YRC Public Data Repository - Protein Complex GO Analysis

Complex Overview

From Publication:	Gavin A.C. et al. (2002) Abstract Functional organization of the yeast proteome by systematic analysis of protein complexes. Nature. 2002 Jan 10;415(6868):141-7.
Notes:	From the published set of protein complexes.
Complex Size:	53 proteins

Complex Member Proteins

Protein	GO Cellular Component	GO Biological Process	GO Molecular Function
ATG26	cytoplasm	sterol metabolic process	sterol 3-beta-glucosyltransferase activity
BEM2	mitochondrion intracellular	small GTPase mediated signal transduction cellular cell wall organization microtubule cytoskeleton organization budding cell bud growth actin cytoskeleton organization	Rho GTPase activator activity signal transducer activity
BUD3	cellular bud neck contractile ring cellular bud neck	axial cellular bud site selection cellular bud site selection cytokinesis	molecular_function
COP1	COPI vesicle coat	ER to Golgi vesicle-mediated transport retrograde vesicle-mediated transport, Golgi to ER	molecular_function
CYR1	mitochondrion plasma membrane	G-protein signaling, coupled to cAMP nucleotide second messenger Ras protein signal transduction age-dependent response to oxidative stress involved in chronological cell aging meiosis	adenylate cyclase activity
HRR25	nucleus plasma membrane	DNA repair nuclear division ribosomal small subunit biogenesis chromosome segregation mitosis meiosis	casein kinase activity
IMG1	mitochondrion mitochondrial large ribosomal subunit	translation	structural constituent of ribosome
IMG2	mitochondrion mitochondrial large ribosomal subunit	telomere maintenance translation	structural constituent of ribosome
IML1	fungal-type vacuole membrane	biological_process	molecular_function
MHR1	nucleus mitochondrion	mitochondrial genome maintenance	transcription regulator activity
MRH4	mitochondrion	ribosome biogenesis	RNA helicase activity
MRM1	mitochondrion	rRNA modification	rRNA (guanine-N1-)-methyltransferase activity
MRP20	mitochondrion mitochondrial large ribosomal subunit	translation	structural constituent of ribosome
MRP49	mitochondrion mitochondrial large ribosomal subunit	translation	structural constituent of ribosome
MRP7	mitochondrion mitochondrial large ribosomal subunit	translation	structural constituent of ribosome peptidyltransferase activity
MRPL1	mitochondrion mitochondrial large ribosomal subunit	aerobic respiration translation	structural constituent of ribosome
MRPL10	mitochondrion mitochondrial large ribosomal subunit	translation	structural constituent of ribosome
MRPL13	mitochondrion mitochondrial large ribosomal subunit	translation	structural constituent of ribosome
MRPL16	mitochondrion mitochondrial large ribosomal subunit	translation	structural constituent of ribosome peptidyltransferase activity
MRPL17	mitochondrion mitochondrial large ribosomal subunit	translation	structural constituent of ribosome
MRPL19	mitochondrion mitochondrial large ribosomal subunit	translation	structural constituent of ribosome
MRPL20	mitochondrion mitochondrial large ribosomal subunit	mitochondrial genome maintenance translation	structural constituent of ribosome
MRPL23	mitochondrion mitochondrial large ribosomal subunit	ribosomal large subunit assembly translation	structural constituent of ribosome
MRPL24	mitochondrion mitochondrial large ribosomal subunit	translation	structural constituent of ribosome
MRPL25	mitochondrion mitochondrial large ribosomal subunit	translation	structural constituent of ribosome
MRPL27	mitochondrion mitochondrial large ribosomal subunit	translation	structural constituent of ribosome
MRPL28	mitochondrion mitochondrial large ribosomal subunit	translation	structural constituent of ribosome
MRPL3	mitochondrion mitochondrial large ribosomal subunit	translation	structural constituent of ribosome
MRPL35	mitochondrion mitochondrial large ribosomal subunit	translation	structural constituent of ribosome
MRPL36	mitochondrion mitochondrial large ribosomal subunit	translation	structural constituent of ribosome
MRPL39	mitochondrion mitochondrial large ribosomal subunit	translation	structural constituent of ribosome
MRPL4	mitochondrion mitochondrial large ribosomal subunit	translation	structural constituent of ribosome
MRPL44	mitochondrion mitochondrial large ribosomal subunit	telomere maintenance translation	structural constituent of ribosome
MRPL51	mitochondrion mitochondrial large ribosomal subunit	aerobic respiration translation	structural constituent of ribosome
MRPL6	mitochondrion mitochondrial large ribosomal subunit	translation	structural constituent of ribosome
MRPL7	mitochondrion mitochondrial large ribosomal subunit	translation	structural constituent of ribosome
MRPL8	mitochondrion mitochondrial large ribosomal subunit	mitochondrial genome maintenance translation	structural constituent of ribosome
NUG1	nucleus nucleolus	ribosome biogenesis rRNA processing	GTPase activity
PRP43	mitochondrion spliceosomal complex nuclear outer membrane	maturation of SSU-rRNA ribosomal large subunit biogenesis ribosome biogenesis rRNA processing processing of 27S pre-rRNA	ATP-dependent RNA helicase activity
RET2	COPI vesicle coat	ER to Golgi vesicle-mediated transport retrograde vesicle-mediated transport, Golgi to ER	protein binding
ROM2	cellular bud tip	small GTPase mediated signal transduction cellular cell wall organization actin filament organization endocytosis budding cell bud growth response to stress	Rho guanyl-nucleotide exchange factor activity signal transducer activity
RTC6	mitochondrial large ribosomal subunit	translation	structural constituent of ribosome
SEC1	cellular bud tip cellular bud neck plasma membrane	vesicle fusion vesicle docking during exocytosis exocytosis	SNARE binding
SEC26	coated vesicle COPI vesicle coat	ER to Golgi vesicle-mediated transport	molecular_function
SEC27	COPI vesicle coat	ER to Golgi vesicle-mediated transport retrograde vesicle-mediated transport, Golgi to ER	molecular_function
SIN4	nucleus mediator complex	transcription from RNA polymerase II promoter	RNA polymerase II transcription mediator activity
SNF2	SWI/SNF complex chromatin remodeling complex	chromatin remodeling double-strand break repair	DNA-dependent ATPase activity general RNA polymerase II transcription factor activity
SWI3	SWI/SNF complex chromatin remodeling complex	chromatin remodeling	general RNA polymerase II transcription factor activity
SYP1	cellular bud tip cellular bud neck mating projection base	biological_process	molecular_function
TAF5	transcription factor TFIID complex SLIK (SAGA-like) complex SAGA complex	chromatin modification protein amino acid acetylation histone acetylation chromatin organization regulation of transcription involved in G1 phase of mitotic cell cycle transcription initiation from RNA polymerase II promoter	general RNA polymerase II transcription factor activity
UTP20	cytoplasm nuclear outer membrane nucleolus small nucleolar ribonucleoprotein complex	endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA) endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) ribosome biogenesis endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) rRNA processing	snoRNA binding
YDR115W	mitochondrial large ribosomal subunit	telomere maintenance aerobic respiration	structural constituent of ribosome
YML6	mitochondrion mitochondrial large ribosomal subunit	ribosomal large subunit assembly translation	structural constituent of ribosome

Cellular Component Analysis

Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

Only showing terms with a p-value less than or equal to 0.01.

GO Term	P-value	A	B	I	T
mitochondrial large ribosomal subunit	8.4559E-54	53	50	30	6292
organellar large ribosomal subunit	8.4559E-54	53	50	30	6292
mitochondrial ribosome	1.0465E-43	53	90	30	6292
organellar ribosome	1.0465E-43	53	90	30	6292
large ribosomal subunit	1.2103E-40	53	110	30	6292
mitochondrial matrix	7.2328E-34	53	176	30	6292
mitochondrial lumen	7.2328E-34	53	176	30	6292
ribosomal subunit	2.5269E-33	53	183	30	6292
ribosome	4.4488E-27	53	290	30	6292
ribonucleoprotein complex	3.8912E-22	53	514	32	6292
organelle lumen	3.986E-21	53	660	34	6292
intracellular organelle lumen	3.986E-21	53	660	34	6292
mitochondrial part	1.1052E-20	53	475	30	6292
membrane-enclosed lumen	2.7181E-20	53	700	34	6292
mitochondrion	1.0523E-15	53	1125	36	6292
non-membrane-bounded organelle	6.2276E-15	53	959	33	6292
intracellular non-membrane-bounded organelle	6.2276E-15	53	959	33	6292
macromolecular complex	5.5456E-14	53	1635	40	6292
intracellular organelle part	2.3378E-11	53	2282	43	6292
organelle part	2.3378E-11	53	2282	43	6292
cytoplasmic part	3.4033E-9	53	2482	42	6292
COPI coated vesicle membrane	5.4812E-7	53	9	4	6292
COPI vesicle coat	5.4812E-7	53	9	4	6292
membrane-bounded organelle	6.7819E-7	53	3771	48	6292
intracellular membrane-bounded organelle	6.7819E-7	53	3771	48	6292
intracellular organelle	2.6373E-6	53	4070	49	6292
organelle	2.6649E-6	53	4071	49	6292
Golgi-associated vesicle membrane	7.5785E-6	53	16	4	6292
COPI-coated vesicle	2.4156E-5	53	21	4	6292
cytoplasm	3.6961E-5	53	3552	44	6292
vesicle coat	1.726E-4	53	34	4	6292
coated vesicle membrane	1.9367E-4	53	35	4	6292
cytoplasmic vesicle membrane	1.9367E-4	53	35	4	6292
vesicle membrane	1.9367E-4	53	35	4	6292
membrane coat	2.6797E-4	53	38	4	6292
coated membrane	2.6797E-4	53	38	4	6292
cell part	2.8341E-4	53	5397	53	6292
cell	2.8905E-4	53	5399	53	6292
cytoplasmic vesicle part	2.9674E-4	53	39	4	6292
Golgi-associated vesicle	3.2767E-4	53	40	4	6292
Golgi membrane	7.1831E-4	53	49	4	6292
intracellular part	1.54E-3	53	4938	50	6292
intracellular	2.0787E-3	53	4975	50	6292
coated vesicle	5.0463E-3	53	83	4	6292
SWI/SNF-type complex	5.1174E-3	53	13	2	6292
SWI/SNF complex	5.1174E-3	53	13	2	6292

Biological Process Analysis

Only showing terms with a p-value less than or equal to 0.01.

GO Term	P-value	A	B	I	T
translation	2.3972E-22	53	376	29	6292
gene expression	6.2252E-13	53	1283	35	6292
cellular protein metabolic process	7.2045E-11	53	1074	30	6292
cellular macromolecule biosynthetic process	1.549E-10	53	1187	31	6292
macromolecule biosynthetic process	1.6197E-10	53	1189	31	6292
protein metabolic process	3.0501E-10	53	1136	30	6292
cellular macromolecule metabolic process	1.559E-7	53	2285	38	6292
cellular biosynthetic process	1.8432E-7	53	1567	31	6292
biosynthetic process	3.1497E-7	53	1602	31	6292
macromolecule metabolic process	3.5683E-7	53	2349	38	6292
cellular process	1.5218E-5	53	4426	50	6292
primary metabolic process	4.0428E-5	53	2896	39	6292
metabolic process	4.1805E-4	53	3157	39	6292
cellular metabolic process	4.2469E-4	53	3033	38	6292
retrograde vesicle-mediated transport, Golgi to ER	1.2797E-3	53	26	3	6292
mitochondrial genome maintenance	2.8087E-3	53	34	3	6292
ER to Golgi vesicle-mediated transport	5.0463E-3	53	83	4	6292
ribosome biogenesis	7.7857E-3	53	346	8	6292

Molecular Function Analysis

Only showing terms with a p-value less than or equal to 0.01.

GO Term	P-value	A	B	I	T
structural constituent of ribosome	2.6933E-31	53	212	30	6292
structural molecule activity	5.0543E-25	53	339	30	6292
peptidyltransferase activity	2.0775E-4	53	3	2	6292
transferase activity, transferring amino-acyl groups	6.8504E-4	53	5	2	6292
general RNA polymerase II transcription factor activity	1.9626E-3	53	64	4	6292
phosphorus-oxygen lyase activity	8.4234E-3	53	1	1	6292
rRNA (guanine-N1-)-methyltransferase activity	8.4234E-3	53	1	1	6292
sterol 3-beta-glucosyltransferase activity	8.4234E-3	53	1	1	6292
casein kinase activity	8.4234E-3	53	1	1	6292
adenylate cyclase activity	8.4234E-3	53	1	1	6292

View Protein Complex Details

Complex Overview

Complex Member Proteins

Cellular Component Analysis

Biological Process Analysis

Molecular Function Analysis