YRC Public Data Repository - Protein Complex GO Analysis

Complex Overview

From Publication:	Gavin A.C. et al. (2002) Abstract Functional organization of the yeast proteome by systematic analysis of protein complexes. Nature. 2002 Jan 10;415(6868):141-7.
Notes:	From the published set of protein complexes.
Complex Size:	35 proteins

Complex Member Proteins

Protein	GO Cellular Component	GO Biological Process	GO Molecular Function
AIR2	nucleus TRAMP complex	mRNA export from nucleus rRNA catabolic process snRNA catabolic process snoRNA catabolic process tRNA catabolic process ncRNA polyadenylation involved in polyadenylation-dependent ncRNA catabolic process	polynucleotide adenylyltransferase activity
BRR1	small nuclear ribonucleoprotein complex	spliceosome assembly	RNA binding
BUR2	nucleus	transcription mitotic sister chromatid segregation response to DNA damage stimulus	cyclin-dependent protein kinase regulator activity
CBC2	commitment complex nuclear cap binding complex	telomere maintenance nuclear mRNA splicing, via spliceosome	RNA cap binding
HTA1	nuclear nucleosome	DNA repair chromatin assembly or disassembly	DNA binding
KAP95	cytoplasm nuclear pore	protein import into nucleus nuclear pore complex assembly	protein transmembrane transporter activity
LUC7	U1 snRNP	mRNA splice site selection	mRNA binding
MSH4	nuclear chromosome	reciprocal meiotic recombination	DNA binding
MUD1	U1 snRNP	nuclear mRNA splicing, via spliceosome	RNA binding
NAB3	nucleus	termination of RNA polymerase II transcription, poly(A)-independent regulation of transcription from RNA polymerase II promoter	poly(A) RNA binding
NAB6	cytoplasm	RNA metabolic process	molecular_function
NAM8	commitment complex U1 snRNP	mRNA splice site selection nuclear mRNA splicing, via spliceosome	RNA binding mRNA binding
NPL3	nucleus cytoplasm	mRNA export from nucleus pseudohyphal growth	poly(A) RNA binding mRNA binding
NRD1	nuclear exosome (RNase complex) nucleus	termination of RNA polymerase II transcription, poly(A)-independent	RNA binding
NUP60	nuclear pore	nucleocytoplasmic transport telomere maintenance protein import into nucleus, docking	structural constituent of nuclear pore
PRP39	commitment complex U1 snRNP	nuclear mRNA 5'-splice site recognition	pre-mRNA 5'-splice site binding
PRP40	U1 snRNP	nuclear mRNA splicing, via spliceosome	RNA binding
PRP42	U1 snRNP	nuclear mRNA splicing, via spliceosome	RNA binding
RSE1	U2 snRNP	spliceosome assembly nuclear mRNA splicing, via spliceosome	U2 snRNA binding
SCP160	endoplasmic reticulum membrane polysome nuclear membrane-endoplasmic reticulum network	meiotic telomere clustering intracellular mRNA localization response to drug chromosome segregation chromatin silencing at silent mating-type cassette chromatin silencing at telomere pheromone-dependent signal transduction involved in conjugation with cellular fusion	RNA binding G-protein alpha-subunit binding
SEN1	nucleus nuclear outer membrane	snRNA processing tRNA processing snoRNA processing transcription termination termination of RNA polymerase II transcription	DNA-dependent ATPase activity RNA helicase activity RNA-dependent ATPase activity RNA polymerase II transcription termination factor activity 5'-3' DNA helicase activity
SGV1	nucleus	transcription protein amino acid phosphorylation	cyclin-dependent protein kinase activity
SMD1	commitment complex U4/U6 x U5 tri-snRNP complex U5 snRNP U1 snRNP	nuclear mRNA splicing, via spliceosome	mRNA binding
SMD2	U4/U6 x U5 tri-snRNP complex U5 snRNP U1 snRNP	nuclear mRNA splicing, via spliceosome	RNA binding molecular_function
SMD3	commitment complex U4/U6 x U5 tri-snRNP complex U5 snRNP U1 snRNP	nuclear mRNA splicing, via spliceosome	mRNA binding
SNP1	commitment complex U1 snRNP	nuclear mRNA splicing, via spliceosome	U1 snRNA binding mRNA binding
SNU56	commitment complex U1 snRNP	nuclear mRNA splicing, via spliceosome	mRNA binding
SNU71	U1 snRNP	nuclear mRNA splicing, via spliceosome	RNA binding
SRO9	polysome	ribosome biogenesis translation	RNA binding
SRP1	nucleus cytoplasm	nucleocytoplasmic transport	protein transmembrane transporter activity
STO1	commitment complex nuclear cap binding complex	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay telomere maintenance nuclear mRNA splicing, via spliceosome	mRNA binding
THO2	nucleus THO complex	mRNA export from nucleus DNA recombination RNA elongation from RNA polymerase II promoter	nucleic acid binding DNA binding
TIF4631	eukaryotic translation initiation factor 4F complex mitochondrion ribosome	ribosome biogenesis translational initiation	translation initiation factor activity
TIF4632	eukaryotic translation initiation factor 4F complex ribosome	translational initiation	translation initiation factor activity
YRA2	nucleus	poly(A)+ mRNA export from nucleus	RNA binding

Cellular Component Analysis

Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

Only showing terms with a p-value less than or equal to 0.01.

GO Term	P-value	A	B	I	T
U1 snRNP	6.383E-25	35	17	12	6292
small nuclear ribonucleoprotein complex	4.3162E-20	35	63	14	6292
U2-type spliceosomal complex	1.8916E-16	35	12	8	6292
commitment complex	1.8916E-16	35	12	8	6292
ribonucleoprotein complex	1.2526E-13	35	514	20	6292
nuclear part	3.3022E-11	35	1103	24	6292
spliceosomal complex	7.2583E-11	35	45	8	6292
nucleus	9.3865E-11	35	2041	30	6292
macromolecular complex	2.8767E-9	35	1635	26	6292
intracellular organelle part	2.3807E-5	35	2282	25	6292
organelle part	2.3807E-5	35	2282	25	6292
membrane-bounded organelle	3.5696E-5	35	3771	32	6292
intracellular membrane-bounded organelle	3.5696E-5	35	3771	32	6292
intracellular organelle	4.5474E-5	35	4070	33	6292
organelle	4.5808E-5	35	4071	33	6292
U5 snRNP	5.5049E-5	35	14	3	6292
nuclear cap binding complex	8.9875E-5	35	3	2	6292
eukaryotic translation initiation factor 4F complex	1.7912E-4	35	4	2	6292
intracellular part	2.0201E-4	35	4938	35	6292
intracellular	2.6256E-4	35	4975	35	6292
RNA cap binding complex	4.4468E-4	35	6	2	6292
U4/U6 x U5 tri-snRNP complex	7.0035E-4	35	32	3	6292
polysome	3.4353E-3	35	16	2	6292
cell part	4.5803E-3	35	5397	35	6292
cell	4.6403E-3	35	5399	35	6292

Biological Process Analysis

Only showing terms with a p-value less than or equal to 0.01.

GO Term	P-value	A	B	I	T
nuclear mRNA splicing, via spliceosome	1.2783E-20	35	99	16	6292
RNA splicing, via transesterification reactions with bulged adenosine as nucleophile	1.5174E-20	35	100	16	6292
RNA splicing, via transesterification reactions	4.7907E-20	35	107	16	6292
RNA splicing	1.6188E-18	35	132	16	6292
mRNA processing	2.5425E-17	35	156	16	6292
mRNA metabolic process	3.9074E-15	35	213	16	6292
RNA processing	1.3575E-13	35	380	18	6292
nucleic acid metabolic process	7.2666E-13	35	1415	28	6292
gene expression	7.6783E-13	35	1283	27	6292
nucleobase, nucleoside, nucleotide and nucleic acid metabolic process	1.0339E-11	35	1566	28	6292
RNA metabolic process	1.5166E-11	35	954	23	6292
cellular macromolecule metabolic process	1.9094E-10	35	2285	31	6292
cellular nitrogen compound metabolic process	2.4446E-10	35	1770	28	6292
nitrogen compound metabolic process	3.3059E-10	35	1791	28	6292
macromolecule metabolic process	4.2528E-10	35	2349	31	6292
spliceosome assembly	3.2189E-8	35	18	5	6292
primary metabolic process	1.6532E-7	35	2896	31	6292
cellular metabolic process	5.9791E-7	35	3033	31	6292
cellular macromolecular complex subunit organization	8.671E-7	35	259	10	6292
metabolic process	1.8016E-6	35	3157	31	6292
mRNA splice site selection	3.1185E-6	35	6	3	6292
cellular process	4.3192E-6	35	4426	35	6292
nuclear transport	5.6783E-6	35	130	7	6292
nucleocytoplasmic transport	5.6783E-6	35	130	7	6292
macromolecular complex subunit organization	1.5608E-5	35	357	10	6292
cellular macromolecular complex assembly	5.1116E-5	35	182	7	6292
ribonucleoprotein complex assembly	1.3754E-4	35	92	5	6292
RNA localization	1.3754E-4	35	92	5	6292
termination of RNA polymerase II transcription	1.4377E-4	35	19	3	6292
transcription termination	1.9584E-4	35	21	3	6292
mRNA export from nucleus	5.0768E-4	35	68	4	6292
mRNA transport	5.0768E-4	35	68	4	6292
macromolecular complex assembly	7.5221E-4	35	281	7	6292
RNA export from nucleus	9.404E-4	35	80	4	6292
RNA transport	9.8536E-4	35	81	4	6292
nucleic acid transport	9.8536E-4	35	81	4	6292
establishment of RNA localization	9.8536E-4	35	81	4	6292
snRNA metabolic process	1.0561E-3	35	9	2	6292
termination of RNA polymerase II transcription, poly(A)-independent	1.0561E-3	35	9	2	6292
protein complex disassembly	1.2565E-3	35	39	3	6292
cellular protein complex disassembly	1.2565E-3	35	39	3	6292
cellular macromolecular complex disassembly	1.3532E-3	35	40	3	6292
macromolecular complex disassembly	1.3532E-3	35	40	3	6292
cellular component disassembly	1.7866E-3	35	44	3	6292
nucleobase, nucleoside, nucleotide and nucleic acid transport	1.8546E-3	35	96	4	6292
nuclear export	2.4013E-3	35	103	4	6292
ribonucleoprotein complex biogenesis	3.9121E-3	35	374	7	6292
snoRNA metabolic process	4.3495E-3	35	18	2	6292
cellular component assembly	4.5932E-3	35	385	7	6292
macromolecule localization	5.4359E-3	35	397	7	6292
pore complex assembly	5.5626E-3	35	1	1	6292
nuclear pore complex assembly	5.5626E-3	35	1	1	6292
nuclear mRNA 5'-splice site recognition	5.5626E-3	35	1	1	6292

Molecular Function Analysis

Only showing terms with a p-value less than or equal to 0.01.

GO Term	P-value	A	B	I	T
nucleic acid binding	2.9566E-20	35	666	27	6292
RNA binding	2.82E-19	35	367	22	6292
mRNA binding	1.1567E-15	35	35	10	6292
binding	4.1356E-15	35	1294	29	6292
poly(A) RNA binding	2.9749E-4	35	5	2	6292
single-stranded RNA binding	2.9749E-4	35	5	2	6292
snRNA binding	2.9749E-4	35	5	2	6292
poly-purine tract binding	2.9749E-4	35	5	2	6292
macromolecule transmembrane transporter activity	1.0561E-3	35	9	2	6292
protein transmembrane transporter activity	1.0561E-3	35	9	2	6292
pre-mRNA 5'-splice site binding	5.5626E-3	35	1	1	6292
U2 snRNA binding	5.5626E-3	35	1	1	6292
U1 snRNA binding	5.5626E-3	35	1	1	6292
G-protein alpha-subunit binding	5.5626E-3	35	1	1	6292
RNA polymerase II transcription termination factor activity	5.5626E-3	35	1	1	6292
translation initiation factor activity	9.6706E-3	35	27	2	6292

View Protein Complex Details

Complex Overview

Complex Member Proteins

Cellular Component Analysis

Biological Process Analysis

Molecular Function Analysis