Protein Overview: RIM11

General Information:
Name(s) found:	RIM11 / YMR139W [SGD]
Description(s) found: SHOW ONLY BEST	gi\|6323788\|ref\|NP_013859.1\| Protein kinase required for signal transduction during entry into meiosis; promotes the formation of the Ime1p-Ume6p complex by phosphorylating Ime1p and Ume6p; shares similarity with mammalian glycogen synthase kinase 3-beta; [NCBI NR] gi\|606437\|emb\|CAA87353.1\| serine/threonine protein kinase [Saccharomyces cerevisiae] [NCBI NR] gi\|585472\|sp\|P38615.1\|MDS1_YEAST RecName: Full=Serine/threonine-protein kinase MDS1/RIM11 [NCBI NR] gi\|535777\|gb\|AAB04166.1\| kinase [NCBI NR] gi\|450781\|gb\|AAC48917.1\| glycogen synthase kinase-3 homolog [NCBI NR] pir\|\|A56347 protein kinase RIM11 (EC 2.7.1.-) - yeast (Saccharomyces cerevisiae) [NCBI NR] Serine/threonine-protein kinase MDS1/RIM11 OS=Saccharomyces cerevisiae GN=MDS1 PE=1 SV=1 [Swiss-Prot] RIM11 Ser/thr protein kinase [mips] Protein kinase required for signal transduction during entry into meiosis; promotes the formation of the Ime1p-Ume6p complex by phosphorylating Ime1p and Ume6p; shares similarity with mammalian glycogen synthase kinase 3-beta [SGD] RIM11, Chr XIII from 546124-547236 [yeast_orfs2] Chr XIII from 546124-547236 [yeastorf3.fasta] (P38615) Serine/threonine-protein kinase MDS1/RIM11 (EC 2.7.1.-) [4932.FASTACCERV.txt] RIM11 SGDID:S0004747, Chr XIII from 546124-547236, Verified ORF [yeastflysequest.fasta] Required for Ime1p phosphorylation, association of the Ime1p-Ume6p meiotic activator, early meiotic gene expression, and sporulation; Serine/threonine protein kinase, phosphorylates the mitotic activator IME1 [Saccharomyces cerevisiae]gi\|606437\|emb\|CAA87 [nrdb_11152004_Chlamydomonas] (P38615) Serine/threonine-protein kinase MDS1/RIM11 (EC 2.7.1.37) [cerv4932.FASTAC] RIM11 SGDID:S000004747, Chr XIII from 546124-547236, Verified ORF, "Protein kinase required for signal transduction during entry into meiosis; promotes the formation of the Ime1p-Ume6p complex by phosphorylating Ime1p and Ume6p; shares similarity with mam [SGD_S-cerevisiae_na_12-16-2005_con_reversed.fasta] glycogen synthase kinase-3 homolog [nr-271106-contam.fasta] Protein kinase required for signal transduction during entry into meiosis; promotes the formation of the Ime1p-Ume6p complex by phosphorylating Ime1p and Ume6p; shares similarity with mammalian glycogen synthase kinase 3-beta; Rim11p [Saccharomyces cerevi [nr-271106-contam.fasta] serine/threonine protein kinase [Saccharomyces cerevisiae] [nr-271106-contam.fasta] Serine/threonine-protein kinase MDS1/RIM11 [nr-271106-contam.fasta] kinase [nr-271106-contam.fasta] RIM11 SGDID:S000004747, Chr XIII from 546124-547236, Verified ORF, "Protein kinase required for signal transduction during entry into meiosis; promotes the formation of the Ime1p-Ume6p complex by phosphorylating Ime1p and Ume6p; shares similarity with mammalian glycogen synthase kinase 3-beta" [yeast-bovrabprots.fasta] [chemostatdb.fasta] Serine/threonine-protein kinase RIM11/MSD1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=RIM11 PE=1 SV=1 [UniProt_drosophila_07-01-2011_reversed.fasta] RIM11 SGDID:S000004747, Chr XIII from 546125-547237, Genome Release 64-1-1, Verified ORF, "Protein kinase required for signal transduction during entry into meiosis; promotes the formation of the Ime1p-Ume6p complex by phosphorylating Ime1p and Ume6p; shares similarity with mammalian glycogen synthase kinase 3-beta" [yeast-030211-contam.fasta] RIM11 SGDID:S000004747, Chr XIII from 546125-547237, Genome Release 64-2-1, Verified ORF, "Protein kinase; required for signal transduction during entry into meiosis; promotes the formation of the Ime1p-Ume6p complex by phosphorylating Ime1p and Ume6p; shares similarity with mammalian glycogen synthase kinase 3-beta; protein abundance increases in response to DNA replication stress; RIM11 has a paralog, MRK1, that arose from the whole genome duplication" [20141208_orf_trans.fasta] TR1526\|c0_g1_i1\|g.1079 ORF TR1526\|c0_g1_i1\|g.1079 TR1526\|c0_g1_i1\|m.1079 type:complete len:371 (+) TR1526\|c0_g1_i1:297-1409(+) [DBVPG6044_S_cerevisiae-Sep2015-contam.fasta] YMR139W SGDID:S000004747, Chr XIII from 546125-547237, Genome Release 64-1-1, Verified ORF, "Protein kinase required for signal transduction during entry into meiosis; promotes the formation of the Ime1p-Ume6p complex by phosphorylating Ime1p and Ume6p; shares similarity with mammalian glycogen synthase kinase 3-beta" [2016-01-SGD_Yeast_Contam_Riffle_20140507-Ska-Hec-110-tubulin.fasta] ID=asmbl_4327\|g.2535 ORF ID=asmbl_4327\|g.2535 ID=asmbl_4327\|m.2535 type:complete len:371 (+) ID=asmbl_4327:228-1340(+) [DBVPG6044_quiverGenomes_Trinity_v2_2_0_PASA_2June2016-contam.fasta]
Organism:	Saccharomyces cerevisiae
Length:	370 amino acids
Gene Ontology:
Cellular Component:	cytoplasm [IDA]
Biological Process:	ascospore formation [IMP] proteolysis [IGI] protein amino acid phosphorylation [IGI][ISS] response to stress [IGI][IMP]
Molecular Function:	protein serine/threonine kinase activity [IDA] glycogen synthase kinase 3 activity [ISS]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MNIQSNNSPN LSNNIVSKQV YYAHPPPTID PNDPVQISFP TTEVVGHGSF GVVFATVIQE  60
   61 TNEKVAIKKV LQDKRFKNRE LEIMKMLSHI NIIDLKYFFY ERDSQDEIYL NLILEYMPQS 120
  121 LYQRLRHFVH QRTPMSRLEI KYYMFQLFKS LNYLHHFANV CHRDIKPQNL LVDPETWSLK 180
  181 LCDFGSAKQL KPTEPNVSYI CSRYYRAPEL IFGATNYTNQ IDIWSSGCVM AELLLGQPMF 240
  241 PGESGIDQLV EIIKILGTPS KQEICSMNPN YMEHKFPQIK PIPLSRVFKK EDDQTVEFLA 300
  301 DVLKYDPLER FNALQCLCSP YFDELKLDDG KINQITTDLK LLEFDENVEL GHLSPDELSS 360
  361 VKKKLYPKSK

Protein Complex Data

	PUBLICATION	TOPOLOGY	COCOMPLEXED PROTEINS
View Details	Krogan NJ, et al. (2006)		GIN4 HFD1 HTZ1 KAP114 KCC4 NAP1 PRO3 REI1 RIM11 RPS6A, RPS6B UBC8 VIP1 WTM1 YKR011C
View Details	Gavin AC, et al. (2002)		NAP1 RIM11
View Details	Ho Y, et al. (2002)		CDC25 CKI1 GCR2 GIN4 HOM3 IRA1 IRA2 MYO2 MYO4 NAP1 PMD1 PRS2 PRS3 PRS5 RIM11 TPS1 TSL1 YDR170W-A YER138C YER160C YJR027W YJR028W

Mass Spectrometry Data

The following runs contain data for this protein:

	BAIT	COMMENTS	PUBLICATION
View Run	MLP2	#32 Asynchronous Prep-No Phosphopeptide enrichment	Keck JM, et al. (2011)

Yeast Two-Hybrid Data

The following interactions contain this protein:

SHOWING SINGLE HITS. [ Hide Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

	BAIT	PREY	HITS	PUBLICATION
View Screen	RIM11	RRG9	1	Unpublished Fields Lab Data
View Screen	RIM11	RPS14A	1	Unpublished Fields Lab Data
View Screen	RIM11	YDR344C	1	Unpublished Fields Lab Data
View Screen	RIM11	YDR541C	1	Unpublished Fields Lab Data
View Screen	RIM11	YAP1802	1	Unpublished Fields Lab Data
View Screen	RIM11	ATG7	1	Unpublished Fields Lab Data
View Screen	RIM11	GVP36	1	Unpublished Fields Lab Data
View Screen	RIM11	FCJ1	1	Unpublished Fields Lab Data
View Screen	RIM11	CHA4	1	Unpublished Fields Lab Data
View Screen	RIM11	RPS31	1	Unpublished Fields Lab Data

Microscopy / Localization Data

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	PROTEIN(S)	PUBLICATION
View Data	RIM11	Huh WK, et al. (2003)

Protein Structure Data

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[View Top Sequence Alignments] [Show Ginzu Version Information]

Domains predicted:

#		Region(s)	Method	Confidence	Match Description
1	View Details	[1..116]	PSI-BLAST	1153.0	Glycogen synthase kinase-3 beta (Gsk3b)
2	View Details	[117..370]	PSI-BLAST	1153.0	Glycogen synthase kinase-3 beta (Gsk3b)

Functions predicted (by domain):

Gene Ontology predictions

Term	Confidence	Notes
acetylcholine receptor activator activity	5.9159846946654	bayes_pls_golite062009
general RNA polymerase II transcription factor activity	5.68265749805481	bayes_pls_golite062009
phosphotransferase activity, alcohol group as acceptor	5.49988294224815	bayes_pls_golite062009
protein kinase activity	5.4586557943719	bayes_pls_golite062009
kinase activity	5.3287080791198	bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups	4.96052051118534	bayes_pls_golite062009
cyclin-dependent protein kinase activity	4.62392503670521	bayes_pls_golite062009
protein serine/threonine kinase activity	4.46381887831481	bayes_pls_golite062009
transferase activity	3.97138602499442	bayes_pls_golite062009
structural molecule activity	3.82327979736517	bayes_pls_golite062009
transmembrane receptor protein tyrosine kinase activity	3.41480681854114	bayes_pls_golite062009
transmembrane receptor protein kinase activity	3.40140621607334	bayes_pls_golite062009
protein tyrosine kinase activity	2.8153155526437	bayes_pls_golite062009
phosphoinositide 3-kinase binding	2.79505438761262	bayes_pls_golite062009
binding	2.74863538127007	bayes_pls_golite062009
transmembrane receptor activity	2.59526003830791	bayes_pls_golite062009
ion transmembrane transporter activity	2.52531786618214	bayes_pls_golite062009
cation transmembrane transporter activity	2.46424348876434	bayes_pls_golite062009
signal transducer activity	2.40586892801446	bayes_pls_golite062009
molecular transducer activity	2.40586892801446	bayes_pls_golite062009
receptor activity	2.39311927684508	bayes_pls_golite062009
substrate-specific transmembrane transporter activity	2.37122853419919	bayes_pls_golite062009
protein binding	2.276111749106	bayes_pls_golite062009
tubulin binding	2.18641675163967	bayes_pls_golite062009
cytoskeletal protein binding	2.12615078788254	bayes_pls_golite062009
receptor signaling protein activity	2.10379226653669	bayes_pls_golite062009
ATP binding	1.97600611746091	bayes_pls_golite062009
ubiquitin-protein ligase activity	1.94085498993561	bayes_pls_golite062009
adenyl ribonucleotide binding	1.93596671856664	bayes_pls_golite062009
adenyl nucleotide binding	1.90928021591891	bayes_pls_golite062009
metal ion transmembrane transporter activity	1.9016235206634	bayes_pls_golite062009
microtubule binding	1.88110801192607	bayes_pls_golite062009
actin binding	1.87817875565699	bayes_pls_golite062009
receptor signaling protein serine/threonine kinase activity	1.81249386965144	bayes_pls_golite062009
telethonin binding	1.75733591474207	bayes_pls_golite062009
small conjugating protein ligase activity	1.74206248731815	bayes_pls_golite062009
fibroblast growth factor 1 binding	1.66976264488423	bayes_pls_golite062009
purine ribonucleotide binding	1.65732943334212	bayes_pls_golite062009
ribonucleotide binding	1.65726906484847	bayes_pls_golite062009
purine nucleotide binding	1.63763394711025	bayes_pls_golite062009
nucleotide binding	1.63195828048121	bayes_pls_golite062009
insulin receptor substrate binding	1.62657794525303	bayes_pls_golite062009
JUN kinase kinase kinase activity	1.60259443694567	bayes_pls_golite062009
transcription regulator activity	1.56748951434625	bayes_pls_golite062009
growth factor binding	1.53863828216563	bayes_pls_golite062009
nucleic acid binding	1.46547714006072	bayes_pls_golite062009
MAP kinase kinase activity	1.42275431028856	bayes_pls_golite062009
DNA binding	1.35333135345112	bayes_pls_golite062009
ErbB-3 class receptor binding	1.34841233233438	bayes_pls_golite062009
ErbB-2 class receptor binding	1.33825339298024	bayes_pls_golite062009
kinase binding	1.26086833316556	bayes_pls_golite062009
acid-amino acid ligase activity	1.2266791546014	bayes_pls_golite062009
catalytic activity	1.21655087018101	bayes_pls_golite062009
transcription elongation regulator activity	1.16995153203536	bayes_pls_golite062009
transcription repressor activity	1.14496167267281	bayes_pls_golite062009
histone kinase activity (H3-S10 specific)	1.14432210832726	bayes_pls_golite062009
transporter activity	1.11833481501707	bayes_pls_golite062009
non-membrane spanning protein tyrosine kinase activity	1.11664317075762	bayes_pls_golite062009
transcription factor activity	1.10928254946881	bayes_pls_golite062009
transmembrane receptor protein serine/threonine kinase activity	1.10045286406485	bayes_pls_golite062009
transforming growth factor beta receptor activity	1.10045286406485	bayes_pls_golite062009
protein kinase binding	1.06030596516506	bayes_pls_golite062009
cation channel activity	1.04999722123563	bayes_pls_golite062009
transcription activator activity	0.997272622653026	bayes_pls_golite062009
PTB domain binding	0.9900774724568	bayes_pls_golite062009
transmembrane transporter activity	0.97575992765505	bayes_pls_golite062009
alpha-actinin binding	0.877087652539674	bayes_pls_golite062009
insulin-like growth factor receptor binding	0.872782211382796	bayes_pls_golite062009
fibroblast growth factor binding	0.870666814073948	bayes_pls_golite062009
MAP kinase activity	0.81943579965027	bayes_pls_golite062009
actin filament binding	0.794152600084	bayes_pls_golite062009
fibroblast growth factor receptor activity	0.75189004129952	bayes_pls_golite062009
substrate-specific transporter activity	0.705905455086486	bayes_pls_golite062009
hormone receptor binding	0.705067960165986	bayes_pls_golite062009
beta-catenin binding	0.693246095477001	bayes_pls_golite062009
structural constituent of cytoskeleton	0.612883428421652	bayes_pls_golite062009
JUN kinase kinase kinase kinase activity	0.546647574638943	bayes_pls_golite062009
cyclin-dependent protein kinase activating kinase activity	0.529121666062889	bayes_pls_golite062009
activin binding	0.510364757301021	bayes_pls_golite062009
steroid hormone receptor binding	0.505233004492768	bayes_pls_golite062009
protein serine/threonine/tyrosine kinase activity	0.48345772948903	bayes_pls_golite062009
enzyme binding	0.46284745266176	bayes_pls_golite062009
protein kinase C activity	0.41587987561486	bayes_pls_golite062009
cyclin-dependent protein kinase regulator activity	0.406297251827056	bayes_pls_golite062009
RNA polymerase II transcription factor activity	0.401250804041384	bayes_pls_golite062009
structural constituent of muscle	0.399773397398032	bayes_pls_golite062009
magnesium ion binding	0.393328812780268	bayes_pls_golite062009
MAP kinase kinase kinase activity	0.37115026509016	bayes_pls_golite062009
JUN kinase kinase activity	0.332372116912461	bayes_pls_golite062009
structure-specific DNA binding	0.318153468064373	bayes_pls_golite062009
channel activity	0.287189255116606	bayes_pls_golite062009
passive transmembrane transporter activity	0.287189255116606	bayes_pls_golite062009
insulin receptor binding	0.266450215230107	bayes_pls_golite062009
substrate-specific channel activity	0.261869836686301	bayes_pls_golite062009
RNA binding	0.245748631571068	bayes_pls_golite062009
ion channel activity	0.241519346930618	bayes_pls_golite062009
nuclear hormone receptor binding	0.240883589532225	bayes_pls_golite062009
protein complex binding	0.239339759110451	bayes_pls_golite062009
insulin receptor activity	0.237134032032089	bayes_pls_golite062009
SH2 domain binding	0.226760162354251	bayes_pls_golite062009
ligase activity, forming carbon-oxygen bonds	0.149958560815481	bayes_pls_golite062009
ligase activity, forming aminoacyl-tRNA and related compounds	0.149958560815481	bayes_pls_golite062009
aminoacyl-tRNA ligase activity	0.14842991990838	bayes_pls_golite062009
peptide binding	0.118578378753757	bayes_pls_golite062009
transforming growth factor beta receptor activity, type I	0.0506751594607393	bayes_pls_golite062009
nucleoside-triphosphatase activity	0.0040394359628233	bayes_pls_golite062009
brain-derived neurotrophic factor binding	0.00315481858218991	bayes_pls_golite062009

No functions predicted.

Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

Philius Transmembrane Prediction:

Protein predicted to be:	GLOBULAR (No transmembrane regions or signal peptide)
Confidence of classification:	0.99

Source: Reynolds et al. (2008)

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2