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Catalysis of the reaction: RPO-R' + H2O = RPOOH + R'H. This reaction is the hydrolysis of any phosphoric ester bond, any ester formed from orthophosphoric acid, O=P(OH)3. Catalysis of the reaction: a phospholipid + H2O = 1,2-diacylglycerol + a phosphatidate. Catalysis of the reaction: a phosphatidylglycerol + H2O = 1,2-diacylglycerol + glycerol 3-phosphate. Catalysis of the hydrolysis of a phosphodiester to give a phosphomonoester and a free hydroxyl group. Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O = D-myo-inositol 1,4,5-trisphosphate + diacylglycerol. Catalysis of the reaction: a phosphatidylcholine + H2O = 1,2-diacylglycerol + choline phosphate; requires Ca2+. Catalysis of the reaction: phosphatidylcholine + H2O = 1,2-diacylglycerol + a choline phosphate. Catalysis of the hydrolysis of a glycerophospholipid. Catalysis of the hydrolysis of a lipid or phospholipid.

View Gene Ontology (GO) Term

GO TERM SUMMARY
Name: phospholipase C activity
Acc: GO:0004629
Aspect: Molecular Function
Desc: Catalysis of the reaction: a phospholipid + H2O = 1,2-diacylglycerol + a phosphatidate.
Synonyms:
  • GO:0042298
  • lecithinase C activity
  • lipophosphodiesterase C
  • phosphatidase C
Proteins in PDR annotated with:
   This term: 92 [Search]
   Term or descendants: 118 [Search]


[geneontology.org]
INTERACTIVE GO GRAPH

GO:0004629 - phospholipase C activity (interactive image map)
YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle