YRC Public Data Repository - Protein Structure Prediction

Protein:	MAC1
Organism:	Saccharomyces cerevisiae
Length:	417 amino acids
Reference:	Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for MAC1.

Description	E-value	Query Range	Subject Range
MAC1_YEAST - Metal-binding activator 1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=MAC1 PE=1 SV=2 MAC1 - Copper-sensing transcription factor involved in regulation of genes required for high affinity coppe... gi\|190408260 - gi\|190408260\|gb\|EDV11525.1\| metal-binding transcriptional activator [Saccharomyces cerevisiae RM11-1...	0.0	[1..417]	[1..417]
AMT1_CANGA - Metal-activated transcriptional activator protein AMT1 OS=Candida glabrata GN=AMT1 PE=1 SV=1 AMT1_CANGA - Metal-activated transcriptional activator protein AMT1 OS=Candida glabrata (strain ATCC 2001 / CBS 1...	1.0E-45	[1..153]	[1..131]
CRF1_YARLI - Copper resistance protein CRF1 OS=Yarrowia lipolytica GN=CRF1 PE=4 SV=1 CRF1_YARLI - Copper resistance protein CRF1 OS=Yarrowia lipolytica (strain CLIB 122 / E 150) GN=CRF1 PE=3 SV=1	6.0E-17	[1..60]	[1..53]
cuf1 - Cu metalloregulatory transcription factor Cuf1 CUF1_SCHPO - Metal-binding regulatory protein cuf1 OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=cuf1...	4.0E-14	[1..48]	[1..48]
gi\|7507776 - gi\|7507776\|pir\|\|T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans	2.0E-12	[1..43]	[1..44]

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Predicted Domain #1

Region A:
Residues: [1-61]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MIIFNGNKYA CASCIRGHRS STCRHSHRML IKVRTRGRPS PMAIRDAILV DSTSQSTEYE  60
   61 N

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	65.703922
Match:	1co4A_
Description:	Zinc domain conserved in yeast copper-regulated transcription factors
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
RNA polymerase II transcription factor activity	3.46199909835403	bayes_pls_golite062009
transcription regulator activity	3.44900037030135	bayes_pls_golite062009
specific RNA polymerase II transcription factor activity	2.99240619437226	bayes_pls_golite062009
binding	2.00508289492248	bayes_pls_golite062009
ligand-regulated transcription factor activity	0.749213234767051	bayes_pls_golite062009
cation binding	0.0994209760375689	bayes_pls_golite062009
metal ion binding	0.0994209760375689	bayes_pls_golite062009
ion binding	0.0960196890797145	bayes_pls_golite062009

Predicted Domain #2

Region A:
Residues: [62-417]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GAQIEGDCCS AMNQQPILFV RASAVRKARM INGKLHILME EGFTAHEPKD ISTFTDDGNK  60
   61 YITETEFLRK HSPKAPATGT ISPDSTKSSS SSEKKERSRL QQEPIRHFSN CCKKDKSQNP 120
  121 ASNGKTNKAP SDDIFTPYGS LESTSAFNDI LQENYNSSVP GAHDSSETLT PQSTTTIAAP 180
  181 HSSDVASKVE VLTHKGIFLS TQCSCEDESC PCVNCLIHRS EEELNSYIQQ SGVPLTNIGE 240
  241 AQITDKMMDY LDDCKCTDKE CICPPDNCTC DGCFSHSTNI IPFEKFFFYG ILNARLTRKT 300
  301 QIKFKGKLVP SKYWWDFLKL QVPLMTDAQL ELLDIHAWFQ KLVSNYAPHL SDATTS

[Run NCBI BLAST on this sequence.]

Detection Method:

deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: