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Protein Overview: PSA1

General Information:
Name(s) found: PSA1 / YDL055C [SGD]
Description(s) found:
Found 32 descriptions.
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  • GDP-mannose pyrophosphorylase (mannose-1-phosphate guanyltransferase), synthesizes GDP-mannose from GTP and mannose-1-phosphate in cell wall biosynthesis; required for normal cell wall structure [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 361 amino acids

    Gene Ontology:
    Cellular Component: cytoplasm [IDALink to PubMed articleLink to PubMed article]
    Biological Process: cell wall mannoprotein biosynthetic process [IMPLink to PubMed article]
    GDP-mannose biosynthetic process [IDALink to PubMed article][IMPLink to PubMed article]
    protein amino acid glycosylation [IMPLink to PubMed article]
    Molecular Function: mannose-1-phosphate guanylyltransferase activity [IDALink to PubMed article][IMPLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MKGLILVGGY GTRLRPLTLT VPKPLVEFGN RPMILHQIEA LANAGVTDIV LAVNYRPEVM  60
   61 VETLKKYEKE YGVNITFSVE TEPLGTAGPL KLAEDVLKKD NSPFFVLNSD VICEYPFKEL 120
  121 ADFHKAHGGK GTIVATKVDE PSKYGVIVHD IATPNLIDRF VEKPKEFVGN RINAGLYILN 180
  181 PEVIDLIEMK PTSIEKETFP ILVEEKQLYS FDLEGFWMDV GQPKDFLSGT VLYLNSLAKR 240
  241 QPKKLATGAN IVGNALIDPT AKISSTAKIG PDVVIGPNVT IGDGVRITRS VVLCNSTIKN 300
  301 HSLVKSTIVG WNSTVGQWCR LEGVTVLGDD VEVKDEIYIN GGKVLPHKSI SDNVPKEAII 360
  361 M

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Riffle et al. (2010) (Unpublished Data) GDH2 PGA2 PSA1 SYP1 YNR062C
    View Details Krogan NJ, et al. (2006) CDC31 HOS3 PSA1 PTK2 RPL1A, RPL1B
    View Details Gavin AC, et al. (2006) ILV1 PSA1 YOL098C
    View Details Gavin AC, et al. (2002) ACC1 CCT8 CLU1 CPA2 FDH1 GCN20 GFA1 GUS1 ILV1 KAP123 LYS12 MRPL3 PSA1 RPA135 RPB2 RPN10 RPN11 RPN12 RPN8 RPT3 RPT5 RPT6 SAM1 SEC27 SMC3 TCB1 TIF1, TIF2 TSA1 TUB3 URA7 VAS1 YOL098C

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run TOR2 No Comments Reinke A, et al. (2004)
    View Run LST8 No Comments Reinke A, et al. (2004)
    View Run SEC10 No Comments De Craene, J., et al. (2006)
    View Run BIR1 No Comments Widlund PO, et al. (2005)
    View Run DAD1 Dam1 complex purified from yeast with Dad1-TAP Shimogawa MM, et al. (2006)
    View Run RPA135 his-HA tag on RPA135 Schneider, DA, et al. (2006)
    View Run RPA135 his-HA tag on RPA135 Schneider, DA, et al. (2006)
    View Run DAD1 Dam1-765 complex purified from yeast with Dad1-TAP Shimogawa MM, et al. (2006)
    View Run BIR1 sample bir 1 from feb 2005 Sandall S, et all (2006)
    View Run DAD1 Dam1-765 complex purified from yeast with Dad1-TAP Shimogawa MM, et al. (2006)
    View Run DAD1 Dam1 complex purified from yeast with Dad1-TAP Shimogawa MM, et al. (2006)
    View Run ZDS1 Sample 2- cpn2 from june 2005 McCusker D, et al (2007)
    View Run ZDS1 Sample 3 - cpn + atp, from june 2005 McCusker D, et al (2007)
    View Run VAM3 Sample: HX11 - both fusion and trans-SNARE complex formation take place. Hao Xu, et al. (2010)
    View Run VAM3 Sample: HX12 - trans-SNARE complex formation and fusion are inhibited (control). Hao Xu, et al. (2010)
    View Run VAM3 Sample: HX14 - mixture in detergent (control). Hao Xu, et al. (2010)
    View Run MLP2 #25 Asynchronous Prep3-TiO2 Flowthrough Keck JM, et al. (2011)
    View Run MLP2 #24 Asynchronous Prep3-TiO2 Phosphopeptide enrichment Keck JM, et al. (2011)
    View Run MLP2 #34 Asynchronous SPB prep Keck JM, et al. (2011)
    View Run MLP2 #32 Asynchronous Prep-No Phosphopeptide enrichment Keck JM, et al. (2011)
    View Run MLP2 #31 Asynchronous Prep (Protease cleavage) Keck JM, et al. (2011)
    View Run MLP2 #08 Alpha Factor Prep4-TiO2 Phosphopeptide enrichment Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data PSA1 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..276] PSI-BLAST 238.66807 RmlA (RfbA)
    2 View Details [277..361] PSI-BLAST 3.0 gamma-carbonic anhydrase

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • mannosyltransferase activity
    		•  3.87594044828967 bayes_pls_golite062009
  • alpha-1,2-mannosyltransferase activity
    		•  3.78995004368368 bayes_pls_golite062009
  • uridylyltransferase activity
    		•  3.74072767898515 bayes_pls_golite062009
  • transferase activity
    		•  3.32517438937547 bayes_pls_golite062009
  • mannose-phosphate guanylyltransferase activity
    		•  3.09763291641741 bayes_pls_golite062009
  • transferase activity, transferring hexosyl groups
    		•  2.70047942699289 bayes_pls_golite062009
  • UTP:glucose-1-phosphate uridylyltransferase activity
    		•  2.65167602524122 bayes_pls_golite062009
  • guanylyltransferase activity
    		•  2.62845487806844 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  2.51696952719873 bayes_pls_golite062009
  • UTP-monosaccharide-1-phosphate uridylyltransferase activity
    		•  2.46432078102948 bayes_pls_golite062009
  • UDP-glycosyltransferase activity
    		•  2.33861720107822 bayes_pls_golite062009
  • mannose-1-phosphate guanylyltransferase activity
    		•  2.30953822963071 bayes_pls_golite062009
  • catalytic activity
    		•  1.88676710996045 bayes_pls_golite062009
  • nucleotidyltransferase activity
    		•  1.50551885980582 bayes_pls_golite062009
  • acetylgalactosaminyltransferase activity
    		•  1.33788133706753 bayes_pls_golite062009
  • polypeptide N-acetylgalactosaminyltransferase activity
    		•  1.10309252319727 bayes_pls_golite062009
  • binding
    		•  1.09657219604879 bayes_pls_golite062009
  • cytidylyltransferase activity
    		•  0.983416157001861 bayes_pls_golite062009
  • glycogenin glucosyltransferase activity
    		•  0.968757748180341 bayes_pls_golite062009
  • transferase activity, transferring glycosyl groups
    		•  0.897978517422275 bayes_pls_golite062009
  • UDP-N-acetylglucosamine diphosphorylase activity
    		•  0.513376694534047 bayes_pls_golite062009
    2 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.98

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle