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Protein Overview: CWC23

General Information:
Name(s) found: CWC23 / YGL128C [SGD]
Description(s) found:
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  • gi|73920199|sp|P52868.2|CWC23_YEAST RecName: Full=Pre-mRNA-splicing factor CWC23; AltName: Full=Complexed with CEF1 protein 23 [NCBI NR]
  • gi|37362651|ref|NP_011387.2| Component of a complex containing Cef1p, putatively involved in pre-mRNA splicing; has similarity to E. coli DnaJ and other DnaJ-like proteins and to S. pombe Cwf23p; Cwc23p [Saccharomyces cerevisiae] [NCBI NR]
  • Pre-mRNA-splicing factor CWC23 OS=Saccharomyces cerevisiae GN=CWC23 PE=1 SV=2 [Swiss-Prot]
  • CWC23 Component of a complex containing Cef1p, putatively involved in pre-mRNA splicing [mips]
  • Component of a complex containing Cef1p, putatively involved in pre-mRNA splicing; has similarity to E. coli DnaJ and other DnaJ-like proteins and to S. pombe Cwf23p [SGD]
  • Chr VII from 270148-269297, reverse complement [yeastorf5.fasta]
  • CWC23 SGDID:S0003096, Chr VII from 270148-269297, reverse complement, Verified ORF [yeastflysequest.fasta]
  • CWC23 SGDID:S0003096, Chr VII from 270150-269299, reverse complement, Verified ORF [10112005cervSGD.fasta]
  • Component of a complex containing Cef1p, putatively involved in pre-mRNA splicing; has similarity to E.coli DnaJ and other DnaJ-like proteins and to S. pombe Cwf23p [Saccharomyces cerevisiae] [nrdb_11152004_Chlamydomonas]
  • CWC23 SGDID:S000003096, Chr VII from 270150-269299, reverse complement, Verified ORF, "Component of a complex containing Cef1p, putatively involved in pre-mRNA splicing; has similarity to E. coli DnaJ and other DnaJ-like proteins and to S. pombe Cwf23p" [SGD_S-cerevisiae_na_12-16-2005_con_reversed.fasta]
  • Component of a complex containing Cef1p, putatively involved in pre-mRNA splicing; has similarity to E. coli DnaJ and other DnaJ-like proteins and to S. pombe Cwf23p; Cwc23p [Saccharomyces cerevisiae] [nr-271106-contam.fasta]
  • Pre-mRNA-splicing factor CWC23 (Complexed with CEF1 protein 23) [nr-271106-contam.fasta]
  • [chemostatdb.fasta]
  • Pre-mRNA-splicing factor CWC23 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=CWC23 PE=1 SV=2 [UniProt_S_cerevisiae_20120516_05-16-2012_reversed.fasta]
  • CWC23 SGDID:S000003096, Chr VII from 270144-269293, Genome Release 64-1-1, reverse complement, Verified ORF, "Component of a complex containing Cef1p, putatively involved in pre-mRNA splicing; has similarity to E. coli DnaJ and other DnaJ-like proteins and to S. pombe Cwf23p" [yeast-030211-contam.fasta]
  • CWC23 SGDID:S000003096, Chr VII from 270144-269293, Genome Release 64-2-1, reverse complement, Verified ORF, "Component of a complex containing Cef1p; putatively involved in pre-mRNA splicing; has similarity to E. coli DnaJ and other DnaJ-like proteins and to S. pombe Cwf23p" [20141208_orf_trans.fasta]
  • YGL128C SGDID:S000003096, Chr VII from 270144-269293, Genome Release 64-1-1, reverse complement, Verified ORF, "Component of a complex containing Cef1p, putatively involved in pre-mRNA splicing; has similarity to E. coli DnaJ and other DnaJ-like proteins and to S. pombe Cwf23p" [2016-01-SGD_Yeast_Contam_Riffle_20140507-Ska-Hec-110-tubulin.fasta]
    • Organism: Saccharomyces cerevisiae
    Length: 283 amino acids

    Gene Ontology:
    Cellular Component: spliceosomal complex [IPILink to PubMed article]
    Biological Process: biological_process [ND]
    Molecular Function: molecular_function [ND]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MPGHELEDVI NQRLNLYDVL ELPTPLDVHT IYDDLPQIKR KYRTLALKYH PDKHPDNPSI  60
   61 IHKFHLLSTA TNILTNADVR PHYDRWLIEF LRKTNDIERN KLIQKLEESE SSTIPTTTPH 120
  121 PDLLQIQRHG ELLRKLKHFN LPYGDWKHLN TQDQENASQH PYYDCSTLRI VLDNFLQSNN 180
  181 KSNCLSHLRN QVFITLSANE IYDIYFSERN NYSKDDSIII YTVFDTPITA QHVFRNWSSG 240
  241 NLIPTVKDIS PLIPLHYYSD FNLETELNDD IARLVSNEPI LLD

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Riffle et al. (2010) (Unpublished Data) AAR2 BRR2 BUD31 CDC40 CEF1 CLF1 CWC2 CWC22 CWC23 ECM2 HSH155 LEA1 NTR2 PRP19 PRP43 PRP46 PRP8 PRP9 RSE1 SMB1 SNT309 SNU114 SPP382 SQS1 SYF1
    View Details Hazbun TR, et al. (2003) BRR2 CDC40 CEF1 CLF1 CWC2 CWC22 CWC23 ECM2 ISY1 LEA1 NTR2 PRP19 PRP43 PRP45 PRP46 PRP8 SMB1 SMD1 SMD3 SMX3 SNT309 SNU114 SPP382 SYF1 SYF2 YJU2
    View Details (MIPS) Mewes HW, et al. (2004) AAR2 BRR1 BRR2 CBC2 CDC40 CWC15 CWC2 CWC22 CWC23 DHR2 LSM4 MAK5 MUD2 PRP16 PRP18 PRP2 PRP22 PRP24 PRP28 PRP31 PRP38 PRP39 PRP4 PRP40 PRP43 PRP5 PRP6 PRP8 SLU7 SMD1 SMD3 SME1 SNP1 SPP2 SPP381 STO1 YHC1
    View Details Krogan NJ, et al. (2006) CWC23 PRP43 SPP382 SQS1
    View Details Gavin AC, et al. (2006) CWC23 SPP382
    View Details Gavin AC, et al. (2002) AAR2 ASC1 BRR1 BUD31 CDC33 CDC40 CEF1 CLF1 CSN12 CUS1 CWC2 CWC22 CWC23 DCP2 DHH1 DIB1 ECM2 ERB1 GCN2 HSH155 HTA1 IMG1 ISY1 KRS1 LEA1 LIN1 LSM1 LSM2 LSM3 LSM4 LSM5 LSM6 LSM7 LUC7 MRP7 MRPL28 MRPL3 MRPL35 MRPL38 MRPL4 MRPL8 MRPS5 MSL1 MUD1 NAM7 NOG2 NOP1 NUG1 PAT1 PRP11 PRP18 PRP19 PRP2 PRP21 PRP22 PRP24 PRP28 PRP3 PRP31 PRP38 PRP39 PRP4 PRP40 PRP42 PRP43 PRP45 PRP46 PRP6 PRP8 PRP9 RSE1 RVB2 SLU7 SMB1 SMD1 SMD2 SMD3 SME1 SMX2 SMX3 SNP1 SNT309 SNU114 SNU23 SNU56 SNU66 SNU71 SPP381 SPP382 SQS1 SRB2 SRO9 STO1 SYF1 TOS4 UTP21 YML6
    View Details Qiu et al. (2008) AAR2 BRR1 BRR2 BUD31 CBC2 CDC40 CEF1 CLF1 CUS1 CWC15 CWC2 CWC21 CWC22 CWC23 CWC25 DHR2 DIB1 ECM2 GTS1 HSH155 ISY1 LEA1 LSM2 LSM3 LSM4 LSM7 LUC7 MAK5 MSL1 MUD1 MUD2 NAM8 PRP11 PRP16 PRP18 PRP19 PRP2 PRP21 PRP22 PRP24 PRP28 PRP3 PRP31 PRP38 PRP39 PRP4 PRP40 PRP42 PRP43 PRP45 PRP46 PRP5 PRP6 PRP8 PRP9 RSE1 SLU7 SMB1 SMD1 SMD2 SMD3 SME1 SMX2 SMX3 SNP1 SNT309 SNU114 SNU23 SNU56 SNU66 SNU71 SPP2 SPP381 SPP382 STO1 SYF1 SYF2 YHC1

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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      PROTEIN(S) PUBLICATION
    View Data CWC23 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..140] PSI-BLAST 23.045757 NMR STRUCTURE OF THE J-DOMAIN (RESIDUES 2-76) IN THE ESCHERICHIA COLI N-TERMINAL FRAGMENT (RESIDUES 2-108) OF THE MOLECULAR CHAPERONE DNAJ, 20 STRUCTURES
    2 View Details [141..283] MSA 1.541991 View MSA. No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • binding
    		•  1.48144960946614 bayes_pls_golite062009
  • protein binding
    		•  0.670977667446543 bayes_pls_golite062009
  • catalytic activity
    		•  0.106988907594358 bayes_pls_golite062009
    2 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle