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Protein Overview: NUP60

General Information:
Name(s) found: NUP60 / YAR002W [SGD]
Description(s) found:
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  • gi|731299|sp|P39705.1|NUP60_YEAST RecName: Full=Nucleoporin NUP60; AltName: Full=Nuclear pore protein NUP60 [NCBI NR]
  • gi|6319318|ref|NP_009401.1| Subunit of the nuclear pore complex (NPC), functions to anchor Nup2p to the NPC in a process controlled by the nucleoplasmic concentration of Gsp1p-GTP; potential Cdc28p substrate; involved in telomere maintenance; Nup60p [Sacc [NCBI NR]
  • pir||S40900 FUN17 protein - yeast (Saccharomyces cerevisiae) [NCBI NR]
  • gi|51013337|gb|AAT92962.1| YAR002W [Saccharomyces cerevisiae] [NCBI NR]
  • gi|349750|gb|AAC04957.1| Yar002wp [Saccharomyces cerevisiae] [NCBI NR]
  • Nucleoporin NUP60 OS=Saccharomyces cerevisiae GN=NUP60 PE=1 SV=1 [Swiss-Prot]
  • (P39705) Nucleoporin NUP60 (Nuclear pore protein NUP60) [Swiss-Prot]
  • NUP60 Nuclear pore protein [mips]
  • Subunit of the nuclear pore complex (NPC), functions to anchor Nup2p to the NPC in a process controlled by the nucleoplasmic concentration of Gsp1p-GTP; potential Cdc28p substrate; involved in telomere maintenance [SGD]
  • NUP60, Chr I from 152254-153873 [yeast_orfs2]
  • Chr I from 152254-153873 [yeastorf3.fasta]
  • Chr I from 152258-153877 [yeastorf4.fasta]
  • (P39705) Hypothetical 59.0 kDa protein in TFC3-RFA1 intergenic region [4932.FASTACCERV.txt]
  • NUP60 SGDID:S0000063, Chr I from 152261-153880, Verified ORF [yeastflysequest.fasta]
  • NUP60 SGDID:S0000063, Chr I from 152259-153878, Verified ORF [10112005cervSGD.fasta]
  • Nup60p [Saccharomyces cerevisiae]gi|51013337|gb|AAT92962.1| YAR002W [Saccharomyces cerevisiae]gi|542303|pir||S40900 FUN17 protein - yeast (Saccharomyces cerevisiae)gi|349750|gb|AAC04957.1| Yar002wp [Saccharomyces cerevisiae]gi|731299|sp|P39705|NU60_YE [nrdb_11152004_Chlamydomonas]
  • NUP60 SGDID:S000000063, Chr I from 152259-153878, Verified ORF, "Subunit of the nuclear pore complex (NPC), functions to anchor Nup2p to the NPC in a dynamic process that is controlled by the nucleoplasmic concentration of Gsp1p-GTP; potential Cdc28p subs [SGD_S-cerevisiae_na_12-16-2005_con_reversed.fasta]
  • NUP60 SGDID:S000000063, Chr I from 152259-153878, Verified ORF, "Subunit of the nuclear pore complex (NPC), functions to anchor Nup2p to the NPC in a process controlled by the nucleoplasmic concentration of Gsp1p-GTP; potential Cdc28p substrate; involved [yeast-contam.fasta]
  • Nucleoporin NUP60 (Nuclear pore protein NUP60) [nr-271106-contam.fasta]
  • YAR002W [Saccharomyces cerevisiae] [nr-271106-contam.fasta]
  • Subunit of the nuclear pore complex (NPC), functions to anchor Nup2p to the NPC in a process controlled by the nucleoplasmic concentration of Gsp1p-GTP; potential Cdc28p substrate; involved in telomere maintenance; Nup60p [Saccharomyces cerevisiae] [nr-271106-contam.fasta]
  • Yar002wp [Saccharomyces cerevisiae] [nr-271106-contam.fasta]
  • NUP60 SGDID:S000000063, Chr I from 152259-153878, Verified ORF, "Subunit of the nuclear pore complex (NPC), functions to anchor Nup2p to the NPC in a process controlled by the nucleoplasmic concentration of Gsp1p-GTP; potential Cdc28p substrate; involved in telomere maintenance" [yeast-bovrabprots.fasta]
  • [chemostatdb.fasta]
  • Nucleoporin NUP60 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=NUP60 PE=1 SV=1 [UniProt_S_cerevisiae_20120516_05-16-2012_reversed.fasta]
  • NUP60 SGDID:S000000063, Chr I from 152257-153876, Genome Release 64-1-1, Verified ORF, "Subunit of the nuclear pore complex (NPC), functions to anchor Nup2p to the NPC in a process controlled by the nucleoplasmic concentration of Gsp1p-GTP; involved in nuclear export and cytoplasmic localization of specific mRNAs such as ASH1" [yeast-030211-contam.fasta]
  • NUP60 SGDID:S000000063, Chr I from 152257-153876, Genome Release 64-2-1, Verified ORF, "FG-nucleoporin component of central core of the nuclear pore complex; contributes directly to nucleocytoplasmic transport and maintenance of the nuclear pore complex (NPC) permeability barrier and is involved in gene tethering at the nuclear periphery; relocalizes to the cytosol in response to hypoxia; both NUP1 and NUP60 are homologous to human NUP153" [20141208_orf_trans.fasta]
  • YAR002W SGDID:S000000063, Chr I from 152257-153876, Genome Release 64-1-1, Verified ORF, "Subunit of the nuclear pore complex (NPC), functions to anchor Nup2p to the NPC in a process controlled by the nucleoplasmic concentration of Gsp1p-GTP; involved in nuclear export and cytoplasmic localization of specific mRNAs such as ASH1" [2016-01-SGD_Yeast_Contam_Riffle_20140507-Ska-Hec-110-tubulin.fasta]
    • Organism: Saccharomyces cerevisiae
    Length: 539 amino acids

    Gene Ontology:
    Cellular Component: nuclear pore [TASLink to PubMed article]
    Biological Process: nucleocytoplasmic transport [IMPLink to PubMed article]
    telomere maintenance [IMPLink to PubMed article]
    protein import into nucleus, docking [IMPLink to PubMed article][IPILink to PubMed article]
    Molecular Function: structural constituent of nuclear pore [TASLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MHRKSLRRAS ATVPSAPYRK QIISNAHNKP SLFSKIKTFF TQKDSARVSP RNNVANKQPR  60
   61 NESFNRRISS MPGGYFHSEI SPDSTVNRSV VVSAVGEARN DIENKEEEYD ETHETNISNA 120
  121 KLANFFSKKG NEPLSEIEIE GVMSLLQKSS KSMITSEGEQ KSAEGNNIDQ SLILKESGST 180
  181 PISISNAPTF NPKYDTSNAS MNTTLGSIGS RKYSFNYSSL PSPYKTTVYR YSAAKKIPDT 240
  241 YTANTSAQSI ASAKSVRSGV SKSAPSKKIS NTAAALVSLL DENDSKKNNA ASELANPYSS 300
  301 YVSQIRKHKR VSPNAAPRQE ISEEETTVKP LFQNVPEQGE EPMKQLNATK ISPSAPSKDS 360
  361 FTKYKPARSS SLRSNVVVAE TSPEKKDGGD KPPSSAFNFS FNTSRNVEPT ENAYKSENAP 420
  421 SASSKEFNFT NLQAKPLVGK PKTELTKGDS TPVQPDLSVT PQKSSSKGFV FNSVQKKSRS 480
  481 NLSQENDNEG KHISASIDND FSEEKAEEFD FNVPVVSKQL GNGLVDENKV EAFKSLYTF

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Riffle et al. (2010) (Unpublished Data) KAP95 NUP2 NUP60 SRP1
    View Details Krogan NJ, et al. (2006) CBC2 KAP95 NUP1 NUP2 NUP60 OGG1 PCT1 RAD53 SRP1 STO1 ULP1 URB2 YRA2
    View Details Gavin AC, et al. (2006) KAP95 NUP2 NUP60 SRP1
    View Details Gavin AC, et al. (2002) AIR2 BRR1 BUR2 CBC2 HTA1 KAP95 LUC7 MSH4 MUD1 NAB3 NAB6 NAM8 NPL3 NRD1 NUP60 PRP39 PRP40 PRP42 RSE1 SCP160 SEN1 SGV1 SMD1 SMD2 SMD3 SNP1 SNU56 SNU71 SRO9 SRP1 STO1 THO2 TIF4631 TIF4632 YRA2
    View Details Ho Y, et al. (2002) DIS3 EAF3 FIP1 HAS1 HPR1 KAP95 MES1 MFT1 NAM8 NOP6 NUP1 NUP2 NUP60 PAP1 PCT1 REB1 RNT1 RRP4 RRP43 RRP6 RTT103 SIF2 SIN3 SNU56 SRP1 STO1 THO2 TRA1 UME1 YPR090W
    View Details Qiu et al. (2008) ASM4 MEX67 NDC1 NUP1 NUP116 NUP170 NUP188 NUP60 POM152

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run SEC10 No Comments De Craene, J., et al. (2006)
    View Run CEP3 sample cbf3 from feb 2005 Sandall S, et all (2006)
    View Run RPA135 No Comments Schneider, DA, et al. (2006)
    View Run MLP2 #25 Asynchronous Prep3-TiO2 Flowthrough Keck JM, et al. (2011)
    View Run MLP2 #32 Asynchronous Prep-No Phosphopeptide enrichment Keck JM, et al. (2011)
    View Run MLP2 #12 Mitotic Prep1-TiO2 Flowthrough Keck JM, et al. (2011)
    View Run MLP2 #02 Alpha Factor Prep1-TiO2 enriched, new search criteria Keck JM, et al. (2011)
    View Run MLP2 #11 Mitotic Prep1-TiO2 enriched, new search criteria Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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      PROTEIN(S) PUBLICATION
    View Data NUP60 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..69] MSA 1.002981 View MSA. No confident structure predictions are available.
    2 View Details [70..198] deduced N/A No confident structure predictions are available.
    3 View Details [199..539] ab initio 11.0 No description for 1m2vB was found.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.92

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle