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Catalysis of the elimination of H2S or substituted H2S. Catalysis of the reaction: L-cystathionine + H2O = L-cysteine + NH3 + 2-oxobutanoate. Catalysis of the cleavage of C-C, C-O, C-N and other bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond. They differ from other enzymes in that two substrates are involved in one reaction direction, but only one in the other direction. When acting on the single substrate, a molecule is eliminated and this generates either a new double bond or a new ring.

View Gene Ontology (GO) Term

GO TERM SUMMARY
Name: cystathionine gamma-lyase activity
Acc: GO:0004123
Aspect: Molecular Function
Desc: Catalysis of the reaction: L-cystathionine + H2O = L-cysteine + NH3 + 2-oxobutanoate.
Synonyms:
  • cystathioninase activity
  • homoserine deaminase-cystathionase activity
  • cystathionase activity
  • cysteine desulfhydrase activity
  • cystalysin
  • homoserine dehydratase activity
  • homoserine deaminase activity
  • L-cystathionine cysteine-lyase (deaminating; 2-oxobutanoate-forming)
  • gamma-cystathionase activity
  • gamma-CTL
  • cystine desulfhydrase activity
  • GO:0016225
  • L-cystathionine cysteine-lyase (deaminating)
Proteins in PDR annotated with:
   This term: 25 [Search]
   Term or descendants: 25 [Search]


[geneontology.org]
INTERACTIVE GO GRAPH

GO:0004123 - cystathionine gamma-lyase activity (interactive image map)
YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle