Protein Overview: RRP17

General Information:
Name(s) found:	RRP17 / YDR412W [SGD]
Description(s) found: SHOW ONLY BEST	gi\|927689\|gb\|AAB64855.1\| Ydr412wp; CAI: 0.16 [Saccharomyces cerevisiae] [NCBI NR] gi\|74583441\|sp\|Q04031.1\|RRP17_YEAST RecName: Full=Ribosomal RNA-processing protein 17 [NCBI NR] gi\|6320620\|ref\|NP_010700.1\| Protein required for cell viability; Rrp17p [Saccharomyces cerevisiae] [NCBI NR] pir\|\|S69697 hypothetical protein YDR412w - yeast (Saccharomyces cerevisiae) [NCBI NR] Ribosomal RNA-processing protein 17 OS=Saccharomyces cerevisiae GN=RRP17 PE=1 SV=1 [Swiss-Prot] Protein of unknown function localised to nucleus [mips] Component of the pre-60S pre-ribosomal particle; required for cell viability under standard (aerobic) conditions but not under anaerobic conditions [SGD] YDR412W, Chr IV from 1294682-1295389 [yeast_orfs2] Chr IV from 1294682-1295389 [yeastorf3.fasta] Chr IV from 1294681-1295388 [yeastorf4.fasta] >Q04031 (Q04031) D9461.3P [4932.FASTACCERV.txt] YDR412W SGDID:S0002820, Chr IV from 1294681-1295388, Uncharacterized ORF [yeastflysequest.fasta] YDR412W SGDID:S0002820, Chr IV from 1294683-1295390, Uncharacterized ORF [10112005cervSGD.fasta] Protein required for cell viability [Saccharomyces cerevisiae]gi\|2131474\|pir\|\|S69697 hypothetical protein YDR412w - yeast (Saccharomyces cerevisiae)gi\|927689\|gb\|AAB64855.1\| Ydr412wp; CAI: 0.16 [Saccharomyces cerevisiae] [nrdb_11152004_Chlamydomonas] (Q04031) Ydr412wp [cerv4932.FASTAC] YDR412W SGDID:S000002820, Chr IV from 1294683-1295390, Uncharacterized ORF, "Protein required for cell viability" [SGD_S-cerevisiae_na_12-16-2005_con_reversed.fasta] YDR412W SGDID:S000002820, Chr IV from 1294685-1295392, Uncharacterized ORF, "Protein required for cell viability" [yeast-contam.fasta] RRP17 SGDID:S000002820, Chr IV from 1294686-1295393, Uncharacterized ORF, "Component of the pre-60S pre-ribosomal particle; required for cell viability" [SGD_S-cerevisiae_na_08-19-2008_con_reversed.fasta] RRP17 SGDID:S000002820, Chr IV from 1294686-1295393, Uncharacterized ORF, "Component of the pre-60S pre-ribosomal particle; required for cell viability under standard (aerobic) conditions but not under anaerobic conditions" [yeast-200209-contam.fasta] Ydr412wp; CAI: 0.16 [Saccharomyces cerevisiae] [nr-271106-contam.fasta] Protein required for cell viability; Rrp17p [Saccharomyces cerevisiae] [nr-271106-contam.fasta] Ribosomal RNA-processing protein 17 [nr-271106-contam.fasta] [chemostatdb.fasta] Ribosomal RNA-processing protein 17 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=RRP17 PE=1 SV=1 [UniProt_S_cerevisiae_20120516_05-16-2012_reversed.fasta] RRP17 SGDID:S000002820, Chr IV from 1294693-1295400, Genome Release 64-1-1, Verified ORF, "Component of the pre-60S pre-ribosomal particle; required for cell viability under standard (aerobic) conditions but not under anaerobic conditions; exonuclease required for 5′ end processing of pre-60S ribosomal RNA" [yeast-030211-contam.fasta] RRP17 SGDID:S000002820, Chr IV from 1294693-1295400, Genome Release 64-2-1, Verified ORF, "Component of the pre-60S pre-ribosomal particle; required for cell viability under standard (aerobic) conditions but not under anaerobic conditions; exonuclease required for 5′ end processing of pre-60S ribosomal RNA" [20141208_orf_trans.fasta] TR8381\|c0_g1_i1\|g.5801 ORF TR8381\|c0_g1_i1\|g.5801 TR8381\|c0_g1_i1\|m.5801 type:complete len:236 (+) TR8381\|c0_g1_i1:69-776(+) [Y12_S_cerevisiae-Sep2015-contam.fasta] TR4370\|c0_g1_i1\|g.2910 ORF TR4370\|c0_g1_i1\|g.2910 TR4370\|c0_g1_i1\|m.2910 type:complete len:236 (+) TR4370\|c0_g1_i1:74-781(+) [DBVPG6044_S_cerevisiae-Sep2015-contam.fasta] YDR412W SGDID:S000002820, Chr IV from 1294693-1295400, Genome Release 64-1-1, Verified ORF, "Component of the pre-60S pre-ribosomal particle; required for cell viability under standard (aerobic) conditions but not under anaerobic conditions; exonuclease required for 5′ end processing of pre-60S ribosomal RNA" [2016-01-SGD_Yeast_Contam_Riffle_20140507-Ska-Hec-110-tubulin.fasta] asmbl_92\|g.52 ORF asmbl_92\|g.52 asmbl_92\|m.52 type:complete len:236 (+) asmbl_92:68-775(+) [DBVPG6044_Trinity_v2_2_0_PASA_6May2016-contam.fasta] asmbl_1120\|g.492 ORF asmbl_1120\|g.492 asmbl_1120\|m.492 type:complete len:236 (+) asmbl_1120:68-775(+) [Y12_Trinity_v2_2_0_PASA_6May2016-contam.fasta] ID=asmbl_92\|g.116 ORF ID=asmbl_92\|g.116 ID=asmbl_92\|m.116 type:complete len:236 (+) ID=asmbl_92:68-775(+) [DBVPG6044_quiverGenomes_Trinity_v2_2_0_PASA_2June2016-contam.fasta] ID=asmbl_1121\|g.632 ORF ID=asmbl_1121\|g.632 ID=asmbl_1121\|m.632 type:complete len:236 (+) ID=asmbl_1121:68-775(+) [Y12_quiver_Trinity_v2_2_0_PASA_2June2016-contam.fasta]
Organism:	Saccharomyces cerevisiae
Length:	235 amino acids
Gene Ontology:
Cellular Component:	cytoplasm [IDA]
Biological Process:	ribosome biogenesis [RCA] rRNA processing [IMP]
Molecular Function:	molecular_function [ND]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MAVHTNRQIL TRGKNYATKQ SKKFGTDEVT FDKDSRLDYL TGFHKRKLQR QKKAQEFIKE  60
   61 QERLRKIEER QKIRQERKEV MEEQLKTFKE SLNLEAEIED AKNDKTEDLQ VESDESWHGF 120
  121 DSDKDDGDND NNESSVKPIL KKGAITEIYD DSTTVELETL EPNDNFEYLA QLNNVKLEKA 180
  181 EKVLKQSINR ATKYAKFLGV DEKQKKKPRV KKFRYLTKNE RRINQRKAND NKRRR

Protein Complex Data

	PUBLICATION	TOPOLOGY	COCOMPLEXED PROTEINS
View Details	Krogan NJ, et al. (2006)		GDT1 MRD1 NOP12 RRP17
View Details	Ho Y, et al. (2002)		BRX1 CFT1 CIC1 CLU1 EBP2 ERB1 EXG1 FIN1 FIP1 FPR3 FPR4 GLC7 GLC8 GPH1 HER1 KEL1 MHP1 MRT4 NOC3 NOG1 NOP15 NOP16 NOP2 NOP7 NSA1 PIB2 REG1 RLP7 RRP17 SCD5 SCS2 SDS22 SEN1 SPB1 SUI2 SUI3 THI21 TIF6 YTM1
View Details	Qiu et al. (2008)		NUG1 RRP15 RRP17

Mass Spectrometry Data

The following runs contain data for this protein:

	BAIT	COMMENTS	PUBLICATION
View Run	MLP2	#10 Mitotic Prep1-TiO2 Phosphopeptide enrichment	Keck JM, et al. (2011)

Yeast Two-Hybrid Data

The following interactions contain this protein:

SHOWING SINGLE HITS. [ Hide Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

	BAIT	PREY	HITS	PUBLICATION
View Screen	RRP17	KIN3	2	Unpublished Fields Lab Data
View Screen	RRP17	HSP10	2	Unpublished Fields Lab Data
View Screen	RRP17	CSM1	2	Unpublished Fields Lab Data
View Screen	RRP17	SMA1	2	Unpublished Fields Lab Data
View Screen	RRP17	FOB1	2	Unpublished Fields Lab Data
View Screen	GLC7	RRP17	2	Uetz P, et al. (2000)
View Screen	RRP17	PDR1	2	Unpublished Fields Lab Data
View Screen	RRP17	ATG7	2	Unpublished Fields Lab Data
View Screen	RRP17	SFH1	2	Unpublished Fields Lab Data
View Screen	RRP17	ATG16	1	Unpublished Fields Lab Data
View Screen	RRP17	YIP3	1	Unpublished Fields Lab Data
View Screen	RRP17	HMO1	1	Unpublished Fields Lab Data
View Screen	ELM1	RRP17	1	Unpublished Fields Lab Data
View Screen	RRP17	YEL028W	1	Unpublished Fields Lab Data
View Screen	RRP17	NUP157	1	Unpublished Fields Lab Data
View Screen	RRP17	PUG1	1	Unpublished Fields Lab Data
View Screen	RRP17	DMA1	1	Unpublished Fields Lab Data
View Screen	RRP17	PFS1	1	Unpublished Fields Lab Data
View Screen	RRP17	PIG1	1	Unpublished Fields Lab Data
View Screen	RRP17	GSF2	1	Unpublished Fields Lab Data

Microscopy / Localization Data

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	PROTEIN(S)	PUBLICATION
View Data	RRP17 and NOP56	Huh WK, et al. (2003)
View Data	RRP17	Huh WK, et al. (2003)

Protein Structure Data

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[View Top Sequence Alignments] [Show Ginzu Version Information]

Domains predicted:

#		Region(s)	Method	Confidence	Match Description
1	View Details	[1..85]	MSA	3.032996	View MSA. No confident structure predictions are available.
2	View Details	[86..235]	MSA	3.032996	View MSA. No confident structure predictions are available.

Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

Philius Transmembrane Prediction:

Protein predicted to be:	GLOBULAR (No transmembrane regions or signal peptide)
Confidence of classification:	0.99

Source: Reynolds et al. (2008)

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2