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Any process that modulates the activity of an enzyme. Any process that stops or reduces the rate of ligase activity, the catalysis of the ligation of two substances with concomitant breaking of a diphosphate linkage, usually in a nucleoside triphosphate. Any process that modulates the frequency, rate or extent of ligase activity, the catalysis of the ligation of two substances with concomitant breaking of a diphosphate linkage, usually in a nucleoside triphosphate. Ligase is the systematic name for any enzyme of EC class 6. Any process that stops or reduces the activity of the enzyme glutamate-cysteine ligase. Any process that stops, prevents or reduces the frequency, rate or extent of ubiquitin ligase activity, the catalysis of the reaction: ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine. Any process that stops or reduces the rate or extent of a molecular function, an elemental biological activity occurring at the molecular level, such as catalysis or binding. Any process that stops or reduces the activity of an enzyme.

View Gene Ontology (GO) Term

GO TERM SUMMARY
Name: negative regulation of ligase activity
Acc: GO:0051352
Aspect: Biological Process
Desc: Any process that stops or reduces the rate of ligase activity, the catalysis of the ligation of two substances with concomitant breaking of a diphosphate linkage, usually in a nucleoside triphosphate.
Synonyms:
  • down regulation of ligase activity
  • down-regulation of ligase activity
  • downregulation of ligase activity
  • inhibition of ligase activity
  • ligase inhibitor
Proteins in PDR annotated with:
   This term: 0
   Term or descendants: 88 [Search]


[geneontology.org]
INTERACTIVE GO GRAPH

GO:0051352 - negative regulation of ligase activity (interactive image map)
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