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View Structure Prediction Details

Protein: FRQ1
Organism: Saccharomyces cerevisiae
Length: 190 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for FRQ1.

Description E-value Query
Range		 Subject
Range
HPCL1_TAEGU - Hippocalcin-like protein 1 OS=Taeniopygia guttata GN=HPCAL1 PE=2 SV=1
HPCL1_CHICK - Hippocalcin-like protein 1 OS=Gallus gallus GN=HPCAL1 PE=1 SV=2
gi|542156952|ref... - PREDICTED: hippocalcin-like protein 1 [Zonotrichia albicollis], hippocalcin-like 1 [Zonotrichia albi...
 1.0E-64 [1..184] [1..184]
HPCL1_MOUSE - Hippocalcin-like protein 1 OS=Mus musculus GN=Hpcal1 PE=1 SV=2
HPCL1_RAT - Hippocalcin-like protein 1 OS=Rattus norvegicus GN=Hpcal1 PE=1 SV=2
tr|G3I2K6|G3I2K6... - Hippocalcin-like protein 1 OS=Cricetulus griseus GN=I79_017643 PE=4 SV=1
 1.0E-63 [1..184] [1..184]
NECX_APLCA - Neurocalcin OS=Aplysia californica PE=2 SV=2
 2.0E-63 [1..184] [1..184]
gi|12052750, gi|... - gi|14042974|ref|NP_114430.1| neurocalcin delta [Homo sapiens], gi|12052750|emb|CAB66547.1| hypotheti...
gi|117646886 - gi|117646886|emb|CAL37558.1| hypothetical protein [synthetic construct]
 2.0E-62 [1..184] [1..184]
NCS1_SCHPO - Calcium-binding protein NCS-1 OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=ncs1 PE=1 SV...
ncs1 - related to neuronal calcium sensor Ncs1
 3.0E-61 [1..190] [1..190]
gi|7507776 - gi|7507776|pir||T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans
 2.0E-60 [1..184] [1..184]
gi|14164385 - gi|14164385|dbj|BAB55793.1| NCS homolog [Magnaporthe grisea]
 5.0E-59 [1..190] [1..190]

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Predicted Domain #1
Region A:
Residues: [1-94] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MGAKTSKLSK DDLTCLKQST YFDRREIQQW HKGFLRDCPS GQLAREDFVK IYKQFFPFGS  60
   61 PEDFANHLFT VFDKDNNGFI HFEEFITVLS TTSR

