YRC Public Data Repository - Protein Complex GO Analysis

Complex Overview

From Publication:	Krogan N. J. et al. (2006) Global landscape of protein complexes in the yeast Saccharomyces cerevisiae. Nature. 2006 Mar 30;440(7084):637-43. Epub 2006 Mar 22.
Notes:	From the published set of core protein complex predictions.
Complex Size:	16 proteins

Complex Member Proteins

Protein	GO Cellular Component	GO Biological Process	GO Molecular Function
ARA2	cellular_component	L-ascorbic acid biosynthetic process	D-arabinose 1-dehydrogenase [NAD(P)+] activity
AYT1	cellular_component	secondary metabolic process	trichothecene 3-O-acetyltransferase activity
BRO1	membrane fraction endosome cytoplasm	protein deubiquitination protein targeting to vacuole during ubiquitin-dependent protein catabolic process via the MVB pathway telomere maintenance vacuolar transport response to nutrient ubiquitin-dependent protein catabolic process	molecular_function
CDC73	nucleus transcription elongation factor complex Cdc73/Paf1 complex	DNA recombination histone methylation telomere maintenance RNA elongation from RNA polymerase II promoter	RNA polymerase II transcription elongation factor activity
CTR9	nucleus transcription elongation factor complex Cdc73/Paf1 complex	histone methylation transcription from RNA polymerase II promoter chromosome segregation RNA elongation from RNA polymerase II promoter	RNA polymerase II transcription elongation factor activity triplex DNA binding
GLO4	mitochondrial matrix mitochondrion	carbohydrate metabolic process methylglyoxal catabolic process to D-lactate telomere maintenance	hydroxyacylglutathione hydrolase activity
HHT1, HHT2	nucleus nuclear nucleosome chromosome replication fork protection complex nucleosome	mitotic cell cycle spindle assembly checkpoint DNA repair negative regulation of biosynthetic process chromatin assembly or disassembly positive regulation of transcription response to DNA damage stimulus aging DNA packaging nucleosome assembly negative regulation of transposition, RNA-mediated chromosome organization negative regulation of transcription negative regulation of transposition regulation of transposition regulation of transposition, RNA-mediated	DNA binding
LEO1	nucleus transcription elongation factor complex Cdc73/Paf1 complex	histone methylation telomere maintenance transcription from RNA polymerase II promoter RNA elongation from RNA polymerase II promoter	RNA polymerase II transcription elongation factor activity
PAF1	nucleus transcription elongation factor complex Cdc73/Paf1 complex	DNA recombination histone methylation telomere maintenance RNA elongation from RNA polymerase II promoter	RNA polymerase II transcription elongation factor activity
PML39	ribosome nuclear pore	mRNA export from nucleus	molecular_function
POB3	nucleus FACT complex nuclear chromatin alpha DNA polymerase:primase complex	chromatin remodeling DNA-dependent DNA replication chromatin assembly or disassembly transcription initiation from RNA polymerase II promoter RNA elongation from RNA polymerase II promoter	chromatin binding
PSH1	nucleus	RNA elongation from RNA polymerase II promoter	molecular_function
RTF1	nucleus transcription elongation factor complex Cdc73/Paf1 complex	histone methylation telomere maintenance transcription from RNA polymerase II promoter RNA elongation from RNA polymerase II promoter	RNA polymerase II transcription elongation factor activity
SEN1	nucleus nuclear outer membrane	snRNA processing tRNA processing snoRNA processing transcription termination termination of RNA polymerase II transcription	DNA-dependent ATPase activity RNA helicase activity RNA-dependent ATPase activity RNA polymerase II transcription termination factor activity 5'-3' DNA helicase activity
SPT16	FACT complex nuclear chromatin alpha DNA polymerase:primase complex transcription elongation factor complex	transcription initiation from RNA polymerase II promoter RNA elongation from RNA polymerase II promoter	transcription elongation regulator activity RNA polymerase II transcription elongation factor activity
YHR035W	cellular_component	biological_process	molecular_function

Cellular Component Analysis

Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

Only showing terms with a p-value less than or equal to 0.01.

GO Term	P-value	A	B	I	T
transcription elongation factor complex	3.5605E-14	16	23	7	6292
Cdc73/Paf1 complex	2.9682E-12	16	8	5	6292
DNA-directed RNA polymerase II, holoenzyme	1.8874E-7	16	56	5	6292
nucleoplasm part	1.0555E-6	16	245	7	6292
nucleoplasm	1.7482E-6	16	264	7	6292
FACT complex	6.0632E-6	16	2	2	6292
nuclear replication fork	1.4984E-5	16	20	3	6292
nuclear lumen	6.1834E-5	16	453	7	6292
nuclear part	7.5837E-5	16	1103	10	6292
organelle lumen	8.4009E-5	16	660	8	6292
intracellular organelle lumen	8.4009E-5	16	660	8	6292
alpha DNA polymerase:primase complex	1.2639E-4	16	7	2	6292
membrane-enclosed lumen	1.2833E-4	16	700	8	6292
replication fork	1.4582E-4	16	42	3	6292
protein-DNA complex	3.6312E-4	16	57	3	6292
protein complex	6.7212E-4	16	1137	9	6292
nuclear chromatin	7.529E-4	16	73	3	6292
chromatin	8.8002E-4	16	77	3	6292
replisome	9.059E-4	16	18	2	6292
nuclear replisome	9.059E-4	16	18	2	6292
nucleus	3.1363E-3	16	2041	11	6292
replication fork protection complex	5.0798E-3	16	2	1	6292
intracellular organelle part	8.3508E-3	16	2282	11	6292
organelle part	8.3508E-3	16	2282	11	6292
macromolecular complex	9.6949E-3	16	1635	9	6292

Biological Process Analysis

Only showing terms with a p-value less than or equal to 0.01.

GO Term	P-value	A	B	I	T
RNA elongation from RNA polymerase II promoter	1.2604E-14	16	39	8	6292
RNA elongation	4.3857E-14	16	45	8	6292
histone methylation	8.075E-10	16	20	5	6292
protein amino acid alkylation	2.2008E-9	16	24	5	6292
protein amino acid methylation	2.2008E-9	16	24	5	6292
transcription from RNA polymerase II promoter	2.5405E-8	16	335	9	6292
macromolecule methylation	4.8477E-8	16	43	5	6292
methylation	4.8477E-8	16	43	5	6292
transcription	1.2303E-7	16	552	10	6292
one-carbon metabolic process	1.7214E-7	16	55	5	6292
chromatin organization	2.9337E-7	16	203	7	6292
transcription, DNA-dependent	8.5506E-7	16	503	9	6292
RNA biosynthetic process	9.3033E-7	16	508	9	6292
covalent chromatin modification	1.8468E-6	16	88	5	6292
histone modification	1.8468E-6	16	88	5	6292
chromosome organization	1.973E-6	16	555	9	6292
chromatin modification	2.1263E-6	16	168	6	6292
nucleic acid metabolic process	1.1687E-5	16	1415	12	6292
DNA metabolic process	3.4901E-5	16	585	8	6292
nucleobase, nucleoside, nucleotide and nucleic acid metabolic process	3.541E-5	16	1566	12	6292
anatomical structure homeostasis	4.556E-5	16	286	6	6292
telomere organization	4.556E-5	16	286	6	6292
telomere maintenance	4.556E-5	16	286	6	6292
cellular nitrogen compound metabolic process	1.3216E-4	16	1770	12	6292
cellular macromolecule biosynthetic process	1.4533E-4	16	1187	10	6292
macromolecule biosynthetic process	1.475E-4	16	1189	10	6292
nitrogen compound metabolic process	1.4982E-4	16	1791	12	6292
post-translational protein modification	1.5755E-4	16	357	6	6292
RNA metabolic process	1.7033E-4	16	954	9	6292
cellular biosynthetic process	2.6982E-4	16	1567	11	6292
gene expression	2.8698E-4	16	1283	10	6292
cellular component organization	2.9556E-4	16	1582	11	6292
homeostatic process	3.2822E-4	16	408	6	6292
biosynthetic process	3.332E-4	16	1602	11	6292
organelle organization	6.2793E-4	16	1127	9	6292
protein modification process	9.7073E-4	16	499	6	6292
small molecule metabolic process	1.5576E-3	16	760	7	6292
regulation of biological quality	1.6369E-3	16	551	6	6292
cellular macromolecule metabolic process	1.8653E-3	16	2285	12	6292
macromolecule modification	1.9357E-3	16	569	6	6292
metabolic process	2.1587E-3	16	3157	14	6292
macromolecule metabolic process	2.4586E-3	16	2349	12	6292
negative regulation of transposition, RNA-mediated	2.5429E-3	16	1	1	6292
regulation of transposition, RNA-mediated	2.5429E-3	16	1	1	6292
L-ascorbic acid metabolic process	2.5429E-3	16	1	1	6292
L-ascorbic acid biosynthetic process	2.5429E-3	16	1	1	6292
chromatin assembly or disassembly	3.4353E-3	16	35	2	6292
transcription initiation from RNA polymerase II promoter	6.1313E-3	16	47	2	6292
cellular metabolic process	7.176E-3	16	3033	13	6292
methylglyoxal metabolic process	7.6106E-3	16	3	1	6292
methylglyoxal catabolic process to D-lactate	7.6106E-3	16	3	1	6292
snRNA processing	7.6106E-3	16	3	1	6292
protein targeting to vacuole during ubiquitin-dependent protein catabolic process via the MVB pathway	7.6106E-3	16	3	1	6292
late endosome to vacuole transport via multivesicular body sorting pathway	7.6106E-3	16	3	1	6292
endosome transport via multivesicular body sorting pathway	7.6106E-3	16	3	1	6292
methylglyoxal catabolic process	7.6106E-3	16	3	1	6292
transcription initiation	9.2242E-3	16	58	2	6292

Molecular Function Analysis

Only showing terms with a p-value less than or equal to 0.01.

GO Term	P-value	A	B	I	T
RNA polymerase II transcription elongation factor activity	1.5832E-13	16	13	6	6292
transcription elongation regulator activity	2.4827E-12	16	19	6	6292
transcription regulator activity	9.2938E-6	16	339	7	6292
triplex DNA binding	2.5429E-3	16	1	1	6292
trichothecene 3-O-acetyltransferase activity	2.5429E-3	16	1	1	6292
RNA polymerase II transcription termination factor activity	2.5429E-3	16	1	1	6292
hydroxyacylglutathione hydrolase activity	5.0798E-3	16	2	1	6292
D-arabinose 1-dehydrogenase [NAD(P)+] activity	5.0798E-3	16	2	1	6292
transcription termination factor activity	5.0798E-3	16	2	1	6292

View Protein Complex Details

Complex Overview

Complex Member Proteins

Cellular Component Analysis

Biological Process Analysis

Molecular Function Analysis