Protein Overview: PCT1

General Information:
Name(s) found:	PCT1 / YGR202C [SGD]
Description(s) found: SHOW ONLY BEST	gi\|790493\|emb\|CAA88995.1\| cholinephosphate cytidylyltransferase [Saccharomyces cerevisiae] [NCBI NR] gi\|6321641\|ref\|NP_011718.1\| Cholinephosphate cytidylyltransferase, also known as CTP:phosphocholine cytidylyltransferase, rate-determining enzyme of the CDP-choline pathway for phosphatidylcholine synthesis, inhibited by Sec14p, activated upon lipid-bindi [NCBI NR] gi\|52788237\|sp\|P13259.2\|PCY1_YEAST RecName: Full=Choline-phosphate cytidylyltransferase; AltName: Full=Phosphorylcholine transferase; AltName: Full=CTP:phosphocholine cytidylyltransferase; Short=CCT; Short=CT [NCBI NR] gi\|45269571\|gb\|AAS56166.1\| YGR202C [Saccharomyces cerevisiae] [NCBI NR] pir\|\|XNBYCP choline-phosphate cytidylyltransferase (EC 2.7.7.15) - yeast (Saccharomyces cerevisiae) [NCBI NR] gi\|1323361\|emb\|CAA97229.1\| PCT1 [Saccharomyces cerevisiae] [NCBI NR] Choline-phosphate cytidylyltransferase OS=Saccharomyces cerevisiae GN=PCT1 PE=1 SV=2 [Swiss-Prot] (P13259) Choline-phosphate cytidylyltransferase (EC 2.7.7.15) (Phosphorylcholine transferase) (CTP:phosphocholine cytidylyltransferase) (CT) (CCT) [Swiss-Prot] PCT1 Cholinephosphate cytidylyltransferase [mips] Cholinephosphate cytidylyltransferase, also known as CTP:phosphocholine cytidylyltransferase, rate-determining enzyme of the CDP-choline pathway for phosphatidylcholine synthesis, inhibited by Sec14p, activated upon lipid-binding [SGD] PCT1, Chr VII from 903469-904743, reverse complement [yeast_orfs2] Chr VII from 903469-904743, reverse complement [yeastorf3.fasta] Chr VII from 903476-904750, reverse complement [yeastorf4.fasta] Chr VII from 904750-903476, reverse complement [yeastorf5.fasta] PCT1 SGDID:S0003434, Chr VII from 904751-903477, reverse complement, Verified ORF [yeastflysequest.fasta] PCT1 SGDID:S0003434, Chr VII from 904753-903479, reverse complement, Verified ORF [10112005cervSGD.fasta] Cholinephosphate cytidylyltransferase, also known as CTP:phosphocholine cytidylyltransferase, rate-determining enzyme of the CDP-choline pathway for phosphatidylcholine synthesis, inhibited by Sec14p, activated upon lipid-binding [Saccharomyces cerevisiae [nrdb_11152004_Chlamydomonas] PCT1 SGDID:S000003434, Chr VII from 904753-903479, reverse complement, Verified ORF, "Cholinephosphate cytidylyltransferase, also known as CTP:phosphocholine cytidylyltransferase, rate-determining enzyme of the CDP-choline pathway for phosphatidylcholine [SGD_S-cerevisiae_na_12-16-2005_con_reversed.fasta] Cholinephosphate cytidylyltransferase, also known as CTP:phosphocholine cytidylyltransferase, rate-determining enzyme of the CDP-choline pathway for phosphatidylcholine synthesis, inhibited by Sec14p, activated upon lipid-binding; Pct1p [Saccharomyces cer [nr-271106-contam.fasta] YGR202C [Saccharomyces cerevisiae] [nr-271106-contam.fasta] cholinephosphate cytidylyltransferase [Saccharomyces cerevisiae] [nr-271106-contam.fasta] PCT1 [Saccharomyces cerevisiae] [nr-271106-contam.fasta] Choline-phosphate cytidylyltransferase (Phosphorylcholine transferase) (CTP:phosphocholine cytidylyltransferase) (CT) (CCT) [nr-271106-contam.fasta] PCT1 SGDID:S000003434, Chr VII from 904753-903479, reverse complement, Verified ORF, "Cholinephosphate cytidylyltransferase, also known as CTP:phosphocholine cytidylyltransferase, rate-determining enzyme of the CDP-choline pathway for phosphatidylcholine synthesis, inhibited by Sec14p, activated upon lipid-binding" [yeast-bovrabprots.fasta] [chemostatdb.fasta] Choline-phosphate cytidylyltransferase OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=PCT1 PE=1 SV=2 [UniProt_S_cerevisiae_20120516_05-16-2012_reversed.fasta] PCT1 SGDID:S000003434, Chr VII from 904748-903474, Genome Release 64-1-1, reverse complement, Verified ORF, "Cholinephosphate cytidylyltransferase, also known as CTP:phosphocholine cytidylyltransferase, rate-determining enzyme of the CDP-choline pathway for phosphatidylcholine synthesis, inhibited by Sec14p, activated upon lipid-binding" [yeast-030211-contam.fasta] PCT1 SGDID:S000003434, Chr VII from 904748-903474, Genome Release 64-2-1, reverse complement, Verified ORF, "Cholinephosphate cytidylyltransferase; a rate-determining enzyme of the CDP-choline pathway for phosphatidylcholine synthesis, inhibited by Sec14p, activated upon lipid-binding; contains an element within the regulatory domain involved in both silencing and activation of enzymatic activity" [20141208_orf_trans.fasta] YGR202C SGDID:S000003434, Chr VII from 904748-903474, Genome Release 64-1-1, reverse complement, Verified ORF, "Cholinephosphate cytidylyltransferase, also known as CTP:phosphocholine cytidylyltransferase, rate-determining enzyme of the CDP-choline pathway for phosphatidylcholine synthesis, inhibited by Sec14p, activated upon lipid-binding" [2016-01-SGD_Yeast_Contam_Riffle_20140507-Ska-Hec-110-tubulin.fasta]
Organism:	Saccharomyces cerevisiae
Length:	424 amino acids
Gene Ontology:
Cellular Component:	nuclear envelope [IDA] nucleus [IDA] Golgi apparatus [TAS]
Biological Process:	CDP-choline pathway [IDA] phosphatidylcholine biosynthetic process [IDA]
Molecular Function:	choline-phosphate cytidylyltransferase activity [IDA]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MANPTTGKSS IRAKLSNSSL SNLFKKNKNK RQREETEEQD NEDKDESKNQ DENKDTQLTP  60
   61 RKRRRLTKEF EEKEARYTNE LPKELRKYRP KGFRFNLPPT DRPIRIYADG VFDLFHLGHM 120
  121 KQLEQCKKAF PNVTLIVGVP SDKITHKLKG LTVLTDKQRC ETLTHCRWVD EVVPNAPWCV 180
  181 TPEFLLEHKI DYVAHDDIPY VSADSDDIYK PIKEMGKFLT TQRTNGVSTS DIITKIIRDY 240
  241 DKYLMRNFAR GATRQELNVS WLKKNELEFK KHINEFRSYF KKNQTNLNNA SRDLYFEVRE 300
  301 ILLKKTLGKK LYSKLIGNEL KKQNQRQRKQ NFLDDPFTRK LIREASPATE FANEFTGENS 360
  361 TAKSPDDNGN LFSQEDDEDT NSNNTNTNSD SDSNTNSTPP SEDDDDNDRL TLENLTQKKK 420
  421 QSAN

Protein Complex Data

	PUBLICATION	TOPOLOGY	COCOMPLEXED PROTEINS
View Details	Krogan NJ, et al. (2006)		CBC2 KAP95 NUP1 NUP2 NUP60 OGG1 PCT1 RAD53 SRP1 STO1 ULP1 URB2 YRA2
View Details	Ho Y, et al. (2002)		ARG4 AYR1 COR1 CPR6 DIS3 EAF3 ERG27 FIP1 GPT2 HAS1 HPR1 KAP95 LIA1 MAE1 MES1 MFT1 NAM8 NOP6 NUP1 NUP2 NUP60 OM45 PAP1 PCT1 PDA1 PET10 PET9 PIL1 PRE10 PRO3 REB1 RET2 RNR2 RNT1 RRP4 RRP43 RRP6 RTN2 RTT103 RVS161 SEC18 SEC21 SEC26 SEC27 SEC28 SIF2 SIN3 SNU56 SRP1 STO1 THO2 TIF34 TIF35 TPA1 TRA1 UME1 YNL181W YPR090W

Mass Spectrometry Data

The following runs contain data for this protein:

	BAIT	COMMENTS	PUBLICATION
View Run	CEP3	sample cbf3 from feb 2005	Sandall S, et all (2006)

Yeast Two-Hybrid Data

The following interactions contain this protein:

NOT SHOWING SINGLE HITS. [ Show Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

No yeast two-hybrid interactions found for this protein.

	PROTEIN(S)	PUBLICATION
View Data	PCT1 and NIC96	Huh WK, et al. (2003)
View Data	PCT1	Huh WK, et al. (2003)

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

#		Region(s)	Method	Confidence	Match Description
1	View Details	[1..100]	deduced	N/A	No confident structure predictions are available.
2	View Details	[101..251]	PSI-BLAST	101.68867	CTP:glycerol-3-phosphate cytidylyltransferase
3	View Details	[252..424]	deduced	N/A	Confident ab initio structure predictions are available.

Protein predicted to be:	GLOBULAR (No transmembrane regions or signal peptide)
Confidence of classification:	0.99

Protein Overview: PCT1

Protein Complex Data

Mass Spectrometry Data

Yeast Two-Hybrid Data

Microscopy / Localization Data

Protein Structure Data

Philius Transmembrane Prediction: