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Protein Overview: SME1

General Information:
Name(s) found: SME1 / YOR159C [SGD]
Description(s) found:
Found 31 descriptions.
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  • Core Sm protein Sm E; part of heteroheptameric complex (with Smb1p, Smd1p, Smd2p, Smd3p, Smx3p, and Smx2p) that is part of the spliceosomal U1, U2, U4, and U5 snRNPs; homolog of human Sm E [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 94 amino acids

    Gene Ontology:
    Cellular Component: U4/U6 x U5 tri-snRNP complex [IDALink to PubMed article][IPILink to PubMed article]
    U5 snRNP [IPILink to PubMed article]
    U1 snRNP [IDALink to PubMed articleLink to PubMed article]
    Biological Process: nuclear mRNA splicing, via spliceosome [IPILink to PubMed article]
    Molecular Function: RNA binding [IEA][RCA]
    molecular_function [ND]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSNKVKTKAM VPPINCIFNF LQQQTPVTIW LFEQIGIRIK GKIVGFDEFM NVVIDEAVEI  60
   61 PVNSADGKED VEKGTPLGKI LLKGDNITLI TSAD

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Riffle et al. (2010) (Unpublished Data) BRR2 CUS1 LSM5 LSM6 LSM7 LSM8 MUD1 PRP3 PRP4 PRP40 PRP6 PRP8 SMB1 SMD1 SMD2 SMD3 SME1 SMX3 SNP1 SNU66 SNU71
    View Details (MIPS) Mewes HW, et al. (2004) AAR2 BRR1 BRR2 CBC2 CDC40 CWC15 CWC2 CWC22 CWC23 DHR2 LSM4 MAK5 MUD2 PRP16 PRP18 PRP2 PRP22 PRP24 PRP28 PRP31 PRP38 PRP39 PRP4 PRP40 PRP43 PRP5 PRP6 PRP8 SLU7 SMD1 SMD3 SME1 SNP1 SPP2 SPP381 STO1 YHC1
    View Details Krogan NJ, et al. (2006) AAR2 BRR1 BRR2 CSE1 LUC7 MUD1 NAM8 PRP2 PRP3 PRP31 PRP39 PRP40 PRP42 PRP6 PRP8 RRG7 SMB1 SMD1 SMD2 SMD3 SME1 SMX2 SMX3 SNP1 SNU114 SNU56 SNU66 SNU71 TAD2 YDL085C-A YHC1 YJU2 YNL092W
    View Details Gavin AC, et al. (2002) AAR2 BRR1 BUD31 CBC2 CDC33 CEF1 CLF1 CSN12 CUS1 CWC2 CWC22 CWC23 DHH1 DIB1 ECM2 GCN2 HRT1 HSH155 HSH49 HTA1 IMG1 LEA1 LIN1 LSM1 LSM2 LSM4 LSM5 LSM6 LSM7 LUC7 MRP7 MRPL28 MRPL3 MRPL35 MRPL38 MRPL4 MRPL8 MRPS5 MSL1 MUD1 NAM8 NPL3 PAT1 PRP11 PRP18 PRP19 PRP21 PRP24 PRP28 PRP3 PRP31 PRP38 PRP39 PRP4 PRP40 PRP42 PRP43 PRP46 PRP6 PRP8 PRP9 RSE1 RVB2 SLU7 SMB1 SMD1 SMD2 SMD3 SME1 SMX2 SMX3 SNP1 SNT309 SNU114 SNU23 SNU56 SNU66 SNU71 SPP381 SPP382 SRB2 STO1 SYF1 TIF4631 TIF4632 TOS4 UTP21 YEF3 YML6
    View Details Qiu et al. (2008) AAR2 BRR1 BRR2 CBC2 CDC40 CEF1 CLF1 CUS1 CUS2 CWC15 CWC2 CWC22 CWC23 CWC25 DHR2 DIB1 ECM2 HSH155 IST3 ISY1 LEA1 LSM2 LSM3 LSM4 LSM5 LSM6 LSM7 LUC7 MAK5 MSL1 MUD1 MUD2 NAM8 NTC20 PRP11 PRP16 PRP18 PRP19 PRP2 PRP21 PRP22 PRP24 PRP28 PRP3 PRP31 PRP38 PRP39 PRP4 PRP40 PRP42 PRP43 PRP45 PRP5 PRP6 PRP8 PRP9 RSE1 SLU7 SMB1 SMD1 SMD2 SMD3 SME1 SMX2 SMX3 SNP1 SNT309 SNU114 SNU13 SNU23 SNU56 SNU66 SNU71 SPP2 SPP381 SPP382 STO1 SUB2 SYF1 SYF2 YHC1

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

      BAIT PREY HITS PUBLICATION
    View Screen GBP2 SME1 1 Unpublished Fields Lab Data
    View Screen RAD51 SME1 1 Unpublished Fields Lab Data

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..94] PSI-BLAST 15.0 Archaeal homoheptameric Sm protein

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
    		• 9.36615441177233 bayes_pls_golite062009
  • RNA binding
    		•  5.81718051012035 bayes_pls_golite062009
  • nucleic acid binding
    		•  2.69031444148163 bayes_pls_golite062009
  • mRNA binding
    		•  2.57166143288861 bayes_pls_golite062009
  • binding
    		•  2.44117021254507 bayes_pls_golite062009
  • protein binding
    		•  0.318488892917007 bayes_pls_golite062009


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.97

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle