Protein Overview: PAT1

General Information:
Name(s) found:	PAT1 / YCR077C [SGD]
Description(s) found: Found 20 descriptions. SHOW ALL	Topoisomerase II-associated deadenylation-dependent mRNA-decapping factor; also required for faithful chromosome transmission, maintenance of rDNA locus stability, and protection of mRNA 3'-UTRs from trimming; functionally linked to Pab1p [SGD]
Organism:	Saccharomyces cerevisiae
Length:	796 amino acids
Gene Ontology:
Cellular Component:	cytoplasmic mRNA processing body [IDA][IMP]
Biological Process:	deadenylation-dependent decapping of nuclear-transcribed mRNA [IMP][IPI] chromosome segregation [IMP] regulation of translational initiation [IGI][IMP]
Molecular Function:	molecular_function [ND]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSFFGLENSG NARDGPLDFE ESYKGYGEHE LEENDYLNDE TFGDNVQVGT DFDFGNPHSS  60
   61 GSSGNAIGGN GVGATARSYV AATAEGISGP RTDGTAAAGP LDLKPMESLW STAPPPAMAP 120
  121 SPQSTMAPAP APQQMAPLQP ILSMQDLERQ QRQMQQQFMN FHAMGHPQGL PQGPPQQQFP 180
  181 MQPASGQPGP SQFAPPPPPP GVNVNMNQMP MGPVQVPVQA SPSPIGMSNT PSPGPVVGAT 240
  241 KMPLQSGRRS KRDLSPEEQR RLQIRHAKVE KILKYSGLMT PRDKDFITRY QLSQIVTEDP 300
  301 YNEDFYFQVY KIIQRGGITS ESNKGLIARA YLEHSGHRLG GRYKRTDIAL QRMQSQVEKA 360
  361 VTVAKERPSK LKDQQAAAGN SSQDNKQANT VLGKISSTLN SKNPRRQLQI PRQQPSDPDA 420
  421 LKDVTDSLTN VDLASSGSSS TGSSAAAVAS KQRRRSSYAF NNGNGATNLN KSGGKKFILE 480
  481 LIETVYEEIL DLEANLRNGQ QTDSTAMWEA LHIDDSSYDV NPFISMLSFD KGIKIMPRIF 540
  541 NFLDKQQKLK ILQKIFNELS HLQIIILSSY KTTPKPTLTQ LKKVDLFQMI ILKIIVSFLS 600
  601 NNSNFIEIMG LLLQLIRNNN VSFLTTSKIG LNLITILISR AALIKQDSSR SNILSSPEIS 660
  661 TWNEIYDKLF TSLESKIQLI FPPREYNVHI MRLQNDKFMD EAYIWQFLAS LALSGKLNHQ 720
  721 RIIIDEVRDE IFATINEAET LQKKEKELSV LPQRSQELDT ELKSIIYNKE KLYQDLNLFL 780
  781 NVMGLVYRDG EISELK

Protein Complex Data

	PUBLICATION	TOPOLOGY	COCOMPLEXED PROTEINS
View Details	Riffle et al. (2010) (Unpublished Data)		BRR2 DHH1 DIB1 KEM1 LSM1 LSM2 LSM3 LSM4 LSM5 LSM6 LSM7 PAT1 PRP24 PRP3 PRP31 PRP4 PRP6 PRP8 SMD2 SMD3 SNU114 SNU66
View Details	Krogan NJ, et al. (2006)		KEM1 LSM1 LSM2 LSM3 LSM4 LSM5 LSM6 LSM7 LSM8 PAT1 PRP24 YGR054W
View Details	Gavin AC, et al. (2006)		KRS1 LSM1 LSM2 LSM4 LSM5 LSM6 LSM7 PAT1
View Details	Gavin AC, et al. (2002)		AAR2 ASC1 BRR1 BUD31 CDC33 CEF1 CLF1 CSN12 CUS1 CWC2 CWC22 CWC23 DCP2 DHH1 DIB1 ECM2 ERB1 GCN2 HSH155 HTA1 IMG1 KRS1 LEA1 LIN1 LSM1 LSM2 LSM3 LSM4 LSM5 LSM6 LSM7 LUC7 MRP7 MRPL28 MRPL3 MRPL35 MRPL38 MRPL4 MRPL8 MRPS5 MSL1 MUD1 NAM7 NOG2 NOP1 NUG1 PAT1 PRP11 PRP18 PRP19 PRP21 PRP24 PRP28 PRP3 PRP31 PRP38 PRP39 PRP4 PRP40 PRP42 PRP43 PRP46 PRP6 PRP8 PRP9 RSE1 RVB2 SLU7 SMB1 SMD1 SMD2 SMD3 SME1 SMX2 SMX3 SNP1 SNT309 SNU114 SNU23 SNU56 SNU66 SNU71 SPP381 SPP382 SQS1 SRB2 SRO9 STO1 SYF1 TOS4 UTP21 YML6
View Details	Ho Y, et al. (2002)		ADE5,7 DCP2 DHH1 GPG1 LSM1 LSM2 LSM4 LSM7 LSM8 PAT1 PEX19 PRP24 RPN6 SEC26 TPS1 UBP15
View Details	Qiu et al. (2008)		DCP1 DCP2 DHH1 KEM1 LSM1 PAT1

Mass Spectrometry Data

The following runs contain data for this protein:

	BAIT	COMMENTS	PUBLICATION
View Run	NAF1	No Comments	Hazbun TR, et al. (2003)
View Run	BOI1	Sample bob1 (2nd set) from october 2005	McCusker D, et al (2007)
View Run	MLP2	#32 Asynchronous Prep-No Phosphopeptide enrichment	Keck JM, et al. (2011)
View Run	MLP2	#10 Mitotic Prep1-TiO2 Phosphopeptide enrichment	Keck JM, et al. (2011)

Yeast Two-Hybrid Data

The following interactions contain this protein:

SHOWING SINGLE HITS. [ Hide Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

	BAIT	PREY	HITS	PUBLICATION
View Screen	SPP382	PAT1	2	Hazbun TR, et al. (2003)
View Screen	PSF1	PAT1	2	Hazbun TR, et al. (2003)
View Screen	PCF11	PAT1	2	Unpublished Fields Lab Data
View Screen	PCF11	PAT1	2	Unpublished Fields Lab Data
View Screen	YPP1	PAT1	1	Hazbun TR, et al. (2003)
View Screen	YHR122W	PAT1	1	Hazbun TR, et al. (2003)
View Screen	YJR023C	PAT1	1	Hazbun TR, et al. (2003)
View Screen	TRZ1	PAT1	1	Hazbun TR, et al. (2003)
View Screen	PSF1	PAT1	1	Hazbun TR, et al. (2003)
View Screen	PCF11	PAT1	1	Unpublished Fields Lab Data
View Screen	CIA1	PAT1	1	Hazbun TR, et al. (2003)
View Screen	SWC4	PAT1	1	Hazbun TR, et al. (2003)

Microscopy / Localization Data

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	PROTEIN(S)	PUBLICATION
View Data	PAT1	Huh WK, et al. (2003)

Protein Structure Data

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[View Top Sequence Alignments] [Show Ginzu Version Information]

Domains predicted:

#		Region(s)	Method	Confidence	Match Description
1	View Details	[1..227]	ab initio	12.04	No description for 1deqA was found.
2	View Details	[228..424]	MSA	1.264971	View MSA. No confident structure predictions are available.
3	View Details	[425..796]	deduced	N/A	No confident structure predictions are available.

Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

Philius Transmembrane Prediction:

Protein predicted to be:	GLOBULAR (No transmembrane regions or signal peptide)
Confidence of classification:	0.85

Source: Reynolds et al. (2008)

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2