YRC Public Data Repository - Protein Complex GO Analysis

Complex Overview

From Publication:	Gavin A.C. et al. (2002) Abstract Functional organization of the yeast proteome by systematic analysis of protein complexes. Nature. 2002 Jan 10;415(6868):141-7.
Notes:	From the published set of protein complexes.
Complex Size:	44 proteins

Complex Member Proteins

Protein	GO Cellular Component	GO Biological Process	GO Molecular Function
BRR1	small nuclear ribonucleoprotein complex	spliceosome assembly	RNA binding
CLF1	chromatin	DNA replication cell cycle cis assembly of pre-catalytic spliceosome nuclear mRNA splicing, via spliceosome	protein binding
CSN12	signalosome	adaptation of signaling pathway by response to pheromone involved in conjugation with cellular fusion	molecular_function
CUS1	U2 snRNP	spliceosome assembly	RNA binding protein binding
CWC2	spliceosomal complex	nuclear mRNA splicing, via spliceosome	molecular_function
DIB1	U4/U6 x U5 tri-snRNP complex U5 snRNP	nuclear mRNA splicing, via spliceosome	molecular_function
ECM2	nucleus	cellular cell wall organization nuclear mRNA splicing, via spliceosome	molecular_function
HRT1	nucleus nuclear ubiquitin ligase complex cytoplasm SCF ubiquitin ligase complex Cul3-RING ubiquitin ligase complex	G2/M transition of mitotic cell cycle G1/S transition of mitotic cell cycle SCF-dependent proteasomal ubiquitin-dependent protein catabolic process protein ubiquitination during ubiquitin-dependent protein catabolic process	ubiquitin-protein ligase activity
HSH155	U2 snRNP	spliceosome assembly	mRNA binding
HSH49	U2 snRNP	nuclear mRNA splicing, via spliceosome	RNA binding
LEA1	cytoplasm U2 snRNP	telomere maintenance nuclear mRNA splicing, via spliceosome	RNA binding molecular_function
LSM4	U4/U6 x U5 tri-snRNP complex nucleolus U6 snRNP small nucleolar ribonucleoprotein complex	mRNA catabolic process nuclear mRNA splicing, via spliceosome	RNA binding
LUC7	U1 snRNP	mRNA splice site selection	mRNA binding
MSL1	U2 snRNP	nuclear mRNA splicing, via spliceosome	RNA binding
MUD1	U1 snRNP	nuclear mRNA splicing, via spliceosome	RNA binding
PRP11	U2 snRNP	spliceosome assembly	RNA binding
PRP19	nucleus cytoplasm mitochondrion spliceosomal complex	nuclear mRNA splicing, via spliceosome ubiquitin-dependent protein catabolic process	ubiquitin-protein ligase activity first spliceosomal transesterification activity RNA binding
PRP21	U2 snRNP	nuclear mRNA splicing, via spliceosome	RNA binding
PRP3	U4/U6 x U5 tri-snRNP complex	nuclear mRNA splicing, via spliceosome	molecular_function
PRP31	mitochondrion U4/U6 x U5 tri-snRNP complex	nuclear mRNA splicing, via spliceosome	RNA binding molecular_function
PRP39	commitment complex U1 snRNP	nuclear mRNA 5'-splice site recognition	pre-mRNA 5'-splice site binding
PRP4	U4/U6 x U5 tri-snRNP complex	nuclear mRNA splicing, via spliceosome	molecular_function
PRP40	U1 snRNP	nuclear mRNA splicing, via spliceosome	RNA binding
PRP42	U1 snRNP	nuclear mRNA splicing, via spliceosome	RNA binding
PRP43	mitochondrion spliceosomal complex nuclear outer membrane	maturation of SSU-rRNA ribosomal large subunit biogenesis ribosome biogenesis rRNA processing processing of 27S pre-rRNA	ATP-dependent RNA helicase activity
PRP46	spliceosomal complex	nuclear mRNA splicing, via spliceosome	molecular_function
PRP6	U4/U6 x U5 tri-snRNP complex	nuclear mRNA splicing, via spliceosome	binding molecular_function
PRP9	U2 snRNP	nuclear mRNA splicing, via spliceosome	RNA binding
RSE1	U2 snRNP	spliceosome assembly nuclear mRNA splicing, via spliceosome	U2 snRNA binding
SMB1	U4/U6 x U5 tri-snRNP complex U5 snRNP U1 snRNP	nuclear mRNA splicing, via spliceosome	RNA binding molecular_function
SMD1	commitment complex U4/U6 x U5 tri-snRNP complex U5 snRNP U1 snRNP	nuclear mRNA splicing, via spliceosome	mRNA binding
SMD2	U4/U6 x U5 tri-snRNP complex U5 snRNP U1 snRNP	nuclear mRNA splicing, via spliceosome	RNA binding molecular_function
SMD3	commitment complex U4/U6 x U5 tri-snRNP complex U5 snRNP U1 snRNP	nuclear mRNA splicing, via spliceosome	mRNA binding
SME1	U4/U6 x U5 tri-snRNP complex U5 snRNP U1 snRNP	nuclear mRNA splicing, via spliceosome	RNA binding molecular_function
SMX2	U4/U6 x U5 tri-snRNP complex U5 snRNP U1 snRNP	nuclear mRNA splicing, via spliceosome	RNA binding molecular_function
SNP1	commitment complex U1 snRNP	nuclear mRNA splicing, via spliceosome	U1 snRNA binding mRNA binding
SNT309	spliceosomal complex	nuclear mRNA splicing, via spliceosome	protein binding
SNU114	U4/U6 x U5 tri-snRNP complex U5 snRNP	generation of catalytic spliceosome for first transesterification step nuclear mRNA splicing, via spliceosome	GTP binding U5 snRNA binding GTPase activity
SNU56	commitment complex U1 snRNP	nuclear mRNA splicing, via spliceosome	mRNA binding
SNU66	U4/U6 x U5 tri-snRNP complex	nuclear mRNA splicing, via spliceosome	RNA binding molecular_function
SNU71	U1 snRNP	nuclear mRNA splicing, via spliceosome	RNA binding
SPP382	nucleus cytoplasm mitochondrion spliceosomal complex	nuclear mRNA splicing, via spliceosome	RNA binding
SRB2	mediator complex	telomere maintenance transcription from RNA polymerase II promoter	RNA polymerase II transcription mediator activity
STO1	commitment complex nuclear cap binding complex	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay telomere maintenance nuclear mRNA splicing, via spliceosome	mRNA binding

Cellular Component Analysis

Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

Only showing terms with a p-value less than or equal to 0.01.

GO Term	P-value	A	B	I	T
small nuclear ribonucleoprotein complex	1.4264E-58	44	63	32	6292
ribonucleoprotein complex	7.1189E-38	44	514	39	6292
nuclear part	5.9385E-30	44	1103	42	6292
U1 snRNP	4.4758E-29	44	17	14	6292
U4/U6 x U5 tri-snRNP complex	2.9015E-23	44	32	14	6292
macromolecular complex	9.4351E-23	44	1635	42	6292
nucleus	2.1138E-20	44	2041	43	6292
intracellular organelle part	2.5437E-18	44	2282	43	6292
organelle part	2.5437E-18	44	2282	43	6292
U2 snRNP	1.1731E-17	44	13	9	6292
spliceosomal complex	6.5255E-17	44	45	12	6292
U5 snRNP	8.5102E-15	44	14	8	6292
U2-type spliceosomal complex	7.3539E-11	44	12	6	6292
commitment complex	7.3539E-11	44	12	6	6292
intracellular organelle	4.3611E-9	44	4070	44	6292
organelle	4.4087E-9	44	4071	44	6292
membrane-bounded organelle	4.5853E-9	44	3771	43	6292
intracellular membrane-bounded organelle	4.5853E-9	44	3771	43	6292
intracellular part	2.2467E-5	44	4938	44	6292
intracellular	3.1248E-5	44	4975	44	6292
cell part	1.1406E-3	44	5397	44	6292
cell	1.1594E-3	44	5399	44	6292

Biological Process Analysis

Only showing terms with a p-value less than or equal to 0.01.

GO Term	P-value	A	B	I	T
nuclear mRNA splicing, via spliceosome	1.1144E-71	44	99	40	6292
RNA splicing, via transesterification reactions with bulged adenosine as nucleophile	1.8562E-71	44	100	40	6292
RNA splicing, via transesterification reactions	5.5413E-70	44	107	40	6292
RNA splicing	1.4581E-65	44	132	40	6292
mRNA processing	3.5171E-62	44	156	40	6292
mRNA metabolic process	4.2055E-56	44	213	40	6292
RNA processing	1.4332E-47	44	380	41	6292
RNA metabolic process	1.2475E-32	44	954	42	6292
gene expression	3.5476E-27	44	1283	42	6292
nucleic acid metabolic process	2.195E-25	44	1415	42	6292
nucleobase, nucleoside, nucleotide and nucleic acid metabolic process	1.5502E-23	44	1566	42	6292
cellular nitrogen compound metabolic process	2.5994E-21	44	1770	42	6292
nitrogen compound metabolic process	4.2521E-21	44	1791	42	6292
cellular macromolecule metabolic process	2.691E-18	44	2285	43	6292
macromolecule metabolic process	8.7854E-18	44	2349	43	6292
primary metabolic process	6.6471E-14	44	2896	43	6292
spliceosome assembly	1.215E-13	44	18	8	6292
cellular metabolic process	4.7299E-13	44	3033	43	6292
metabolic process	2.5832E-12	44	3157	43	6292
ribonucleoprotein complex assembly	9.5672E-9	44	92	9	6292
cellular process	1.7788E-7	44	4426	44	6292
cellular macromolecular complex assembly	3.4416E-6	44	182	9	6292
cellular macromolecular complex subunit organization	5.8994E-5	44	259	9	6292
macromolecular complex assembly	1.1096E-4	44	281	9	6292
nuclear mRNA cis splicing, via spliceosome	1.4276E-4	44	3	2	6292
ribonucleoprotein complex biogenesis	1.9578E-4	44	374	10	6292
macromolecular complex subunit organization	6.646E-4	44	357	9	6292
mRNA splice site selection	7.043E-4	44	6	2	6292
cellular component assembly	1.1427E-3	44	385	9	6292
nuclear mRNA 5'-splice site recognition	6.993E-3	44	1	1	6292

Molecular Function Analysis

Only showing terms with a p-value less than or equal to 0.01.

GO Term	P-value	A	B	I	T
RNA binding	4.1866E-29	44	367	31	6292
nucleic acid binding	4.1752E-21	44	666	31	6292
binding	8.8207E-16	44	1294	34	6292
mRNA binding	5.9909E-11	44	35	8	6292
snRNA binding	3.1605E-6	44	5	3	6292
pre-mRNA 5'-splice site binding	6.993E-3	44	1	1	6292
U2 snRNA binding	6.993E-3	44	1	1	6292
U1 snRNA binding	6.993E-3	44	1	1	6292

View Protein Complex Details

Complex Overview

Complex Member Proteins

Cellular Component Analysis

Biological Process Analysis

Molecular Function Analysis