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Protein Overview: STU1

General Information:
Name(s) found: STU1 / YBL034C [SGD]
Description(s) found:
Found 32 descriptions.
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  • Component of the mitotic spindle that binds to interpolar microtubules via its association with beta-tubulin (Tub2p); required for interpolar microtubules to provide an outward force on the spindle poles [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 1513 amino acids

    Gene Ontology:
    Cellular Component: spindle pole body [IDALink to PubMed article]
    Biological Process: microtubule nucleation [IPILink to PubMed article]
    Molecular Function: structural constituent of cytoskeleton [IPILink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSSFNNETNN NSNTNTHPDD SFPLYTVFKD ESVPIEEKMA LLTRFKGHVK KELVNESSIQ  60
   61 AYFAALLFIS GHYAYRSYPR LIFLSHSSLC YLIKRVAMQS PVQFNDTLVE QLLNHLIFEL 120
  121 PNEKKFWLAS IKAIEAIYLV NPSKIQAILA NFLRRPSENQ NGDYLNRIKS TLLTIDELIQ 180
  181 INEKNNSNHL QLLRFFMLSF TNLLNNNLNE HANDDNNNVI IELIFDIMYK YLKMDDENSQ 240
  241 DLIDGFINDL EVEKFKQKFI SLAKSQDQHG SQEDKSTLFD EEYEFQLLLA EAKLPQLSNN 300
  301 LSSKDPAMKK NYESLNQLQQ DLENLLAPFQ SVKETEQNWK LRQSNIIELD NIISGNIPKD 360
  361 NPEEFVTVIK EVQLIELISR ATSSLRTTLS LTALLFLKRL IHILNDQLPL SILDQIFVIF 420
  421 KNLLSSTKKI SSQTAFHCLI TLIIDINHFH NKLFQLSFLL INEKTVTPRF CSAILLRSFL 480
  481 IKFNDSNLSL NNSNTTSPTS KLENNIIYIE EWLKKGISDS QTTVREAMRL TFWYFYKCYP 540
  541 TNAKRLLSSS FSPQLKKATE LAIPAHLNIN YQVSRVSSTA SASSATSRLY SHSSNNSSRK 600
  601 TSLLEQKRNY PSYAQPTQSS STSLLNAPAV TAGGSVIASK LSNKLKTNLR STSEYSSKEN 660
  661 EKRARHHDSM NSVSNSNTKD NNNVTKRKVS APPSSTAATK VSENYTNFDD FPSNQIDLTD 720
  721 ELSNSYSNPL IKKYMDKNDV SMSSSPISLK GSNKLGEYET LYKKFNDASF PAQIKDALQY 780
  781 LQKELLLTSQ QSSSAPKFEF PMIMKKLRQI MIKSPNDFKP FLSIEKFTNG VPLNYLIELY 840
  841 SINSFDYAEI LKNRMNPEKP YELTNLIITI ADLFNFLNAN NCPNDFKLYY MKYKTTFFNY 900
  901 NFKLLLEIFR NLNIKHDNTL RSGTNDLMPK ISMILFQIYG KEFDYTCYFN LIFEIYKFDN 960
  961 NRFNKLLADF DIVSTKMKIC HELEKKDANF KVEDIISRES SVSFTPIDNK KSEGDEESDD1020
 1021 AVDENDVKKC MEMTMINPFK NLETDKTLEL KNNVGKRTSS TDSVVIHDDN DKDKKLSEMT1080
 1081 KIVSVYQLDQ PNPAKEEDDI DMENSQKSDL NLSEIFQNSG ENTERKLKDD NEPTVKFSTD1140
 1141 PPKIINEPEK LIGNGNENEK PDLETMSPIK INGDENMGQK QRITVKRERD VALTEQDINS1200
 1201 KKMKLVNNKK SEKMHLLIMD NFPRDSLTVY EISHLLMVDS NGNTLMDFDV YFNHMSKAIN1260
 1261 RIKSGSFTMK HINYLIEPLI TCFQNQKMTD WLTNENGFDE LLDVAIMLLK STDDTPSIPS1320
 1321 KISSKSIILV HCLLVWKKFL NTLSENADDD GVSVRMCFEE VWEQILLMLN KFSDYGNEIY1380
 1381 KLAQEFRDSL MLSHFFKKHS ATRILSMLVT EIQPDTAGVK ETFLIETLWK MLQSPTICQQ1440
 1441 FKKSNISEII QTMSYFIMGT DNTSWNFTSA VVLARCLRVL QTTPDYTEQE TERLFDCLPK1500
 1501 NVFKMIMFIA SNE

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details (MIPS) Mewes HW, et al. (2004) AME1 ARP1 ASE1 ATG4 ATG8 BIK1 BIM1 CBF5 CIK1 CIN2 CIN4 DYN1 JNM1 KAR3 KAR5 MHP1 NUF2 RBL2 SPC19 SPC34 SPC98 STU1 STU2 TID3 YTM1
    View Details Ho Y, et al. (2002) ADR1 BMH1 BNR1 BOI2 CSR2 CYK3 GSY2 KCS1 NTH1 REG1 SOK1 STU1 SVL3 YFR017C YIL028W
    View Details Qiu et al. (2008) ARP1 ASE1 BBP1 BFA1 BIK1 BIM1 BUB1 CDC31 CIK1 CIN8 CNM67 DYN1 JNM1 KAR3 KAR9 KIP1 KIP2 MHP1 NDC1 NUD1 NUF2 SGO1 SLK19 SPC105 SPC110 SPC19 SPC24 SPC25 SPC29 SPC34 SPC42 SPC72 SPC97 SPC98 STU1 STU2 TID3 TUB2 TUB4 VIK1

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run MIF2 No Comments Cheeseman IM, et al. (2002)
    View Run STU1 No Comments Cheeseman IM, et al. (2002)
    View Run CAB3 No Comments Hazbun TR, et al. (2003)
    View Run CEP3 sample cbf3 from feb 2005 Sandall S, et all (2006)
    View Run ASF1 3906: TAP-tagged Green EM, et al (2005)
    View Run RPA135 No Comments Schneider, DA, et al. (2006)
    View Run MLP2 #26 Asynchronous Prep4-TiO2 Phosphopeptide enriched, Steps1-2 Keck JM, et al. (2011)
    View Run MLP2 #29 Asynchronous Prep5-TiO2 Flowthrough Keck JM, et al. (2011)
    View Run MLP2 #12 Mitotic Prep1-TiO2 Flowthrough Keck JM, et al. (2011)
    View Run MLP2 #10 Mitotic Prep1-TiO2 Phosphopeptide enrichment Keck JM, et al. (2011)
    View Run MLP2 #11 Mitotic Prep1-TiO2 enriched, new search criteria Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data STU1 Huh WK, et al. (2003)
    View Data STU1 and SPC42 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..216] deduced N/A No confident structure predictions are available.
    2 View Details [217..459] MSA 2.038996 View MSA. No confident structure predictions are available.
    3 View Details [460..519] deduced N/A No confident structure predictions are available.
    4 View Details [520..881] MSA 270.841998 View MSA. No confident structure predictions are available.
    5 View Details [882..1513] deduced N/A No confident structure predictions are available.
    6 View Details [1318..1513] deduced N/A No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • cytoskeletal protein binding
    		•  2.57708254106901 bayes_pls_golite062009
  • binding
    		•  2.38363524631144 bayes_pls_golite062009
  • protein binding
    		•  1.81870125631028 bayes_pls_golite062009
  • actin binding
    		•  1.74253257307802 bayes_pls_golite062009
    2 No functions predicted.
    3 No functions predicted.
    4 No functions predicted.
    5 No functions predicted.
    6 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.62

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle