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Protein Overview: MTQ2

General Information:
Name(s) found: MTQ2 / YDR140W [SGD]
Description(s) found:
Found 29 descriptions.
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  • S-adenosylmethionine-dependent methyltransferase of the seven beta-strand family; subunit of complex with Trm112p that methylates translation release factor Sup45p (eRF1) in the ternary complex eRF1-eRF3-GTP; similar to E.coli PrmC [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 221 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IDALink to PubMed article]
    cytoplasm [IDALink to PubMed article]
    Biological Process: peptidyl-glutamine methylation [IDALink to PubMed article]
    Molecular Function: protein methyltransferase activity [IDALink to PubMed article]
    S-adenosylmethionine-dependent methyltransferase activity [IDALink to PubMed article][IMPLink to PubMed article][ISSLink to PubMed articleLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MLPTPYVKCD YDKVYEPAED SFLILDCLEK EHDFLKQKFG NRLAIVCEIG SGSGIVTTFL  60
   61 MQNKIIPQEN SIHLAVDINP WALEATLDTA KLNSCKSSFL EVIQADLNSS IRNNQVDVLI 120
  121 FNPPYVPAEC VPDVPGSREE ADQWLDLALL GGKDGMAITD KLLRQLEQIL SPDGVAYILF 180
  181 CARNKPKEVI KRFVDTYKWN VKLIETRKAG WEVLSVYSFT R

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Krogan NJ, et al. (2006) MTQ2 PCL7 TYW3
    View Details Gavin AC, et al. (2002) LYS9 MTQ2 TRM11 TRM112 TRM9

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data MTQ2 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..221] PSI-BLAST 17.69897 DNA methylase TaqI

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • protein methyltransferase activity
    		•  5.03267617653315 bayes_pls_golite062009
  • S-adenosylmethionine-dependent methyltransferase activity
    		•  4.4632173842967 bayes_pls_golite062009
  • methyltransferase activity
    		•  4.15445027778357 bayes_pls_golite062009
  • N-methyltransferase activity
    		•  4.07806017452628 bayes_pls_golite062009
  • transferase activity, transferring one-carbon groups
    		•  4.07153733729662 bayes_pls_golite062009
  • histone methyltransferase activity
    		•  3.97658336148086 bayes_pls_golite062009
  • protein-arginine N-methyltransferase activity
    		•  3.26663548517117 bayes_pls_golite062009
  • arginine N-methyltransferase activity
    		•  3.26663548517117 bayes_pls_golite062009
  • transferase activity
    		•  2.926540904444 bayes_pls_golite062009
  • histone-arginine N-methyltransferase activity
    		•  2.86617323549909 bayes_pls_golite062009
  • protein-arginine omega-N monomethyltransferase activity
    		•  2.48017990451667 bayes_pls_golite062009
  • DNA-methyltransferase activity
    		•  2.18991764495147 bayes_pls_golite062009
  • histone methyltransferase activity (H4-R3 specific)
    		•  1.91133457052099 bayes_pls_golite062009
  • protein-arginine omega-N asymmetric methyltransferase activity
    		•  1.69391860928068 bayes_pls_golite062009
  • transcription regulator activity
    		•  1.61435611638306 bayes_pls_golite062009
  • DNA binding
    		•  1.53375495589674 bayes_pls_golite062009
  • nucleic acid binding
    		•  1.31440474302645 bayes_pls_golite062009
  • catalytic activity
    		•  1.25333584501255 bayes_pls_golite062009
  • protein-arginine omega-N symmetric methyltransferase activity
    		•  1.15089820497406 bayes_pls_golite062009
  • binding
    		•  0.976078016260105 bayes_pls_golite062009
  • protein binding
    		•  0.871386560666009 bayes_pls_golite062009
  • RNA methyltransferase activity
    		•  0.817509452491588 bayes_pls_golite062009
  • site-specific DNA-methyltransferase (adenine-specific) activity
    		•  0.703178429468566 bayes_pls_golite062009
  • lysine N-methyltransferase activity
    		•  0.469870476227704 bayes_pls_golite062009
  • protein-lysine N-methyltransferase activity
    		•  0.469870476227704 bayes_pls_golite062009
  • histone-lysine N-methyltransferase activity
    		•  0.469870476227704 bayes_pls_golite062009
  • rRNA methyltransferase activity
    		•  0.230719796976667 bayes_pls_golite062009


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.70

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle