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Protein Overview: MUD1

General Information:
Name(s) found: MUD1 / YBR119W [SGD]
Description(s) found:
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  • gi|6319595|ref|NP_009677.1| U1 snRNP A protein, homolog of human U1-A; involved in nuclear mRNA splicing; Mud1p [Saccharomyces cerevisiae] [NCBI NR]
  • gi|536398|emb|CAA85076.1| MUD1 [Saccharomyces cerevisiae] [NCBI NR]
  • pir||A46301 U1 snRNP-specific protein A - yeast (Saccharomyces cerevisiae) [NCBI NR]
  • gi|417742|sp|P32605.1|RU1A_YEAST RecName: Full=U1 small nuclear ribonucleoprotein A; Short=U1 snRNP protein A; Short=U1-A; AltName: Full=Mutant U1 die protein 1 [NCBI NR]
  • gi|297483|emb|CAA50378.1| U1 snRNP A protein [Saccharomyces cerevisiae] [NCBI NR]
  • U1 small nuclear ribonucleoprotein A OS=Saccharomyces cerevisiae GN=MUD1 PE=1 SV=1 [Swiss-Prot]
  • MUD1 U1 snRNP-specific A protein [mips]
  • U1 snRNP A protein, homolog of human U1-A; involved in nuclear mRNA splicing [SGD]
  • MUD1, Chr II from 479296-479303,479393-480281 [yeast_orfs2]
  • Chr II from 479296-479303,479393-480281 [yeastorf3.fasta]
  • Chr II from 479295-479302,479392-480280 [yeastorf4.fasta]
  • Chr II from 479293-479300,479390-480278 [yeastorf5.fasta]
  • (P32605) U1 small nuclear ribonucleoprotein A (U1 snRNP protein A) (U1-A) [4932.FASTACCERV.txt]
  • MUD1 SGDID:S0000323, Chr II from 479294-479301,479391-480279, Verified ORF [yeastflysequest.fasta]
  • MUD1 SGDID:S0000323, Chr II from 479332-479339,479429-480317, Verified ORF [10112005cervSGD.fasta]
  • Mud1p [Saccharomyces cerevisiae]gi|297483|emb|CAA50378.1| U1 snRNP A protein [Saccharomyces cerevisiae]gi|536398|emb|CAA85076.1| MUD1 [Saccharomyces cerevisiae]gi|417742|sp|P32605|RU1A_YEAST U1 small nuclear ribonucleoprotein A (U1 snRNP protein A) (U1 [nrdb_11152004_Chlamydomonas]
  • MUD1 SGDID:S000000323, Chr II from 479332-479339,479429-480317, Verified ORF, "U1 snRNP A protein, homolog of human U1-A; involved in nuclear mRNA splicing" [SGD_S-cerevisiae_na_12-16-2005_con_reversed.fasta]
  • U1 small nuclear ribonucleoprotein A (U1 snRNP protein A) (U1-A) [nr-271106-contam.fasta]
  • MUD1 [Saccharomyces cerevisiae] [nr-271106-contam.fasta]
  • U1 snRNP A protein [Saccharomyces cerevisiae] [nr-271106-contam.fasta]
  • U1 snRNP A protein, homolog of human U1-A; involved in nuclear mRNA splicing; Mud1p [Saccharomyces cerevisiae] [nr-271106-contam.fasta]
  • [chemostatdb.fasta]
  • U1 small nuclear ribonucleoprotein A OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=MUD1 PE=1 SV=1 [UniProt_S_cerevisiae_20120516_05-16-2012_reversed.fasta]
  • MUD1 SGDID:S000000323, Chr II from 479338-479345,479435-480323, Genome Release 64-1-1, Verified ORF, "U1 snRNP A protein, homolog of human U1-A; involved in nuclear mRNA splicing" [yeast-030211-contam.fasta]
  • MUD1 SGDID:S000000323, Chr II from 479338-479345,479435-480323, Genome Release 64-2-1, Verified ORF, "U1 snRNP A protein; homolog of human U1-A; involved in nuclear mRNA splicing" [20141208_orf_trans.fasta]
  • YBR119W SGDID:S000000323, Chr II from 479338-479345,479435-480323, Genome Release 64-1-1, Verified ORF, "U1 snRNP A protein, homolog of human U1-A; involved in nuclear mRNA splicing" [2016-01-SGD_Yeast_Contam_Riffle_20140507-Ska-Hec-110-tubulin.fasta]
    • Organism: Saccharomyces cerevisiae
    Length: 298 amino acids

    Gene Ontology:
    Cellular Component: U1 snRNP [IDALink to PubMed articleLink to PubMed article]
    Biological Process: nuclear mRNA splicing, via spliceosome [IGILink to PubMed article]
    Molecular Function: RNA binding [IGILink to PubMed article][ISSLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSALYFQNLP SRPANKENYT RLLLKHINPN NKYAINPSLP LPHNKLQISS QPLMLLDDQM  60
   61 GLLEVSISRS SKMTNQAFLT FVTQEEADRF LEKYTTTALK VQGRKVRMGK ARTNSLLGLS 120
  121 IEMQKKKGND ETYNLDIKKV LKARKLKRKL RSDDICAKKF RLKRQIRRLK HKLRSRKVEE 180
  181 AEIDRIVKEF ETRRLENMKS QQENLKQSQK PLKRAKVSNT MENPPNKVLL IQNLPSGTTE 240
  241 QLLSQILGNE ALVEIRLVSV RNLAFVEYET VADATKIKNQ LGSTYKLQNN DVTIGFAK

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Riffle et al. (2010) (Unpublished Data) BRR1 CBC2 LUC7 MUD1 NAM8 PRP11 PRP39 PRP4 PRP40 PRP42 SMB1 SMD1 SMD2 SMD3 SME1 SMX3 SNP1 SNU56 SNU71 STO1 YHC1
    View Details Krogan NJ, et al. (2006) AAR2 BRR1 BRR2 CSE1 LUC7 MUD1 NAM8 PRP2 PRP3 PRP31 PRP39 PRP40 PRP42 PRP6 PRP8 RRG7 SMB1 SMD1 SMD2 SMD3 SME1 SMX2 SMX3 SNP1 SNU114 SNU56 SNU66 SNU71 TAD2 YDL085C-A YHC1 YJU2 YNL092W
    View Details Gavin AC, et al. (2006) LUC7 MUD1 NAM8 PRP39 PRP40 PRP42 SNP1 SNU56 SNU71 YHC1
    View Details Gavin AC, et al. (2002) AAR2 AIR2 BRR1 BUD31 BUR2 CBC2 CDC33 CEF1 CLF1 CSN12 CUS1 CWC2 CWC22 CWC23 DHH1 DIB1 ECM2 GCN2 HRT1 HSH155 HSH49 HTA1 IMG1 KAP95 LEA1 LIN1 LSM1 LSM2 LSM4 LSM5 LSM6 LSM7 LUC7 MRP7 MRPL28 MRPL3 MRPL35 MRPL38 MRPL4 MRPL8 MRPS5 MSH4 MSL1 MUD1 NAB3 NAB6 NAM8 NPL3 NRD1 NUP60 PAT1 PRP11 PRP18 PRP19 PRP21 PRP24 PRP28 PRP3 PRP31 PRP38 PRP39 PRP4 PRP40 PRP42 PRP43 PRP46 PRP6 PRP8 PRP9 RSE1 RVB2 SCP160 SEN1 SGV1 SLU7 SMB1 SMD1 SMD2 SMD3 SME1 SMX2 SMX3 SNP1 SNT309 SNU114 SNU23 SNU56 SNU66 SNU71 SPP381 SPP382 SRB2 SRO9 SRP1 STO1 SYF1 THO2 TIF4631 TIF4632 TOS4 UTP21 YEF3 YML6 YRA2
    View Details Qiu et al. (2008) AAR2 BRR1 BRR2 BUD31 CBC2 CDC40 CEF1 CLF1 CUS1 CUS2 CWC15 CWC2 CWC22 CWC23 CWC25 DIB1 ECM2 HSH155 HSH49 IST3 ISY1 LEA1 LSM2 LSM3 LSM4 LSM5 LSM7 LSM8 LUC7 MAK5 MSL1 MUD1 MUD2 NAM8 NTC20 PRP11 PRP16 PRP18 PRP19 PRP2 PRP21 PRP22 PRP24 PRP28 PRP3 PRP31 PRP38 PRP39 PRP4 PRP40 PRP42 PRP43 PRP45 PRP46 PRP5 PRP6 PRP8 PRP9 RSE1 SLU7 SMB1 SMD1 SMD2 SMD3 SME1 SMX2 SMX3 SNP1 SNT309 SNU114 SNU23 SNU56 SNU66 SNU71 SPP2 SPP381 SPP382 STO1 SUB2 SYF2 YHC1

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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      PROTEIN(S) PUBLICATION
    View Data MUD1 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..113] PSI-BLAST 38.221849 Poly(A)-binding protein
    2 View Details [114..212] PSI-BLAST 38.221849 Poly(A)-binding protein
    3 View Details [213..298] PSI-BLAST 78.917458 Splicesomal U1A protein

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • RNA binding
    		•  6.73097473547076 bayes_pls_golite062009
    		• 6.62953239642182 bayes_pls_golite062009
  • mRNA binding
    		•  5.29759606920196 bayes_pls_golite062009
  • U1 snRNA binding
    		•  4.22094068431436 bayes_pls_golite062009
  • snRNA binding
    		•  4.06596327298973 bayes_pls_golite062009
  • nucleic acid binding
    		•  3.81920018903278 bayes_pls_golite062009
  • poly-pyrimidine tract binding
    		•  3.11990160533699 bayes_pls_golite062009
  • binding
    		•  3.05116833253954 bayes_pls_golite062009
  • single-stranded RNA binding
    		•  2.93798024346416 bayes_pls_golite062009
  • structural molecule activity
    		•  1.29928829870122 bayes_pls_golite062009
  • transcription regulator activity
    		•  1.07788694919471 bayes_pls_golite062009
  • DNA binding
    		•  0.978604858165557 bayes_pls_golite062009
  • mRNA 3'-UTR binding
    		•  0.591700155096213 bayes_pls_golite062009
  • protein binding
    		•  0.42571879933058 bayes_pls_golite062009
  • transcription factor activity
    		•  0.234742017105535 bayes_pls_golite062009
    2 No functions predicted.
    3 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle