YRC Logo
PROTEIN SEARCH:
Descriptions Names[Advanced Search]

View Protein Complex Details

Complex Overview

From Publication: Gavin A.C. et al. (2002) Abstract Functional organization of the yeast proteome by systematic analysis of protein complexes. Nature. 2002 Jan 10;415(6868):141-7.
Notes: From the published set of protein complexes.
Complex Size: 14 proteins

Complex Member Proteins

Protein

 GO Cellular Component GO Biological Process GO Molecular Function
CCL1
  • mitochondrion
  • holo TFIIH complex
    		•
  • negative regulation of transcription from RNA polymerase II promoter, mitotic
  • transcription initiation from RNA polymerase II promoter
    		•
  • cyclin-dependent protein kinase regulator activity
  • general RNA polymerase II transcription factor activity
    		•
    DCS2
  • cytoplasm
  • cytoplasmic mRNA processing body
    		•
  • deadenylation-dependent decapping of nuclear-transcribed mRNA
    		•
  • m7G(5')pppN diphosphatase activity
    		•
    FAP1
  • cellular_component
    		•
  • biological_process
    		•
  • transcription factor activity
    		•
    FPR1
  • nucleus
  • cytoplasm
  • mitochondrion
    		•
  • chromatin organization
  • homoserine metabolic process
    		•
  • peptidyl-prolyl cis-trans isomerase activity
    		•
    KAP95
  • cytoplasm
  • nuclear pore
    		•
  • protein import into nucleus
  • nuclear pore complex assembly
    		•
  • protein transmembrane transporter activity
    		•
    KIN28
  • holo TFIIH complex
    		•
  • protein amino acid phosphorylation
  • positive regulation of transcription from RNA polymerase II promoter
  • transcription initiation from RNA polymerase II promoter
    		•
  • cyclin-dependent protein kinase activating kinase activity
  • RNA polymerase II carboxy-terminal domain kinase activity
  • general RNA polymerase II transcription factor activity
  • cyclin-dependent protein kinase activity
    		•
    MRPS28
  • mitochondrion
  • mitochondrial small ribosomal subunit
    		•
  • ribosomal small subunit assembly
  • translation
    		•
  • RNA binding
  • structural constituent of ribosome
    		•
    SPT7
  • SLIK (SAGA-like) complex
  • mitochondrion
  • SAGA complex
    		•
  • chromatin modification
  • protein complex assembly
  • conjugation with cellular fusion
  • histone acetylation
    		•
  • structural molecule activity
    		•
    SSL1
  • holo TFIIH complex
  • nucleotide-excision repair factor 3 complex
    		•
  • negative regulation of transcription from RNA polymerase II promoter, mitotic
  • nucleotide-excision repair, DNA duplex unwinding
  • nucleotide-excision repair
  • transcription initiation from RNA polymerase II promoter
    		•
  • general RNA polymerase II transcription factor activity
    		•
    TFA1
  • mitochondrion
  • transcription factor TFIIE complex
    		•
  • transcription initiation from RNA polymerase II promoter
    		•
  • general RNA polymerase II transcription factor activity
    		•
    TFB1
  • holo TFIIH complex
  • nucleotide-excision repair factor 3 complex
    		•
  • negative regulation of transcription from RNA polymerase II promoter, mitotic
  • nucleotide-excision repair, DNA duplex unwinding
  • nucleotide-excision repair
  • transcription initiation from RNA polymerase II promoter
    		•
  • general RNA polymerase II transcription factor activity
    		•
    TFB3
  • holo TFIIH complex
  • nucleotide-excision repair factor 3 complex
    		•
  • negative regulation of transcription from RNA polymerase II promoter, mitotic
  • nucleotide-excision repair, DNA duplex unwinding
  • nucleotide-excision repair
  • transcription initiation from RNA polymerase II promoter
    		•
  • general RNA polymerase II transcription factor activity
    		•
    TFB4
  • holo TFIIH complex
    		•
  • negative regulation of transcription from RNA polymerase II promoter, mitotic
  • transcription initiation from RNA polymerase II promoter
    		•
  • general RNA polymerase II transcription factor activity
    		•
    TIF6
  • nucleus
  • cytoplasm
  • nuclear outer membrane
  • nucleolus
    		•
  • ribosomal subunit export from nucleus
  • ribosomal large subunit biogenesis
  • processing of 27S pre-rRNA
    		•
  • ribosomal large subunit binding
    		•

    Cellular Component Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    		 P-value

    		 A

    		 B

    		 I

    		 T
    holo TFIIH complex 7.3032E-15 14 10 6 6292
    DNA-directed RNA polymerase II, holoenzyme 9.8272E-12 14 56 7 6292
    transcription factor complex 5.5528E-11 14 71 7 6292
    nucleoplasm part 1.1576E-8 14 245 8 6292
    nucleoplasm 2.0868E-8 14 264 8 6292
    nuclear lumen 6.9578E-8 14 453 9 6292
    organelle lumen 1.0231E-7 14 660 10 6292
    intracellular organelle lumen 1.0231E-7 14 660 10 6292
    membrane-enclosed lumen 1.8033E-7 14 700 10 6292
    nucleotide-excision repair factor 3 complex 3.0541E-7 14 7 3 6292
    nucleotide-excision repair complex 1.1394E-5 14 21 3 6292
    nuclear part 1.3343E-5 14 1103 10 6292
    macromolecular complex 5.7632E-5 14 1635 11 6292
    protein complex 1.6664E-4 14 1137 9 6292
    nucleus 5.2308E-4 14 2041 11 6292
    intracellular organelle part 1.5376E-3 14 2282 11 6292
    organelle part 1.5376E-3 14 2282 11 6292
    transcription factor TFIIE complex 4.4455E-3 14 2 1 6292

    Biological Process Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    		 P-value

    		 A

    		 B

    		 I

    		 T
    negative regulation of transcription from RNA polymerase II promoter, mitotic 1.3615E-12 14 8 5 6292
    regulation of transcription from RNA polymerase II promoter, mitotic 1.3615E-12 14 8 5 6292
    transcription initiation from RNA polymerase II promoter 2.6886E-12 14 47 7 6292
    regulation of transcription, mitotic 3.0598E-12 14 9 5 6292
    negative regulation of transcription, mitotic 3.0598E-12 14 9 5 6292
    protein complex biogenesis 4.7773E-12 14 155 9 6292
    protein complex assembly 4.7773E-12 14 155 9 6292
    transcription initiation 1.2716E-11 14 58 7 6292
    macromolecular complex assembly 2.3062E-11 14 281 10 6292
    macromolecular complex subunit organization 2.4983E-10 14 357 10 6292
    cellular component assembly 5.2747E-10 14 385 10 6292
    cellular component biogenesis 7.2756E-9 14 694 11 6292
    negative regulation of transcription from RNA polymerase II promoter 1.2477E-7 14 60 5 6292
    nucleotide-excision repair, DNA duplex unwinding 1.7475E-7 14 6 3 6292
    transcription from RNA polymerase II promoter 2.8286E-6 14 335 7 6292
    regulation of transcription from RNA polymerase II promoter 4.9896E-6 14 228 6 6292
    DNA geometric change 9.7792E-6 14 20 3 6292
    DNA duplex unwinding 9.7792E-6 14 20 3 6292
    negative regulation of transcription, DNA-dependent 1.5149E-5 14 157 5 6292
    negative regulation of RNA metabolic process 1.5625E-5 14 158 5 6292
    negative regulation of transcription 1.8733E-5 14 164 5 6292
    negative regulation of gene expression 1.8733E-5 14 164 5 6292
    negative regulation of macromolecule biosynthetic process 2.5673E-5 14 175 5 6292
    negative regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process 2.9425E-5 14 180 5 6292
    negative regulation of nitrogen compound metabolic process 2.9425E-5 14 180 5 6292
    negative regulation of biosynthetic process 3.7246E-5 14 189 5 6292
    negative regulation of cellular biosynthetic process 3.7246E-5 14 189 5 6292
    negative regulation of macromolecule metabolic process 4.0184E-5 14 192 5 6292
    cellular component organization 4.1288E-5 14 1582 11 6292
    transcription, DNA-dependent 4.1825E-5 14 503 7 6292
    RNA biosynthetic process 4.461E-5 14 508 7 6292
    negative regulation of cellular metabolic process 6.0417E-5 14 209 5 6292
    negative regulation of metabolic process 6.1815E-5 14 210 5 6292
    regulation of transcription, DNA-dependent 6.6152E-5 14 358 6 6292
    nucleotide-excision repair 7.0675E-5 14 38 3 6292
    regulation of RNA metabolic process 7.1526E-5 14 363 6 6292
    transcription 7.6467E-5 14 552 7 6292
    regulation of transcription 9.8088E-5 14 384 6 6292
    negative regulation of cellular process 1.4185E-4 14 250 5 6292
    negative regulation of biological process 1.5009E-4 14 253 5 6292
    regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process 1.5129E-4 14 415 6 6292
    regulation of nitrogen compound metabolic process 1.5333E-4 14 416 6 6292
    regulation of gene expression 2.2274E-4 14 445 6 6292
    DNA conformation change 2.5179E-4 14 58 3 6292
    regulation of macromolecule biosynthetic process 2.5486E-4 14 456 6 6292
    regulation of cellular biosynthetic process 3.0807E-4 14 472 6 6292
    regulation of biosynthetic process 3.1166E-4 14 473 6 6292
    RNA metabolic process 3.4699E-4 14 954 8 6292
    regulation of macromolecule metabolic process 3.6978E-4 14 488 6 6292
    regulation of primary metabolic process 4.9071E-4 14 514 6 6292
    regulation of cellular metabolic process 6.1586E-4 14 536 6 6292
    regulation of metabolic process 6.8724E-4 14 547 6 6292
    cellular macromolecule biosynthetic process 1.5934E-3 14 1187 8 6292
    macromolecule biosynthetic process 1.6118E-3 14 1189 8 6292
    pore complex assembly 2.225E-3 14 1 1 6292
    nuclear pore complex assembly 2.225E-3 14 1 1 6292
    gene expression 2.6989E-3 14 1283 8 6292
    regulation of cellular process 4.9068E-3 14 796 6 6292
    cellular nitrogen compound metabolic process 5.1472E-3 14 1770 9 6292
    nucleic acid metabolic process 5.169E-3 14 1415 8 6292
    nitrogen compound metabolic process 5.6129E-3 14 1791 9 6292
    regulation of biological process 5.8422E-3 14 824 6 6292
    DNA repair 7.9417E-3 14 192 3 6292
    cellular macromolecule metabolic process 8.0823E-3 14 2285 10 6292
    nucleobase, nucleoside, nucleotide and nucleic acid metabolic process 9.9462E-3 14 1566 8 6292
    cellular biosynthetic process 9.9866E-3 14 1567 8 6292

    Molecular Function Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    		 P-value

    		 A

    		 B

    		 I

    		 T
    general RNA polymerase II transcription factor activity 2.6117E-11 14 64 7 6292
    RNA polymerase II transcription factor activity 4.1614E-9 14 130 7 6292
    transcription regulator activity 1.4786E-7 14 339 8 6292
    ribosomal large subunit binding 2.225E-3 14 1 1 6292
    RNA polymerase II carboxy-terminal domain kinase activity 2.225E-3 14 1 1 6292
    cyclin-dependent protein kinase activating kinase activity 4.4455E-3 14 2 1 6292
    protein kinase regulator activity 4.4999E-3 14 46 2 6292
    kinase regulator activity 5.0935E-3 14 49 2 6292
    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle