Protein Overview: DCP1

General Information:
Name(s) found:	DCP1 / YOL149W [SGD]
Description(s) found: SHOW ONLY BEST	gi\|886947\|emb\|CAA88278.1\| orf3 [Saccharomyces cerevisiae] [NCBI NR] gi\|74645065\|sp\|Q12517.1\|DCP1_YEAST RecName: Full=mRNA-decapping enzyme subunit 1 [NCBI NR] gi\|6324423\|ref\|NP_014492.1\| Subunit of the Dcp1p-Dcp2p decapping enzyme complex, which removes the 5' cap structure from mRNAs prior to their degradation; enhances the activity of catalytic subunit Dcp2p; regulated by DEAD box protein Dhh1p; Dcp1p [Saccha [NCBI NR] gi\|46015331\|pdb\|1Q67\|B Chain B, Crystal Structure Of Dcp1p [NCBI NR] gi\|46015330\|pdb\|1Q67\|A Chain A, Crystal Structure Of Dcp1p [NCBI NR] gi\|45270752\|gb\|AAS56757.1\| YOL149W [Saccharomyces cerevisiae] [NCBI NR] pir\|\|S60387 decapping enzyme chain DCP1 - yeast (Saccharomyces cerevisiae) [NCBI NR] gi\|1420054\|emb\|CAA99170.1\| DCP1 [Saccharomyces cerevisiae] [NCBI NR] mRNA-decapping enzyme subunit 1 OS=Saccharomyces cerevisiae GN=DCP1 PE=1 SV=1 [Swiss-Prot] DCP1 mRNA decapping enzyme [mips] Subunit of the Dcp1p-Dcp2p decapping enzyme complex, which removes the 5' cap structure from mRNAs prior to their degradation; enhances the activity of catalytic subunit Dcp2p; regulated by DEAD box protein Dhh1p [SGD] >Q12517 (Q12517) Chromosome XV reading frame ORF YOL149W [4932.FASTACCERV.txt] Chr XV from 44936-45631 [hmr_yeast5_DM3-1_pombe.fasta] DCP1, Chr XV from 44936-45631 [yeast_orfs2] DCP1 SGDID:S0005509, Chr XV from 44936-45631, Verified ORF [yeastflysequest.fasta] Dcp1p [Saccharomyces cerevisiae]gi\|886947\|emb\|CAA88278.1\| orf3 [Saccharomyces cerevisiae]gi\|1420054\|emb\|CAA99170.1\| DCP1 [Saccharomyces cerevisiae]gi\|46015331\|pdb\|1Q67\|B Chain B, Crystal Structure Of Dcp1pgi\|46015330\|pdb\|1Q67\|A Chain A, Crystal Struct [nrdb_11152004_Chlamydomonas] (Q12517) DCP1 protein (Orf3 protein) (YOL149W) [cerv4932.FASTAC] DCP1 SGDID:S000005509, Chr XV from 44936-45631, Verified ORF, "Decapping enzyme, essential phosphoprotein component of mRNA decapping complex, plays key role in mRNA decay by cleaving off the 5' cap to leave the end susceptible to exonucleolytic degradati [SGD_S-cerevisiae_na_12-16-2005_con_reversed.fasta] DCP1 SGDID:S000005509, Chr XV from 44937-45632, Verified ORF, "Subunit of the Dcp1p-Dcp2p decapping enzyme complex, which removes the 5' cap structure from mRNAs prior to their degradation; enhances the activity of catalytic subunit Dcp2p; regulated by DE [yeast-contam.fasta] DCP1 [Saccharomyces cerevisiae] [nr-271106-contam.fasta] Chain B, Crystal Structure Of Dcp1p [nr-271106-contam.fasta] Chain A, Crystal Structure Of Dcp1p [nr-271106-contam.fasta] mRNA decapping enzyme subunit 1 [nr-271106-contam.fasta] Subunit of the Dcp1p-Dcp2p decapping enzyme complex, which removes the 5' cap structure from mRNAs prior to their degradation; enhances the activity of catalytic subunit Dcp2p; regulated by DEAD box protein Dhh1p; Dcp1p [Saccharomyces cerevisiae] [nr-271106-contam.fasta] YOL149W [Saccharomyces cerevisiae] [nr-271106-contam.fasta] orf3 [Saccharomyces cerevisiae] [nr-271106-contam.fasta] DCP1 SGDID:S000005509, Chr XV from 44937-45632, Verified ORF, "Subunit of the Dcp1p-Dcp2p decapping enzyme complex, which removes the 5' cap structure from mRNAs prior to their degradation; enhances the activity of catalytic subunit Dcp2p; regulated by DEAD box protein Dhh1p" [yeast-bovrabprots.fasta] [chemostatdb.fasta] mRNA-decapping enzyme subunit 1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=DCP1 PE=1 SV=1 [UniProt_S_cerevisiae_20120516_05-16-2012_reversed.fasta] DCP1 SGDID:S000005509, Chr XV from 44938-45633, Genome Release 64-1-1, Verified ORF, "Subunit of the Dcp1p-Dcp2p decapping enzyme complex, which removes the 5' cap structure from mRNAs prior to their degradation; enhances the activity of catalytic subunit Dcp2p; regulated by DEAD box protein Dhh1p" [yeast-030211-contam.fasta] DCP1 SGDID:S000005509, Chr XV from 44938-45633, Genome Release 64-2-1, Verified ORF, "Subunit of the Dcp1p-Dcp2p decapping enzyme complex; decapping complex removes the 5' cap structure from mRNAs prior to their degradation; enhances the activity of catalytic subunit Dcp2p; regulated by DEAD box protein Dhh1p; forms cytoplasmic foci upon DNA replication stress" [20141208_orf_trans.fasta] TR707\|c0_g1_i1\|g.472 ORF TR707\|c0_g1_i1\|g.472 TR707\|c0_g1_i1\|m.472 type:complete len:232 (+) TR707\|c0_g1_i1:78-773(+) [Y12_S_cerevisiae-Sep2015-contam.fasta] TR6632\|c0_g1_i1\|g.4809 ORF TR6632\|c0_g1_i1\|g.4809 TR6632\|c0_g1_i1\|m.4809 type:complete len:232 (+) TR6632\|c0_g1_i1:75-770(+) [DBVPG6044_S_cerevisiae-Sep2015-contam.fasta] YOL149W SGDID:S000005509, Chr XV from 44938-45633, Genome Release 64-1-1, Verified ORF, "Subunit of the Dcp1p-Dcp2p decapping enzyme complex, which removes the 5' cap structure from mRNAs prior to their degradation; enhances the activity of catalytic subunit Dcp2p; regulated by DEAD box protein Dhh1p" [2016-01-SGD_Yeast_Contam_Riffle_20140507-Ska-Hec-110-tubulin.fasta] asmbl_2091\|g.1824 ORF asmbl_2091\|g.1824 asmbl_2091\|m.1824 type:complete len:232 (+) asmbl_2091:74-769(+) [DBVPG6044_Trinity_v2_2_0_PASA_6May2016-contam.fasta] asmbl_2189\|g.1864 ORF asmbl_2189\|g.1864 asmbl_2189\|m.1864 type:complete len:232 (+) asmbl_2189:90-785(+) [Y12_Trinity_v2_2_0_PASA_6May2016-contam.fasta] ID=asmbl_2095\|g.1349 ORF ID=asmbl_2095\|g.1349 ID=asmbl_2095\|m.1349 type:complete len:232 (+) ID=asmbl_2095:74-769(+) [DBVPG6044_quiverGenomes_Trinity_v2_2_0_PASA_2June2016-contam.fasta] ID=asmbl_2192\|g.1333 ORF ID=asmbl_2192\|g.1333 ID=asmbl_2192\|m.1333 type:complete len:232 (+) ID=asmbl_2192:90-785(+) [Y12_quiver_Trinity_v2_2_0_PASA_2June2016-contam.fasta]
Organism:	Saccharomyces cerevisiae
Length:	231 amino acids
Gene Ontology:
Cellular Component:	cytoplasmic mRNA processing body [IDA][IMP]
Biological Process:	deadenylation-dependent decapping of nuclear-transcribed mRNA [IDA] mRNA catabolic process [TAS]
Molecular Function:	mRNA binding [IPI] enzyme activator activity [IDA] m7G(5')pppN diphosphatase activity [IDA]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MTGAATAAEN SATQLEFYRK ALNFNVIGRY DPKIKQLLFH TPHASLYKWD FKKDEWNKLE  60
   61 YQGVLAIYLR DVSQNTNLLP VSPQEVDIFD SQNGSNNIQV NNGSDNSNRN SSGNGNSYKS 120
  121 NDSLTYNCGK TLSGKDIYNY GLIILNRINP DNFSMGIVPN SVVNKRKVFN AEEDTLNPLE 180
  181 CMGVEVKDEL VIIKNLKHEV YGIWIHTVSD RQNIYELIKY LLENEPKDSF A

Protein Complex Data

	PUBLICATION	TOPOLOGY	COCOMPLEXED PROTEINS
View Details	Riffle et al. (2010) (Unpublished Data)		DCP1 DCP2 EDC3
View Details	Krogan NJ, et al. (2006)		DCP1 DCP2 EDC2 EDC3 PBY1
View Details	Gavin AC, et al. (2006)		DCP1 DCP2 EDC3
View Details	Gavin AC, et al. (2002)		DCP1 DCP2 EDC3 RPM2
View Details	Ho Y, et al. (2002)		ABP1 ACO1 AIM41 ATP4 BUD14 CAR2 COR1 CRZ1 CYS4 DCP1 DCP2 DNM1 EDC3 EDE1 EGD2 ENP1 GAS1 GCN3 GPH1 HHF1, HHF2 HRR25 HSP104 HXT7 HYP2 IPP1 LOC1 LSP1 LTV1 MDH1 MDS3 MGE1 NSA1 NUG1 OYE2 PEX19 PIL1 PIN4 PTC4 PUF3 RIO2 RPC19 RPM2 SAP185 SAP190 SAS10 SEC2 SEC23 SES1 SFB3 SGM1 SIT4 TMA19 TSR1 VMA4 YBR225W YER138C
View Details	Qiu et al. (2008)		DCP1 DCP2 DCS1 DCS2 EDC3 KEM1 LSM1 PAT1 RPB4

Mass Spectrometry Data

The following runs contain data for this protein:

	BAIT	COMMENTS	PUBLICATION
View Run	CEP3	sample cbf3 from feb 2005	Sandall S, et all (2006)

Yeast Two-Hybrid Data

The following interactions contain this protein:

NOT SHOWING SINGLE HITS. [ Show Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

	BAIT	PREY	HITS	PUBLICATION
View Screen	LSM2	DCP1	2	Uetz P, et al. (2000)
View Screen	LSM4	DCP1	2	Uetz P, et al. (2000)
View Screen	LSM8	DCP1	2	Uetz P, et al. (2000)

Microscopy / Localization Data

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	PROTEIN(S)	PUBLICATION
View Data	DCP1	Huh WK, et al. (2003)

Protein Structure Data

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[View Top Sequence Alignments] [Show Ginzu Version Information]

Domains predicted:

#		Region(s)	Method	Confidence	Match Description
1	View Details	[1..231]	deduced	N/A	No confident structure predictions are available.

Functions predicted (by domain):

Gene Ontology predictions

Term	Confidence	Notes
m7G(5')pppN diphosphatase activity	7.99932341873003	bayes_pls_golite062009
RNA binding	2.55097133772064	bayes_pls_golite062009
binding	2.05807773136211	bayes_pls_golite062009
protein binding	1.42524730253104	bayes_pls_golite062009
mRNA binding	1.14723961298833	bayes_pls_golite062009
structural molecule activity	0.748515192577617	bayes_pls_golite062009
hydrolase activity	0.223484823985325	bayes_pls_golite062009
nucleic acid binding	0.0780836662661571	bayes_pls_golite062009

Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

Philius Transmembrane Prediction:

Protein predicted to be:	GLOBULAR (No transmembrane regions or signal peptide)
Confidence of classification:	0.99

Source: Reynolds et al. (2008)

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2