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View Protein Complex Details

Complex Overview

From Publication: Mewes, H. W. et al. MIPS: Analysis and annotation of proteins from whole genomes. Nucleic Acids Res. 32, D41-D44
Notes: MIPS hand-curated complex set. MIPS complex ID: 410.30
Complex Size: 16 proteins

Complex Member Proteins

Protein

 GO Cellular Component GO Biological Process GO Molecular Function
CDC45
  • replication fork
  • pre-replicative complex
    		•
  • DNA replication initiation
  • DNA strand elongation involved in DNA replication
  • pre-replicative complex assembly
    		•
  • DNA binding
    		•
    CDC6
  • pre-replicative complex
    		•
  • pre-replicative complex assembly
    		•
  • ATPase activity
  • DNA clamp loader activity
  • protein binding
    		•
    DPB11
  • replication fork
    		•
  • DNA replication initiation
  • DNA replication checkpoint
  • lagging strand elongation
  • recombinational repair
  • leading strand elongation
  • nucleotide-excision repair
  • mismatch repair
    		•
  • protein binding
    		•
    MCM2
  • nucleus
  • pre-replicative complex
  • cytoplasm
  • MCM complex
    		•
  • DNA replication initiation
  • pre-replicative complex assembly
  • DNA unwinding involved in replication
    		•
  • chromatin binding
  • ATP-dependent DNA helicase activity
    		•
    MCM3
  • nucleus
  • pre-replicative complex
  • cytoplasm
  • MCM complex
    		•
  • DNA replication initiation
  • pre-replicative complex assembly
  • DNA unwinding involved in replication
    		•
  • chromatin binding
  • ATP-dependent DNA helicase activity
    		•
    MCM4
  • nucleus
  • pre-replicative complex
  • cytoplasm
  • MCM complex
    		•
  • DNA replication initiation
  • pre-replicative complex assembly
  • DNA unwinding involved in replication
    		•
  • chromatin binding
  • ATP-dependent DNA helicase activity
    		•
    MCM5
  • replication fork
  • pre-replicative complex
  • cytoplasm
  • MCM complex
    		•
  • DNA replication initiation
  • establishment of chromatin silencing
  • pre-replicative complex assembly
  • DNA unwinding involved in replication
    		•
  • chromatin binding
  • ATP-dependent DNA helicase activity
    		•
    MCM6
  • nucleus
  • pre-replicative complex
  • cytoplasm
  • MCM complex
    		•
  • DNA replication initiation
  • DNA unwinding involved in replication
    		•
  • chromatin binding
  • ATP-dependent DNA helicase activity
    		•
    MCM7
  • nucleus
  • pre-replicative complex
  • cytoplasm
  • MCM complex
    		•
  • DNA replication initiation
  • pre-replicative complex assembly
  • DNA unwinding involved in replication
    		•
  • ATP binding
  • chromatin binding
  • ATP-dependent DNA helicase activity
    		•
    ORC1
  • pre-replicative complex
  • nuclear origin of replication recognition complex
    		•
  • DNA replication initiation
  • pre-replicative complex assembly
  • chromatin silencing at silent mating-type cassette
    		•
  • ATPase activity
  • DNA replication origin binding
    		•
    ORC2
  • pre-replicative complex
  • nuclear origin of replication recognition complex
    		•
  • DNA replication initiation
  • pre-replicative complex assembly
  • chromatin silencing at silent mating-type cassette
    		•
  • DNA replication origin binding
    		•
    ORC3
  • pre-replicative complex
  • nuclear origin of replication recognition complex
    		•
  • DNA replication initiation
  • pre-replicative complex assembly
  • chromatin silencing at silent mating-type cassette
    		•
  • DNA replication origin binding
    		•
    ORC4
  • pre-replicative complex
  • nuclear origin of replication recognition complex
    		•
  • DNA replication initiation
  • pre-replicative complex assembly
  • chromatin silencing at silent mating-type cassette
    		•
  • DNA replication origin binding
    		•
    ORC5
  • pre-replicative complex
  • nuclear origin of replication recognition complex
    		•
  • DNA replication initiation
  • pre-replicative complex assembly
  • chromatin silencing at silent mating-type cassette
    		•
  • ATPase activity
  • DNA replication origin binding
    		•
    ORC6
  • pre-replicative complex
  • nuclear origin of replication recognition complex
    		•
  • DNA replication initiation
  • pre-replicative complex assembly
  • chromatin silencing at silent mating-type cassette
    		•
  • DNA replication origin binding
    		•
    SLD3
  • nuclear chromatin
    		•
  • DNA replication initiation
  • DNA unwinding involved in replication
    		•
  • chromatin binding
    		•

    Cellular Component Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    		 P-value

    		 A

    		 B

    		 I

    		 T
    pre-replicative complex 8.3513E-39 16 16 14 6292
    protein-DNA complex 5.2899E-28 16 57 14 6292
    chromosomal part 4.3618E-21 16 237 15 6292
    chromosome 4.0665E-20 16 274 15 6292
    nucleoplasm part 1.4323E-18 16 245 14 6292
    nucleoplasm 4.1655E-18 16 264 14 6292
    nuclear chromosome part 5.9735E-18 16 190 13 6292
    nuclear chromosome 6.7455E-17 16 228 13 6292
    origin recognition complex 9.3145E-17 16 6 6 6292
    nuclear origin of replication recognition complex 9.3145E-17 16 6 6 6292
    MCM complex 6.5113E-16 16 7 6 6292
    nuclear lumen 8.7309E-15 16 453 14 6292
    organelle lumen 1.6907E-12 16 660 14 6292
    intracellular organelle lumen 1.6907E-12 16 660 14 6292
    membrane-enclosed lumen 3.8332E-12 16 700 14 6292
    non-membrane-bounded organelle 6.9667E-12 16 959 15 6292
    intracellular non-membrane-bounded organelle 6.9667E-12 16 959 15 6292
    nuclear part 5.6187E-11 16 1103 15 6292
    organelle part 8.6662E-8 16 2282 16 6292
    intracellular organelle part 8.6662E-8 16 2282 16 6292
    macromolecular complex 4.2472E-7 16 1635 14 6292
    nucleus 4.992E-7 16 2041 15 6292
    protein complex 1.0222E-6 16 1137 12 6292
    replication fork 1.4582E-4 16 42 3 6292
    intracellular organelle 9.2974E-4 16 4070 16 6292
    organelle 9.334E-4 16 4071 16 6292
    membrane-bounded organelle 3.212E-3 16 3771 15 6292
    intracellular membrane-bounded organelle 3.212E-3 16 3771 15 6292

    Biological Process Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    		 P-value

    		 A

    		 B

    		 I

    		 T
    pre-replicative complex assembly 1.4575E-37 16 13 13 6292
    DNA replication initiation 2.2947E-35 16 33 15 6292
    DNA-dependent DNA replication 1.4751E-31 16 82 16 6292
    DNA replication 1.6728E-28 16 123 16 6292
    protein-DNA complex assembly 1.1702E-27 16 39 13 6292
    cellular macromolecular complex assembly 3.3631E-18 16 182 13 6292
    DNA metabolic process 2.5839E-17 16 585 16 6292
    cellular macromolecular complex subunit organization 3.6391E-16 16 259 13 6292
    DNA unwinding involved in replication 5.041E-16 16 14 7 6292
    macromolecular complex assembly 1.0652E-15 16 281 13 6292
    DNA geometric change 1.1301E-14 16 20 7 6292
    DNA duplex unwinding 1.1301E-14 16 20 7 6292
    macromolecular complex subunit organization 2.4546E-14 16 357 13 6292
    cellular component assembly 6.5712E-14 16 385 13 6292
    cellular macromolecule biosynthetic process 2.3702E-12 16 1187 16 6292
    macromolecule biosynthetic process 2.4353E-12 16 1189 16 6292
    nucleic acid metabolic process 4.0069E-11 16 1415 16 6292
    DNA conformation change 4.1786E-11 16 58 7 6292
    chromatin silencing at silent mating-type cassette 9.9428E-11 16 33 6 6292
    cellular component biogenesis 1.3172E-10 16 694 13 6292
    nucleobase, nucleoside, nucleotide and nucleic acid metabolic process 2.0462E-10 16 1566 16 6292
    cellular biosynthetic process 2.0673E-10 16 1567 16 6292
    biosynthetic process 2.9487E-10 16 1602 16 6292
    cellular nitrogen compound metabolic process 1.4646E-9 16 1770 16 6292
    nitrogen compound metabolic process 1.7702E-9 16 1791 16 6292
    negative regulation of gene expression, epigenetic 2.1095E-9 16 100 7 6292
    gene silencing 2.1095E-9 16 100 7 6292
    regulation of gene expression, epigenetic 2.1095E-9 16 100 7 6292
    chromatin silencing 2.1095E-9 16 100 7 6292
    negative regulation of macromolecule biosynthetic process 3.2508E-9 16 175 8 6292
    negative regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process 4.0676E-9 16 180 8 6292
    negative regulation of nitrogen compound metabolic process 4.0676E-9 16 180 8 6292
    negative regulation of biosynthetic process 5.9929E-9 16 189 8 6292
    negative regulation of cellular biosynthetic process 5.9929E-9 16 189 8 6292
    negative regulation of macromolecule metabolic process 6.7901E-9 16 192 8 6292
    negative regulation of cellular metabolic process 1.3285E-8 16 209 8 6292
    negative regulation of metabolic process 1.3795E-8 16 210 8 6292
    negative regulation of transcription, DNA-dependent 4.9925E-8 16 157 7 6292
    negative regulation of RNA metabolic process 5.2173E-8 16 158 7 6292
    negative regulation of cellular process 5.4288E-8 16 250 8 6292
    negative regulation of biological process 5.9595E-8 16 253 8 6292
    negative regulation of transcription 6.7545E-8 16 164 7 6292
    negative regulation of gene expression 6.7545E-8 16 164 7 6292
    cellular macromolecule metabolic process 8.851E-8 16 2285 16 6292
    macromolecule metabolic process 1.379E-7 16 2349 16 6292
    regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process 2.6951E-6 16 415 8 6292
    regulation of nitrogen compound metabolic process 2.7446E-6 16 416 8 6292
    cellular component organization 3.9276E-6 16 1582 13 6292
    primary metabolic process 3.9666E-6 16 2896 16 6292
    regulation of macromolecule biosynthetic process 5.4858E-6 16 456 8 6292
    regulation of cellular biosynthetic process 7.1059E-6 16 472 8 6292
    regulation of biosynthetic process 7.2195E-6 16 473 8 6292
    cellular metabolic process 8.3256E-6 16 3033 16 6292
    regulation of macromolecule metabolic process 9.1185E-6 16 488 8 6292
    regulation of transcription, DNA-dependent 1.3324E-5 16 358 7 6292
    regulation of primary metabolic process 1.3425E-5 16 514 8 6292
    regulation of RNA metabolic process 1.4599E-5 16 363 7 6292
    metabolic process 1.5832E-5 16 3157 16 6292
    regulation of cellular metabolic process 1.832E-5 16 536 8 6292
    regulation of transcription 2.1121E-5 16 384 7 6292
    regulation of metabolic process 2.1289E-5 16 547 8 6292
    regulation of gene expression 5.5118E-5 16 445 7 6292
    regulation of cellular process 3.1978E-4 16 796 8 6292
    regulation of biological process 4.0754E-4 16 824 8 6292
    transcription, DNA-dependent 1.0128E-3 16 503 6 6292
    RNA biosynthetic process 1.0673E-3 16 508 6 6292
    transcription 1.6525E-3 16 552 6 6292
    DNA strand elongation 2.7007E-3 16 31 2 6292
    DNA strand elongation involved in DNA replication 2.7007E-3 16 31 2 6292
    cellular process 3.565E-3 16 4426 16 6292
    biological regulation 5.4863E-3 16 1213 8 6292
    establishment of chromatin silencing 7.6106E-3 16 3 1 6292

    Molecular Function Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    		 P-value

    		 A

    		 B

    		 I

    		 T
    DNA replication origin binding 1.5832E-13 16 13 6 6292
    chromatin binding 6.1269E-13 16 33 7 6292
    ATP-dependent DNA helicase activity 1.701E-12 16 18 6 6292
    binding 9.51E-12 16 1294 16 6292
    DNA-dependent ATPase activity 2.8308E-11 16 55 7 6292
    DNA helicase activity 1.2057E-10 16 34 6 6292
    ATPase activity 4.2269E-10 16 211 9 6292
    ATP-dependent helicase activity 1.0792E-9 16 48 6 6292
    purine NTP-dependent helicase activity 1.0792E-9 16 48 6 6292
    sequence-specific DNA binding 1.3937E-9 16 50 6 6292
    nucleoside-triphosphatase activity 2.1684E-8 16 329 9 6292
    helicase activity 3.1637E-8 16 83 6 6292
    ATPase activity, coupled 3.4718E-8 16 149 7 6292
    hydrolase activity, acting on acid anhydrides 4.0151E-8 16 353 9 6292
    hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 4.0151E-8 16 353 9 6292
    pyrophosphatase activity 4.0151E-8 16 353 9 6292
    DNA binding 6.5346E-8 16 256 8 6292
    nucleic acid binding 8.9684E-5 16 666 8 6292
    hydrolase activity 1.1792E-4 16 911 9 6292
    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle