Protein Overview: SHP1

General Information:
Name(s) found:	SHP1 / YBL058W [SGD]
Description(s) found: Found 25 descriptions. SHOW ALL	UBX (ubiquitin regulatory X) domain-containing protein that regulates Glc7p phosphatase activity and interacts with Cdc48p; interacts with ubiquitylated proteins in vivo and is required for degradation of a ubiquitylated model substrate [SGD]
Organism:	Saccharomyces cerevisiae
Length:	423 amino acids
Gene Ontology:
Cellular Component:	nucleus [IDA] cytoplasm [IDA]
Biological Process:	ascospore formation [IMP] proteasomal ubiquitin-dependent protein catabolic process [IMP] glycogen metabolic process [IMP] telomere maintenance [IMP]
Molecular Function:	protein phosphatase type 1 regulator activity [IMP]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MAEIPDETIQ QFMALTNVSH NIAVQYLSEF GDLNEALNSY YASQTDDQKD RREEAHWNRQ  60
   61 QEKALKQEAF STNSSNKAIN TEHVGGLCPK PGSSQGSNEY LKRKGSTSPE PTKGSSRSGS 120
  121 GNNSRFMSFS DMVRGQADDD DEDQPRNTFA GGETSGLEVT DPSDPNSLLK DLLEKARRGG 180
  181 QMGAENGFRD DEDHEMGANR FTGRGFRLGS TIDAADEVVE DNTSQSQRRP EKVTREITFW 240
  241 KEGFQVADGP LYRYDDPANS FYLSELNQGR APLKLLDVQF GQEVEVNVYK KLDESYKAPT 300
  301 RKLGGFSGQG QRLGSPIPGE SSPAEVPKNE TPAAQEQPMP DNEPKQGDTS IQIRYANGKR 360
  361 EVLHCNSTDT VKFLYEHVTS NANTDPSRNF TLNYAFPIKP ISNDETTLKD ADLLNSVVVQ 420
  421 RWA

Protein Complex Data

	PUBLICATION	TOPOLOGY	COCOMPLEXED PROTEINS
View Details	Riffle et al. (2010) (Unpublished Data)		CDC48 NPL4 SHP1
View Details	Krogan NJ, et al. (2006)		BFA1 CDC48 DOA1 FBP1 MRM1 NDT80 NPL4 OTU1 RDS2 SHP1 TEM1 TUP1 UBX4 UBX5 UBX7 UFD1 UFD2 YDR049W YGL108C YJR098C YNL155W YOR342C
View Details	Gavin AC, et al. (2006)		CDC48 NPL4 SHP1 UFD1 YDR049W
View Details	Gavin AC, et al. (2002)		BNI1 CDC48 DOA1 MRPS28 NPL4 PDC1 RAI1 REG1 RPA135 RPA190 RPO31 SHP1 UFD1 YDR049W
View Details	Ho Y, et al. (2002)		DSK2 GND1 HHF1, HHF2 HMF1 HTB2 HTZ1 NPL4 RAD16 RAD23 RAD7 RNQ1 SHP1 TDP1 TMA29 TSA2 TSL1 UBI4 UFD2 YDR049W

Mass Spectrometry Data

The following runs contain data for this protein:

	BAIT	COMMENTS	PUBLICATION
View Run	CEP3	sample cbf3 from feb 2005	Sandall S, et all (2006)
View Run	MLP2	#26 Asynchronous Prep4-TiO2 Phosphopeptide enriched, Steps1-2	Keck JM, et al. (2011)

Yeast Two-Hybrid Data

The following interactions contain this protein:

SHOWING SINGLE HITS. [ Hide Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

	BAIT	PREY	HITS	PUBLICATION
View Screen	NUP1	SHP1	2	Unpublished Fields Lab Data
View Screen	UBC12	SHP1	1	Unpublished Fields Lab Data
View Screen	APC5	SHP1	1	Unpublished Fields Lab Data
View Screen	HTA1	SHP1	1	Unpublished Fields Lab Data
View Screen	MET18	SHP1	1	Unpublished Fields Lab Data
View Screen	YJR056C	SHP1	1	Unpublished Fields Lab Data

Microscopy / Localization Data

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	PROTEIN(S)	PUBLICATION
View Data	SHP1	Huh WK, et al. (2003)

Protein Structure Data

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[View Top Sequence Alignments] [Show Ginzu Version Information]

Domains predicted:

#		Region(s)	Method	Confidence	Match Description
1	View Details	[1..121]	deduced	N/A	No confident structure predictions are available.
2	View Details	[122..340]	MSA	1.067995	View MSA. No confident structure predictions are available.
3	View Details	[341..423]	PSI-BLAST	77.071898	p47
4	View Details	[313..423]	PSI-BLAST	34.221849	Crystal structure of AAA ATPase p97/VCP ND1 in complex with p47 C

Functions predicted (by domain):

Gene Ontology predictions

No functions predicted.

Term	Confidence	Notes
ubiquitin binding	3.08647023955532	bayes_pls_golite062009
small conjugating protein binding	2.81420954636829	bayes_pls_golite062009
binding	2.2560795328149	bayes_pls_golite062009
protein binding	1.0980671422772	bayes_pls_golite062009
nucleic acid binding	0.603841502857006	bayes_pls_golite062009
hydrolase activity	0.356947688028291	bayes_pls_golite062009
catalytic activity	0.25774924710417	bayes_pls_golite062009
DNA binding	0.227398235412559	bayes_pls_golite062009
transcription regulator activity	0.194425568150525	bayes_pls_golite062009
peptidase activity	0.0141774634963068	bayes_pls_golite062009

No functions predicted.

Term	Confidence	Notes
binding	2.63877637096497	bayes_pls_golite062009
protein binding	1.89134588490127	bayes_pls_golite062009
small conjugating protein ligase activity	1.83465130904364	bayes_pls_golite062009
ubiquitin-protein ligase activity	1.16468510691469	bayes_pls_golite062009
acid-amino acid ligase activity	0.919595189902044	bayes_pls_golite062009
nucleic acid binding	0.383121378043805	bayes_pls_golite062009
hydrolase activity	0.247201449341942	bayes_pls_golite062009
DNA binding	0.0840213088061073	bayes_pls_golite062009
transcription regulator activity	0.0485636215870291	bayes_pls_golite062009
cytoskeletal protein binding	0.00343080662821671	bayes_pls_golite062009

Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

Philius Transmembrane Prediction:

Protein predicted to be:	GLOBULAR (No transmembrane regions or signal peptide)
Confidence of classification:	0.99

Source: Reynolds et al. (2008)

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2