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Protein Overview: SGN1

General Information:
Name(s) found: SGN1 / YIR001C [SGD]
Description(s) found:
Found 27 descriptions.
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  • Cytoplasmic RNA-binding protein, contains an RNA recognition motif (RRM); may have a role in mRNA translation, as suggested by genetic interactions with genes encoding proteins involved in translational initiation [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 250 amino acids

    Gene Ontology:
    Cellular Component: cytoplasm [IDALink to PubMed article]
    Biological Process: mRNA metabolic process [IGILink to PubMed article]
    Molecular Function: poly(A) RNA binding [IDALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSQEEKVDAK ATLKTEISNN KKNDKQELEL DELVGKLSIE GTPQVSQKLS KEEKHAHQLE  60
   61 ADSRSIFVGN ITPDVTPEQI EDHFKDCGQI KRITLLYDRN TGTPKGYGYI EFESPAYREK 120
  121 ALQLNGGELK GKKIAVSRKR TNIPGFNRHY NSQNQYFQQW QWNYPLMAYP NPDTFPYYPP 180
  181 YPPNQSPNQN FGYNKNNYYR SPYNNKNRTF QKKHFNSAKD STKNIRSTSQ KPVVMPSDNV 240
  241 KSSTQEKDSK

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Riffle et al. (2010) (Unpublished Data) NAM7 PUB1 SGN1 TIF4631 TIF4632 YGR250C
    View Details Krogan NJ, et al. (2006) ARG3 ATP3 BUD30 CIK1 GAL80 PMI40 SGN1 YGR250C YML002W YOR1
    View Details Gavin AC, et al. (2002) HCA4 IML1 LHP1 NAB3 NAB6 NAM7 NPL3 NRD1 NRP1 POL2 PUB1 SGN1 SMD3 SNF2 SRV2 STO1 SWI1 TDH3 TIF4631 TIF4632 YGR250C
    View Details Ho Y, et al. (2002) CLU1 FUN12 NPL3 PDI1 PUB1 SGN1 SPT2 TIF4631 TIF4632 YGR250C

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run ZDS1 Sample 2- cpn2 from june 2005 McCusker D, et al (2007)
    View Run BOI1 Sample bob1 (2nd set) from october 2005 McCusker D, et al (2007)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

      BAIT PREY HITS PUBLICATION
    View Screen SGN1 GET3 1 Unpublished Fields Lab Data
    View Screen SGN1 DIG1 1 Unpublished Fields Lab Data
    View Screen SGN1 SIZ1 1 Unpublished Fields Lab Data
    View Screen SGN1 SNF1 1 Unpublished Fields Lab Data
    View Screen SGN1 CRP1 1 Unpublished Fields Lab Data
    View Screen SGN1 SGN1 1 Unpublished Fields Lab Data
    View Screen SGN1 PHO86 1 Unpublished Fields Lab Data
    View Screen SGN1 SPT23 1 Unpublished Fields Lab Data
    View Screen SGN1 YKL063C 1 Unpublished Fields Lab Data
    View Screen SGN1 OAF3 1 Unpublished Fields Lab Data
    View Screen CIT2 SGN1 1 Unpublished Fields Lab Data
    View Screen SGN1 YLL007C 1 Unpublished Fields Lab Data
    View Screen EHD3 SGN1 1 Unpublished Fields Lab Data
    View Screen SGN1 GTT2 1 Unpublished Fields Lab Data
    View Screen RAD51 SGN1 1 Unpublished Fields Lab Data
    View Screen SGN1 SIN4 1 Unpublished Fields Lab Data
    View Screen SGN1 YBL077W 1 Unpublished Fields Lab Data
    View Screen SGN1 YOR302W 1 Unpublished Fields Lab Data
    View Screen SGN1 PHO87 1 Unpublished Fields Lab Data
    View Screen SGN1 VTS1 1 Unpublished Fields Lab Data
    View Screen SGN1 TUP1 1 Unpublished Fields Lab Data
    View Screen SGN1 MRS6 1 Unpublished Fields Lab Data
    View Screen SGN1 CSM1 1 Unpublished Fields Lab Data
    View Screen SGN1 YPL025C 1 Unpublished Fields Lab Data

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data SGN1 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..142] PSI-BLAST 86.056057 Nuclear ribonucleoprotein A1 (RNP A1, UP1)
    2 View Details [143..250] PSI-BLAST 86.056057 Nuclear ribonucleoprotein A1 (RNP A1, UP1)

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • RNA binding
    		•  4.63987691433124 bayes_pls_golite062009
  • mRNA binding
    		•  3.54495985180603 bayes_pls_golite062009
  • nucleic acid binding
    		•  3.14140374009254 bayes_pls_golite062009
  • binding
    		•  2.41127885655304 bayes_pls_golite062009
  • single-stranded RNA binding
    		•  1.46469774223879 bayes_pls_golite062009
    		• 1.35163561991147 bayes_pls_golite062009
  • poly-pyrimidine tract binding
    		•  0.544292786424842 bayes_pls_golite062009
  • protein binding
    		•  0.42571879933058 bayes_pls_golite062009
  • mRNA 3'-UTR binding
    		•  0.366474768004238 bayes_pls_golite062009
  • transcription regulator activity
    		•  0.0376525951141159 bayes_pls_golite062009
  • DNA binding
    		•  0.017779252073686 bayes_pls_golite062009
    2 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle