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Protein Overview: MSL1

General Information:
Name(s) found: MSL1 / YIR009W [SGD]
Description(s) found:
Found 31 descriptions.
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  • U2B component of U2 snRNP, involved in splicing, binds the U2 snRNA stem-loop IV in vitro but requires association of Lea1p for in vivo binding; does not contain the conserved C-terminal RNA binding domain found in other family members [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 111 amino acids

    Gene Ontology:
    Cellular Component: U2 snRNP [IDALink to PubMed article]
    Biological Process: nuclear mRNA splicing, via spliceosome [IPILink to PubMed article][ISSLink to PubMed article]
    Molecular Function: RNA binding [IDALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MVEPARKKQR IDRDTHHTVA EPVTEAKNTL YVSQLNEKIN MQRLRVNLFL LFATFGEVLK  60
   61 VSMNFKKQRG QAFITMRTID QASLAQISLN GERFFGKPLK VEFSKSETKT L

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Riffle et al. (2010) (Unpublished Data) CSN12 CUS1 HSH155 LEA1 MSL1 PRP21 PRP31 PRP4 PRP6 PRP9 RSE1 SMB1 SNU114
    View Details Krogan NJ, et al. (2006) CHS3 LYS14 MSL1 NMD2 SUR7 UPF3
    View Details Gavin AC, et al. (2006) CUS1 HSH155 HSH49 LEA1 MSL1 PRP11 PRP21 PRP9 RSE1
    View Details Gavin AC, et al. (2002) AAR2 BRR1 BUD31 CBC2 CDC33 CEF1 CLF1 CSN12 CUS1 CWC2 CWC22 CWC23 DHH1 DIB1 ECM2 GCN2 HRT1 HSH155 HSH49 HTA1 IMG1 LEA1 LIN1 LSM1 LSM2 LSM4 LSM5 LSM6 LSM7 LUC7 MRP7 MRPL28 MRPL3 MRPL35 MRPL38 MRPL4 MRPL8 MRPS5 MSL1 MUD1 NAM8 NPL3 PAT1 PRP11 PRP18 PRP19 PRP21 PRP24 PRP28 PRP3 PRP31 PRP38 PRP39 PRP4 PRP40 PRP42 PRP43 PRP46 PRP6 PRP8 PRP9 RSE1 RVB2 SLU7 SMB1 SMD1 SMD2 SMD3 SME1 SMX2 SMX3 SNP1 SNT309 SNU114 SNU23 SNU56 SNU66 SNU71 SPP381 SPP382 SRB2 STO1 SYF1 TIF4631 TIF4632 TOS4 UTP21 YEF3 YML6
    View Details Qiu et al. (2008) AAR2 BRR1 BRR2 CBC2 CDC40 CUS1 CUS2 CWC15 CWC2 CWC22 CWC23 HSH155 HSH49 IST3 LEA1 LSM3 LSM5 LSM8 LUC7 MAK5 MSL1 MUD1 NAM8 PRP11 PRP2 PRP21 PRP22 PRP24 PRP28 PRP3 PRP31 PRP38 PRP39 PRP4 PRP40 PRP42 PRP43 PRP46 PRP5 PRP6 PRP8 PRP9 RSE1 SLU7 SMB1 SMD1 SMD2 SMD3 SME1 SMX2 SMX3 SNP1 SNT309 SNU114 SNU23 SNU56 SNU66 SNU71 SPP2 SPP381 SPP382 STO1 SUB2 SYF2 YHC1

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run CWC2 No Comments Hazbun TR, et al. (2003)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

      BAIT PREY HITS PUBLICATION
    View Screen KAP104 MSL1 1 Unpublished Fields Lab Data
    View Screen VPS64 MSL1 1 Unpublished Fields Lab Data
    View Screen RPT3 MSL1 1 Unpublished Fields Lab Data
    View Screen TPT1 MSL1 1 Unpublished Fields Lab Data
    View Screen HSH49 MSL1 1 Unpublished Fields Lab Data

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data MSL1 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..111] PSI-BLAST 128.927757 No description for 1nrcA_ was found.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • RNA binding
    		•  6.73097473547076 bayes_pls_golite062009
    		• 6.62953239642182 bayes_pls_golite062009
  • mRNA binding
    		•  5.29759606920196 bayes_pls_golite062009
  • nucleic acid binding
    		•  4.50398990564944 bayes_pls_golite062009
  • binding
    		•  4.16717332578111 bayes_pls_golite062009
  • snRNA binding
    		•  4.06596327298973 bayes_pls_golite062009
  • poly-pyrimidine tract binding
    		•  3.11990160533699 bayes_pls_golite062009
  • U1 snRNA binding
    		•  3.02511982045347 bayes_pls_golite062009
  • single-stranded RNA binding
    		•  2.93798024346416 bayes_pls_golite062009
  • transcription regulator activity
    		•  2.18211199677674 bayes_pls_golite062009
  • DNA binding
    		•  1.73925834998328 bayes_pls_golite062009
  • structural molecule activity
    		•  1.3693462485782 bayes_pls_golite062009
  • U2 snRNA binding
    		•  1.34078165372485 bayes_pls_golite062009
  • protein binding
    		•  0.922113825487632 bayes_pls_golite062009
  • transcription factor activity
    		•  0.873765500321315 bayes_pls_golite062009
  • mRNA 3'-UTR binding
    		•  0.591700155096213 bayes_pls_golite062009
  • hydrolase activity
    		•  0.389390547875764 bayes_pls_golite062009
  • sequence-specific DNA binding
    		•  0.294937517750882 bayes_pls_golite062009


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.83

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle