Protein Overview: NGG1

General Information:
Name(s) found:	NGG1 / YDR176W [SGD]
Description(s) found: SHOW ONLY BEST	gi\|6320381\|ref\|NP_010461.1\| Transcriptional regulator involved in glucose repression of Gal4p-regulated genes; component of transcriptional adaptor and histone acetyltransferase complexes, the ADA complex, the SAGA complex, and the SLIK complex; Ngg1p [Sa [NCBI NR] pir\|\|S41685 NGG1 protein - yeast (Saccharomyces cerevisiae) [NCBI NR] gi\|417358\|sp\|P32494.1\|NGG1_YEAST RecName: Full=Chromatin-remodeling complexes subunit NGG1; AltName: Full=Transcriptional adapter 3 [NCBI NR] gi\|172040\|gb\|AAA21684.1\| NGG1 [Saccharomyces cerevisiae] [NCBI NR] gi\|1289291\|emb\|CAA86681.1\| Ngg1p [Saccharomyces cerevisiae] [NCBI NR] Chromatin-remodeling complexes subunit NGG1 OS=Saccharomyces cerevisiae GN=NGG1 PE=1 SV=1 [Swiss-Prot] Transcriptional adapter 3 - Saccharomyces cerevisiae (Baker's yeast) [Swiss-Prot] NGG1 General transcriptional adaptor or co-activator [mips] Transcriptional regulator involved in glucose repression of Gal4p-regulated genes; component of transcriptional adaptor and histone acetyltransferase complexes, the ADA complex, the SAGA complex, and the SLIK complex [SGD] NGG1, Chr IV from 814445-816553 [yeast_orfs2] Chr IV from 814445-816553 [yeastorf3.fasta] (P32494) Transcriptional adapter 3 (NGG1 protein) [4932.FASTACCERV.txt] NGG1 SGDID:S0002583, Chr IV from 814446-816554, Verified ORF [yeastflysequest.fasta] NGG1 SGDID:S0002583, Chr IV from 814447-816555, Verified ORF [10112005cervSGD.fasta] Involved in glucose repression of GAL4p-regulated transcription; transcription factor; genetic and mutant analyses suggest that Ngg1p (Ada3p) is part of two transcriptional adaptor/HAT (histone acetyltransferase complexes, the 0.8 MD ADA complex and the 1 [nrdb_11152004_Chlamydomonas] NGG1 SGDID:S000002583, Chr IV from 814447-816555, Verified ORF, "Transcriptional regulator involved in glucose repression of Gal4p-regulated genes; component of transcriptional adaptor and histone acetyltransferase complexes, the ADA complex, the SAGA com [SGD_S-cerevisiae_na_12-16-2005_con_reversed.fasta] NGG1 SGDID:S000002583, Chr IV from 814449-816557, Verified ORF, "Transcriptional regulator involved in glucose repression of Gal4p-regulated genes; component of transcriptional adaptor and histone acetyltransferase complexes, the ADA complex, the SAGA com [yeast-contam.fasta] NGG1 SGDID:S000002583, Chr IV from 814450-816558, Verified ORF, "Transcriptional regulator involved in glucose repression of Gal4p-regulated genes; component of transcriptional adaptor and histone acetyltransferase complexes, the ADA complex, the SAGA com [SGD_S-cerevisiae_na_08-19-2008_con_reversed.fasta] Transcriptional regulator involved in glucose repression of Gal4p-regulated genes; component of transcriptional adaptor and histone acetyltransferase complexes, the ADA complex, the SAGA complex, and the SLIK complex; Ngg1p [Saccharomyces cerevisiae] [nr-271106-contam.fasta] NGG1 [nr-271106-contam.fasta] Transcriptional adapter 3 (Protein NGG1) [nr-271106-contam.fasta] Ngg1p [Saccharomyces cerevisiae] [nr-271106-contam.fasta] NGG1 SGDID:S000002583, Chr IV from 814450-816558, Verified ORF, "Transcriptional regulator involved in glucose repression of Gal4p-regulated genes; component of transcriptional adaptor and histone acetyltransferase complexes, the ADA complex, the SAGA complex, and the SLIK complex" [yeast-bovrabprots.fasta] NGG1 SGDID:S000002583, Chr IV from 814449-816557, Verified ORF, "Transcriptional regulator involved in glucose repression of Gal4p-regulated genes; component of transcriptional adaptor and histone acetyltransferase complexes, the ADA complex, the SAGA complex, and the SLIK complex" [yeast-contam_custom.fasta] [chemostatdb.fasta] Chromatin-remodeling complexes subunit NGG1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=NGG1 PE=1 SV=1 [UniProt_S_cerevisiae_20120516_05-16-2012_reversed.fasta] NGG1 SGDID:S000002583, Chr IV from 814452-816560, Genome Release 64-1-1, Verified ORF, "Transcriptional regulator involved in glucose repression of Gal4p-regulated genes; component of transcriptional adaptor and histone acetyltransferase complexes, the ADA complex, the SAGA complex, and the SLIK complex" [yeast-030211-contam.fasta] NGG1 SGDID:S000002583, Chr IV from 814452-816560, Genome Release 64-2-1, Verified ORF, "Subunit of chromatin modifying histone acetyltransferase complexes; member of the ADA complex, the SAGA complex, and the SLIK complex; transcriptional regulator involved in glucose repression of Gal4p-regulated genes" [20141208_orf_trans.fasta] YDR176W SGDID:S000002583, Chr IV from 814452-816560, Genome Release 64-1-1, Verified ORF, "Transcriptional regulator involved in glucose repression of Gal4p-regulated genes; component of transcriptional adaptor and histone acetyltransferase complexes, the ADA complex, the SAGA complex, and the SLIK complex" [2016-01-SGD_Yeast_Contam_Riffle_20140507-Ska-Hec-110-tubulin.fasta]
Organism:	Saccharomyces cerevisiae
Length:	702 amino acids
Gene Ontology:
Cellular Component:	SLIK (SAGA-like) complex [IPI] Ada2/Gcn5/Ada3 transcription activator complex [IPI] SAGA complex [IDA]
Biological Process:	chromatin modification [TAS] response to drug [IMP] histone acetylation [TAS]
Molecular Function:	transcription cofactor activity [TAS]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MPRHGRRGKL PKGEKLPKKE GGDNTPSKLL SSMLKTLDLT FERDIGMLNG KSVRSIPNKK  60
   61 TLLELQSQLD SLNEILGTIA RGDQETIEAL RKIRDSKNEK QANDEKQETS NADGQHESST 120
  121 ATEETNIIDK GVQSPPKPPP SNEISGTIEN DVESIKQAAD NMAKEEINED KDLQVHRDQP 180
  181 REKRPFDSET ENRATENENT QRPDNKKQKI DVDKMENDPT VKNPKSEFVV SQTLPRAAAA 240
  241 LGLFNEEGLE STGEDFLKKK YNVASYPTND LKDLLPGELP DMDFSHPKPT NQIQFNTFLA 300
  301 FVENFFKDLS DDNLKFLKMK YIIPDSLQFD KTYDPEVNPF IIPKLGPLYT DVWFKDENDK 360
  361 NSAYKKPSPY SNDASTILPK KSANELDDNA LESGSISCGP LLSRLLSAVL KDDNDKSELQ 420
  421 SSKIIRDGGL PRTGGEDDIQ SFRNNNNDTV DMTLSQENGP SVQTPDNDID EEASFQAKLA 480
  481 ENKGSNGGTT STLPQQIGWI TNGINLDYPT FEERLKRELK YVGIYMNLPK DENNPNSDDP 540
  541 DWVTGREDDE ISAELRELQG TLKQVTKKNQ KRKAQLIPLV ERQLAWQEYS SILEDLDKQI 600
  601 DQAYVKRIRV PKKRKKHHTA ASNNVNTGTT SQIAQQKAAN SSLKSLLDKR QRWINKIGPL 660
  661 FDKPEIMKRI PNESVFKDMD QEEDEDEADV FAQNTNKDVE LN

Protein Complex Data

	PUBLICATION	TOPOLOGY	COCOMPLEXED PROTEINS
View Details	Riffle et al. (2010) (Unpublished Data)		ADA2 GCN5 HFI1 NGG1 SGF11 SGF29 SGF73 SPT20 SPT3 SPT7 SPT8 TAF1 TAF10 TAF11 TAF12 TAF3 TAF4 TAF5 TAF6 TAF7 TAF9 TRA1 UBP8
View Details	(MIPS) Mewes HW, et al. (2004)		ADA2 GCN5 HFI1 NGG1 SGF29 SGF73 SPT20 SPT3 SPT7 SPT8 TAF10 TAF12 TAF5 TAF6 TAF9 TRA1
View Details	Krogan NJ, et al. (2006)		ADA2 AHC1 AHC2 FMP40 GCN5 HFI1 MSS4 NGG1 PDR15 RAD59 REV3 SGF11 SGF29 SGF73 SNL1 SPT20 SPT3 SPT7 SPT8 TAF1 TAF10 TAF11 TAF12 TAF13 TAF3 TAF4 TAF5 TAF6 TAF7 TAF9 UBP8 YMR007W
View Details	Gavin AC, et al. (2006)		ADA2 HFI1 NGG1 SGF29 SGF73 SPT20 SPT3 SPT7 SPT8
View Details	Gavin AC, et al. (2002)		ADA2 ADH1 CLU1 FUN19 GCN5 HEM13 HFI1 KAP114 KAP123 MED4 MES1 MNN4 MOT1 MYO1 MYO4 NGG1 NOP1 PFK2 PSK1 PTC1 PUF6 RPB2 RPN9 RPO21 RPT5 RVB2 SGF29 SGF73 SIN3 SIN4 SPT15 SPT20 SPT7 SPT8 TAF1 TAF10 TAF11 TAF12 TAF13 TAF14 TAF2 TAF3 TAF4 TAF5 TAF6 TAF7 TAF8 TAF9 TBF1 TEF4 UBP8 VAS1 VPS1
View Details	Qiu et al. (2008)		ADA2 AHC1 CHD1 GCN5 HFI1 MED1 MED2 NGG1 SGF29 SGF73 SPT20 SPT3 SPT7 SPT8 TAF10 TAF11 TAF12 TAF14 TAF3 TAF5 TAF6 TAF9 TFB5 TRA1 UBP8

Mass Spectrometry Data

The following runs contain data for this protein:

	BAIT	COMMENTS	PUBLICATION
View Run	CEP3	sample cbf3 from feb 2005	Sandall S, et all (2006)
View Run	MLP2	#32 Asynchronous Prep-No Phosphopeptide enrichment	Keck JM, et al. (2011)
View Run	MLP2	#04 Alpha Factor Prep2	Keck JM, et al. (2011)

Yeast Two-Hybrid Data

The following interactions contain this protein:

SHOWING SINGLE HITS. [ Hide Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

	BAIT	PREY	HITS	PUBLICATION
View Screen	FUN19	NGG1	1	Unpublished Fields Lab Data
View Screen	NPA3	NGG1	1	Unpublished Fields Lab Data
View Screen	YLR140W	NGG1	1	Unpublished Fields Lab Data
View Screen	NAF1	NGG1	1	Hazbun TR, et al. (2003)
View Screen	VPS5	NGG1	1	Unpublished Fields Lab Data

Microscopy / Localization Data

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	PROTEIN(S)	PUBLICATION
View Data	NGG1	Huh WK, et al. (2003)

Protein Structure Data

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[View Top Sequence Alignments] [Show Ginzu Version Information]

Domains predicted:

#		Region(s)	Method	Confidence	Match Description
1	View Details	[1..702]	deduced	N/A	No confident structure predictions are available.

Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

Philius Transmembrane Prediction:

Protein predicted to be:	GLOBULAR (No transmembrane regions or signal peptide)
Confidence of classification:	0.99

Source: Reynolds et al. (2008)

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2