinositol 4-kinase Pik1p; member of the recoverin/frequenin branch of the EF-hand superfamily [SGD]
Organism:	Saccharomyces cerevisiae
Length:	190 amino acids
Gene Ontology:
Cellular Component:	membrane [ISS]
Biological Process:	regulation of signal transduction [IMP][IPI]
Molecular Function:	calcium ion binding [ISS] enzyme activator activity [IDA]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MGAKTSKLSK DDLTCLKQST YFDRREIQQW HKGFLRDCPS GQLAREDFVK IYKQFFPFGS  60
   61 PEDFANHLFT VFDKDNNGFI HFEEFITVLS TTSRGTLEEK LSWAFELYDL NHDGYITFDE 120
  121 MLTIVASVYK MMGSMVTLNE DEATPEMRVK KIFKLMDKNE DGYITLDEFR EGSKVDPSII 180
  181 GALNLYDGLI

Protein Complex Data

No complex found for this protein.

Mass Spectrometry Data

No mass spectrometry results found for this protein.

Yeast Two-Hybrid Data

The following interactions contain this protein:

NOT SHOWING SINGLE HITS. [ Show Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

	BAIT	PREY	HITS	PUBLICATION
View Screen	FRQ1	PEX14	2	Unpublished Fields Lab Data
View Screen	FRQ1	YSP3	2	Unpublished Fields Lab Data
View Screen	FRQ1	VMA22	2	Unpublished Fields Lab Data
View Screen	FRQ1	YDL218W	2	Unpublished Fields Lab Data
View Screen	FRQ1	USE1	2	Unpublished Fields Lab Data

Microscopy / Localization Data

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	PROTEIN(S)	PUBLICATION
View Data	FRQ1	Huh WK, et al. (2003)

Protein Structure Data

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[View Top Sequence Alignments] [Show Ginzu Version Information]

Domains predicted:

#		Region(s)	Method	Confidence	Match Description
1	View Details	[1..94]	PSI-BLAST	1095.522879	Frequenin (neuronal calcium sensor 1)
2	View Details	[95..190]	PSI-BLAST	1095.522879	Frequenin (neuronal calcium sensor 1)

Functions predicted (by domain):

Gene Ontology predictions

Term	Confidence	Notes
troponin T binding	7.68526659589559	bayes_pls_golite062009
phosphoprotein phosphatase activity	7.47426847861728	bayes_pls_golite062009
protein serine/threonine phosphatase activity	6.37104157544514	bayes_pls_golite062009
structural constituent of muscle	6.34041234021534	bayes_pls_golite062009
phosphatase activity	6.28157965296365	bayes_pls_golite062009
phosphoric ester hydrolase activity	6.17799259119197	bayes_pls_golite062009
microfilament motor activity	5.62061944255026	bayes_pls_golite062009
calcium-dependent protein serine/threonine phosphatase activity	5.58369939851095	bayes_pls_golite062009
hydrolase activity, acting on ester bonds	5.11186887221409	bayes_pls_golite062009
actin-dependent ATPase activity	4.74535289044761	bayes_pls_golite062009
calcium-dependent protein serine/threonine phosphatase regulator activity	4.70715233640875	bayes_pls_golite062009
motor activity	4.684407141745	bayes_pls_golite062009
actin binding	3.96919556235483	bayes_pls_golite062009
calcium ion binding	3.79609619542776	bayes_pls_golite062009
myosin heavy chain binding	3.63014173976595	bayes_pls_golite062009
cytoskeletal protein binding	3.49668552859347	bayes_pls_golite062009
myosin II heavy chain binding	3.44552916899378	bayes_pls_golite062009
binding	3.17556402087346	bayes_pls_golite062009
cation binding	2.62077305565026	bayes_pls_golite062009
metal ion binding	2.62077305565026	bayes_pls_golite062009
ion binding	2.61312132078717	bayes_pls_golite062009
ion transmembrane transporter activity	2.57032504567157	bayes_pls_golite062009
cation transmembrane transporter activity	2.55650624542181	bayes_pls_golite062009
myosin II binding	2.4656485800839	bayes_pls_golite062009
substrate-specific transmembrane transporter activity	2.37465721152046	bayes_pls_golite062009
clathrin binding	2.36616108128297	bayes_pls_golite062009
actin filament binding	2.35534489389161	bayes_pls_golite062009
myosin binding	2.34125070430971	bayes_pls_golite062009
protein binding	2.21291432166051	bayes_pls_golite062009
metal ion transmembrane transporter activity	1.99763594451773	bayes_pls_golite062009
transcription regulator activity	1.9739523190593	bayes_pls_golite062009
DNA binding	1.55722307354604	bayes_pls_golite062009
nucleic acid binding	1.53225451586959	bayes_pls_golite062009
calcium-dependent protein kinase inhibitor activity	1.29632226581856	bayes_pls_golite062009
transporter activity	1.15928534291452	bayes_pls_golite062009
molecular transducer activity	1.11607939838219	bayes_pls_golite062009
signal transducer activity	1.11607939838219	bayes_pls_golite062009
actin monomer binding	0.9954841049256	bayes_pls_golite062009
nitric-oxide synthase binding	0.965098383344279	bayes_pls_golite062009
transmembrane transporter activity	0.945691505472547	bayes_pls_golite062009
phosphatase regulator activity	0.87149881541475	bayes_pls_golite062009
guanylate cyclase regulator activity	0.84389905735679	bayes_pls_golite062009
cyclase regulator activity	0.84389905735679	bayes_pls_golite062009
protein phosphatase regulator activity	0.822713961141111	bayes_pls_golite062009
cation channel activity	0.802117767859521	bayes_pls_golite062009
structural molecule activity	0.800850121197479	bayes_pls_golite062009
phosphotransferase activity, alcohol group as acceptor	0.787740261079819	bayes_pls_golite062009
kinase activity	0.782396352346639	bayes_pls_golite062009
calcium channel regulator activity	0.7164851905066	bayes_pls_golite062009
tubulin binding	0.710693016758742	bayes_pls_golite062009
substrate-specific transporter activity	0.693724160233023	bayes_pls_golite062009
transcription repressor activity	0.666488715029225	bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups	0.654002071540024	bayes_pls_golite062009
calcium sensitive guanylate cyclase activator activity	0.630360514213104	bayes_pls_golite062009
channel activity	0.386960491413065	bayes_pls_golite062009
passive transmembrane transporter activity	0.386960491413065	bayes_pls_golite062009
substrate-specific channel activity	0.362205423422174	bayes_pls_golite062009
	0.34446792626966	bayes_pls_golite062009
ion channel activity	0.343477643719352	bayes_pls_golite062009
channel regulator activity	0.32809521759917	bayes_pls_golite062009
voltage-gated channel activity	0.308919475701377	bayes_pls_golite062009
voltage-gated ion channel activity	0.304496519713588	bayes_pls_golite062009
microtubule binding	0.278596514315141	bayes_pls_golite062009
voltage-gated cation channel activity	0.278054748078249	bayes_pls_golite062009
active transmembrane transporter activity	0.246383459363256	bayes_pls_golite062009
potassium channel activity	0.200283164564768	bayes_pls_golite062009
gated channel activity	0.150185445887481	bayes_pls_golite062009
structural constituent of cytoskeleton	0.116648335890738	bayes_pls_golite062009
voltage-gated potassium channel activity	0.109511951498555	bayes_pls_golite062009
protein complex binding	0.0676093357928913	bayes_pls_golite062009

No functions predicted.

Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

Philius Transmembrane Prediction:

Protein predicted to be:	GLOBULAR (No transmembrane regions or signal peptide)
Confidence of classification:	0.99

Source: Reynolds et al. (2008)

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2