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 1095.522879
Match: 1fpwA_
Description: Frequenin (neuronal calcium sensor 1)
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
troponin T binding 7.68526659589559 bayes_pls_golite062009
phosphoprotein phosphatase activity 7.47426847861728 bayes_pls_golite062009
protein serine/threonine phosphatase activity 6.37104157544514 bayes_pls_golite062009
structural constituent of muscle 6.34041234021534 bayes_pls_golite062009
phosphatase activity 6.28157965296365 bayes_pls_golite062009
phosphoric ester hydrolase activity 6.17799259119197 bayes_pls_golite062009
microfilament motor activity 5.62061944255026 bayes_pls_golite062009
calcium-dependent protein serine/threonine phosphatase activity 5.58369939851095 bayes_pls_golite062009
hydrolase activity, acting on ester bonds 5.11186887221409 bayes_pls_golite062009
actin-dependent ATPase activity 4.74535289044761 bayes_pls_golite062009
calcium-dependent protein serine/threonine phosphatase regulator activity 4.70715233640875 bayes_pls_golite062009
motor activity 4.684407141745 bayes_pls_golite062009
actin binding 3.96919556235483 bayes_pls_golite062009
calcium ion binding 3.79609619542776 bayes_pls_golite062009
myosin heavy chain binding 3.63014173976595 bayes_pls_golite062009
cytoskeletal protein binding 3.49668552859347 bayes_pls_golite062009
myosin II heavy chain binding 3.44552916899378 bayes_pls_golite062009
binding 3.17556402087346 bayes_pls_golite062009
cation binding 2.62077305565026 bayes_pls_golite062009
metal ion binding 2.62077305565026 bayes_pls_golite062009
ion binding 2.61312132078717 bayes_pls_golite062009
ion transmembrane transporter activity 2.57032504567157 bayes_pls_golite062009
cation transmembrane transporter activity 2.55650624542181 bayes_pls_golite062009
myosin II binding 2.4656485800839 bayes_pls_golite062009
substrate-specific transmembrane transporter activity 2.37465721152046 bayes_pls_golite062009
clathrin binding 2.36616108128297 bayes_pls_golite062009
actin filament binding 2.35534489389161 bayes_pls_golite062009
myosin binding 2.34125070430971 bayes_pls_golite062009
protein binding 2.21291432166051 bayes_pls_golite062009
metal ion transmembrane transporter activity 1.99763594451773 bayes_pls_golite062009
transcription regulator activity 1.9739523190593 bayes_pls_golite062009
DNA binding 1.55722307354604 bayes_pls_golite062009
nucleic acid binding 1.53225451586959 bayes_pls_golite062009
calcium-dependent protein kinase inhibitor activity 1.29632226581856 bayes_pls_golite062009
transporter activity 1.15928534291452 bayes_pls_golite062009
molecular transducer activity 1.11607939838219 bayes_pls_golite062009
signal transducer activity 1.11607939838219 bayes_pls_golite062009
actin monomer binding 0.9954841049256 bayes_pls_golite062009
nitric-oxide synthase binding 0.965098383344279 bayes_pls_golite062009
transmembrane transporter activity 0.945691505472547 bayes_pls_golite062009
phosphatase regulator activity 0.87149881541475 bayes_pls_golite062009
guanylate cyclase regulator activity 0.84389905735679 bayes_pls_golite062009
cyclase regulator activity 0.84389905735679 bayes_pls_golite062009
protein phosphatase regulator activity 0.822713961141111 bayes_pls_golite062009
cation channel activity 0.802117767859521 bayes_pls_golite062009
structural molecule activity 0.800850121197479 bayes_pls_golite062009
phosphotransferase activity, alcohol group as acceptor 0.787740261079819 bayes_pls_golite062009
kinase activity 0.782396352346639 bayes_pls_golite062009
calcium channel regulator activity 0.7164851905066 bayes_pls_golite062009
tubulin binding 0.710693016758742 bayes_pls_golite062009
substrate-specific transporter activity 0.693724160233023 bayes_pls_golite062009
transcription repressor activity 0.666488715029225 bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups 0.654002071540024 bayes_pls_golite062009
calcium sensitive guanylate cyclase activator activity 0.630360514213104 bayes_pls_golite062009
channel activity 0.386960491413065 bayes_pls_golite062009
passive transmembrane transporter activity 0.386960491413065 bayes_pls_golite062009
substrate-specific channel activity 0.362205423422174 bayes_pls_golite062009
0.34446792626966 bayes_pls_golite062009
ion channel activity 0.343477643719352 bayes_pls_golite062009
channel regulator activity 0.32809521759917 bayes_pls_golite062009
voltage-gated channel activity 0.308919475701377 bayes_pls_golite062009
voltage-gated ion channel activity 0.304496519713588 bayes_pls_golite062009
microtubule binding 0.278596514315141 bayes_pls_golite062009
voltage-gated cation channel activity 0.278054748078249 bayes_pls_golite062009
active transmembrane transporter activity 0.246383459363256 bayes_pls_golite062009
potassium channel activity 0.200283164564768 bayes_pls_golite062009
gated channel activity 0.150185445887481 bayes_pls_golite062009
structural constituent of cytoskeleton 0.116648335890738 bayes_pls_golite062009
voltage-gated potassium channel activity 0.109511951498555 bayes_pls_golite062009
protein complex binding 0.0676093357928913 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [95-190] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GTLEEKLSWA FELYDLNHDG YITFDEMLTI VASVYKMMGS MVTLNEDEAT PEMRVKKIFK  60
   61 LMDKNEDGYI TLDEFREGSK VDPSIIGALN LYDGLI

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 1095.522879
Match: 1fpwA_
Description: Frequenin (neuronal calcium sensor 1)
Matching Structure (courtesy of the PDB):
YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle