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Protein Overview: SAY1

General Information:
Name(s) found: SAY1 / YGR263C [SGD]
Description(s) found:
Found 26 descriptions.
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  • Sterol deacetylase; component of the sterol acetylation/deacetylation cycle along with Atf2p; integral membrane protein with active site in the ER lumen; green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 424 amino acids

    Gene Ontology:
    Cellular Component: endoplasmic reticulum [IDALink to PubMed article]
    Biological Process: biological_process [ND]
    Molecular Function: molecular_function [ND]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MAANSGLDSK VEYYRLQENE IISAVSSEDA DQNDAGFRLS TIHLHLFHGL KFAALLFTVV  60
   61 PVFIILDSMK IIFQRKRRFC LDHVNRSFLR QSSWILDERI CQYVLNPLFV CLYPSTFSSP 120
  121 TYVKCNIPIE DQKSPENNIF QDHQLNAPKI VSTKFYQYVM PEGFDPTTDP VLVFYHGGGY 180
  181 ALKLTPTSFS FLNNMRNAFP KMAILVPDYT VTATDDQSKK YPLQILQNVA IFDYVVKTMG 240
  241 CKNVVIMGDS AGGNAVLNIV LYLRKCHREI YPKKVIAISP WANATFFHEG EKEYMQGTQE 300
  301 WDGLCLKSHS MFGRMFVGNN PNVDFTSDPF VNIEKNFETK MWQDILKKCS VMITYGSDEL 360
  361 LSFQNKILAK KMSDASEGCN HFTAKNVLVE HQGYHTGPIL NYSRNMDRWT NIPSIARILE 420
  421 FMQS

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Krogan NJ, et al. (2006) ASH1 COQ6 CTI6 DEP1 EAF3 GRX5 PHO23 RCO1 RPD3 RXT2 RXT3 SAP30 SAY1 SDS3 SIN3 UME1
    View Details Ho Y, et al. (2002) CMD1 CNA1 SAY1

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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      PROTEIN(S) PUBLICATION
    View Data SAY1 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..424] PSI-BLAST 63.0 Mammalian carboxylesterase (liver carboxylesterase I)

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • catalytic activity
    		•  1.39629727416851 bayes_pls_golite062009
  • sterol esterase activity
    		•  1.21262745914703 bayes_pls_golite062009
  • lipase activity
    		•  0.849473630399459 bayes_pls_golite062009
  • carboxylesterase activity
    		•  0.424330502936163 bayes_pls_golite062009
  • hydrolase activity, acting on ester bonds
    		•  0.264183693934251 bayes_pls_golite062009
  • hydrolase activity
    		•  0.0199633894876208 bayes_pls_golite062009


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle