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View Protein Complex Details

Complex Overview

Complex Member Proteins

Protein

GO Cellular Component GO Biological Process GO Molecular Function
AAR2
  • U5 snRNP
  • assembly of spliceosomal tri-snRNP
  • molecular_function
  • BRX1
  • nucleolus
  • ribosome biogenesis
  • ribosomal large subunit assembly
  • 5S rRNA binding
  • rRNA primary transcript binding
  • CBF5
  • box H/ACA snoRNP complex
  • nuclear outer membrane
  • nucleolus
  • rRNA pseudouridine synthesis
  • ribosome biogenesis
  • pseudouridylate synthase activity
  • CIC1
  • proteasome complex
  • nucleolus
  • protein catabolic process
  • ribosomal large subunit biogenesis
  • ribosome biogenesis
  • protein binding, bridging
  • DBP9
  • nuclear outer membrane
  • nucleolus
  • ribosome biogenesis
  • ribosomal large subunit assembly
  • ATP-dependent RNA helicase activity
  • DRS1
  • nuclear outer membrane
  • nucleolus
  • ribosome biogenesis
  • ribosomal large subunit assembly
  • ATP-dependent RNA helicase activity
  • ERB1
  • nucleus
  • nucleolus
  • rRNA processing
  • molecular_function
  • FUN12
  • mitochondrion
  • translational initiation
  • translation initiation factor activity
  • GTPase activity
  • GAR1
  • box H/ACA snoRNP complex
  • nuclear outer membrane
  • nucleolus
  • small nucleolar ribonucleoprotein complex
  • ribosome biogenesis
  • RNA binding
  • HAS1
  • nuclear envelope
  • nucleolus
  • ribosome biogenesis
  • rRNA processing
  • RNA binding
  • RNA-dependent ATPase activity
  • ATP-dependent RNA helicase activity
  • KRE33
  • nucleolus
  • ribosome biogenesis
  • molecular_function
  • KRR1
  • nuclear outer membrane
  • nucleolus
  • small nucleolar ribonucleoprotein complex
  • ribosome biogenesis
  • rRNA processing
  • molecular_function
  • LHP1
  • nucleus
  • nucleolus
  • nucleoplasm
  • tRNA processing
  • RNA binding
  • MAK21
  • Noc1p-Noc2p complex
  • ribosome biogenesis
  • ribosomal large subunit assembly
  • molecular_function
  • MDN1
  • nucleus
  • mitochondrion
  • nucleoplasm
  • protein complex assembly
  • rRNA processing
  • ribosomal large subunit assembly
  • ATPase activity
  • MIS1
  • mitochondrion
  • ribosome biogenesis
  • folic acid biosynthetic process
  • anaerobic purine catabolic process
  • nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
  • acetate biosynthetic process from carbon monoxide
  • formate-tetrahydrofolate ligase activity
  • methenyltetrahydrofolate cyclohydrolase activity
  • methylenetetrahydrofolate dehydrogenase (NADP+) activity
  • MRP7
  • mitochondrion
  • mitochondrial large ribosomal subunit
  • translation
  • structural constituent of ribosome
  • peptidyltransferase activity
  • NHP2
  • nuclear outer membrane
  • small nucleolar ribonucleoprotein complex
  • rRNA modification
  • rRNA pseudouridine synthesis
  • RNA binding
  • NIP1
  • multi-eIF complex
  • cytoplasm
  • eukaryotic translation initiation factor 3 complex
  • ribosome biogenesis
  • translational initiation
  • translation initiation factor activity
  • NOC2
  • nucleus
  • Noc2p-Noc3p complex
  • mitochondrion
  • Noc1p-Noc2p complex
  • ribosomal subunit export from nucleus
  • ribosome biogenesis
  • ribosome assembly
  • molecular_function
  • NOG1
  • nuclear outer membrane
  • nucleolus
  • preribosome, large subunit precursor
  • ribosomal subunit export from nucleus
  • ribosomal large subunit biogenesis
  • ribosome biogenesis
  • GTP binding
  • NOP1
  • nuclear outer membrane
  • nucleolus
  • ribosome
  • small nucleolar ribonucleoprotein complex
  • rRNA modification
  • RNA methylation
  • maturation of SSU-rRNA
  • ribosome biogenesis
  • ribosomal large subunit assembly
  • snoRNA 3'-end processing
  • methyltransferase activity
  • NOP12
  • nucleolus
  • rRNA metabolic process
  • RNA binding
  • NOP2
  • nucleolus
  • ribosome biogenesis
  • rRNA processing
  • RNA methyltransferase activity
  • S-adenosylmethionine-dependent methyltransferase activity
  • NOP4
  • nucleolus
  • ribosome biogenesis
  • rRNA processing
  • RNA binding
  • NOP56
  • box C/D snoRNP complex
  • nucleus
  • nuclear outer membrane
  • nucleolus
  • small nucleolar ribonucleoprotein complex
  • rRNA modification
  • maturation of SSU-rRNA
  • ribosome biogenesis
  • molecular_function
  • NOP6
  • nucleolus
  • rRNA processing
  • molecular_function
  • NOP7
  • nucleus
  • nucleolus
  • cell proliferation
  • maturation of SSU-rRNA
  • ribosomal large subunit biogenesis
  • ribosome biogenesis
  • cell cycle
  • molecular_function
  • NUG1
  • nucleus
  • nucleolus
  • ribosome biogenesis
  • rRNA processing
  • GTPase activity
  • POL2
  • replication fork
  • epsilon DNA polymerase complex
  • lagging strand elongation
  • leading strand elongation
  • nucleotide-excision repair
  • mismatch repair
  • DNA synthesis involved in DNA repair
  • chromatin silencing at telomere
  • nucleotide binding
  • nucleic acid binding
  • DNA binding
  • zinc ion binding
  • DNA-directed DNA polymerase activity
  • nucleotidyltransferase activity
  • metal ion binding
  • double-stranded DNA binding
  • transferase activity
  • PRP4
  • U4/U6 x U5 tri-snRNP complex
  • nuclear mRNA splicing, via spliceosome
  • molecular_function
  • PUF6
  • nucleus
  • nucleolus
  • regulation of transcription, mating-type specific
  • ribosome biogenesis
  • mRNA binding
  • specific transcriptional repressor activity
  • RLP7
  • nucleolus
  • ribosomal large subunit biogenesis
  • ribosome biogenesis
  • processing of 27S pre-rRNA
  • rRNA binding
  • RRP12
  • nucleus
  • ribosome
  • maturation of SSU-rRNA
  • ribosome biogenesis
  • molecular_function
  • SMB1
  • U4/U6 x U5 tri-snRNP complex
  • U5 snRNP
  • U1 snRNP
  • nuclear mRNA splicing, via spliceosome
  • RNA binding
  • molecular_function
  • SNU114
  • U4/U6 x U5 tri-snRNP complex
  • U5 snRNP
  • generation of catalytic spliceosome for first transesterification step
  • nuclear mRNA splicing, via spliceosome
  • GTP binding
  • U5 snRNA binding
  • GTPase activity
  • SNU66
  • U4/U6 x U5 tri-snRNP complex
  • nuclear mRNA splicing, via spliceosome
  • RNA binding
  • molecular_function
  • SRO9
  • polysome
  • ribosome biogenesis
  • translation
  • RNA binding
  • TIF4631
  • eukaryotic translation initiation factor 4F complex
  • mitochondrion
  • ribosome
  • ribosome biogenesis
  • translational initiation
  • translation initiation factor activity
  • TIF4632
  • eukaryotic translation initiation factor 4F complex
  • ribosome
  • translational initiation
  • translation initiation factor activity
  • URB1
  • nucleolus
  • rRNA processing
  • processing of 27S pre-rRNA
  • molecular_function
  • UTP10
  • mitochondrion
  • small nucleolar ribonucleoprotein complex
  • maturation of SSU-rRNA
  • ribosome biogenesis
  • snoRNA binding
  • UTP20
  • cytoplasm
  • nuclear outer membrane
  • nucleolus
  • small nucleolar ribonucleoprotein complex
  • endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
  • endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
  • ribosome biogenesis
  • endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
  • rRNA processing
  • snoRNA binding
  • UTP21
  • nucleus
  • nuclear outer membrane
  • nucleolus
  • small nucleolar ribonucleoprotein complex
  • ribosome biogenesis
  • snoRNA binding
  • YMR310C
  • nucleus
  • ribosome biogenesis
  • molecular_function
  • YTM1
  • nucleus
  • nucleolus
  • ribosomal large subunit biogenesis
  • ribosome biogenesis
  • molecular_function
  • Cellular Component Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    nucleolus 1.4188E-30 46 211 28 6292
    nuclear lumen 1.7192E-22 46 453 29 6292
    nuclear part 2.4622E-19 46 1103 36 6292
    organelle lumen 4.4302E-19 46 660 30 6292
    intracellular organelle lumen 4.4302E-19 46 660 30 6292
    membrane-enclosed lumen 2.4109E-18 46 700 30 6292
    non-membrane-bounded organelle 9.2692E-18 46 959 33 6292
    intracellular non-membrane-bounded organelle 9.2692E-18 46 959 33 6292
    ribonucleoprotein complex 8.2548E-14 46 514 23 6292
    nucleus 2.7287E-12 46 2041 38 6292
    nuclear outer membrane 1.4605E-11 46 86 11 6292
    nuclear membrane 5.6101E-11 46 97 11 6292
    intracellular organelle part 9.6529E-10 46 2282 37 6292
    organelle part 9.6529E-10 46 2282 37 6292
    small nucleolar ribonucleoprotein complex 1.5828E-9 46 72 9 6292
    nuclear envelope 1.0893E-8 46 199 12 6292
    outer membrane 3.8476E-8 46 178 11 6292
    organelle outer membrane 3.8476E-8 46 178 11 6292
    membrane-bounded organelle 2.7573E-7 46 3771 43 6292
    intracellular membrane-bounded organelle 2.7573E-7 46 3771 43 6292
    nuclear membrane-endoplasmic reticulum network 5.7629E-7 46 232 11 6292
    intracellular organelle 6.185E-7 46 4070 44 6292
    organelle 6.2473E-7 46 4071 44 6292
    intracellular part 1.3784E-5 46 4938 46 6292
    nucleolar part 1.6415E-5 46 45 5 6292
    endomembrane system 1.8886E-5 46 398 12 6292
    intracellular 1.9462E-5 46 4975 46 6292
    preribosome, large subunit precursor 2.9796E-5 46 9 3 6292
    macromolecular complex 3.7615E-5 46 1635 25 6292
    box H/ACA snoRNP complex 5.2295E-5 46 2 2 6292
    Noc1p-Noc2p complex 5.2295E-5 46 2 2 6292
    U4/U6 x U5 tri-snRNP complex 7.7429E-5 46 32 4 6292
    small nuclear ribonucleoprotein complex 8.5626E-5 46 63 5 6292
    U5 snRNP 1.2584E-4 46 14 3 6292
    envelope 1.9401E-4 46 505 12 6292
    organelle envelope 1.9401E-4 46 505 12 6292
    eukaryotic translation initiation factor 4F complex 3.1085E-4 46 4 2 6292
    Noc complex 5.1567E-4 46 5 2 6292
    cell part 8.3718E-4 46 5397 46 6292
    cell 8.5164E-4 46 5399 46 6292
    preribosome 1.8675E-3 46 34 3 6292
    90S preribosome 6.6321E-3 46 17 2 6292
    membrane part 6.8797E-3 46 662 11 6292
    organelle membrane 9.5422E-3 46 692 11 6292

    Biological Process Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    ribonucleoprotein complex biogenesis 5.2317E-38 46 374 37 6292
    ribosome biogenesis 1.1659E-35 46 346 35 6292
    cellular component biogenesis 6.5635E-28 46 694 37 6292
    rRNA metabolic process 6.5395E-19 46 137 18 6292
    rRNA processing 6.3152E-18 46 128 17 6292
    RNA processing 1.0966E-16 46 380 23 6292
    ncRNA processing 2.4044E-15 46 215 18 6292
    ncRNA metabolic process 3.2744E-15 46 257 19 6292
    ribosomal large subunit biogenesis 5.9547E-13 46 65 11 6292
    gene expression 5.9356E-12 46 1283 31 6292
    RNA metabolic process 9.6948E-11 46 954 26 6292
    ribonucleoprotein complex assembly 1.4516E-8 46 92 9 6292
    cellular process 8.7488E-8 46 4426 46 6292
    ribosome assembly 3.1563E-7 46 64 7 6292
    ribosomal large subunit assembly 4.0451E-7 46 41 6 6292
    organelle assembly 5.3341E-7 46 69 7 6292
    nucleic acid metabolic process 5.5267E-7 46 1415 26 6292
    nucleobase, nucleoside, nucleotide and nucleic acid metabolic process 1.0305E-6 46 1566 27 6292
    macromolecule metabolic process 2.0917E-6 46 2349 33 6292
    ribosomal subunit assembly 2.4156E-6 46 55 6 6292
    maturation of SSU-rRNA 3.6731E-6 46 59 6 6292
    cellular macromolecule metabolic process 4.3799E-6 46 2285 32 6292
    cellular macromolecular complex assembly 5.0878E-6 46 182 9 6292
    rRNA modification 7.1009E-6 46 18 4 6292
    cellular nitrogen compound metabolic process 1.3103E-5 46 1770 27 6292
    nitrogen compound metabolic process 1.662E-5 46 1791 27 6292
    cellular macromolecular complex subunit organization 8.5292E-5 46 259 9 6292
    primary metabolic process 1.0939E-4 46 2896 34 6292
    macromolecular complex assembly 1.5941E-4 46 281 9 6292
    translational initiation 2.2847E-4 46 42 4 6292
    rRNA pseudouridine synthesis 3.1085E-4 46 4 2 6292
    nuclear mRNA splicing, via spliceosome 7.1641E-4 46 99 5 6292
    RNA splicing, via transesterification reactions with bulged adenosine as nucleophile 7.5003E-4 46 100 5 6292
    metabolic process 8.5584E-4 46 3157 34 6292
    macromolecular complex subunit organization 9.3406E-4 46 357 9 6292
    cellular metabolic process 9.9663E-4 46 3033 33 6292
    RNA splicing, via transesterification reactions 1.0196E-3 46 107 5 6292
    cellular component assembly 1.5931E-3 46 385 9 6292
    RNA modification 1.6121E-3 46 70 4 6292
    pseudouridine synthesis 1.8221E-3 46 9 2 6292
    RNA splicing 2.5901E-3 46 132 5 6292
    mRNA processing 5.3057E-3 46 156 5 6292
    processing of 27S pre-rRNA 5.8791E-3 46 16 2 6292
    pteridine and derivative biosynthetic process 7.3109E-3 46 1 1 6292
    folic acid biosynthetic process 7.3109E-3 46 1 1 6292
    nitrogenous compound catabolic process 7.3109E-3 46 1 1 6292
    anaerobic purine catabolic process 7.3109E-3 46 1 1 6292
    acetate biosynthetic process from carbon monoxide 7.3109E-3 46 1 1 6292

    Molecular Function Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    P-value

    A

    B

    I

    T

    nucleic acid binding 1.3044E-9 46 666 21 6292
    RNA binding 2.5741E-9 46 367 16 6292
    binding 7.9573E-6 46 1294 23 6292
    translation initiation factor activity 3.8812E-5 46 27 4 6292
    translation factor activity, nucleic acid binding 2.7415E-4 46 44 4 6292
    ATP-dependent RNA helicase activity 1.0542E-3 46 28 3 6292
    RNA-dependent ATPase activity 1.1699E-3 46 29 3 6292
    snoRNA binding 1.4245E-3 46 31 3 6292
    RNA helicase activity 3.4395E-3 46 42 3 6292
    ATP-dependent helicase activity 5.0261E-3 46 48 3 6292
    purine NTP-dependent helicase activity 5.0261E-3 46 48 3 6292
    rRNA binding 5.8791E-3 46 16 2 6292
    guanyl ribonucleotide binding 5.8791E-3 46 16 2 6292
    GTP binding 5.8791E-3 46 16 2 6292
    guanyl nucleotide binding 7.4266E-3 46 18 2 6292
    nucleotide binding 8.9333E-3 46 59 3 6292
    nucleoside-triphosphatase activity 9.2161E-3 46 329 7 6292
    GTPase activity 9.7901E-3 46 61 3 6292

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle