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View Protein Complex Details

Complex Overview

From Publication: Ho Y. et al. (2002) Systematic identification of protein complexes in Saccharomyces cerevisiae by mass spectrometry. Nature. 2002 Jan 10;415(6868):180-3.
Notes: This molecular complex record represents a population of complexes co-purified by immunoprecipitation of FLAG-tagged Prp6. The topolgies of protein complexes in this experiment are unknown.
Complex Size: 39 proteins

Complex Member Proteins

Protein

GO Cellular Component GO Biological Process GO Molecular Function
ACS2
  • nucleus
  • cytosol
  • acetyl-CoA biosynthetic process
  • histone acetylation
  • acetate-CoA ligase activity
  • ADE3
  • nucleus
  • cytoplasm
  • folic acid and derivative metabolic process
  • purine base biosynthetic process
  • formate-tetrahydrofolate ligase activity
  • methenyltetrahydrofolate cyclohydrolase activity
  • methylenetetrahydrofolate dehydrogenase (NADP+) activity
  • ADE6
  • cytoplasm
  • purine nucleotide biosynthetic process
  • 'de novo' IMP biosynthetic process
  • phosphoribosylformylglycinamidine synthase activity
  • ADO1
  • nucleus
  • cytoplasm
  • telomere maintenance
  • purine base metabolic process
  • adenosine kinase activity
  • ALA1
  • cytoplasm
  • mitochondrion
  • alanyl-tRNA aminoacylation
  • alanine-tRNA ligase activity
  • APE2
  • cytoplasm
  • mitochondrion
  • cell wall-bounded periplasmic space
  • peptide metabolic process
  • leucyl aminopeptidase activity
  • ARA1
  • cytosol
  • carbohydrate metabolic process
  • aldehyde reductase activity
  • aldo-keto reductase activity
  • D-arabinose 1-dehydrogenase [NAD(P)+] activity
  • BAT1
  • mitochondrial matrix
  • mitochondrion
  • branched chain family amino acid catabolic process
  • branched chain family amino acid biosynthetic process
  • branched-chain-amino-acid transaminase activity
  • CDC10
  • cellular bud neck septin ring
  • axial cellular bud site selection
  • bipolar cellular bud site selection
  • cell morphogenesis
  • conjugation with cellular fusion
  • cellular cell wall organization
  • cytokinesis
  • cell morphogenesis involved in conjugation with cellular fusion
  • ascospore wall assembly
  • GTPase activity
  • structural constituent of cytoskeleton
  • phosphatidylinositol binding
  • CLU1
  • cytoplasm
  • eukaryotic translation initiation factor 3 complex
  • translational initiation
  • mitochondrion organization
  • molecular_function
  • CYS3
  • cytoplasm
  • sulfur amino acid metabolic process
  • response to drug
  • transsulfuration
  • cysteine metabolic process
  • cystathionine gamma-lyase activity
  • DED81
  • cytoplasm
  • asparaginyl-tRNA aminoacylation
  • ATP binding
  • asparagine-tRNA ligase activity
  • DPS1
  • cytoplasm
  • translation
  • RNA binding
  • aspartate-tRNA ligase activity
  • ERG10
  • cytosol
  • ergosterol biosynthetic process
  • acetyl-CoA C-acetyltransferase activity
  • ERG20
  • cytosol
  • ergosterol biosynthetic process
  • isoprenoid biosynthetic process
  • farnesyl diphosphate biosynthetic process
  • geranyltranstransferase activity
  • dimethylallyltranstransferase activity
  • GCY1
  • nucleus
  • cytoplasm
  • response to salt stress
  • arabinose catabolic process
  • D-xylose catabolic process
  • aldo-keto reductase activity
  • GPH1
  • cytoplasm
  • glycogen catabolic process
  • glycogen phosphorylase activity
  • GRS1
  • cytoplasm
  • mitochondrion
  • glycyl-tRNA aminoacylation
  • transcription termination
  • glycine-tRNA ligase activity
  • HOM2
  • nucleus
  • cytoplasm
  • response to drug
  • methionine metabolic process
  • threonine metabolic process
  • homoserine biosynthetic process
  • aspartate-semialdehyde dehydrogenase activity
  • HYP2
  • cytoplasm
  • mitochondrion
  • ribosome
  • translational initiation
  • translation initiation factor activity
  • protein binding
  • ILS1
  • cytosol
  • translation
  • isoleucine-tRNA ligase activity
  • IMD3
  • cytoplasm
  • GTP biosynthetic process
  • IMP dehydrogenase activity
  • KRS1
  • cytoplasm
  • lysyl-tRNA aminoacylation
  • lysine-tRNA ligase activity
  • LSP1
  • cytoplasm
  • mitochondrion
  • mitochondrial outer membrane
  • eisosome
  • response to heat
  • endocytosis
  • protein kinase inhibitor activity
  • MDH3
  • peroxisome
  • peroxisomal matrix
  • fatty acid beta-oxidation
  • malate metabolic process
  • NADH regeneration
  • glyoxylate cycle
  • L-malate dehydrogenase activity
  • OLA1
  • cytoplasm
  • biological_process
  • molecular_function
  • PAB1
  • nucleus
  • cytoplasm
  • ribosome
  • regulation of translational initiation
  • poly(A) RNA binding
  • PFK2
  • 6-phosphofructokinase complex
  • cytoplasm
  • mitochondrion
  • glycolysis
  • 6-phosphofructokinase activity
  • PGM2
  • cytosol
  • response to temperature stimulus
  • energy reserve metabolic process
  • UDP-glucose metabolic process
  • trehalose biosynthetic process
  • alcohol metabolic process
  • glucose metabolic process
  • cellular calcium ion homeostasis
  • vacuolar protein catabolic process
  • carbohydrate metabolic process
  • glycogen biosynthetic process
  • glucose 6-phosphate metabolic process
  • cellular carbohydrate metabolic process
  • galactose catabolic process
  • glucose 1-phosphate metabolic process
  • cellular cation homeostasis
  • phosphoglucomutase activity
  • PMI40
  • nucleus
  • cytoplasm
  • cell wall mannoprotein biosynthetic process
  • GDP-mannose biosynthetic process
  • protein amino acid glycosylation
  • mannose-6-phosphate isomerase activity
  • PRP6
  • U4/U6 x U5 tri-snRNP complex
  • nuclear mRNA splicing, via spliceosome
  • binding
  • molecular_function
  • SAC6
  • actin cortical patch
  • bipolar cellular bud site selection
  • response to osmotic stress
  • actin filament organization
  • endocytosis
  • actin filament binding
  • protein binding, bridging
  • SCP160
  • endoplasmic reticulum membrane
  • polysome
  • nuclear membrane-endoplasmic reticulum network
  • meiotic telomere clustering
  • intracellular mRNA localization
  • response to drug
  • chromosome segregation
  • chromatin silencing at silent mating-type cassette
  • chromatin silencing at telomere
  • pheromone-dependent signal transduction involved in conjugation with cellular fusion
  • RNA binding
  • G-protein alpha-subunit binding
  • SOD1
  • mitochondrial intermembrane space
  • mitochondrion
  • cytosol
  • age-dependent response to reactive oxygen species involved in chronological cell aging
  • response to cold
  • superoxide metabolic process
  • cellular copper ion homeostasis
  • response to drug
  • cellular zinc ion homeostasis
  • antioxidant activity
  • metal ion binding
  • oxidoreductase activity
  • superoxide dismutase activity
  • SSZ1
  • cytoplasm
  • regulation of translational fidelity
  • translation
  • unfolded protein binding
  • THR4
  • nucleus
  • cytoplasm
  • endocytosis
  • threonine metabolic process
  • threonine synthase activity
  • TRR1
  • cytoplasm
  • response to oxidative stress
  • thioredoxin-disulfide reductase activity
  • UBA1
  • nucleus
  • cytoplasm
  • ubiquitin cycle
  • ubiquitin activating enzyme activity
  • YDL124W
  • nucleus
  • cytoplasm
  • metabolic process
  • alpha-keto amide reductase activity
  • alpha-keto ester reductase activity
  • aldo-keto reductase activity
  • Cellular Component Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    cytoplasm 5.9302E-9 39 3552 38 6292
    intracellular part 7.6145E-5 39 4938 39 6292
    intracellular 1.0199E-4 39 4975 39 6292
    cytosol 2.826E-4 39 284 8 6292
    cell part 2.4698E-3 39 5397 39 6292
    cell 2.5059E-3 39 5399 39 6292

    Biological Process Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    small molecule metabolic process 2.5141E-9 39 760 20 6292
    metabolic process 7.4352E-6 39 3157 33 6292
    cellular amino acid metabolic process 2.302E-5 39 199 8 6292
    carboxylic acid metabolic process 2.4172E-5 39 333 10 6292
    organic acid metabolic process 2.4172E-5 39 333 10 6292
    oxoacid metabolic process 2.4172E-5 39 333 10 6292
    cellular ketone metabolic process 3.3673E-5 39 346 10 6292
    tRNA aminoacylation for protein translation 4.533E-5 39 33 4 6292
    tRNA aminoacylation 4.533E-5 39 33 4 6292
    amino acid activation 4.533E-5 39 33 4 6292
    cellular amine metabolic process 5.0577E-5 39 222 8 6292
    translation 6.8566E-5 39 376 10 6292
    primary metabolic process 8.0165E-5 39 2896 30 6292
    cellular amino acid and derivative metabolic process 9.5938E-5 39 243 8 6292
    amine metabolic process 9.5938E-5 39 243 8 6292
    biosynthetic process 1.3687E-4 39 1602 21 6292
    cellular metabolic process 2.29E-4 39 3033 30 6292
    cellular biosynthetic process 3.3881E-4 39 1567 20 6292
    alcohol metabolic process 3.4365E-4 39 220 7 6292
    response to abiotic stimulus 7.0893E-4 39 117 5 6292
    homoserine metabolic process 7.7096E-4 39 7 2 6292
    nucleotide-sugar metabolic process 7.7096E-4 39 7 2 6292
    response to temperature stimulus 8.7785E-4 39 31 3 6292
    small molecule catabolic process 9.5714E-4 39 125 5 6292
    cellular carbohydrate catabolic process 9.5809E-4 39 72 4 6292
    carbohydrate catabolic process 1.1169E-3 39 75 4 6292
    threonine metabolic process 1.3113E-3 39 9 2 6292
    monosaccharide metabolic process 1.3525E-3 39 135 5 6292
    carbohydrate metabolic process 1.4765E-3 39 281 7 6292
    translational initiation 2.1389E-3 39 42 3 6292
    small molecule biosynthetic process 2.5925E-3 39 310 7 6292
    nucleobase, nucleoside and nucleotide metabolic process 2.6329E-3 39 157 5 6292
    purine base metabolic process 3.7359E-3 39 15 2 6292
    monosaccharide catabolic process 4.3905E-3 39 54 3 6292
    cellular carbohydrate metabolic process 5.0468E-3 39 262 6 6292
    alcohol catabolic process 5.1135E-3 39 57 3 6292
    tRNA metabolic process 6.1831E-3 39 120 4 6292
    homocysteine metabolic process 6.1983E-3 39 1 1 6292
    asparaginyl-tRNA aminoacylation 6.1983E-3 39 1 1 6292
    alanyl-tRNA aminoacylation 6.1983E-3 39 1 1 6292
    transsulfuration 6.1983E-3 39 1 1 6292
    superoxide metabolic process 6.1983E-3 39 1 1 6292
    hexose metabolic process 6.9373E-3 39 124 4 6292
    response to drug 7.7505E-3 39 128 4 6292

    Molecular Function Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    aminoacyl-tRNA ligase activity 9.0678E-8 39 38 6 6292
    ligase activity, forming aminoacyl-tRNA and related compounds 9.0678E-8 39 38 6 6292
    ligase activity, forming carbon-oxygen bonds 9.0678E-8 39 38 6 6292
    ligase activity 2.2519E-7 39 150 9 6292
    catalytic activity 3.2117E-7 39 2150 29 6292
    aldo-keto reductase activity 1.8029E-5 39 9 3 6292
    oxidoreductase activity 4.0378E-5 39 281 9 6292
    oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor 7.7525E-5 39 73 5 6292
    oxidoreductase activity, acting on CH-OH group of donors 1.2755E-4 39 81 5 6292
    glycogen phosphorylase activity 6.1983E-3 39 1 1 6292
    alanine-tRNA ligase activity 6.1983E-3 39 1 1 6292
    threonine synthase activity 6.1983E-3 39 1 1 6292
    adenosine kinase activity 6.1983E-3 39 1 1 6292
    phosphoribosylformylglycinamidine synthase activity 6.1983E-3 39 1 1 6292
    alpha-keto amide reductase activity 6.1983E-3 39 1 1 6292
    alpha-keto ester reductase activity 6.1983E-3 39 1 1 6292
    phosphorylase activity 6.1983E-3 39 1 1 6292
    geranyltranstransferase activity 6.1983E-3 39 1 1 6292
    C-acetyltransferase activity 6.1983E-3 39 1 1 6292
    aspartate-semialdehyde dehydrogenase activity 6.1983E-3 39 1 1 6292
    mannose-6-phosphate isomerase activity 6.1983E-3 39 1 1 6292
    dimethylallyltranstransferase activity 6.1983E-3 39 1 1 6292
    acetyl-CoA C-acetyltransferase activity 6.1983E-3 39 1 1 6292
    G-protein alpha-subunit binding 6.1983E-3 39 1 1 6292
    ubiquitin activating enzyme activity 6.1983E-3 39 1 1 6292

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle