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View Protein Complex Details

Complex Overview

From Publication: Gavin A.C. et al. (2002) Abstract Functional organization of the yeast proteome by systematic analysis of protein complexes. Nature. 2002 Jan 10;415(6868):141-7.
Notes: From the published set of protein complexes.
Complex Size: 20 proteins

Complex Member Proteins

Protein

 GO Cellular Component GO Biological Process GO Molecular Function
BMH1
  • nucleus
    		•
  • ascospore formation
  • DNA damage checkpoint
  • glycogen metabolic process
  • pseudohyphal growth
  • Ras protein signal transduction
  • signal transduction during filamentous growth
  • negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
    		•
  • DNA binding
  • protein binding
    		•
    BMH2
  • nucleus
    		•
  • ascospore formation
  • DNA damage checkpoint
  • glycogen metabolic process
  • pseudohyphal growth
  • Ras protein signal transduction
  • signal transduction during filamentous growth
  • negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
    		•
  • DNA binding
  • protein binding
    		•
    CLU1
  • cytoplasm
  • eukaryotic translation initiation factor 3 complex
    		•
  • translational initiation
  • mitochondrion organization
    		•
  • molecular_function
    		•
    CRM1
  • nucleus
    		•
  • mRNA export from nucleus
  • ribosomal large subunit export from nucleus
  • protein export from nucleus
    		•
  • protein transmembrane transporter activity
    		•
    ECM29
  • nucleus
  • cytoplasm
  • proteasome complex
    		•
  • protein catabolic process
    		•
  • protein binding
    		•
    FKS1
  • mitochondrion
  • 1,3-beta-glucan synthase complex
  • actin cortical patch
  • actin cap
    		•
  • 1,3-beta-glucan biosynthetic process
  • regulation of cell size
  • cellular cell wall organization
  • endocytosis
    		•
  • 1,3-beta-glucan synthase activity
    		•
    GCN1
  • mitochondrion
  • cytosol
    		•
  • regulation of translational elongation
    		•
  • molecular_function
    		•
    GEA2
  • Golgi cis cisterna
  • Golgi-associated vesicle
    		•
  • ER to Golgi vesicle-mediated transport
  • retrograde vesicle-mediated transport, Golgi to ER
  • intra-Golgi vesicle-mediated transport
  • actin cytoskeleton organization
    		•
  • ARF guanyl-nucleotide exchange factor activity
    		•
    GFA1
  • cellular_component
    		•
  • cell wall chitin biosynthetic process
    		•
  • glutamine-fructose-6-phosphate transaminase (isomerizing) activity
    		•
    HRP1
  • nucleus
  • cytoplasm
  • mRNA cleavage factor complex
    		•
  • mRNA polyadenylation
  • mRNA cleavage
    		•
  • RNA binding
    		•
    KAP104
  • cytosol
    		•
  • mRNA-binding (hnRNP) protein import into nucleus
  • protein import into nucleus
  • cell cycle
    		•
  • nuclear localization sequence binding
    		•
    KAP123
  • nucleus
  • cytoplasm
  • nuclear pore
    		•
  • protein import into nucleus
    		•
  • protein transmembrane transporter activity
    		•
    LCB1
  • membrane fraction
  • microsome
  • serine C-palmitoyltransferase complex
    		•
  • sphingolipid biosynthetic process
    		•
  • serine C-palmitoyltransferase activity
    		•
    LCB2
  • membrane fraction
  • microsome
  • serine C-palmitoyltransferase complex
    		•
  • sphingolipid biosynthetic process
    		•
  • serine C-palmitoyltransferase activity
    		•
    LYS12
  • mitochondrion
    		•
  • lysine biosynthetic process
    		•
  • homoisocitrate dehydrogenase activity
    		•
    MIR1
  • mitochondrion
  • mitochondrial envelope
    		•
  • phosphate transport
    		•
  • inorganic phosphate transmembrane transporter activity
    		•
    NAB2
  • nucleus
  • cytoplasm
    		•
  • mRNA polyadenylation
  • poly(A)+ mRNA export from nucleus
    		•
  • poly(A) RNA binding
    		•
    SAM1
  • cytoplasm
    		•
  • methionine metabolic process
    		•
  • methionine adenosyltransferase activity
    		•
    SAM2
  • cellular_component
    		•
  • methionine metabolic process
    		•
  • methionine adenosyltransferase activity
    		•
    YHR020W
  • ribosome
    		•
  • tRNA aminoacylation for protein translation
    		•
  • proline-tRNA ligase activity
    		•

    Cellular Component Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    		 P-value

    		 A

    		 B

    		 I

    		 T
    serine C-palmitoyltransferase complex 9.6001E-6 20 2 2 6292
    palmitoyltransferase complex 5.7381E-5 20 4 2 6292
    microsome 1.7624E-3 20 20 2 6292
    vesicular fraction 1.7624E-3 20 20 2 6292
    1,3-beta-glucan synthase complex 9.5071E-3 20 3 1 6292

    Biological Process Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    		 P-value

    		 A

    		 B

    		 I

    		 T
    cellular polysaccharide metabolic process 2.2825E-5 20 55 4 6292
    negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle 2.8745E-5 20 3 2 6292
    negative regulation of protein ubiquitination 2.8745E-5 20 3 2 6292
    negative regulation of ubiquitin-protein ligase activity 2.8745E-5 20 3 2 6292
    negative regulation of ligase activity 2.8745E-5 20 3 2 6292
    polysaccharide metabolic process 3.2303E-5 20 60 4 6292
    negative regulation of protein modification process 5.7381E-5 20 4 2 6292
    regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle 9.5453E-5 20 5 2 6292
    regulation of ubiquitin-protein ligase activity 1.4291E-4 20 6 2 6292
    regulation of protein ubiquitination 1.4291E-4 20 6 2 6292
    regulation of ligase activity 1.4291E-4 20 6 2 6292
    regulation of protein modification process 1.9969E-4 20 7 2 6292
    signal transduction during filamentous growth 2.6574E-4 20 8 2 6292
    cellular glucan metabolic process 3.1261E-4 20 43 3 6292
    glucan metabolic process 3.1261E-4 20 43 3 6292
    negative regulation of molecular function 3.4102E-4 20 9 2 6292
    negative regulation of catalytic activity 3.4102E-4 20 9 2 6292
    aspartate family amino acid metabolic process 3.5799E-4 20 45 3 6292
    nuclear transport 6.5205E-4 20 130 4 6292
    nucleocytoplasmic transport 6.5205E-4 20 130 4 6292
    amine metabolic process 7.9368E-4 20 243 5 6292
    DNA damage checkpoint 8.5383E-4 20 14 2 6292
    DNA damage response, signal transduction 8.5383E-4 20 14 2 6292
    negative regulation of cellular protein metabolic process 9.8331E-4 20 15 2 6292
    negative regulation of protein metabolic process 1.1216E-3 20 16 2 6292
    regulation of cellular protein metabolic process 1.2067E-3 20 68 3 6292
    regulation of protein metabolic process 1.542E-3 20 74 3 6292
    sphingolipid biosynthetic process 1.5892E-3 20 19 2 6292
    membrane lipid biosynthetic process 1.5892E-3 20 19 2 6292
    mRNA polyadenylation 1.5892E-3 20 19 2 6292
    DNA integrity checkpoint 1.7624E-3 20 20 2 6292
    methionine metabolic process 2.5408E-3 20 24 2 6292
    RNA polyadenylation 2.9805E-3 20 26 2 6292
    cellular amino acid metabolic process 3.1586E-3 20 199 4 6292
    membrane lipid metabolic process 3.959E-3 20 30 2 6292
    sphingolipid metabolic process 3.959E-3 20 30 2 6292
    mRNA 3'-end processing 4.2239E-3 20 31 2 6292
    glycogen metabolic process 4.497E-3 20 32 2 6292
    cellular polysaccharide biosynthetic process 4.497E-3 20 32 2 6292
    energy reserve metabolic process 4.497E-3 20 32 2 6292
    cellular amine metabolic process 4.6811E-3 20 222 4 6292
    regulation of cell size 4.8951E-3 20 111 3 6292
    sulfur amino acid metabolic process 5.067E-3 20 34 2 6292
    regulation of cellular component size 5.2745E-3 20 114 3 6292
    regulation of anatomical structure size 5.2745E-3 20 114 3 6292
    polysaccharide biosynthetic process 5.3639E-3 20 35 2 6292
    cellular amino acid and derivative metabolic process 6.451E-3 20 243 4 6292
    Ras protein signal transduction 7.3084E-3 20 41 2 6292
    RNA 3'-end processing 7.6592E-3 20 42 2 6292
    primary metabolic process 8.2283E-3 20 2896 15 6292
    regulation of catalytic activity 8.3834E-3 20 44 2 6292
    regulation of molecular function 8.3834E-3 20 44 2 6292
    cellular carbohydrate metabolic process 8.3987E-3 20 262 4 6292
    protein localization in nucleus 9.9207E-3 20 48 2 6292
    protein import into nucleus 9.9207E-3 20 48 2 6292
    nuclear import 9.9207E-3 20 48 2 6292

    Molecular Function Analysis

    Given the number of proteins in the complex (A), total proteins annotated with a given GO term (B), and the total number of annotated proteins (T); the p-value represents the chances of randomly having the number of proteins in the complex annotated with a specific GO term (I).

    Only showing terms with a p-value less than or equal to 0.01.

    GO Term

    		 P-value

    		 A

    		 B

    		 I

    		 T
    C-palmitoyltransferase activity 9.6001E-6 20 2 2 6292
    methionine adenosyltransferase activity 9.6001E-6 20 2 2 6292
    serine C-palmitoyltransferase activity 9.6001E-6 20 2 2 6292
    C-acyltransferase activity 5.7381E-5 20 4 2 6292
    macromolecule transmembrane transporter activity 3.4102E-4 20 9 2 6292
    protein transmembrane transporter activity 3.4102E-4 20 9 2 6292
    palmitoyltransferase activity 5.1901E-4 20 11 2 6292
    homoisocitrate dehydrogenase activity 3.1786E-3 20 1 1 6292
    glutamine-fructose-6-phosphate transaminase (isomerizing) activity 3.1786E-3 20 1 1 6292
    proline-tRNA ligase activity 6.3477E-3 20 2 1 6292
    transferase activity, transferring alkyl or aryl (other than methyl) groups 6.6294E-3 20 39 2 6292
    1,3-beta-glucan synthase activity 9.5071E-3 20 3 1 6292
    nuclear localization sequence binding 9.5071E-3 20 3 1 6292
    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle