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Protein Overview: GLY1

General Information:
Name(s) found: GLY1 / YEL046C [SGD]
Description(s) found:
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  • gi|6320789|ref|NP_010868.1| Threonine aldolase, catalyzes the cleavage of L-allo-threonine and L-threonine to glycine; involved in glycine biosynthesis; Gly1p [Saccharomyces cerevisiae] [NCBI NR]
  • gi|603634|gb|AAB64996.1| Gly1p [Saccharomyces cerevisiae] [NCBI NR]
  • pir||S30831 GLY1 protein - yeast (Saccharomyces cerevisiae) [NCBI NR]
  • GLY1 L-threonine aldolase, low-specific [mips]
  • Threonine aldolase, catalyzes the cleavage of L-allo-threonine and L-threonine to glycine; involved in glycine biosynthesis [SGD]
  • GLY1, Chr V from 67629-68792, reverse complement [yeast_orfs2]
  • Chr V from 67629-68792, reverse complement [yeastorf3.fasta]
  • Chr V from 68792-67629, reverse complement [yeastorf5.fasta]
  • GLY1 SGDID:S0000772, Chr V from 68792-67629, reverse complement, Verified ORF [yeastflysequest.fasta]
  • Gly1p [Saccharomyces cerevisiae]gi|320732|pir||S30831 GLY1 protein - yeast (Saccharomyces cerevisiae)gi|603634|gb|AAB64996.1| Gly1p [Saccharomyces cerevisiae] [nrdb_11152004_Chlamydomonas]
  • GLY1 SGDID:S000000772, Chr V from 68792-67629, reverse complement, Verified ORF, "Threonine aldolase, catalyzes the cleavage of L-allo-threonine and L-threonine to glycine; involved in glycine biosynthesis" [SGD_S-cerevisiae_na_12-16-2005_con_reversed.fasta]
  • Threonine aldolase, catalyzes the cleavage of L-allo-threonine and L-threonine to glycine; involved in glycine biosynthesis; Gly1p [Saccharomyces cerevisiae] [nr-271106-contam.fasta]
  • Gly1p [Saccharomyces cerevisiae] [nr-271106-contam.fasta]
  • [chemostatdb.fasta]
  • Low specificity L-threonine aldolase OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=GLY1 PE=1 SV=2 [UniProt_S_cerevisiae_20120516_05-16-2012_reversed.fasta]
  • GLY1 SGDID:S000000772, Chr V from 68792-67629, Genome Release 64-1-1, reverse complement, Verified ORF, "Threonine aldolase, catalyzes the cleavage of L-allo-threonine and L-threonine to glycine; involved in glycine biosynthesis" [yeast-030211-contam.fasta]
  • GLY1 SGDID:S000000772, Chr V from 68792-67629, Genome Release 64-2-1, reverse complement, Verified ORF, "Threonine aldolase; catalyzes the cleavage of L-allo-threonine and L-threonine to glycine; involved in glycine biosynthesis" [20141208_orf_trans.fasta]
  • YEL046C SGDID:S000000772, Chr V from 68792-67629, Genome Release 64-1-1, reverse complement, Verified ORF, "Threonine aldolase, catalyzes the cleavage of L-allo-threonine and L-threonine to glycine; involved in glycine biosynthesis" [2016-01-SGD_Yeast_Contam_Riffle_20140507-Ska-Hec-110-tubulin.fasta]
    • Organism: Saccharomyces cerevisiae
    Length: 387 amino acids

    Gene Ontology:
    Cellular Component: cytosol [IDALink to PubMed article]
    Biological Process: glycine biosynthetic process [IDALink to PubMed article]
    threonine catabolic process [IDALink to PubMed article]
    Molecular Function: threonine aldolase activity [IDALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MTEFELPPKY ITAANDLRSD TFTTPTAEMM EAALEASIGD AVYGEDVDTV RLEQTVARMA  60
   61 GKEAGLFCVS GTLSNQIAIR THLMQPPYSI LCDYRAHVYT HEAAGLAILS QAMVVPVVPS 120
  121 NGDYLTLEDI KSHYVPDDGD IHGAPTRLIS LENTLHGIVY PLEELVRIKA WCMENGLKLH 180
  181 CDGARIWNAA AQSGVPLKQY GEIFDSISIC LSKSMGAPIG SVLVGNLKFV KKATHFRKQQ 240
  241 GGGIRQSGMM ARMALVNINN DWKSQLLYSH SLAHELAEYC EAKGIPLESP ADTNFVFINL 300
  301 KAARMDPDVL VKKGLKYNVK LMGGRVSFHY QVTRDTLEKV KLAISEAFDY AKEHPFDCNG 360
  361 PTQIYRSEST EVDVDGNAIR EIKTYKY

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Gavin AC, et al. (2002) BDF2 CDC55 CKB1 DYN1 ECM5 GLY1 HAT1 HAT2 HHF1, HHF2 HIF1 HSM3 ICL1 IML1 KAP123 KRE33 LIP2 MAC1 MDN1 MIS1 MSB1 NIP1 NMD5 PFK1 PRO1 PRT1 PSD2 PSE1 PSH1 RPA135 RPC40 RPG1 RPN12 RPN3 RPN6 RPN8 RPN9 RPT2 RPT3 RPT5 RPT6 RSC3 SAM1 TEL1 TSC11 USO1 UTP20 VTH2 YFR006W YPR077C

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run RPA135 his-HA tag on RPA135 Schneider, DA, et al. (2006)
    View Run MLP2 #19 Asynchronous Prep1-TiO2 Phosphopeptide enrichment Keck JM, et al. (2011)
    View Run MLP2 #19b Asynchronous Prep1-new search criteria Keck JM, et al. (2011)
    View Run MLP2 #19a Asynchronous Prep1-new search criteria Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

      BAIT PREY HITS PUBLICATION
    View Screen SPE1 GLY1 2 Unpublished Fields Lab Data
    View Screen YHR122W GLY1 1 Hazbun TR, et al. (2003)

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data GLY1 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..19]
    [269..387]    		 PSI-BLAST 524.39794 Low-specificity threonine aldolase
    2 View Details [20..268] PSI-BLAST 524.39794 Low-specificity threonine aldolase

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • glycine dehydrogenase (decarboxylating) activity
    		•  2.63753310919108 bayes_pls_golite062009
  • oxidoreductase activity, acting on the CH-NH2 group of donors, disulfide as acceptor
    		•  2.63753310919108 bayes_pls_golite062009
  • transferase activity
    		•  2.59075614411581 bayes_pls_golite062009
  • threonine aldolase activity
    		•  2.36742457876142 bayes_pls_golite062009
  • catalytic activity
    		•  2.29878871754893 bayes_pls_golite062009
  • L-aspartate:2-oxoglutarate aminotransferase activity
    		•  1.87460342369605 bayes_pls_golite062009
  • transcription regulator activity
    		•  1.67701710033155 bayes_pls_golite062009
  • DNA binding
    		•  1.4774443071095 bayes_pls_golite062009
  • nucleic acid binding
    		•  1.39741122443159 bayes_pls_golite062009
  • transferase activity, transferring nitrogenous groups
    		•  1.28316822767388 bayes_pls_golite062009
  • transaminase activity
    		•  1.24990480711889 bayes_pls_golite062009
  • transcription factor activity
    		•  1.15775909410582 bayes_pls_golite062009
  • binding
    		•  1.09053123792737 bayes_pls_golite062009
  • O-phospho-L-serine:2-oxoglutarate aminotransferase activity
    		•  0.994935084630764 bayes_pls_golite062009
  • methyltransferase activity
    		•  0.681623261233707 bayes_pls_golite062009
  • transferase activity, transferring one-carbon groups
    		•  0.60304280865376 bayes_pls_golite062009
  • glycine C-acetyltransferase activity
    		•  0.367632398200112 bayes_pls_golite062009
  • structural molecule activity
    		•  0.347975812448725 bayes_pls_golite062009
  • glycine hydroxymethyltransferase activity
    		•  0.271623203801431 bayes_pls_golite062009
  • pyridoxal phosphate binding
    		•  0.16957228630576 bayes_pls_golite062009
  • vitamin B6 binding
    		•  0.16957228630576 bayes_pls_golite062009
  • L-allo-threonine aldolase activity
    		•  0.140152839681041 bayes_pls_golite062009
  • carbon-carbon lyase activity
    		•  0.11598778799668 bayes_pls_golite062009
  • 4-aminobutyrate transaminase activity
    		•  0.0779403509221881 bayes_pls_golite062009
    2 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.96

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle