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Protein Overview: GDE1

General Information:
Name(s) found: GDE1 / YPL110C [SGD]
Description(s) found:
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  • gi|74676330|sp|Q02979.1|GDE1_YEAST RecName: Full=Glycerophosphodiester phosphodiesterase GDE1 [NCBI NR]
  • gi|6325147|ref|NP_015215.1| Glycerophosphocholine (GroPCho) phosphodiesterase; hydrolyzes GroPCho to choline and glycerolphosphate, for use as a phosphate source and as a precursor for phosphocholine synthesis; may interact with ribosomes; Gde1p [Saccharo [NCBI NR]
  • pir||S62011 PHO85 protein - yeast (Saccharomyces cerevisiae) [NCBI NR]
  • gi|1163103|gb|AAB68251.1| Ypl110cp [Saccharomyces cerevisiae] [NCBI NR]
  • Glycerophosphodiester phosphodiesterase GDE1 OS=Saccharomyces cerevisiae GN=GDE1 PE=1 SV=1 [Swiss-Prot]
  • GDE1 Glycerophosphocholine (GroPCho) phosphodiesterase [mips]
  • Glycerophosphocholine (GroPCho) phosphodiesterase; hydrolyzes GroPCho to choline and glycerolphosphate, for use as a phosphate source and as a precursor for phosphocholine synthesis; may interact with ribosomes [SGD]
  • >Q02979 (Q02979) PHO85P,LPH16P [4932.FASTACCERV.txt]
  • Chr XVI from 344738-341067, reverse complement [hmr_yeast5_DM3-1_pombe.fasta]
  • Chr XVI from 341067-344738, reverse complement [yeastorf3.fasta]
  • YPL110C, Chr XVI from 341067-344738, reverse complement [yeast_orfs2]
  • YPL110C SGDID:S0006031, Chr XVI from 344738-341067, reverse complement, Uncharacterized ORF [yeastflysequest.fasta]
  • Ypl110cp [Saccharomyces cerevisiae]gi|2132388|pir||S62011 PHO85 protein - yeast (Saccharomyces cerevisiae)gi|1163103|gb|AAB68251.1| Lph16p [nrdb_11152004_Chlamydomonas]
  • (Q02979) Ypl110cp [cerv4932.FASTAC]
  • GDE1 SGDID:S000006031, Chr XVI from 344738-341067, reverse complement, Verified ORF, "Glycerophosphocholine (GroPCho) phosphodiesterase; hydrolyzes GroPCho to choline and glycerolphosphate after its uptake by Git1p permease, for use as a phosphate source [SGD_S-cerevisiae_na_12-16-2005_con_reversed.fasta]
  • GDE1 SGDID:S000006031, Chr XVI from 344738-341067, reverse complement, Verified ORF, "Major cellular glycerophosphocholine (GroPCho) phosphodiesterase; hydrolyzes GroPCho to choline and glycerolphosphate after its uptake by Git1p permease, for use as a ph [yeast-contam.fasta]
  • GDE1 SGDID:S000006031, Chr XVI from 344738-341067, reverse complement, Verified ORF, "Glycerophosphocholine (GroPCho) phosphodiesterase; hydrolyzes GroPCho to choline and glycerolphosphate, for use as a phosphate source and as a precursor for phosphocholi [SGD_S-cerevisiae_na_08-19-2008_con_reversed.fasta]
  • Major cellular glycerophosphocholine (GroPCho) phosphodiesterase; hydrolyzes GroPCho to choline and glycerolphosphate after its uptake by Git1p permease, for use as a phosphate source and as a precursor for phosphocholine synthesis; Gde1p [Saccharomyces c [nr-271106-contam.fasta]
  • Ypl110cp [Saccharomyces cerevisiae] [nr-271106-contam.fasta]
  • Glycerophosphodiester phosphodiesterase GDE1 [nr-271106-contam.fasta]
  • GDE1 SGDID:S000006031, Chr XVI from 344738-341067, reverse complement, Verified ORF, "Glycerophosphocholine (GroPCho) phosphodiesterase; hydrolyzes GroPCho to choline and glycerolphosphate, for use as a phosphate source and as a precursor for phosphocholine synthesis; may interact with ribosomes" [yeast-bovrabprots.fasta]
  • GDE1 SGDID:S000006031, Chr XVI from 344738-341067, reverse complement, Verified ORF, "Major cellular glycerophosphocholine (GroPCho) phosphodiesterase; hydrolyzes GroPCho to choline and glycerolphosphate after its uptake by Git1p permease, for use as a phosphate source and as a precursor for phosphocholine synthesis" [yeast-contam_custom.fasta]
  • [chemostatdb.fasta]
  • Glycerophosphodiester phosphodiesterase GDE1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=GDE1 PE=1 SV=1 [UniProt_S_cerevisiae_20120516_05-16-2012_reversed.fasta]
  • GDE1 SGDID:S000006031, Chr XVI from 344739-341068, Genome Release 64-1-1, reverse complement, Verified ORF, "Glycerophosphocholine (GroPCho) phosphodiesterase; hydrolyzes GroPCho to choline and glycerolphosphate, for use as a phosphate source and as a precursor for phosphocholine synthesis; may interact with ribosomes" [yeast-030211-contam.fasta]
  • GDE1 SGDID:S000006031, Chr XVI from 344739-341068, Genome Release 64-2-1, reverse complement, Verified ORF, "Glycerophosphocholine (GroPCho) phosphodiesterase; hydrolyzes GroPCho to choline and glycerolphosphate, for use as a phosphate source and as a precursor for phosphocholine synthesis; may interact with ribosomes" [20141208_orf_trans.fasta]
  • YPL110C SGDID:S000006031, Chr XVI from 344739-341068, Genome Release 64-1-1, reverse complement, Verified ORF, "Glycerophosphocholine (GroPCho) phosphodiesterase; hydrolyzes GroPCho to choline and glycerolphosphate, for use as a phosphate source and as a precursor for phosphocholine synthesis; may interact with ribosomes" [2016-01-SGD_Yeast_Contam_Riffle_20140507-Ska-Hec-110-tubulin.fasta]
  • Glycerophosphocholine phosphodiesterase GDE1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=GDE1 PE=1 SV=1 [Swanson-Carlisle-Scereplusabalone-contam.fasta]
    • Organism: Saccharomyces cerevisiae
    Length: 1223 amino acids

    Gene Ontology:
    Cellular Component: cytoplasm [IDALink to PubMed article]
    ribosome [IDALink to PubMed article]
    Biological Process: glycerophospholipid catabolic process [IMPLink to PubMed article][ISSLink to PubMed article]
    Molecular Function: glycerophosphocholine phosphodiesterase activity [IMPLink to PubMed article][ISSLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MKFGKTFANH RIPEWSSQYV GYKSLKKMIK EITRLQEDIY RAHNKNSYDE GRPPTKMRDS  60
   61 SNSAQNYLDS PKIQKLLASF FFAVDRDIEK VDTFYNSQYA EYKKRFERLL SSNQFNEIKS 120
  121 TLVVDANKED AVAQTLLTKD TREMNMLLKG TSQASRLSYH KDDLIEIQSI LAELRKQFRN 180
  181 LKWYAELNKR AFGKILKKLD KKVGTNQQMS TMKTRILPLQ FANDSLITKD LSLLKTIWEQ 240
  241 VTFRINSYER VMRSTSPNAN ANDNTEFFKI ICVFIEEDDS KGLIRELTNL YSELSLIPTR 300
  301 IMISVLNKAA LSKSLACIDA ILKVIPSLND SEDINRRNFF HHHIIAIGKL IRKQEILSRK 360
  361 KKSQPSKYTN SEGEIVTDLR TLHTTLSAPA ESDSITEEEK SSACTLSYIL EELPIHLRPC 420
  421 LFQHDNYKRT PLHYSCQYGL SEVTKLIIKL MKEWNIWNEI PIDDVSAFGD AESLTPLHLC 480
  481 VLGAHPKTTE VLLQSLDPNV KLKSSSLLHL ATEWNNYPLL HVLLSSKRFD INYQDNELHE 540
  541 TPLYLACRLN FFEAAVCLLY NGADLEIREK LFGWTAIFVA AAEGFTDIVK LLIANNANFD 600
  601 IEDEGGWTPM EHAVLRGHLH IADMVQIRDE LVTHPHSQLN SGSEEKEPLN EISAGELNER 660
  661 NENGNGGNKG SLGKLAGPIK SYGHRFLDNN ESLILITLGS NDTRNKSPSI SLSSEALAKV 720
  721 IGLETDCALS LVISCNDSID KSSVILDLPL DDNVDAVDFK VPFKVDYSHT LYFDIVPTYG 780
  781 TRSLETHNRI DCQKNNNNYV MARGVSMLNK SYSSVGVNRS ILNGSVTVPI IANHTLEILG 840
  841 TLKFEYIIIT PFEHPQLPLE RTETYWKSLV STRVIGHRGL GKNNPNKSLQ IGENTVESFI 900
  901 MAASLGASYV EFDVQLTKDN VPVVYHDFLV AETGVDIPMH ELTLEQFLDL NNADKEHIQR 960
  961 GAGHSPHHVN GADTALQKYR GRSVDDSDVS TLRRAWDLHD NDPNGKSNNA HWSDNRMRLT1020
 1021 KTFKKNNFKG NARGHSIASS FVTLKELFKK IPANVGFNIE CKFPMLDEAE EEELGQIMME1080
 1081 MNHWVDTVLK VVFDNANGRD IIFSSFHPDI CIMLSLKQPV IPILFLTEGG SEQMADLRAS1140
 1141 SLQNGIRFAK KWNLLGIVSA AAPILKAPRL VQVVKSNGLV CVTYGVDNND PENASIQIEA1200
 1201 GVDAVIVDSV LAIRRGLTKK NEK

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Krogan NJ, et al. (2006) GDE1 NET1
    View Details Ho Y, et al. (2002) ACO1 CDC60 CIC1 CKA1 CKA2 CKB1 CKB2 DBP10 DEF1 DMA2 DNL4 ENP2 FAA1 GDE1 HEF3 HHF1, HHF2 HOT1 HTA1 KGD1 KRI1 MAK16 MDH1 MRPL1 NOC3 NOP12 NOP15 NOP2 NOP7 NSA1 PDI1 PHO84 POB3 POL2 PRO2 PTC6 PUF6 PWP1 PXR1 PYC1 RAD1 RPF2 RRP14 RRP5 RRT6 SFP1 SPT16 SSF1 STH1 TEL1 TIF1, TIF2 TIF4631 TIF6 TPS1 TRL1 UTP22 VMR1 VPS73 WTM2 YFL034W YME2 YRA1 YTM1

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run PAN1 No Comments Toshima J, et al (2006)
    View Run ASF1 3912: TAP-tagged, strain background includes hpc2(delta) Green EM, et al (2005)
    View Run ZDS1 Sample 2- cpn2 from june 2005 McCusker D, et al (2007)
    View Run MLP2 #03 Alpha Factor Prep1-TiO2 Flowthrough Keck JM, et al. (2011)
    View Run MLP2 #12 Mitotic Prep1-TiO2 Flowthrough Keck JM, et al. (2011)
    View Run MLP2 #11 Mitotic Prep1-TiO2 enriched, new search criteria Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data GDE1 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..202] Pfam 50.102373 SPX domain No confident structure predictions are available.
    2 View Details [203..262] deduced N/A No confident structure predictions are available.
    3 View Details [263..366] PSI-BLAST 177.045757 Ankyrin-R
    4 View Details [367..499]
    [516..527]    		 PSI-BLAST 177.045757 Ankyrin-R
    5 View Details [500..515]
    [528..680]    		 PSI-BLAST 177.045757 Ankyrin-R
    6 View Details [681..748] PSI-BLAST 9.0 Swi6 ankyrin-repeat fragment
    7 View Details [749..857] deduced N/A No confident structure predictions are available.
    8 View Details [858..1039] PSI-BLAST 47.69897 Hypothetical protein TM1621
    9 View Details [1040..1223] Pfam 14.130768 Glycerophosphoryl diester phosphodiesterase family No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2 No functions predicted.
    3
    Term Confidence Notes
  • structural molecule activity
    		•  2.22255916855045 bayes_pls_golite062009
  • binding
    		•  1.62593430784178 bayes_pls_golite062009
  • protein binding
    		•  1.39636607384619 bayes_pls_golite062009
  • calcium-independent phospholipase A2 activity
    		•  0.621306773219824 bayes_pls_golite062009
    4 No functions predicted.
    5 No functions predicted.
    6
    Term Confidence Notes
  • glycerophosphodiester phosphodiesterase activity
    		•  4.27697417361287 bayes_pls_golite062009
  • phosphoric diester hydrolase activity
    		•  3.6633363681844 bayes_pls_golite062009
  • phospholipase activity
    		•  3.3535603060637 bayes_pls_golite062009
  • phosphoric ester hydrolase activity
    		•  2.89024275707278 bayes_pls_golite062009
  • phospholipase C activity
    		•  2.81479108775786 bayes_pls_golite062009
  • inositol or phosphatidylinositol phosphodiesterase activity
    		•  2.13368269358874 bayes_pls_golite062009
  • phosphoinositide phospholipase C activity
    		•  2.13368269358874 bayes_pls_golite062009
  • hydrolase activity
    		•  1.64631444998344 bayes_pls_golite062009
  • lipase activity
    		•  1.30779031242608 bayes_pls_golite062009
  • phosphatidylglycerol phospholipase C activity
    		•  1.28645679518658 bayes_pls_golite062009
  • catalytic activity
    		•  1.22328099675039 bayes_pls_golite062009
  • hydrolase activity, acting on ester bonds
    		•  1.21202479488854 bayes_pls_golite062009
  • binding
    		•  0.701659508863933 bayes_pls_golite062009
  • protein binding
    		•  0.137516733383577 bayes_pls_golite062009
    7 No functions predicted.
    8 No functions predicted.
    9 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.98

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle