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Protein Overview: CDC40

General Information:
Name(s) found: CDC40 / YDR364C [SGD]
Description(s) found:
Found 28 descriptions.
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  • Pre-mRNA splicing factor, important for catalytic step II of pre-mRNA splicing and plays a role in cell cycle progression; required for DNA synthesis during mitosis and meiosis; has WD repeats [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 455 amino acids

    Gene Ontology:
    Cellular Component: spliceosomal complex [IDALink to PubMed article]
    Biological Process: nuclear mRNA branch site recognition [IGILink to PubMed article]
    nuclear mRNA 3'-splice site recognition [IGILink to PubMed articleLink to PubMed article]
    Molecular Function: second spliceosomal transesterification activity [IGI][IMP]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MGLVDGYDTS SDSDLNFDEG KSVHEKKNGN LHEDTSYEPS SNNIHKRKSH FTKSELKRRR  60
   61 KTRKGDGPWG SWSSSDDETS QASETQKEDQ DIFVHALAED NLDSEQIEVE EVSHFYGKSE 120
  121 KDYQGRGYLY PPNDVDVDLR EERISFRCYL PKKVIRNYPG HPEGTTALKF LPKTGHLILS 180
  181 GGNDHTIKIW DFYHDYECLR DFQGHNKPIK ALRFTEDCQS FLSSSFDRSV KIWDTETGKV 240
  241 KTRLHLNSTP ADVESRPTNP HEFIVGLSNS KILHYDDRVS ENQGLVQTYD HHLSSILALK 300
  301 YFPDGSKFIS SSEDKTVRIW ENQINVPIKQ ISDTAQHSMP FLNVHPSQNY FCAQSMDNRI 360
  361 YSFSLKPKYK RHPKKIFKGH SSAGYGISLA FSGDGRYICS GDSKSRLFTW DWNTSRLLNN 420
  421 IKIPGNKPIT QVDWHPQETS KVICSGAAGK IYVCD

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Riffle et al. (2010) (Unpublished Data) BRR2 CDC40 CLF1 CWC2 CWC22 CWC23 HSH155 LEA1 PRP19 PRP43 PRP45 PRP46 RSE1 SNT309 SNU114 SYF1
    View Details Hazbun TR, et al. (2003) BRR2 CDC40 CEF1 CLF1 CWC2 CWC22 CWC23 ECM2 ISY1 LEA1 NTR2 PRP19 PRP43 PRP45 PRP46 PRP8 SMB1 SMD1 SMD3 SMX3 SNT309 SNU114 SPP382 SYF1 SYF2 YJU2
    View Details (MIPS) Mewes HW, et al. (2004) AAR2 BRR1 BRR2 CBC2 CDC40 CWC15 CWC2 CWC22 CWC23 DHR2 LSM4 MAK5 MUD2 PRP16 PRP18 PRP2 PRP22 PRP24 PRP28 PRP31 PRP38 PRP39 PRP4 PRP40 PRP43 PRP5 PRP6 PRP8 SLU7 SMD1 SMD3 SME1 SNP1 SPP2 SPP381 STO1 YHC1
    View Details Gavin AC, et al. (2006) CDC40 CEF1 CLF1 CWC2 CWC22 ECM2 PRP19 PRP45 PRP46 SYF1
    View Details Gavin AC, et al. (2002) BUD31 CDC40 CEF1 CLF1 CWC2 CWC22 CWC23 ECM2 HSH155 ISY1 LEA1 PRP19 PRP2 PRP21 PRP22 PRP43 PRP45 PRP46 RSE1 SMD2 SNT309 SNU114 SPP382 STO1 SYF1
    View Details Qiu et al. (2008) AAR2 BRR1 BRR2 BUD31 CBC2 CDC40 CEF1 CLF1 CUS1 CWC15 CWC2 CWC21 CWC22 CWC23 CWC25 DHR2 DIB1 ECM2 HSH155 IST3 ISY1 LEA1 LSM2 LSM3 LSM4 LSM5 LSM6 LSM7 LSM8 LUC7 MAK5 MSL1 MUD1 MUD2 NAM8 NTC20 PRP11 PRP16 PRP18 PRP19 PRP2 PRP21 PRP22 PRP24 PRP28 PRP3 PRP31 PRP38 PRP39 PRP4 PRP40 PRP42 PRP43 PRP45 PRP46 PRP5 PRP6 PRP8 PRP9 RSE1 SLU7 SMB1 SMD1 SMD2 SMD3 SME1 SMX2 SMX3 SNP1 SNT309 SNU114 SNU23 SNU56 SNU66 SNU71 SPP2 SPP381 SPP382 STO1 SUB2 SYF1 SYF2 YHC1

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run CWC2 No Comments Hazbun TR, et al. (2003)
    View Run SPP382 No Comments Hazbun TR, et al. (2003)
    View Run CWC25 No Comments Hazbun TR, et al. (2003)
    View Run CEP3 sample cbf3 from feb 2005 Sandall S, et all (2006)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

      BAIT PREY HITS PUBLICATION
    View Screen CDC40 PIN3 1 Unpublished Fields Lab Data
    View Screen PPT1 CDC40 1 Unpublished Fields Lab Data
    View Screen APC5 CDC40 1 Unpublished Fields Lab Data
    View Screen CDC40 AGP2 1 Unpublished Fields Lab Data
    View Screen CDC40 AME1 1 Unpublished Fields Lab Data
    View Screen CDC40 IWR1 1 Unpublished Fields Lab Data
    View Screen CDC40 MTQ2 1 Unpublished Fields Lab Data
    View Screen CDC40 ACA1 1 Unpublished Fields Lab Data
    View Screen CDC40 COG3 1 Unpublished Fields Lab Data
    View Screen CDC40 YJL169W 1 Unpublished Fields Lab Data
    View Screen CDC40 RFA3 1 Unpublished Fields Lab Data

    Microscopy / Localization Data

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      PROTEIN(S) PUBLICATION
    View Data CDC40 Huh WK, et al. (2003)

    Protein Structure Data


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    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..124] MSA 3.725996 View MSA. No confident structure predictions are available.
    2 View Details [125..455] PSI-BLAST 159.626727 Tup1, C-terminal domain


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle