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Protein Overview: ASH1

General Information:
Name(s) found: ASH1 / YKL185W [SGD]
Description(s) found:
Found 28 descriptions.
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  • Zinc-finger inhibitor of HO transcription; mRNA is localized and translated in the distal tip of anaphase cells, resulting in accumulation of Ash1p in daughter cell nuclei and inhibition of HO expression; potential Cdc28p substrate [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 588 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IDALink to PubMed articleLink to PubMed articleLink to PubMed article]
    cellular bud [IDALink to PubMed article]
    Biological Process: negative regulation of transcription, DNA-dependent [IDALink to PubMed article]
    pseudohyphal growth [IGILink to PubMed article][IMPLink to PubMed articleLink to PubMed article]
    regulation of transcription, mating-type specific [IMPLink to PubMed articleLink to PubMed article]
    Molecular Function: histone deacetylase activity [IDALink to PubMed article]
    specific transcriptional repressor activity [IDALink to PubMed article][IMPLink to PubMed articleLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSSLYIKTPL HALSAGPDSH ANSSYYDNLL LPSFSNLSSN ISRNNITTDN NINSASPRKY  60
   61 SFHSLNVSPI LSPISLANEI LGKKSNTAPA SPHHMDYNPI SSLTPGNSPE FNKASLSQIS 120
  121 FTNPLNYGSG LGFSSNSQPR LPLLDRLSSV SLSKRPERPQ QSLPSLRHLQ LLPSPLLQEN 180
  181 AARFPDTSKR TSNWKTDLTH WCKDTNYQDY VKIREEVAHF KPLSIPNLTN NQNNDSFNYG 240
  241 KELESTRSSK FHSPSKESFD RTKLIPSILE AKDQFKDLSN NAWSITPPVT PPMSPPTNRT 300
  301 MERTTLRGVE ASFFEGKSSN NDSIFNPIIS EKLVQEVKHQ RQLRGNSFPM PNASHKKTNS 360
  361 FKALQIKKLL ANRDILSNNS KSNVRKPSKN KISKQASNVF GNTARQLVMK LDNASYSSVS 420
  421 ASSSPSPSTP TKSGKMRSRS SSPVRPKAYT PSPRSPNYHR FALDSPPQSP RRSSNSSITK 480
  481 KGSRRSSGSS PTRHTTRVCV SCHSSDSPCW RPSWSPRKQD QLCNSCGLRY KKTHTRCLND 540
  541 LCRKIPTKGE INIMKSNGID KEFVPERNCE IEGYRCLFCN YITETVEN

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Krogan NJ, et al. (2006) ASH1 COQ6 CTI6 DEP1 EAF3 GRX5 PHO23 RCO1 RPD3 RXT2 RXT3 SAP30 SAY1 SDS3 SIN3 UME1
    View Details Qiu et al. (2008) ASH1 PUF6 RPD3 SUM1 TFB5

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run ZDS1 Sample 3 - cpn + atp, from june 2005 McCusker D, et al (2007)
    View Run MLP2 #13 Mitotic Prep2-TiO2 Phosphopeptide enrichment Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data ASH1 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..236] deduced N/A No confident structure predictions are available.
    2 View Details [237..475] MSA 5.157997 View MSA. No confident structure predictions are available.
    3 View Details [476..588] PSI-BLAST 14.221849 Erythroid transcription factor GATA-1

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2 No functions predicted.
    3
    Term Confidence Notes
  • transcription regulator activity
    		•  4.00967542385368 bayes_pls_golite062009
  • DNA binding
    		•  3.60745514727532 bayes_pls_golite062009
  • nucleic acid binding
    		•  3.47256374293954 bayes_pls_golite062009
  • binding
    		•  2.96409924710655 bayes_pls_golite062009
  • transcription factor activity
    		•  2.90769972671972 bayes_pls_golite062009
  • general RNA polymerase II transcription factor activity
    		•  2.55186574506963 bayes_pls_golite062009
  • RNA polymerase II transcription factor activity
    		•  2.40923942043513 bayes_pls_golite062009
  • transcription repressor activity
    		•  1.88834375049208 bayes_pls_golite062009
  • sequence-specific DNA binding
    		•  1.62841402245495 bayes_pls_golite062009
  • transcription activator activity
    		•  1.62405765585032 bayes_pls_golite062009
  • ligand-dependent nuclear receptor activity
    		•  1.49515149729803 bayes_pls_golite062009
  • protein binding
    		•  1.39455913713025 bayes_pls_golite062009
  • transcription factor binding
    		•  1.38523780690867 bayes_pls_golite062009
  • specific RNA polymerase II transcription factor activity
    		•  1.26452462867497 bayes_pls_golite062009
  • structural constituent of ribosome
    		•  1.14370842685155 bayes_pls_golite062009
  • structural molecule activity
    		•  1.03433454627943 bayes_pls_golite062009
  • transcription coactivator activity
    		•  0.61572149323953 bayes_pls_golite062009
  • transcription cofactor activity
    		•  0.58115018700114 bayes_pls_golite062009
  • cytoskeletal protein binding
    		•  0.405267736307896 bayes_pls_golite062009
  • catalytic activity
    		•  0.101795606736461 bayes_pls_golite062009


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
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