YRC Logo
PROTEIN SEARCH:
Descriptions Names[Advanced Search]

Protein Overview: RPN14

General Information:
Name(s) found: RPN14 / YGL004C [SGD]
Description(s) found:
Found 33 descriptions.
SHOW ALL
  • Proteasome-interacting protein involved in the assembly of the base subcomplex of the 19S proteasome regulatory particle (RP); null mutants accumulate ubiquitinated Gcn4p and display decreased 26S proteasome stability; interacts with Rpt5p [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 417 amino acids

    Gene Ontology:
    Cellular Component: cytoplasm [IDALink to PubMed article]
    proteasome regulatory particle [RCALink to PubMed article]
    Biological Process: proteolysis [RCALink to PubMed article]
    ubiquitin-dependent protein catabolic process [RCALink to PubMed article]
    Molecular Function: molecular_function [ND]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MTKTITVAHI QYDFKAVLEE NDENDDEFYI NVDKNLNEIK EHKIVVLGNS RGVDAGKGNT  60
   61 FEKVGSHLYK ARLDGHDFLF NTIIRDGSKM LKRADYTAVD TAKLQMRRFI LGTTEGDIKV 120
  121 LDSNFNLQRE IDQAHVSEIT KLKFFPSGEA LISSSQDMQL KIWSVKDGSN PRTLIGHRAT 180
  181 VTDIAIIDRG RNVLSASLDG TIRLWECGTG TTIHTFNRKE NPHDGVNSIA LFVGTDRQLH 240
  241 EISTSKKNNL EFGTYGKYVI AGHVSGVITV HNVFSKEQTI QLPSKFTCSC NSLTVDGNNA 300
  301 NYIYAGYENG MLAQWDLRSP ECPVGEFLIN EGTPINNVYF AAGALFVSSG FDTSIKLDII 360
  361 SDPESERPAI EFETPTFLVS NDDEVSQFCY VSDDESNGEV LEVGKNNFCA LYNLSNP

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Riffle et al. (2010) (Unpublished Data) RPN1 RPN11 RPN14 RPN5 RPN6 RPT2 RPT4 RPT5
    View Details Krogan NJ, et al. (2006) CSI1 CSN9 ERV46 FPR2 HUL5 IQG1 MOT1 MPT5 NAS6 NMD3 NPT1 PCI8 PEP1 PST1 PUS9 RPN1 RPN10 RPN11 RPN12 RPN13 RPN14 RPN2 RPN5 RPN6 RPN7 RPN8 RPN9 RPT1 RPT2 RPT3 RPT4 RPT5 RPT6 RRI1 RRI2 SEC18 SEM1 SKP1 SPG5 SPO77 SQT1 SWA2 TCB2 TIP41 TOD6 TOR2 TSR4 UBP6 YEN1 YKL027W YMR258C YNL022C YPR003C YPT52
    View Details Ho Y, et al. (2002) ARP2 CPR6 HSM3 HYP2 IDH2 LHS1 MDN1 MKT1 NAS6 POR1 RPN1 RPN10 RPN11 RPN12 RPN13 RPN14 RPN3 RPN5 RPN6 RPN7 RPN8 RPN9 RPT1 RPT2 RPT3 RPT4 RPT5 RVB2 STI1 UBC12

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run MLP2 #26 Asynchronous Prep4-TiO2 Phosphopeptide enriched, Steps1-2 Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

      BAIT PREY HITS PUBLICATION
    View Screen UBP6 RPN14 1 Unpublished Fields Lab Data
    View Screen YLR132C RPN14 1 Hazbun TR, et al. (2003)

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data RPN14 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..417] PSI-BLAST 126.68867 Tup1, C-terminal domain
    2 View Details [358..417] PSI-BLAST 65.39794 F-box/WD-repeat protein 1 (beta-TRCP1)

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • binding
    		•  2.2778252170547 bayes_pls_golite062009
  • protein binding
    		•  1.42618832381942 bayes_pls_golite062009
  • ubiquitin-protein ligase activity
    		•  1.27579156500929 bayes_pls_golite062009
  • small conjugating protein ligase activity
    		•  1.25374976623953 bayes_pls_golite062009
  • nucleic acid binding
    		•  0.693814013902061 bayes_pls_golite062009
  • acid-amino acid ligase activity
    		•  0.372795124253564 bayes_pls_golite062009
  • transcription regulator activity
    		•  0.190100099674138 bayes_pls_golite062009
    2 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.97

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle