YRC Logo
PROTEIN SEARCH:
Descriptions Names[Advanced Search]

View Protein Complex Details

Complex Overview

From Publication: Ho Y. et al. (2002) Systematic identification of protein complexes in Saccharomyces cerevisiae by mass spectrometry. Nature. 2002 Jan 10;415(6868):180-3.
Notes: This molecular complex record represents a population of complexes co-purified by immunoprecipitation of FLAG-tagged Slt2. The topolgies of protein complexes in this experiment are unknown.
Complex Size: 30 proteins

Complex Member Proteins

Protein

GO Cellular Component GO Biological Process GO Molecular Function
AHA1
  • cytoplasm
  • protein folding
  • response to stress
  • chaperone binding
  • chaperone activator activity
  • ATPase activator activity
  • ARP2
  • mitochondrion
  • Arp2/3 protein complex
  • mitochondrion inheritance
  • actin filament organization
  • ATP binding
  • actin binding
  • structural constituent of cytoskeleton
  • BCK1
  • intracellular
  • response to acid
  • endoplasmic reticulum unfolded protein response
  • intracellular protein kinase cascade
  • response to nutrient
  • protein amino acid phosphorylation
  • MAP kinase kinase kinase activity
  • CPR6
  • cytoplasm
  • protein folding
  • peptidyl-prolyl cis-trans isomerase activity
  • unfolded protein binding
  • EGD2
  • nascent polypeptide-associated complex
  • 'de novo' cotranslational protein folding
  • unfolded protein binding
  • FOL2
  • nucleus
  • cytoplasm
  • folic acid and derivative biosynthetic process
  • GTP cyclohydrolase I activity
  • GAL7
  • cytoplasm
  • galactose catabolic process
  • UTP:galactose-1-phosphate uridylyltransferase activity
  • GND1
  • cytoplasm
  • mitochondrion
  • response to oxidative stress
  • pentose-phosphate shunt, oxidative branch
  • phosphogluconate dehydrogenase (decarboxylating) activity
  • IDH1
  • mitochondrial matrix
  • mitochondrion
  • mitochondrial nucleoid
  • glutamate biosynthetic process
  • isocitrate metabolic process
  • tricarboxylic acid cycle
  • isocitrate dehydrogenase (NAD+) activity
  • ILV5
  • mitochondrion
  • mitochondrial nucleoid
  • branched chain family amino acid biosynthetic process
  • mitochondrial genome maintenance
  • ketol-acid reductoisomerase activity
  • IPP1
  • cytosol
  • phosphate metabolic process
  • inorganic diphosphatase activity
  • KIC1
  • incipient cellular bud site
  • cellular bud
  • cytoplasm
  • mating projection tip
  • cell morphogenesis during vegetative growth
  • cell morphogenesis
  • cellular cell wall organization
  • kinase activity
  • KIN2
  • membrane fraction
  • plasma membrane
  • exocytosis
  • protein kinase activity
  • LHS1
  • endoplasmic reticulum lumen
  • protein transport
  • response to unfolded protein
  • unfolded protein binding
  • LYS12
  • mitochondrion
  • lysine biosynthetic process
  • homoisocitrate dehydrogenase activity
  • MKK2
  • intracellular
  • signal transduction
  • protein amino acid phosphorylation
  • MAP kinase kinase activity
  • MKT1
  • polysome
  • cytoplasm
  • interspecies interaction between organisms
  • positive regulation of translation
  • nuclease activity
  • OYE2
  • nucleus
  • cytoplasm
  • mitochondrion
  • biological_process
  • NADPH dehydrogenase activity
  • PDC6
  • cytoplasm
  • ethanol metabolic process
  • pyruvate decarboxylase activity
  • PIL1
  • cytoplasm
  • mitochondrion
  • mitochondrial outer membrane
  • eisosome
  • response to heat
  • protein localization
  • endocytosis
  • protein kinase inhibitor activity
  • PMA1
  • mitochondrion
  • membrane raft
  • plasma membrane
  • proton transport
  • regulation of pH
  • hydrogen-exporting ATPase activity, phosphorylative mechanism
  • QCR2
  • mitochondrion
  • mitochondrial respiratory chain complex III
  • mitochondrial electron transport, ubiquinol to cytochrome c
  • aerobic respiration
  • ubiquinol-cytochrome-c reductase activity
  • RCN2
  • cytoplasm
  • biological_process
  • molecular_function
  • RPN6
  • proteasome regulatory particle, lid subcomplex
  • ubiquitin-dependent protein catabolic process
  • structural molecule activity
  • RPT3
  • proteasome regulatory particle, base subcomplex
  • ubiquitin-dependent protein catabolic process
  • ATPase activity
  • endopeptidase activity
  • SIS1
  • nucleus
  • cytoplasm
  • cytosolic small ribosomal subunit
  • translational initiation
  • protein folding
  • unfolded protein binding
  • chaperone regulator activity
  • SKG3
  • cellular bud
  • cytoplasm
  • cellular bud neck
  • biological_process
  • molecular_function
  • SLT2
  • nucleus
  • cellular bud tip
  • cytoplasm
  • response to acid
  • signal transduction
  • endoplasmic reticulum unfolded protein response
  • regulation of cell size
  • cellular cell wall organization
  • protein amino acid phosphorylation
  • MAP kinase activity
  • SMK1
  • mitochondrion
  • negative regulation of sporulation resulting in formation of a cellular spore
  • protein amino acid phosphorylation
  • ascospore wall assembly
  • MAP kinase activity
  • TIF1, TIF2
  • plasma membrane enriched fraction
  • eukaryotic translation initiation factor 4F complex
  • cytoplasm
  • ribosome
  • regulation of translation
  • translational initiation
  • regulation of translational initiation
  • translation
  • nucleotide binding
  • nucleic acid binding
  • translation initiation factor activity
  • ATP binding
  • RNA binding
  • ATP-dependent helicase activity
  • helicase activity
  • ATP-dependent RNA helicase activity
  • hydrolase activity
  • Cellular Component Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    cytoplasm 1.7668E-3 30 3552 25 6292
    plasma membrane enriched fraction 4.768E-3 30 1 1 6292
    proteasome regulatory particle 5.2251E-3 30 23 2 6292
    proteasome accessory complex 5.2251E-3 30 23 2 6292
    nucleoid 6.6528E-3 30 26 2 6292
    mitochondrial nucleoid 6.6528E-3 30 26 2 6292
    intracellular 7.6883E-3 30 4975 29 6292
    eisosome 9.5139E-3 30 2 1 6292
    cell part 9.9064E-3 30 5397 30 6292

    Biological Process Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    response to protein stimulus 1.0559E-4 30 20 3 6292
    response to unfolded protein 1.0559E-4 30 20 3 6292
    response to biotic stimulus 1.0559E-4 30 20 3 6292
    protein folding 4.6892E-4 30 78 4 6292
    phosphorus metabolic process 6.2009E-4 30 229 6 6292
    phosphate metabolic process 6.2009E-4 30 229 6 6292
    cellular response to unfolded protein 9.6584E-4 30 10 2 6292
    response to endoplasmic reticulum stress 9.6584E-4 30 10 2 6292
    cellular response to biotic stimulus 9.6584E-4 30 10 2 6292
    cellular response to protein stimulus 9.6584E-4 30 10 2 6292
    ER-nucleus signaling pathway 9.6584E-4 30 10 2 6292
    endoplasmic reticulum unfolded protein response 9.6584E-4 30 10 2 6292
    response to acid 1.177E-3 30 11 2 6292
    protein amino acid phosphorylation 1.338E-3 30 103 4 6292
    phosphorylation 1.4086E-3 30 179 5 6292
    cellular protein metabolic process 2.4443E-3 30 1074 12 6292
    cellular response to organic substance 3.959E-3 30 20 2 6292
    protein metabolic process 3.9764E-3 30 1136 12 6292
    negative regulation of developmental process 9.5139E-3 30 2 1 6292
    regulation of sporulation 9.5139E-3 30 2 1 6292
    negative regulation of sporulation 9.5139E-3 30 2 1 6292
    regulation of sporulation resulting in formation of a cellular spore 9.5139E-3 30 2 1 6292
    negative regulation of sporulation resulting in formation of a cellular spore 9.5139E-3 30 2 1 6292
    interspecies interaction between organisms 9.5139E-3 30 2 1 6292
    regulation of cell differentiation 9.5139E-3 30 2 1 6292
    negative regulation of cell differentiation 9.5139E-3 30 2 1 6292

    Molecular Function Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    catalytic activity 6.4612E-5 30 2150 21 6292
    unfolded protein binding 1.8149E-4 30 61 4 6292
    MAP kinase activity 2.1784E-4 30 5 2 6292
    oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor 3.6378E-4 30 73 4 6292
    kinase activity 5.2572E-4 30 222 6 6292
    oxidoreductase activity, acting on CH-OH group of donors 5.4153E-4 30 81 4 6292
    receptor signaling protein serine/threonine kinase activity 6.2815E-4 30 36 3 6292
    receptor signaling protein activity 6.8138E-4 30 37 3 6292
    protein kinase activity 7.5828E-4 30 156 5 6292
    oxidoreductase activity 1.8023E-3 30 281 6 6292
    phosphotransferase activity, alcohol group as acceptor 2.2012E-3 30 198 5 6292
    transferase activity, transferring phosphorus-containing groups 2.9796E-3 30 420 7 6292
    UTP:galactose-1-phosphate uridylyltransferase activity 4.768E-3 30 1 1 6292
    homoisocitrate dehydrogenase activity 4.768E-3 30 1 1 6292
    GTP cyclohydrolase activity 4.768E-3 30 1 1 6292
    GTP cyclohydrolase I activity 4.768E-3 30 1 1 6292
    ketol-acid reductoisomerase activity 4.768E-3 30 1 1 6292
    ATP binding 5.6833E-3 30 24 2 6292
    adenyl ribonucleotide binding 6.1593E-3 30 25 2 6292
    molecular transducer activity 6.2765E-3 30 80 3 6292
    signal transducer activity 6.2765E-3 30 80 3 6292
    adenyl nucleotide binding 8.8E-3 30 30 2 6292
    protein serine/threonine kinase activity 8.9598E-3 30 91 3 6292
    purine nucleoside binding 9.3792E-3 30 31 2 6292
    inorganic diphosphatase activity 9.5139E-3 30 2 1 6292
    NADPH dehydrogenase activity 9.5139E-3 30 2 1 6292
    phosphogluconate dehydrogenase (decarboxylating) activity 9.5139E-3 30 2 1 6292
    hydrogen-exporting ATPase activity, phosphorylative mechanism 9.5139E-3 30 2 1 6292
    UTP-monosaccharide-1-phosphate uridylyltransferase activity 9.5139E-3 30 2 1 6292
    isocitrate dehydrogenase (NAD+) activity 9.5139E-3 30 2 1 6292
    nucleoside binding 9.975E-3 30 32 2 6292

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle