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Protein Overview: SIZ1

General Information:
Name(s) found: SIZ1 / YDR409W [SGD]
Description(s) found:
Found 28 descriptions.
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  • SUMO/Smt3 ligase that promotes the attachment of sumo (Smt3p; small ubiquitin-related modifier) to proteins; binds Ubc9p and may bind septins; specifically required for sumoylation of septins in vivo; localized to the septin ring [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 904 amino acids

    Gene Ontology:
    Cellular Component: nuclear chromatin [IDALink to PubMed article]
    septin ring [IDALink to PubMed article]
    Biological Process: protein sumoylation [IMPLink to PubMed article][ISSLink to PubMed article]
    chromosome segregation [IMPLink to PubMed article]
    Molecular Function: SUMO ligase activity [IDALink to PubMed article][IMPLink to PubMed articleLink to PubMed article][IPILink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MINLEDYWED ETPGPDREPT NELRNEVEET ITLMELLKVS ELKDICRSVS FPVSGRKAVL  60
   61 QDLIRNFLQN ALVVGKSDPY RVQAVKFLIE RIRKNEPLPV YKDLWNALRK GTPLSAITVR 120
  121 SMEGPPTVQQ QSPSVIRQSP TQRRKTSTTS STSRAPPPTN PDASSSSSSF AVPTIHFKES 180
  181 PFYKIQRLIP ELVMNVEVTG GRGMCSAKFK LSKADYNLLS NPNSKHRLYL FSGMINPLGS 240
  241 RGNEPIQFPF PNELRCNNVQ IKDNIRGFKS KPGTAKPADL TPHLKPYTQQ NNVELIYAFT 300
  301 TKEYKLFGYI VEMITPEQLL EKVLQHPKII KQATLLYLKK TLREDEEMGL TTTSTIMSLQ 360
  361 CPISYTRMKY PSKSINCKHL QCFDALWFLH SQLQIPTWQC PVCQIDIALE NLAISEFVDD 420
  421 ILQNCQKNVE QVELTSDGKW TAILEDDDDS DSDSNDGSRS PEKGTSVSDH HCSSSHPSEP 480
  481 IIINLDSDDD EPNGNNPHVT NNHDDSNRHS NDNNNNSIKN NDSHNKNNNN NNNNNNNNND 540
  541 NNNSIENNDS NSNNKHDHGS RSNTPSHNHT KNLMNDNDDD DDDRLMAEIT SNHLKSTNTD 600
  601 ILTEKGSSAP SRTLDPKSYN IVASETTTPV TNRVIPEYLG NSSSYIGKQL PNILGKTPLN 660
  661 VTAVDNSSHL ISPDVSVSSP TPRNTASNAS SSALSTPPLI RMSSLDPRGS TVPDKTIRPP 720
  721 INSNSYTASI SDSFVQPQES SVFPPREQNM DMSFPSTVNS RFNDPRLNTT RFPDSTLRGA 780
  781 TILSNNGLDQ RNNSLPTTEA ITRNDVGRQN STPVLPTLPQ NVPIRTNSNK SGLPLINNEN 840
  841 SVPNPPNTAT IPLQKSRLIV NPFIPRRPYS NVLPQKRQLS NTSSTSPIMG TWKTQDYGKK 900
  901 YNSG

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Krogan NJ, et al. (2006) FRA1 MET17 SIZ1
    View Details Qiu et al. (2008) CST9 NFI1 SIZ1

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run CEP3 sample cbf3 from feb 2005 Sandall S, et all (2006)
    View Run MLP2 #03 Alpha Factor Prep1-TiO2 Flowthrough Keck JM, et al. (2011)
    View Run MLP2 #29 Asynchronous Prep5-TiO2 Flowthrough Keck JM, et al. (2011)
    View Run MLP2 #10 Mitotic Prep1-TiO2 Phosphopeptide enrichment Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data SIZ1 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..106] Pfam 10.236572 SAP domain No confident structure predictions are available.
    2 View Details [107..219] MSA 2.025996 View MSA. No confident structure predictions are available.
    3 View Details [220..289] deduced N/A No confident structure predictions are available.
    4 View Details [290..410] Pfam 33.60206 MIZ zinc finger No confident structure predictions are available.
    5 View Details [411..529] MSA 2.172996 View MSA. No confident structure predictions are available.
    6 View Details [530..904] ORFEUS 8.34 RBP1

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • SUMO ligase activity
    		•  7.09211721404578 bayes_pls_golite062009
  • small conjugating protein ligase activity
    		•  5.19208367271658 bayes_pls_golite062009
  • acid-amino acid ligase activity
    		•  4.23914967265256 bayes_pls_golite062009
  • ligase activity, forming carbon-nitrogen bonds
    		•  2.74673402515898 bayes_pls_golite062009
  • binding
    		•  2.26662406320154 bayes_pls_golite062009
  • protein binding
    		•  1.60046728943053 bayes_pls_golite062009
  • nucleic acid binding
    		•  1.45346081057303 bayes_pls_golite062009
  • DNA binding
    		•  1.3220534257427 bayes_pls_golite062009
  • transcription regulator activity
    		•  1.24563554819776 bayes_pls_golite062009
  • transcription factor binding
    		•  0.6524624181863 bayes_pls_golite062009
  • transcription cofactor activity
    		•  0.55208373081056 bayes_pls_golite062009
  • catalytic activity
    		•  0.454272578060498 bayes_pls_golite062009
  • ligase activity
    		•  0.36302660895622 bayes_pls_golite062009
  • RNA polymerase II transcription factor activity
    		•  0.11065840905983 bayes_pls_golite062009
  • nuclear hormone receptor binding
    		•  0.0906176057893404 bayes_pls_golite062009
  • steroid hormone receptor binding
    		•  0.0808240821039099 bayes_pls_golite062009
  • transcription activator activity
    		•  0.0459673376823702 bayes_pls_golite062009
    2 No functions predicted.
    3 No functions predicted.
    4 No functions predicted.
    5 No functions predicted.
    6 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle