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Protein Overview: TSL1

General Information:
Name(s) found: TSL1 / YML100W [SGD]
Description(s) found:
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  • gi|6323537|ref|NP_013608.1| Large subunit of trehalose 6-phosphate synthase (Tps1p)/phosphatase (Tps2p) complex, which converts uridine-5'-diphosphoglucose and glucose 6-phosphate to trehalose, homologous to Tps3p and may share function; Tsl1p [Saccharomy [NCBI NR]
  • gi|586133|sp|P38427.1|TSL1_YEAST RecName: Full=Trehalose synthase complex regulatory subunit TSL1; AltName: Full=Alpha,alpha-trehalose-phosphate synthase [UDP-forming] 123 kDa subunit [NCBI NR]
  • gi|530344|emb|CAA56797.1| ts11 [Saccharomyces cerevisiae] [NCBI NR]
  • pir||S36868 alpha,alpha-trehalose-phosphate synthase (UDP-forming) (EC 2.4.1.15) 123K chain - yeast (Saccharomyces cerevisiae) [NCBI NR]
  • gi|288437|emb|CAA51303.1| alpha,alpha-trehalose-phosphate synthase (UDP-forming) [Saccharomyces cerevisiae] [NCBI NR]
  • Trehalose synthase complex regulatory subunit TSL1 OS=Saccharomyces cerevisiae GN=TSL1 PE=1 SV=1 [Swiss-Prot]
  • TSL1 Alpha,alpha-trehalose-phosphate synthase, 123 KD subunit [mips]
  • Large subunit of trehalose 6-phosphate synthase (Tps1p)/phosphatase (Tps2p) complex, which converts uridine-5'-diphosphoglucose and glucose 6-phosphate to trehalose, homologous to Tps3p and may share function [SGD]
  • TSL1, Chr XIII from 70624-73920 [yeast_orfs2]
  • Chr XIII from 70624-73920 [yeastorf3.fasta]
  • (P38427) Alpha,alpha-trehalose-phosphate synthase [UDP-forming] 123 kDa subunit (EC 2.4.1.15) (Trehalose-6-phosphate synthase) (UDP-glucose-glucosephosphate glucosyltransferase) [4932.FASTACCERV.txt]
  • TSL1 SGDID:S0004566, Chr XIII from 70624-73920, Verified ORF [yeastflysequest.fasta]
  • 123 kD regulatory subunit of trehalose-6-phosphate synthase/phosphatase complex; homologous to TPS3 gene product [Saccharomyces cerevisiae]gi|530344|emb|CAA56797.1| ts11 [Saccharomyces cerevisiae]gi|288437|emb|CAA51303.1| alpha,alpha-trehalose-phosphate [nrdb_11152004_Chlamydomonas]
  • TSL1 SGDID:S000004566, Chr XIII from 70624-73920, Verified ORF, "Large subunit of trehalose 6-phosphate synthase (Tps1p)/phosphatase (Tps2p) complex, which converts uridine-5'-diphosphoglucose and glucose 6-phosphate to trehalose, homologous to Tps3p and [SGD_S-cerevisiae_na_12-16-2005_con_reversed.fasta]
  • alpha,alpha-trehalose-phosphate synthase (UDP-forming) [Saccharomyces cerevisiae] [nr-271106-contam.fasta]
  • Trehalose synthase complex regulatory subunit TSL1 (Alpha,alpha-trehalose-phosphate synthase [UDP-forming] 123 kDa subunit) [nr-271106-contam.fasta]
  • Large subunit of trehalose 6-phosphate synthase (Tps1p)/phosphatase (Tps2p) complex, which converts uridine-5'-diphosphoglucose and glucose 6-phosphate to trehalose, homologous to Tps3p and may share function; Tsl1p [Saccharomyces cerevisiae] [nr-271106-contam.fasta]
  • ts11 [Saccharomyces cerevisiae] [nr-271106-contam.fasta]
  • TSL1 SGDID:S000004566, Chr XIII from 70624-73920, Verified ORF, "Large subunit of trehalose 6-phosphate synthase (Tps1p)/phosphatase (Tps2p) complex, which converts uridine-5'-diphosphoglucose and glucose 6-phosphate to trehalose, homologous to Tps3p and may share function" [yeast-bovrabprots.fasta]
  • [chemostatdb.fasta]
  • Trehalose synthase complex regulatory subunit TSL1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=TSL1 PE=1 SV=1 [UniProt_S_cerevisiae_20120516_05-16-2012_reversed.fasta]
  • TSL1 SGDID:S000004566, Chr XIII from 70624-73920, Genome Release 64-1-1, Verified ORF, "Large subunit of trehalose 6-phosphate synthase (Tps1p)/phosphatase (Tps2p) complex, which converts uridine-5'-diphosphoglucose and glucose 6-phosphate to trehalose, similar to Tps3p and may share function; mutant has aneuploidy tolerance" [yeast-030211-contam.fasta]
  • TSL1 SGDID:S000004566, Chr XIII from 70624-73920, Genome Release 64-2-1, Verified ORF, "Large subunit of trehalose 6-phosphate synthase/phosphatase complex; Tps1p-Tps2p complex converts uridine-5'-diphosphoglucose and glucose 6-phosphate to trehalose; contributes to survival to acute lethal heat stress; mutant has aneuploidy tolerance; protein abundance increases in response to DNA replication stress; TSL1 has a paralog, TPS3, that arose from the whole genome duplication" [20141208_orf_trans.fasta]
  • YML100W SGDID:S000004566, Chr XIII from 70624-73920, Genome Release 64-1-1, Verified ORF, "Large subunit of trehalose 6-phosphate synthase (Tps1p)/phosphatase (Tps2p) complex, which converts uridine-5'-diphosphoglucose and glucose 6-phosphate to trehalose, similar to Tps3p and may share function; mutant has aneuploidy tolerance" [2016-01-SGD_Yeast_Contam_Riffle_20140507-Ska-Hec-110-tubulin.fasta]
    • Organism: Saccharomyces cerevisiae
    Length: 1098 amino acids

    Gene Ontology:
    Cellular Component: alpha,alpha-trehalose-phosphate synthase complex (UDP-forming) [IGILink to PubMed article][IMPLink to PubMed article][IPILink to PubMed article]
    Biological Process: trehalose biosynthetic process [IGILink to PubMed article][IMPLink to PubMed article][IPILink to PubMed article]
    response to stress [IMPLink to PubMed article]
    Molecular Function: alpha,alpha-trehalose-phosphate synthase (UDP-forming) activity [IMPLink to PubMed article]
    trehalose-phosphatase activity [IGILink to PubMed article]
    enzyme regulator activity [IDALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MALIVASLFL PYQPQFELDT SLPENSQVDS SLVNIQAMAN DQQQQRALSN NISQESLVAP  60
   61 APEQGVPPAI SRSATRSPSA FNRASSTTNT ATLDDLVSSD IFMENLTANA TTSHTPTSKT 120
  121 MLKPRKNGSV ERFFSPSSNI PTDRIASPIQ HEHDSGSRIA SPIQQQQQDP TTNLLKNVNK 180
  181 SLLVHSLLNN TSQTSLEGPN NHIVTPKSRA GNRPTSAATS LVNRTKQGSA SSGSSGSSAP 240
  241 PSIKRITPHL TASAAKQRPL LAKQPSNLKY SELADISSSE TSSQHNESDP DDLTTAPDEE 300
  301 YVSDLEMDDA KQDYKVPKFG GYSNKSKLKK YALLRSSQEL FSRLPWSIVP SIKGNGAMKN 360
  361 AINTAVLENI IPHRHVKWVG TVGIPTDEIP ENILANISDS LKDKYDSYPV LTDDDTFKAA 420
  421 YKNYCKQILW PTLHYQIPDN PNSKAFEDHS WKFYRNLNQR FADAIVKIYK KGDTIWIHDY 480
  481 HLMLVPQMVR DVLPFAKIGF TLHVSFPSSE VFRCLAQREK ILEGLTGADF VGFQTREYAR 540
  541 HFLQTSNRLL MADVVHDEEL KYNGRVVSVR FTPVGIDAFD LQSQLKDGSV MQWRQLIRER 600
  601 WQGKKLIVCR DQFDRIRGIH KKLLAYEKFL VENPEYVEKS TLIQICIGSS KDVELERQIM 660
  661 IVVDRINSLS TNISISQPVV FLHQDLDFSQ YLALSSEADL FVVSSLREGM NLTCHEFIVC 720
  721 SEDKNAPLLL SEFTGSASLL NDGAIIINPW DTKNFSQAIL KGLEMPFDKR RPQWKKLMKD 780
  781 IINNDSTNWI KTSLQDIHIS WQFNQEGSKI FKLNTKTLME DYQSSKKRMF VFNIAEPPSS 840
  841 RMISILNDMT SKGNIVYIMN SFPKPILENL YSRVQNIGLI AENGAYVSLN GVWYNIVDQV 900
  901 DWRNDVAKIL EDKVERLPGS YYKINESMIK FHTENAEDQD RVASVIGDAI THINTVFDHR 960
  961 GIHAYVYKNV VSVQQVGLSL SAAQFLFRFY NSASDPLDTS SGQITNIQTP SQQNPSDQEQ1020
 1021 QPPASPTVSM NHIDFACVSG SSSPVLEPLF KLVNDEASEG QVKAGHAIVY GDATSTYAKE1080
 1081 HVNGLNELFT IISRIIED

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Riffle et al. (2010) (Unpublished Data) TPS1 TPS2 TPS3 TSL1
    View Details Krogan NJ, et al. (2006) TPS1 TPS2 TPS3 TSL1
    View Details Gavin AC, et al. (2002) CTR3 DAL3 GLN1 GTO3 IML1 MCM2 MKS1 REG1 TIF1, TIF2 TPS1 TPS2 TPS3 TSC10 TSL1 YIL177C
    View Details Ho Y, et al. (2002) CDC25 CKI1 DSK2 GCR2 GIN4 HMF1 HOM3 IRA1 IRA2 MYO2 MYO4 NAP1 NPL4 PMD1 PRS2 PRS3 PRS5 PTC1 RAD23 RIM11 SHP1 TPS1 TSL1 UBI4 UFD2 YDR049W YDR170W-A YER138C YER160C YJR027W YJR028W
    View Details Qiu et al. (2008) GIP2 REG1 TPS1 TPS2 TSL1

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run RPA135 his-HA tag on RPA135 Schneider, DA, et al. (2006)
    View Run CEP3 sample cbf3 from feb 2005 Sandall S, et all (2006)
    View Run ZDS1 Sample 2- cpn2 from june 2005 McCusker D, et al (2007)
    View Run ZDS1 Sample 3 - cpn + atp, from june 2005 McCusker D, et al (2007)
    View Run BOI1 Sample boi 1 with ha tag from october 2005 McCusker D, et al (2007)
    View Run MLP2 #29 Asynchronous Prep5-TiO2 Flowthrough Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data TSL1 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..251] MSA 2.067997 View MSA. No confident structure predictions are available.
    2 View Details [252..809] Pfam 248.022276 Glycosyltransferase family 20 No confident structure predictions are available.
    3 View Details [810..1098] Pfam 73.136677 Trehalose-phosphatase No confident structure predictions are available.
    4 View Details [814..1098] PSI-BLAST 10.09691 Crystal structure of trehalose-6-phosphate phosphatase related protein

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2 No functions predicted.
    3
    Term Confidence Notes
  • alpha,alpha-trehalose-phosphate synthase (UDP-forming) activity
    		•  11.2045941324603 bayes_pls_golite062009
  • glucosyltransferase activity
    		•  8.25064561355471 bayes_pls_golite062009
  • UDP-glucosyltransferase activity
    		•  8.0463972704113 bayes_pls_golite062009
  • trehalose-phosphatase activity
    		•  7.58500038184065 bayes_pls_golite062009
  • transferase activity, transferring hexosyl groups
    		•  3.70184884300914 bayes_pls_golite062009
  • catalytic activity
    		•  2.65148466065976 bayes_pls_golite062009
  • transferase activity, transferring glycosyl groups
    		•  2.62403914335522 bayes_pls_golite062009
  • transferase activity
    		•  2.18054407163329 bayes_pls_golite062009
  • UDP-glycosyltransferase activity
    		•  2.13085705769565 bayes_pls_golite062009
  • carbohydrate phosphatase activity
    		•  0.78952375993773 bayes_pls_golite062009
  • UDP-N-acetylglucosamine 2-epimerase activity
    		•  0.690032302126686 bayes_pls_golite062009
  • glycogen phosphorylase activity
    		•  0.607220464589157 bayes_pls_golite062009
  • binding
    		•  0.345236672370351 bayes_pls_golite062009
  • phosphorylase activity
    		•  0.296436712681472 bayes_pls_golite062009
  • mannosyltransferase activity
    		•  0.253888301381021 bayes_pls_golite062009
  • protein binding
    		•  0.198267161626932 bayes_pls_golite062009
    4
    Term Confidence Notes
  • trehalose-phosphatase activity
    		•  3.78859922218487 bayes_pls_golite062009
  • transporter activity
    		•  2.28749015584769 bayes_pls_golite062009
  • hydrolase activity
    		•  2.23636068759523 bayes_pls_golite062009
  • transmembrane transporter activity
    		•  2.17051010073814 bayes_pls_golite062009
  • substrate-specific transporter activity
    		•  2.14633664297706 bayes_pls_golite062009
  • substrate-specific transmembrane transporter activity
    		•  2.05684652641195 bayes_pls_golite062009
  • ion transmembrane transporter activity
    		•  2.05060633349756 bayes_pls_golite062009
  • cation transmembrane transporter activity
    		•  1.84740904871745 bayes_pls_golite062009
  • catalytic activity
    		•  1.55296860681783 bayes_pls_golite062009
  • ATPase activity, coupled to transmembrane movement of ions
    		•  1.53201151596704 bayes_pls_golite062009
  • inorganic cation transmembrane transporter activity
    		•  1.45647470429539 bayes_pls_golite062009
  • ATPase activity, coupled
    		•  1.44542004757594 bayes_pls_golite062009
  • nucleoside-triphosphatase activity
    		•  1.42792997211574 bayes_pls_golite062009
  • ATPase activity
    		•  1.40341876769691 bayes_pls_golite062009
  • pyrophosphatase activity
    		•  1.352553895791 bayes_pls_golite062009
  • ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism
    		•  1.33388154652051 bayes_pls_golite062009
  • hydrolase activity, acting on acid anhydrides
    		•  1.33292469269496 bayes_pls_golite062009
  • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
    		•  1.33065047107664 bayes_pls_golite062009
  • metal ion transmembrane transporter activity
    		•  1.31602086166435 bayes_pls_golite062009
  • di-, tri-valent inorganic cation transmembrane transporter activity
    		•  0.28050944646617 bayes_pls_golite062009
  • active transmembrane transporter activity
    		•  0.194344891491143 bayes_pls_golite062009
  • phosphatase activity
    		•  0.159899259988948 bayes_pls_golite062009
  • cation-transporting ATPase activity
    		•  0.15490458026932 bayes_pls_golite062009
  • phosphoric ester hydrolase activity
    		•  0.103902756538853 bayes_pls_golite062009
  • primary active transmembrane transporter activity
    		•  0.053543166906854 bayes_pls_golite062009
  • P-P-bond-hydrolysis-driven transmembrane transporter activity
    		•  0.041293091790546 bayes_pls_golite062009
  • binding
    		•  0.0209333912048011 bayes_pls_golite062009


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.94

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle