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Protein Overview: MAC1

General Information:
Name(s) found: MAC1 / YMR021C [SGD]
Description(s) found:
Found 22 descriptions.
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  • Copper-sensing transcription factor involved in regulation of genes required for high affinity copper transport [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 417 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IDALink to PubMed article]
    Biological Process: response to drug [IMPLink to PubMed article]
    regulation of protein catabolic process [IMPLink to PubMed article]
    positive regulation of transcription from RNA polymerase II promoter [IDALink to PubMed article]
    cellular cadmium ion homeostasis [IMPLink to PubMed article]
    Molecular Function: specific RNA polymerase II transcription factor activity [IDALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MIIFNGNKYA CASCIRGHRS STCRHSHRML IKVRTRGRPS PMAIRDAILV DSTSQSTEYE  60
   61 NGAQIEGDCC SAMNQQPILF VRASAVRKAR MINGKLHILM EEGFTAHEPK DISTFTDDGN 120
  121 KYITETEFLR KHSPKAPATG TISPDSTKSS SSSEKKERSR LQQEPIRHFS NCCKKDKSQN 180
  181 PASNGKTNKA PSDDIFTPYG SLESTSAFND ILQENYNSSV PGAHDSSETL TPQSTTTIAA 240
  241 PHSSDVASKV EVLTHKGIFL STQCSCEDES CPCVNCLIHR SEEELNSYIQ QSGVPLTNIG 300
  301 EAQITDKMMD YLDDCKCTDK ECICPPDNCT CDGCFSHSTN IIPFEKFFFY GILNARLTRK 360
  361 TQIKFKGKLV PSKYWWDFLK LQVPLMTDAQ LELLDIHAWF QKLVSNYAPH LSDATTS

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Riffle et al. (2010) (Unpublished Data) MAC1 YFR006W
    View Details Gavin AC, et al. (2002) BDF2 CDC55 CKB1 DYN1 ECM5 GLY1 HAT1 HAT2 HHF1, HHF2 HIF1 HSM3 ICL1 IML1 KAP123 KRE33 LIP2 MAC1 MDN1 MIS1 MSB1 NIP1 NMD5 PFK1 PRO1 PRT1 PSD2 PSE1 PSH1 RPA135 RPC40 RPG1 RPN12 RPN3 RPN6 RPN8 RPN9 RPT2 RPT3 RPT5 RPT6 RSC3 SAM1 TEL1 TSC11 USO1 UTP20 VTH2 YFR006W YPR077C

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run RPA135 No Comments Schneider, DA, et al. (2006)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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      PROTEIN(S) PUBLICATION
    View Data MAC1 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..61] PSI-BLAST 65.703922 Zinc domain conserved in yeast copper-regulated transcription factors
    2 View Details [62..417] deduced N/A No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • RNA polymerase II transcription factor activity
    		•  3.46199909835403 bayes_pls_golite062009
  • transcription regulator activity
    		•  3.44900037030135 bayes_pls_golite062009
  • specific RNA polymerase II transcription factor activity
    		•  2.99240619437226 bayes_pls_golite062009
  • binding
    		•  2.00508289492248 bayes_pls_golite062009
  • ligand-regulated transcription factor activity
    		•  0.749213234767051 bayes_pls_golite062009
  • cation binding
    		•  0.0994209760375689 bayes_pls_golite062009
  • metal ion binding
    		•  0.0994209760375689 bayes_pls_golite062009
  • ion binding
    		•  0.0960196890797145 bayes_pls_golite062009
    2 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle