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The covalent transfer of a methyl group to either N-6 of adenine or C-5 or N-4 of cytosine. Posttranscriptional addition of a methyl group to either a nucleotide or 2'-O ribose in a polyribonucleotide. Usually uses S-adenosylmethionine as a cofactor. The chemical reactions and pathways involving macromolecules, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass, as carried out by individual cells. The addition of a methyl group to a protein amino acid. A methyl group is derived from methane by the removal of a hydrogen atom. The covalent attachment of a methyl residue to one or more monomeric units in a polypeptide, polynucleotide, polysaccharide, or other biological macromolecule. The covalent alteration of one or more monomeric units in a polypeptide, polynucleotide, polysaccharide, or other biological macromolecule, resulting in a change in its properties. The chemical reactions and pathways involving the transfer of one-carbon units in various oxidation states. The process by which a methyl group is covalently attached to a molecule. The chemical reactions and pathways involving macromolecules, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass. The chemical reactions and pathways by which individual cells transform chemical substances.

View Gene Ontology (GO) Term

GO TERM SUMMARY
Name: macromolecule methylation
Acc: GO:0043414
Aspect: Biological Process
Desc: The covalent attachment of a methyl residue to one or more monomeric units in a polypeptide, polynucleotide, polysaccharide, or other biological macromolecule.
Proteins in PDR annotated with:
   This term: 0
   Term or descendants: 514 [Search]


[geneontology.org]
INTERACTIVE GO GRAPH

GO:0043414 - macromolecule methylation (interactive image map)
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