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View Protein Complex Details

Complex Overview

From Publication: Krogan N. J. et al. (2006) Global landscape of protein complexes in the yeast Saccharomyces cerevisiae. Nature. 2006 Mar 30;440(7084):637-43. Epub 2006 Mar 22.
Notes: From the published set of core protein complex predictions.
Complex Size: 16 proteins

Complex Member Proteins

Protein

 GO Cellular Component GO Biological Process GO Molecular Function
ASH1
  • nucleus
  • cellular bud
    		•
  • negative regulation of transcription, DNA-dependent
  • pseudohyphal growth
  • regulation of transcription, mating-type specific
    		•
  • histone deacetylase activity
  • specific transcriptional repressor activity
    		•
    COQ6
  • mitochondrion
  • mitochondrial inner membrane
    		•
  • ubiquinone biosynthetic process
    		•
  • ubiquinone biosynthetic process monooxygenase activity
    		•
    CTI6
  • nucleus
    		•
  • positive regulation of transcription
  • histone deacetylation
    		•
  • histone deacetylase activity
  • transcription factor binding
    		•
    DEP1
  • nucleus
    		•
  • telomere maintenance
  • phospholipid metabolic process
  • histone deacetylation
  • regulation of transcription from RNA polymerase II promoter
    		•
  • histone deacetylase activity
  • transcription regulator activity
    		•
    EAF3
  • NuA4 histone acetyltransferase complex
  • histone acetyltransferase complex
    		•
  • DNA repair
  • histone acetylation
  • histone deacetylation
  • regulation of transcription from RNA polymerase II promoter
    		•
  • histone acetyltransferase activity
  • histone deacetylase activity
    		•
    GRX5
  • mitochondrial matrix
  • mitochondrion
    		•
  • response to oxidative stress
  • response to osmotic stress
  • iron-sulfur cluster assembly
    		•
  • thiol-disulfide exchange intermediate activity
    		•
    PHO23
  • nucleus
  • histone deacetylase complex
    		•
  • chromatin modification
  • histone deacetylation
    		•
  • histone deacetylase activity
    		•
    RCO1
  • nucleus
  • histone deacetylase complex
    		•
  • histone deacetylation
    		•
  • histone deacetylase activity
    		•
    RPD3
  • histone deacetylase complex
    		•
  • negative regulation of transcription from RNA polymerase II promoter
  • chromatin silencing at rDNA
  • loss of chromatin silencing involved in replicative cell aging
  • protein amino acid deacetylation
  • chromatin silencing
  • double-strand break repair via nonhomologous end joining
  • chromatin organization
  • histone deacetylation
  • chromatin silencing at silent mating-type cassette
  • positive regulation of transcription from RNA polymerase II promoter
  • chromatin silencing at telomere
  • mitotic recombination
    		•
  • transcription coactivator activity
  • histone deacetylase activity
  • transcription corepressor activity
    		•
    RXT2
  • nucleus
    		•
  • negative regulation of transcription from RNA polymerase II promoter
  • conjugation with cellular fusion
  • invasive growth in response to glucose limitation
  • histone deacetylation
    		•
  • histone deacetylase activity
    		•
    RXT3
  • nucleus
    		•
  • chromatin silencing
  • histone deacetylation
    		•
  • histone deacetylase activity
    		•
    SAP30
  • histone deacetylase complex
    		•
  • chromatin silencing at rDNA
  • telomere maintenance
  • histone deacetylation
  • chromatin silencing at silent mating-type cassette
  • chromatin silencing at telomere
    		•
  • histone deacetylase activity
    		•
    SAY1
  • endoplasmic reticulum
    		•
  • biological_process
    		•
  • molecular_function
    		•
    SDS3
  • nucleus
  • Rpd3L-Expanded complex
  • Rpd3L complex
    		•
  • chromatin silencing
  • histone deacetylation
    		•
  • histone deacetylase activity
    		•
    SIN3
  • Sin3 complex
  • histone deacetylase complex
    		•
  • negative regulation of transcription from RNA polymerase II promoter
  • chromatin silencing at rDNA
  • telomere maintenance
  • double-strand break repair via nonhomologous end joining
  • histone deacetylation
  • chromatin silencing at silent mating-type cassette
  • positive regulation of transcription from RNA polymerase II promoter
  • chromatin silencing at telomere
    		•
  • transcription coactivator activity
  • histone deacetylase activity
  • transcription corepressor activity
    		•
    UME1
  • nucleus
    		•
  • regulation of meiosis
  • histone deacetylation
    		•
  • histone deacetylase activity
  • transcription corepressor activity
    		•

    Cellular Component Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    		 P-value

    		 A

    		 B

    		 I

    		 T
    histone deacetylase complex 9.1869E-12 16 23 6 6292
    chromatin remodeling complex 9.1873E-8 16 99 6 6292
    nucleoplasm part 1.0555E-6 16 245 7 6292
    nucleoplasm 1.7482E-6 16 264 7 6292
    Sin3-type complex 6.0363E-5 16 5 2 6292
    nuclear lumen 6.1834E-5 16 453 7 6292
    nucleus 8.2656E-5 16 2041 13 6292
    organelle lumen 8.4009E-5 16 660 8 6292
    intracellular organelle lumen 8.4009E-5 16 660 8 6292
    membrane-enclosed lumen 1.2833E-4 16 700 8 6292
    membrane-bounded organelle 2.7361E-4 16 3771 16 6292
    intracellular membrane-bounded organelle 2.7361E-4 16 3771 16 6292
    intracellular organelle 9.2974E-4 16 4070 16 6292
    organelle 9.334E-4 16 4071 16 6292
    Rpd3L complex 2.5429E-3 16 1 1 6292
    Rpd3L-Expanded complex 2.5429E-3 16 1 1 6292

    Biological Process Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    		 P-value

    		 A

    		 B

    		 I

    		 T
    histone deacetylation 3.9429E-27 16 27 12 6292
    protein amino acid deacetylation 1.1757E-26 16 29 12 6292
    covalent chromatin modification 4.4929E-20 16 88 12 6292
    histone modification 4.4929E-20 16 88 12 6292
    chromatin modification 1.4721E-16 16 168 12 6292
    chromatin organization 1.4987E-15 16 203 12 6292
    post-translational protein modification 1.3792E-12 16 357 12 6292
    protein modification process 7.4049E-11 16 499 12 6292
    chromosome organization 2.5957E-10 16 555 12 6292
    macromolecule modification 3.4794E-10 16 569 12 6292
    regulation of transcription 3.6802E-9 16 384 10 6292
    regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process 7.8441E-9 16 415 10 6292
    regulation of nitrogen compound metabolic process 8.0299E-9 16 416 10 6292
    regulation of gene expression 1.5448E-8 16 445 10 6292
    regulation of macromolecule biosynthetic process 1.9569E-8 16 456 10 6292
    regulation of cellular biosynthetic process 2.7314E-8 16 472 10 6292
    regulation of biosynthetic process 2.7878E-8 16 473 10 6292
    regulation of macromolecule metabolic process 3.7677E-8 16 488 10 6292
    regulation of transcription, DNA-dependent 4.5396E-8 16 358 9 6292
    negative regulation of transcription, DNA-dependent 4.9925E-8 16 157 7 6292
    regulation of RNA metabolic process 5.1234E-8 16 363 9 6292
    negative regulation of RNA metabolic process 5.2173E-8 16 158 7 6292
    regulation of primary metabolic process 6.2093E-8 16 514 10 6292
    negative regulation of transcription 6.7545E-8 16 164 7 6292
    negative regulation of gene expression 6.7545E-8 16 164 7 6292
    regulation of cellular metabolic process 9.2834E-8 16 536 10 6292
    negative regulation of macromolecule biosynthetic process 1.0579E-7 16 175 7 6292
    regulation of metabolic process 1.1277E-7 16 547 10 6292
    transcription 1.2303E-7 16 552 10 6292
    negative regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process 1.2846E-7 16 180 7 6292
    negative regulation of nitrogen compound metabolic process 1.2846E-7 16 180 7 6292
    negative regulation of biosynthetic process 1.7971E-7 16 189 7 6292
    negative regulation of cellular biosynthetic process 1.7971E-7 16 189 7 6292
    negative regulation of macromolecule metabolic process 2.0024E-7 16 192 7 6292
    regulation of cellular process 2.9753E-7 16 796 11 6292
    negative regulation of cellular metabolic process 3.5804E-7 16 209 7 6292
    negative regulation of metabolic process 3.6991E-7 16 210 7 6292
    regulation of biological process 4.2629E-7 16 824 11 6292
    cellular protein metabolic process 5.3711E-7 16 1074 12 6292
    transcription, DNA-dependent 8.5506E-7 16 503 9 6292
    organelle organization 9.2537E-7 16 1127 12 6292
    RNA biosynthetic process 9.3033E-7 16 508 9 6292
    protein metabolic process 1.0121E-6 16 1136 12 6292
    negative regulation of cellular process 1.2102E-6 16 250 7 6292
    negative regulation of biological process 1.3118E-6 16 253 7 6292
    negative regulation of gene expression, epigenetic 3.4871E-6 16 100 5 6292
    gene silencing 3.4871E-6 16 100 5 6292
    regulation of gene expression, epigenetic 3.4871E-6 16 100 5 6292
    chromatin silencing 3.4871E-6 16 100 5 6292
    chromatin silencing at rDNA 1.0759E-5 16 18 3 6292
    biological regulation 2.2007E-5 16 1213 11 6292
    cellular biosynthetic process 3.5656E-5 16 1567 12 6292
    cellular component organization 3.9539E-5 16 1582 12 6292
    biosynthetic process 4.5302E-5 16 1602 12 6292
    chromatin silencing at silent mating-type cassette 7.028E-5 16 33 3 6292
    cellular macromolecule biosynthetic process 1.4533E-4 16 1187 10 6292
    macromolecule biosynthetic process 1.475E-4 16 1189 10 6292
    cellular metabolic process 1.5217E-4 16 3033 15 6292
    RNA metabolic process 1.7033E-4 16 954 9 6292
    regulation of transcription from RNA polymerase II promoter 1.8825E-4 16 228 5 6292
    metabolic process 2.6858E-4 16 3157 15 6292
    gene expression 2.8698E-4 16 1283 10 6292
    cellular macromolecule metabolic process 3.0772E-4 16 2285 13 6292
    chromatin silencing at telomere 3.2659E-4 16 55 3 6292
    macromolecule metabolic process 4.2263E-4 16 2349 13 6292
    negative regulation of transcription from RNA polymerase II promoter 4.227E-4 16 60 3 6292
    nucleic acid metabolic process 6.6624E-4 16 1415 10 6292
    transcription from RNA polymerase II promoter 1.114E-3 16 335 5 6292
    nucleobase, nucleoside, nucleotide and nucleic acid metabolic process 1.5629E-3 16 1566 10 6292
    double-strand break repair via nonhomologous end joining 1.7579E-3 16 25 2 6292
    positive regulation of transcription 2.5968E-3 16 112 3 6292
    positive regulation of gene expression 2.5968E-3 16 112 3 6292
    positive regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process 3.0128E-3 16 118 3 6292
    positive regulation of nitrogen compound metabolic process 3.0128E-3 16 118 3 6292
    positive regulation of macromolecule biosynthetic process 3.0128E-3 16 118 3 6292
    positive regulation of biosynthetic process 3.2354E-3 16 121 3 6292
    positive regulation of cellular biosynthetic process 3.2354E-3 16 121 3 6292
    non-recombinational repair 3.2438E-3 16 34 2 6292
    positive regulation of macromolecule metabolic process 3.6287E-3 16 126 3 6292
    positive regulation of metabolic process 3.8781E-3 16 129 3 6292
    positive regulation of cellular metabolic process 3.8781E-3 16 129 3 6292
    cellular nitrogen compound metabolic process 4.2446E-3 16 1770 10 6292
    primary metabolic process 4.3709E-3 16 2896 13 6292
    positive regulation of cellular process 4.5006E-3 16 136 3 6292
    positive regulation of biological process 4.5942E-3 16 137 3 6292
    nitrogen compound metabolic process 4.6641E-3 16 1791 10 6292
    double-strand break repair 8.9193E-3 16 57 2 6292

    Molecular Function Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    		 P-value

    		 A

    		 B

    		 I

    		 T
    protein deacetylase activity 5.0203E-29 16 32 13 6292
    histone deacetylase activity 5.0203E-29 16 32 13 6292
    deacetylase activity 2.1308E-28 16 35 13 6292
    hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides 2.7684E-26 16 48 13 6292
    hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds 4.4579E-23 16 80 13 6292
    hydrolase activity 4.1705E-9 16 911 13 6292
    transcription factor binding 3.2432E-6 16 43 4 6292
    transcription repressor activity 3.5621E-6 16 44 4 6292
    transcription corepressor activity 7.4064E-6 16 16 3 6292
    transcription cofactor activity 1.2589E-4 16 40 3 6292
    catalytic activity 1.5195E-4 16 2150 13 6292
    transcription regulator activity 1.1754E-3 16 339 5 6292
    transcription coactivator activity 1.2379E-3 16 21 2 6292
    ubiquinone biosynthetic process monooxygenase activity 2.5429E-3 16 1 1 6292
    YRC Informatics Platform - Version 3.0
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